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Rta2p is required for the calcineurin-mediated resistance to fulconazole and the localization of proteins to lipid rafts in Candida albicans

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Rta2p is required for the calcineurin-mediated resistance to...

Steel Surface Defect Detection Using Learnable Memory Vision Transformer

中国药理学会第十一次全国学术会议

作者： jia Xin-ming~1,wang Yu-jia~2,TANG Ren-jie~2,CAO Yong-bing~2,jiaNG Yuan-ying~2 (1.Department of Immunology,Tongji University School of Medicine,Shanghai 200092,China 2.School of Pharmacy,Second Military Medical University,Shanghai 200433,China)

Candida albicans,the major opportunistic fungi of humans,causes life-threatening infections in immuno-compromised individuals such as AIDS patients,organ transplant patients,patients receiving parenteral nutrition,and cancer patients undergoing radiation *** to limited available therapy options and the emergence of drug resistance,treating fungal infections is challenging. To improve current treatment strategies,we have identified that Rta2p significantly reduced the sensitivity of fluconazole(FLC) to *** modulated by calcium signaling and the expression of RTA2 was under the control of the calcium-activated-calcineurin via its transcriptional factor Crz1p in *** the present study,we found genetically Rta2p was responsible for the reduced effect of calcium on the sensitivity of FLC to *** in a calcineurin dependent *** impairment of FLC to the plasma membrane of *** was calcineurin-dependently attenuated by ***,Rta2p was predominantly localized in lipid rafts,but not involved in its ***2p was required for the localization of 10 proteins to lipid *** these,5 proteins(Pma1p,Gas1p homologue,Erg11p,Pmt2p and Ali1p) have been reported to be raft-associated and Erg11p is a well-known target of azoles in ***. Rta2p was not involved in ***,genetically compromising the function of Rta2p significantly increased therapeutic efficacy of FLC against *** bloodstream ***-introduction of either one RTA2 allele or the fusion of oestradiol-inducible promoter and ORF of RTA2 significantly reduced FLC efficacy against ***-expression of RTA2 induced by oestradiol in vivo also significantly reduced FLC *** therapeutic potential of the influence of Rta2p on FLC efficacy was further demonstrated by in vivo studies that FLC therapy was significantly more efficacious when the function of Crz1p and Rta2p was alternatively and genetically *** conclus

关键词： Candida albicans azole resistance calcineurin pathway RTA2 lipid rafts

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Computers, Materials & Continua 2025年第1期82卷 499-520页

作者： Syed Tasnimul Karim Ayon Farhan Md.Siraj jia Uddin Department of Computer Science and Engineering BRAC UniversityDhaka1212Bangladesh Department of AI and Big Data Endicott CollegeWoosong UniversityDaejeon34606Republic of Korea

This study investigates the application of Learnable Memory Vision Transformers(LMViT)for detecting metal surface flaws,comparing their performance with traditional CNNs,specifically ResNet18 and ResNet50,as well as other transformer-based models including Token to Token ViT,ViT withoutmemory,and Parallel *** awidely-used steel surface defect dataset,the research applies data augmentation and t-distributed stochastic neighbor embedding(t-SNE)to enhance feature extraction and *** techniques mitigated overfitting,stabilized training,and improved generalization *** LMViT model achieved a test accuracy of 97.22%,significantly outperforming ResNet18(88.89%)and ResNet50(88.90%),aswell as the Token to TokenViT(88.46%),ViT without memory(87.18),and Parallel ViT(91.03%).Furthermore,LMViT exhibited superior training and validation performance,attaining a validation accuracy of 98.2%compared to 91.0%for ResNet 18,96.0%for ResNet50,and 89.12%,87.51%,and 91.21%for Token to Token ViT,ViT without memory,and Parallel ViT,*** findings highlight the LMViT’s ability to capture long-range dependencies in images,an areawhere CNNs struggle due to their reliance on local receptive fields and hierarchical feature *** additional transformer-based models also demonstrate improved performance in capturing complex features over CNNs,with LMViT excelling particularly at detecting subtle and complex defects,which is critical for maintaining product quality and operational efficiency in industrial *** instance,the LMViT model successfully identified fine scratches and minor surface irregularities that CNNs often *** study not only demonstrates LMViT’s potential for real-world defect detection but also underscores the promise of other transformer-based architectures like Token to Token ViT,ViT without memory,and Parallel ViT in industrial scenarios where complex spatial relationships are *** research m

关键词： Learnable Memory Vision Transformer(LMViT) Convolutional Neural Networks(CNN) metal surface defect detection deep learning,computer vision image classification learnable memory gradient clipping label smoothing t-SNE visualization

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凋亡在肺炎中的作用及在治疗中的运用

国际呼吸杂志 2009年第17期29卷 1080-1082页

作者：贾明旺黄文杰广州军区广州总医院呼吸内科 510010

肺炎作为威胁人类生命的主要疾病之一，是目前临床关注的问题，而凋亡作为一个重要的病理生理事件在肺炎中的作用也被更多的学者关注。在肺炎发生时，肺部炎性细胞和上皮细胞的凋亡均对肺炎的发展和预后有着影响，而针对凋亡所进行的治... 详细信息

肺炎作为威胁人类生命的主要疾病之一，是目前临床关注的问题，而凋亡作为一个重要的病理生理事件在肺炎中的作用也被更多的学者关注。在肺炎发生时，肺部炎性细胞和上皮细胞的凋亡均对肺炎的发展和预后有着影响，而针对凋亡所进行的治疗或许能成为治疗肺炎的一个新兴方法。

关键词：肺炎凋亡治疗

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有机酸对低盐腌渍黄瓜品质影响的初步研究

食品研究与开发 2018年第16期39卷 8-11页

作者：沈文凤崔文甲王月明王文亮弓志青贾凤娟王延圣山东省农业科学院农产品研究所山东济南250100 山东省农产品精深加工技术重点实验室山东济南250100 农业部新食品资源加工重点实验室山东济南250100

探究不同有机酸对低盐腌渍黄瓜品质的影响。以黄瓜为原料,在黄瓜的腌渍液中分别加入醋酸、乳酸、柠檬酸、苹果酸4种有机酸,以水分活度、p H值、含盐量以及感官评定结果为指标,筛选适合低盐腌渍黄瓜的有机酸。结果表明:醋酸腌渍的黄瓜的... 详细信息

探究不同有机酸对低盐腌渍黄瓜品质的影响。以黄瓜为原料,在黄瓜的腌渍液中分别加入醋酸、乳酸、柠檬酸、苹果酸4种有机酸,以水分活度、p H值、含盐量以及感官评定结果为指标,筛选适合低盐腌渍黄瓜的有机酸。结果表明:醋酸腌渍的黄瓜的水分活度值较低,p H值较为稳定(p H值为5左右),对含盐量的影响较小,感官评价结果较好,所以最后选择醋酸为黄瓜低盐腌渍的有机酸。

关键词：有机酸低盐腌渍黄瓜

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Dynamic performance enhancement in Ti/Au ohmic contacts on β-Ga2O3-on-Si C substrates: evidence from pulsed measurements

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Science China(Information Sciences) 2025年第1期68卷 400-401页

作者： Chenyu LIU Yibo wang Wenhui XU Shuqi HUANG Chunxiao YU Zeyu YANG Xiaole jia Xiaoxi LI Bochang LI Zhengdong LUO Cizhe FANG Yan LIU Tiangui YOU Xin OU Genquan HAN School of Microelectronics Xidian University Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Hangzhou Institute of Technology Xidian University

Titanium/Gold （Ti/Au） metals have been widely employed as ohmic metal contacts on n+Ga2O3,exhibiting the specific contact resistance （ρc） of 10-5-10-6Ω·cm2[1].But previous studies have revealed the presence of a defective Ga2O3layer and reactive Ti-Ga2O3layer at the annealed Ti/*** an interfacial layer can afect the performance of ohmic contact,which may become more pronounced in power devices subjected to electrical stress and high-frequency ***,there have been no reports on the impact of bias stress effects and dynamic degradation of Ti/Au ohmic contacts on n+Ga2O3.

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Evaluation of the therapeutic significance of Glehniae Radix polysaccharides on the ulcerative colitis through DSS-induced rat model

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Food Science and Human Wellness 2025年

作者： Jie Liu Xufang Geng Yuxin Yang jiao Xu Haoran Feng Tianshuo Zhang Guangzhao Zhou Man wang Changshun wang Dongsheng jia Yuting Chen Bin Cong Ding Zhao The Postdoctoral Mobile Station of Basic Medicine， Hebei Medical University The Department of Pharmacognosy， School of Pharmacy， Hebei Medical University Hebei Key Laboratory of Forensic Medicine， College of Forensic Medicine， Hebei Medical University

Glehniae Radix has a wide range of pharmaceutical applications， and research on its main components has mainly focused on coumarins， alkaloids， lignans， and flavonoids， while neglecting the research on polysaccharides. Literature reports and our previous studies have shown that polysaccharides have certain therapeutic significance in immune regulation， antioxidant， anti-inflammatory and other aspects. Herein， the rat model of ulcerative colitis (UC) was established to evaluate the anti-inflammatory efficacy of the prepared Glehniae Radix polysaccharide (GLP) from the perspectives of inflammatory factors， intestinal tissue morphology， and microflora changes. The polysaccharides are mainly composed of galacturonic acid， rhamnose， glucose， galactose， and arabinose in molar ratios of 1.4:9.2:33.3:2.5:2.9， and GLP could downregulate the expression pro-inflammatory factors (interleukin-6， tumor necrosis factor-α， and interferon-γ) and significantly upregulate the expression of anti-inflammatory factor (interleukin-10). In addition， Glehniae Radix aqueous extract (GLA)， GLP with low dosage (GLPL) and GLP with high dosage (GLPH) could increase the number of goblet cells， enhance the integrity of crypt structure， and reverse the status of inflammatory infiltrating cells. Moreover， GLA and GLPH could upregulate Lactobacillus and Lachnoclostridium in UC rats， and appropriately downregulate Lachnospiraceae＿NK4A136＿group， thereby optimizing the proportion of bacterial flora and improving the intestinal microbial environment. Our findings not only be valuable as theoretical materials for the further clinical applications of GLP， but the identified biomarkers and metabolic pathways also provide new clues for the diagnosis of UC.

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu Ke wang jia-Zhu Wen Li-Kang Luo jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

Synthesis of chiral phosphine derivatives through a copper（I）-catalyzed desymmetric SNAr reaction

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Science China Chemistry 2025年

作者： Shuai Zhang Pei-Zhi Liu Yan-Bo Li Qi Zhang Jun-Zhao Xiao Yi-Fan wang Tian-Yu Wei jia-Wei jiang Ye wang Qian Peng Liang Yin Key Laboratory of Fluorine and Nitrogen Chemistry and Advanced Materials Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences State Key Laboratory of Elemento-Organic Chemistry and Tianjin Key Laboratory of Biosensing and Molecular Recognition College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Haihe Laboratory of Sustainable Chemical Transformations

Axially chiral phosphines are a class of extremely important ligands in asymmetric catalysis. Herein, an unprecedented copper（I）-catalyzed asymmetric SNAr reaction with HP（S）R2is uncovered, which delivers a series of axially chiral phosphine derivatives in high yields with excellent enantioselectivity. Furthermore, the diastereoselective reaction with the kinetic resolution of racemic HP（S）ArR proceeds smoothly, providing the products with moderate diastereoselectivity and excellent enantioselectivity. Control experiments indicate that HP（S）Ph2is much more active than HPPh2and HP（O）Ph2as the pronucleophile in the present reaction. It is found that the SNAr reaction （the first SNAr） proceeds in a desymmetric manner, providing the desired chiral products while a continued SNAr reaction （the second SNAr） slightly occurs in a kinetic resolution manner in the present catalytic system, which enhances the ee of the desired chiral products. DFTcalculations support a concerted reaction pathway rather than a step-wise mechanism. Finally, axially chiral olefin-phosphines produced by the present method work as suitable ligands in Pdcatalyzed asymmetric allylic substitution with C-, N-, and O-nucleophiles and Rh-catalyzed asymmetric addition of arylboronic acid to benzil.

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Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan Yu-ming wang Han-Zhou Li Wei-Quan Xu jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle