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Living Chinese Herbal Scaffolds from Microfluidic Bioprinting for Wound Healing

Research 2024年第1期2023卷 107-118页

作者： Xiaocheng Wang Jinxuan jia Mengying niu Wenzhao Li Yuanjin Zhao Department of Rheumatology and Immunology Nanjing Drum Tower HospitalSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China Chemistry and Biomedicine Innovation Center Nanjing UniversityNanjing 210023China

Biological scaffolds have been widely employed in wound healing applications,while their practical efficiency is compromised by insufficient oxygen delivery to the 3-dimensional constructs and inadequate nutrient supply for the long-term healing process.Here,we present an innovative living Chinese herbal scaffold to provide a sustainable oxygen and nutrient supply for promoting wound healing.Through a facile microfluidic bioprinting strategy,a traditional Chinese herbal medicine(Panax notoginseng saponins[PNS])and a living autotrophic microorganism(microalgae Chlorella pyrenoidosa[MA])were successfully encapsulated into the scaffolds.The encapsulated PNS could be gradually released from the scaffolds,which promoted cell adhesion,proliferation,migration,and tube formation in vitro.In addition,benefiting from the photosynthetic oxygenation of the alive MA,the obtained scaffolds would produce sustainable oxygen under light illumination,exerting a protective effect against hypoxia-induced cell death.Based on these features,we have demonstrated through in vivo experiments that these living Chinese herbal scaffolds could efficiently alleviate local hypoxia,enhance angiogenesis,and thereby accelerate wound closure in diabetic mice,indicating their great potential in wound healing and other tissue repair applications.

关键词： healing wound protective

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mutual Information Maximization via Joint Power Allocation in Integrated Sensing and Communications System

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China Communications 2024年第2期21卷 129-142页

作者： jia Zhu Junsheng mu Yuanhao Cui Xiaojun Jing School of Information and Communication Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China

In this paper, we focus on the power allocation of Integrated Sensing and Communication(ISAC) with orthogonal frequency division multiplexing(OFDM) waveform. In order to improve the spectrum utilization efficiency in ISAC, we propose a design scheme based on spectrum sharing, that is,to maximize the mutual information(MI) of radar sensing while ensuring certain communication rate and transmission power constraints. In the proposed scheme, three cases are considered for the scattering off the target due to the communication signals,as negligible signal, beneficial signal, and interference signal to radar sensing, respectively, thus requiring three power allocation schemes. However,the corresponding power allocation schemes are nonconvex and their closed-form solutions are unavailable as a consequence. Motivated by this, alternating optimization(AO), sequence convex programming(SCP) and Lagrange multiplier are individually combined for three suboptimal solutions corresponding with three power allocation schemes. By combining the three algorithms, we transform the non-convex problem which is difficult to deal with into a convex problem which is easy to solve and obtain the suboptimal solution of the corresponding optimization problem. Numerical results show that, compared with the allocation results of the existing algorithms, the proposed joint design algorithm significantly improves the radar performance.

关键词： coexistence communications multicarrier radar mutual information spectrum sharing

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Energy Efficiency Maximization in Mobile Edge Computing Networks via IRS assisted UAV Communications

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1865-1884页

作者： Ying Zhang Weiming niu Supu Xiu Guangchen mu School of Electronic Information Engineering Henan Institute of TechnologyXinxiang453003China Houde College Henan Institute of TechnologyXinxiang453003China Department of Science Henan Institute of TechnologyXinxiang453003China

In this paper,we investigate the energy efficiency maximization for mobile edge computing(MEC)in intelligent reflecting surface(IRS)assisted unmanned aerial vehicle(UAV)communications.In particular,UAVcan collect the computing tasks of the terrestrial users and transmit the results back to them after computing.We jointly optimize the users’transmitted beamforming and uploading ratios,the phase shift matrix of IRS,and the UAV trajectory to improve the energy efficiency.The formulated optimization problem is highly non-convex and difficult to be solved directly.Therefore,we decompose the original problem into three sub-problems.We first propose the successive convex approximation(SCA)based method to design the beamforming of the users and the phase shift matrix of IRS,and apply the Lagrange dual method to obtain a closed-form expression of the uploading ratios.For the trajectory optimization,we propose a block coordinate descent(BCD)based method to obtain a local optimal solution.Finally,we propose the alternating optimization(AO)based overall algorithmand analyzed its complexity to be equivalent or lower than existing algorithms.Simulation results show the superiority of the proposedmethod compared with existing schemes in energy efficiency.

关键词： Mobile edge computing(MEC) unmanned aerial vehicle(UAV) intelligent reflecting surface(IRS) energy efficiency

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Identification of novel genes associated with atherosclerosis in Bama miniature pig

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Animal Models and Experimental Medicine 2024年第3期7卷 377-387页

作者： Dengfeng Ding Yuqiong Zhao Yunxiao jia Miaomiao niu Xuezhuang Li Xinou Zheng Hua Chen Laboratory Animal Center Chinese PLA General HospitalBeijingChina

Background:Atherosclerosis is a chronic cardiovascular disease of great concern.However,it is difficult to establish a direct connection between conventional small animal models and clinical practice.The pig's genome,physiology,and anatomy reflect human biology better than other laboratory animals,which is crucial for studying the pathogenesis of atherosclerosis.Methods:We used whole-genome sequencing data from nine Bama minipigs to perform a genome-wide linkage analysis,and further used bioinformatic tools to filter and identify underlying candidate genes.Candidate gene function prediction was performed using the online prediction tool STRING 12.0.Immunohistochemistry and immunofluorescence were used to detect the expression of proteins encoded by candidate genes.Results:We mapped differential single nucleotide polymorphisms(SNPs)to genes and obtained a total of 102 differential genes,then we used GO and KEGG pathway enrichment analysis to identify four candidate genes,including SLA-1,SLA-2,SLA-3,and TAP2.nsSNPs cause changes in the primary and tertiary structures of SLA-I and TAP2 proteins,the primary structures of these two proteins have undergone amino acid changes,and the tertiary structures also show slight changes.In addition,immunohistochemistry and immunofluorescence results showed that the expression changes of TAP2 protein in coronary arteries showed a trend of increasing from the middle layer to the inner layer.Conclusions:We have identified SLA-I and TAP2 as potential susceptibility genes of atherosclerosis,highlighting the importance of antigen processing and immune response in atherogenesis.

关键词： atherosclerosis candidate genes genome-wide linkage analysis major histocompatibility complex whole genome sequencing

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Engineering molecular regulation for SiO_(x) with long-term stable cycle and high Coulombic efficiency as lithium-ion battery anodes

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Rare Metals 2024年第2期43卷 588-598页

作者： Fei Wang Han Gao Zhao-Yu niu Yao-Peng Zheng Ming-Yan Chuai jia-Nan Xu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China University of Science and Technology of China Hefei230026China

In the current situation where the practical application of silicon anode materials encounters great challenges,silicon oxide(SiO_(x),0≤x≤2)has attracted the attention of researchers due to its relatively small volume expansion,stable cycling performance,and low cost,which is possible to realize commercial applications earlier than silicon anode.However,it remains a challenge to prepare SiO_(x)materials with long-term stable cycling performance and high Coulombic efficiency using low-cost methods.In this work,SiO_(x)anode material with high Coulombic efficiency and good long-term cycling stability was prepared at a low cost by hydrolysis of siloxane and in situ polymerization of phenolic resin.The hydrolysis of siloxane was further regulated by different silane coupling agents to regulate the size and microstructure of prepared SiO_(x)materials,which displayed the substantially improved electrochemical performance.The excellent electrochemical performance of SiO_(x)prepared by regulated hydrolysis of siloxane with silane coupling agents is attributed to the effect of silane coupling agent on size and microstructure of SiO_(x),revealing that the strategy of modulating the hydrolysis of siloxane by silane coupling agent is a potential method to prepare high-performance SiO_(x)materials.

关键词： Hydrolysis Silane coupling agent Long cycle SiO_(x) anode Lithium-ion battery(LIB)

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The effect of Ti and Zr content on the structure,mechanics and energy-release characteristics of Ti—Zr—Ta alloys

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Defence Technology（防务技术） 2024年第1期31卷 343-350页

作者： jia-yu Meng Jing-zhi He Bin Zhang Jin Chen Shun Li Dun niu Yu Tang Xi’an Modern Chemistry Research Institute Xi'an710065China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha410073China

Energetic structural materials(ESMs)are a new type of structural materials with bearing and damage characteristics.In this work the microstructure,mechanical properties and energy release characteristics of multi-element Ti-Zr-Ta alloys with good casting performance were studied.The microstructure of the Ti_(x)ZrTa alloys gradually change from BCC+HCP to single BCC structure with the increase of Ti.While the Ti_(2)Zr_(y)Ta alloys was still uniform and single BCC structure with the increase of Zr.The evolution of microstructure and composition then greatly affect the mechanical properties and energy-release characteristics of Ti-Zr-Ta alloys.The synergistic effect of dual phase structure increases the fracture strain of Ti_(x)ZrTa(x=0.2,0.5)with the Ti content decreases,while the fracture strain of Ti_(x)ZrTa(x=2.0,3.0,4.0)gradually increase with the Ti content increases caused by the annihilation of the obstacles for dislocation movement.And as Zr content increases,the fracture strain of Ti_(2)Zr_(y)Ta alloys decrease,then the oxidation reaction rate and fragmentation degree gradually increase.The higher oxidation rate and the lager exposed oxidation area jointly leads the higher releasing energy efficiency of Ti_(x)ZrTa alloys with low Ti content and Ti_(2)Zr_(y)Ta alloys with high Zr content.

关键词： Energetic structural materials Ti-Zr-Ta multi-element alloy Energy release characteristics

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Treatment of hemolymphangioma by robotic surgery: A case report

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 596-600页

作者： Tian-Ning Li Yan-Hong Liu jia Zhao Hong mu Lei Cao Department of Clinical Lab Tianjin First Central HospitalTianjin 300000China Nankai University Tianjin Union Medical CenterTianjin 300000China Tianjin Medical University Tianjin First Center HospitalTianjin 300000China

BACKGROUND Hemolymphangioma of the jejunum is rare and lacks clinical specificity,and can manifest as gastrointestinal bleeding,abdominal pain,and intestinal obstruction.Computed tomography,magnetic resonance imaging,and other examinations show certain characteristics of the disease,but lack accuracy.Although capsule endoscopy and enteroscopy make up for this deficiency,the diagnosis also still re-quires pathology.CASE SUMMARY A male patient was admitted to the hospital due to abdominal distension and abdominal pain,but a specific diagnosis by computed tomography examination was not obtained.Partial resection of the small intestine was performed by robotic surgery,and postoperative pathological biopsy confirmed the diagnosis of hemo-lymphangioma.No recurrence in the follow-up examination was observed.CONCLUSION Robotic surgery is an effective way to treat hemolymphangioma through minima-lly invasive techniques under the concept of rapid rehabilitation.

关键词： Hemolymphangioma Enteroscopy Robotic surgery Rehabilitation Case report

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Recent advances in electrocatalytic generation of indole-derived radical cations and their applications in organic synthesis

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Chinese Chemical Letters 2024年第4期35卷 106-123页

作者： Wei Zhou Xi Chen Lin Lu Xian-Rong Song mu-jia Luo Qiang Xiao Key Laboratory of Organic Chemistry of jiangxi Province Jiangxi Science&Technology Normal UniversityNanchang 330013China

Indole-derived radical cations, open-shell reactive species, display distinctive dual reactivity due to the carbon-centered radical and more electrophilic carbocation, which frequently appear in a variety of single electron oxidation reactions for synthesizing structurally diverse functionalized indoles and indolines. Electrocatalysis is considered as a synthetically attractive and environmentally friendly alternative for driving the single electron oxidation of indoles. Remarkable achievements in electrocatalytic indolederived radical cation-mediated indole functionalization have been realized so far. This review comprehensively summarizes the recent progresses in the applications of electrocatalytic indole radical cations,including C(sp~2)–H functionalization, dearomative 2,3-difunctionalization, and ring-opening reaction, emphasizing the vital single electron oxidation steps of indoles, the substrates scope and limitations, and the reaction mechanisms.

关键词： Electrocatalysis Indole radical cation C-H functionalizatin Dearomative 2 3-difunctionalization

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multi-scale persistent spatiotemporal transformer for long-term urban traffic flow prediction

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Journal of Electronic Science and Technology 2024年第1期22卷 53-69页

作者： jia-Jun Zhong Yong Ma Xin-Zheng niu Philippe Fournier-Viger Bing Wang Zu-kuan Wei School of Computer Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China College of Computer Science&Software Engineering Shenzhen UniversityShenzhen518060China School of Computer Science Southwest Petroleum UniversityChengdu610500China

Long-term urban traffic flow prediction is an important task in the field of intelligent transportation,as it can help optimize traffic management and improve travel efficiency.To improve prediction accuracy,a crucial issue is how to model spatiotemporal dependency in urban traffic data.In recent years,many studies have adopted spatiotemporal neural networks to extract key information from traffic data.However,most models ignore the semantic spatial similarity between long-distance areas when mining spatial dependency.They also ignore the impact of predicted time steps on the next unpredicted time step for making long-term predictions.Moreover,these models lack a comprehensive data embedding process to represent complex spatiotemporal dependency.This paper proposes a multi-scale persistent spatiotemporal transformer(MSPSTT)model to perform accurate long-term traffic flow prediction in cities.MSPSTT adopts an encoder-decoder structure and incorporates temporal,periodic,and spatial features to fully embed urban traffic data to address these issues.The model consists of a spatiotemporal encoder and a spatiotemporal decoder,which rely on temporal,geospatial,and semantic space multi-head attention modules to dynamically extract temporal,geospatial,and semantic characteristics.The spatiotemporal decoder combines the context information provided by the encoder,integrates the predicted time step information,and is iteratively updated to learn the correlation between different time steps in the broader time range to improve the model’s accuracy for long-term prediction.Experiments on four public transportation datasets demonstrate that MSPSTT outperforms the existing models by up to 9.5%on three common metrics.

关键词： Graph neural network multi-head attention mechanism Spatio-temporal dependency Traffic flow prediction

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Transplantation of human placental chorionic plate-derived mesenchymal stem cells for repair of neurological damage in neonatal hypoxic-ischemic encephalopathy

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Neural Regeneration Research 2024年第9期19卷 2027-2035页

作者： Lulu Xue Ruolan Du Ning Bi Qiuxia Xiao Yifei Sun Ruize niu Yaxin Tan Li Chen jia Liu Tinghua Wang Liulin Xiong Transformation Research Laboratory The Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina State Key Laboratory of Biotherapy Sichuan UniversityChengduSichuan ProvinceChina Institute of Neurological Disease Translational Neuroscience CenterWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Animal Zoology Institute of NeuroscienceKunming Medical UniversityKunmingYunnan ProvinceChina Department of Anesthesiology The Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina Department of Pediatrics the People’s Liberation Army Rocket Force Characteristic Medical CenterBeijingChina

Neonatal hypoxic-ischemic encephalopathy is often associated with permanent cerebral palsy,neurosensory impairments,and cognitive deficits,and there is no effective treatment for complications related to hypoxic-ischemic encephalopathy.The therapeutic potential of human placental chorionic plate-derived mesenchymal stem cells for various diseases has been explored.However,the potential use of human placental chorionic plate-derived mesenchymal stem cells for the treatment of neonatal hypoxic-ischemic encephalopathy has not yet been investigated.In this study,we injected human placental chorionic plate-derived mesenchymal stem cells into the lateral ventricle of a neonatal hypoxic-ischemic encephalopathy rat model and observed significant improvements in both cognitive and motor function.Protein chip analysis showed that interleukin-3 expression was significantly elevated in neonatal hypoxic-ischemic encephalopathy model rats.Following transplantation of human placental chorionic plate-derived mesenchymal stem cells,interleukin-3 expression was downregulated.To further investigate the role of interleukin-3 in neonatal hypoxic-ischemic encephalopathy,we established an in vitro SH-SY5Y cell model of hypoxic-ischemic injury through oxygen-glucose deprivation and silenced interleukin-3 expression using small interfering RNA.We found that the activity and proliferation of SH-SY5Y cells subjected to oxygen-glucose deprivation were further suppressed by interleukin-3 knockdown.Furthermore,interleukin-3 knockout exacerbated neuronal damage and cognitive and motor function impairment in rat models of hypoxic-ischemic encephalopathy.The findings suggest that transplantation of hpcMSCs ameliorated behavioral impairments in a rat model of hypoxic-ischemic encephalopathy,and this effect was mediated by interleukin-3-dependent neurological function.

关键词： behavioral evaluations gene knockout human neuroblastoma cells(SH-SY5Y) human placental chorionic derived mesenchymal stem cells interleukin-3 neonatal hypoxic-ischemic encephalopathy nerve injury oxygen-glucose deprivation protein chip small interfering RNA

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