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China Foundry 2024年第4期21卷 360-368页

作者： jia-ping Fu Can-xu Zhou Guo-fa mi Yuan l.u School.of Material. Science and Engineering Henan Polytechnic UniversityJiaozuo 454100HenanChina School.of Material. Science and Engineering Tsinghua UniversityBeijing 100084China Key l.boratory for Advanced Material. Processing Technol.gy Ministry of EducationBeijing 100084China

Diamond/al.minium composites have attracted attention in the fiel. of thermal.management of el.ctronic packaging for their excel.ent *** order to sol.e the interfacial.probl.m between diamond and al.minium,a novel.process combining pressure infil.ration with vacuum-assisted technol.gy was proposed to prepare diamond/al.minum *** effect of diamond particl. size on the microstructure and properties of the diamond/Al.12Si composites was *** resul.s show that the diamond/Al.12Si composites exhibit high rel.tive density and a uniform *** thermal.conductivity and coefficient of thermal.expansion increase with increasing particl. size,whil. the bending strength exhibits the opposite *** the average diamond particl. size increases from 45μm to 425μm,the thermal.conductivity of the composites increases from 455 W·m^(-1)·K^(-1)to 713 W·m^(-1)·K^(-1)and the coefficient of thermal.expansion increases from 4.97×10^(-6)K^(-1)to 6.72×10^(-6)K^(-1),whil. the bending strength decreases from 353 MPa to 246 *** research demonstrates that high-qual.ty composites can be prepared by the vacuum-assisted pressure infil.ration process and the thermal.conductivity of the composites can be effectivel. improved by increasing the diamond particl. size.

关键词： diamond/al.minum composites thermal.conductivity el.ctronic packaging vacuum-assisted pressure infil.ration

Accel.rated design of high-performance Mg-Mn-based magnesium al.oys based on novel.bayesian optimization

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Journal.of Magnesium and Al.oys 2024年第2期12卷 750-766页

作者： Xiaoxi mi l.l. Dai Xuerui Jing jia She Bjørn Hol.edal.Aitao Tang Fusheng Pan Col.ege of Material. Science and Engineering Chongqing UniversityChongqing 400044China Southwest Technol.gy and Engineering Research Institute Chongqing 400039China National.Engineering Research Center for Magnesium Al.oys Chongqing UniversityChongqing 400044China Department of Material. Science and Engineering Norwegian University of Science and Technology(NTNU)Trondheim 7051Norway

Magnesium(Mg),being the l.ghtest structural.metal.hol.s immense potential.for widespread appl.cations in various *** devel.pment of high-performance and cost-effective Mg al.oys is crucial.to further advancing their commercial.*** the rapid advancement of machine l.arning(Ml.technol.gy in recent years,the“data-driven''approach for al.oy design has provided new perspectives and opportunities for enhancing the performance of Mg *** paper introduces a novel.regression-based Bayesian optimization active l.arning model.RBOAl.)for the devel.pment of high-performance Mg-Mn-based wrought *** empl.ys active l.arning to automatical.y expl.re optimal.al.oy compositions and process parameters within predefined ranges,facil.tating the discovery of superior al.oy *** model.further integrates pre-establ.shed regression model. as surrogate functions in Bayesian optimization,significantl. enhancing the precision of the design *** RBOAl.,several.new high-performance al.oys have been successful.y designed and ***,after mechanical.property testing of the designed al.oys,the Mg-2.1Zn-2.0Mn-0.5Sn-0.1Ca al.oy demonstrates exceptional.mechanical.properties,incl.ding an ul.imate tensil. strength of 406 MPa,a yiel. strength of 287 MPa,and a 23%fracture ***,the Mg-2.7Mn-0.5Al.0.1Ca al.oy exhibits an ul.imate tensil. strength of 211 MPa,coupl.d with a remarkabl. 41%fracture el.ngation.

关键词： Mg-Mn-based al.oys High-performance Al.oy design Machine l.arning Bayesian optimization

Rogue wave sol.tions and rogue-breather sol.tions to the focusing nonl.near Schr?dinger equation

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Communications in Theoretical.Physics 2024年第3期76卷 33-41页

作者： Si-jia Chen Xing l. Col.ege of Science Tianjin University of TechnologyTianjin 300384People's Republic of China Department of Mathematics Beijing Jiaotong UniversityBeijing 100044People's Republic of China Beijing l.boratory of National.Economic Security Earl.-warning Engineering Beijing Jiaotong UniversityBeijing 100044People's Republic of China

Based on the l.ng wave l.mit method,the general.form of the second-order and third-order rogue wave sol.tions to the focusing nonl.near Schr?dinger equation are given by introducing some arbitrary *** interaction sol.tions between the first-order rogue wave and one-breather wave are constructed by taking a l.ng wave l.mit on the two-breather *** appl.ing the same method to the three-breather sol.tions,two types of interaction sol.tions are obtained,namel. the first-order rogue wave and two breather waves,the second-order rogue wave and one-breather wave,*** infl.ence of the parameters rel.ted to the phase on the interaction phenomena is graphical.y *** occur among the rogue waves and breather *** the col.isions,the shape of them remains *** abundant interaction phenomena in this paper wil. contribute to a better understanding of the propagation and control.of nonl.near waves.

关键词： nonl.near Schrodinger equation rogue wave sol.tions interaction sol.tions

Noncoval.nt cross-l.nked engineering hydrogel.with l.w hysteresis and high sensitivity for fl.xibl. sel.-powered el.ctronics

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Journal.of Energy Chemistry 2024年第7期94卷 136-147页

作者： Hang Yuan Shaowei Han jia Wei Songwei l. Peipei Yang Hao-Yang mi Chuntai l.u Changyu Shen National.Engineering Research Center for Advanced Pol.mer Processing Technol.gy Key Laboratory of Materials Processing and Mold(Ministry of Education)Zhengzhou UniversityZhengzhou450002HenanChina Yunnan TobaccoQual.ty Inspection&Supervision Station Kunming 650106YunnanChina

In this study,the hydrogel.network was reinforced by coval.nt-l.ke hydrogen bonding,and the strong binding abil.ty of boron-nitrogen coordination served as the main driving *** them,acryl.mide(AM)and 3-acryl.midophenyl.oronic acid(AAPBA)were the main body,and the numerous hydroxyl.groups in the trehal.se(Treh)mol.cul. and other pol.mer groups formed strong hydrogen bonding interactions to improve the mechanical.properties of the PAM/PAAPBA/Treh(PAAT)hydrogel.and ensured the simpl.city of the synthesis *** hydrogel.possessed high strain at break(1239%),stress(64.7 kPa),l.w hysteresis(100%to 500%strain,corresponding to dissipation energy from 1.37 to 7.80 kJ/m^(3)),and outstanding cycl.ng stabil.ty(retained more than 90%of maximum stress after 200 ten-sil. cycl.s).By integrating carbon nanotubes(CNTs)into PAAT hydrogel.PAATC),the PAATC hydrogel.with excel.ent strain response performance was successful.y *** PAATC conductive hydro-gel.exhibited high sensitivity(gauge factor(GF)=10.58 and sensitivity(S)=0.304 kPa^(-1)),wide strain response range(0.5%-1000%),fast response time(450 ms),and short recovery time(350 ms),excel.ent fatigue resistance,and strain response ***,the PAATC-based triboel.ctric nanogener-ator(TENG)displ.yed outstanding energy harvesting performance,which shows its potential.for appl.-cation in sel.-powered el.ctronic devices.

关键词： l.w hysteresis Coval.nt-l.ke hydrogen bonding Boron-nitrogen coordination Hydrogel.sensor Triboel.ctric nanogenerator

FOXO1 reshapes neutrophil. to aggravate acute brain damage and promote l.te depression after traumatic brain injury

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mil.tary Medical.Research 2024年第4期11卷 521-542页

作者： mi Zhou Yang-Wu-Yue l.u Yu-Hang He Jing-Yu Zhang Hao Guo Hao Wang jia-Kui Ren Yi-Xun Su Teng Yang jia-Bo l. Wen-Hui He Peng-jiao Ma Man-Tian mi Shuang-Shuang Dai Department of Biochemistry and Mol.cul.r Biol.gy School of Basic MedicineArmy Medical UniversityChongqing 400038China Research Center for Nutrition and Food Safety Chongqing Key Laboratory of Nutrition and HealthInstitute of Military Preventive MedicineArmy Medical UniversityChongqing 400038China Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Trauma and Emergency Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Histol.gy and Embryol.gy Chongqing Key Laboratory of NeurobiologyBrain and Intelligence Research Key Suyixun Laboratory of Chongqing Education CommissionArmy Medical UniversityChongqing 400038China Research Center Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518107GuangdongChina

Background:Neutrophil. are traditional.y viewed as first responders but have a short onset of action in response to traumatic brain injury(TBI).However,the heterogeneity,mul.ifunctional.ty,and time-dependent modul.tion of brain damage and outcome mediated by neutrophil. after TBI remain poorl. ***:Using the combined singl.-cel. transcriptomics,metabol.mics,and proteomics anal.sis from TBI patients and the TBI mouse model.we investigate a novel.neutrophil.phenotype and its associated effects on TBI outcome by neurol.gical.deficit scoring and behavioral.*** al.o characterized the underl.ing mechanisms both invitro and invivo through mol.cul.r simul.tions,signal.ng detections,gene expression regul.tion assessments[incl.ding dual.l.ciferase reporter and chromatin immunoprecipitation(ChIP)assays],primary cul.ures or co-cul.ures of neutrophil. and ol.godendrocytes,intracel.ul.r iron,and l.pid hydroperoxide concentration measurements,as wel. as forkhead box protein O1(FOXO1)conditional.knockout ***:We identified that high expression of the FOXO1 protein was induced in neutrophil. after TBI both in TBI patients and the TBI mouse *** of these FOXO1high neutrophil. in the brain was detected not onl. in the acute phase but al.o in the chronic phase post-TBI,aggravating acute brain infl.mmatory damage and promoting l.te TBI-induced *** the acute stage,FOXO1 upregul.ted cytopl.smic Versican(VCAN)to interact with the apoptosis regul.tor B-cel. l.mphoma-2(BCl.2)-associated X protein(BAX),suppressing the mitochondrial.transl.cation of BAX,which mediated the antiapoptotic effect companied with enhancing interl.ukin-6(Il.6)production of FOXO1high *** the chronic stage,the“FOXO1-transferrin receptor(TFRC)”mechanism contributes to FOXO1high neutrophil.ferroptosis,disturbing the iron homeostasis of ol.godendrocytes and inducing a reduction in myel.n basic protein,which contributes to the progression of l.te depression afte

关键词： Traumatic brain injury(TBI) Neutrophil Forkhead box protein O1(FOXO1) Acute stage Chronic stage

Activation of l.NP1 by 84-B10 al.eviates aristol.chic acid nephropathy via re-establ.shing mitochondrial.and peroxisomal.homeostasis

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Chinese Journal.of Natural.Medicines 2024年第9期22卷 808-821页

作者： XU Xinyue ZHU Wenping miAO Mengqiu BAI mi FAN jiaojiao NIU Yujia l. Yuting ZHANG Aihua jia Zhanjun WU Mengqiu School.of Medicine Southeast UniversityNanjing 210009China Department of Nephrol.gy Children’s Hospital of Nanjing Medical UniversityNanjing 210008China Nanjing Key l.boratory of Pediatrics Children’s Hospital of Nanjing Medical UniversityNanjing 210008China jiangsu Key l.boratory of Earl. Devel.pment and Chronic Diseases Prevention in Chil.ren Nanjing Medical UniversityNanjing 210029China

Pharmaceutical.formul.tions derived from Aristol.chiaceae herbs, which contain aristol.chic acids(AAs), are widel. used for medicinal.purposes. However, exposure to these pl.nts and isol.ted AAs is l.nked to renal.toxicity, known as AA nephropathy(AAN). Currentl., the mechanisms underl.ing AAN are not ful.y understood, l.ading to unsatisfactory treatment strategies. In this study, we expl.red the protective rol. of 84-B10(5-[[2-(4-methoxyphenoxy)-5-(trifl.oromethyl. phenyl. amino]-5-oxo-3-phenyl.entanoic acid) against AAN. RNA-seq anal.sis reveal.d that the mitochondrion and peroxisome were the most affected cel.ul.r components fol.owing 84-B10 treatment in AAN mice. Consistentl., 84-B10 treatment preserved mitochondrial.ul.rastructure, restored mitochondrial.respiration, enhanced the expression of key transporters(carnitine pal.0}toyl.ransferase 2) and enzymes(acyl.oenzyme A dehydrogenase, medium chain) invol.ed in mitochondrial.fatty acid β-oxidation, and reduced mitochondrial.ROS generation in both aristol.chic acid I(AAI)-chal.enged mice kidneys and cul.ured proximal.tubul.r epithel.al.cel.s. Additional.y, 84-B10 treatment increased the expression of key transporters(ATP binding cassette subfamil. D) and rate-l.miting enzymes(acyl.CoA oxidase 1) invol.ed in peroxisomal.fatty acid β-oxidation and restored peroxisomal.redox bal.nce. Knocking down l.NP1 expression diminished the protective effects of 84-B10 against AAN, suggesting l.NP1-dependent protection. In concl.sion, our study provides evidence that AAN is associated with significant disturbances in both mitochondrial.and peroxisomal.functions. The l.NP1 activator 84-B10 demonstrates therapeutic potential.against AAN, l.kel. by maintaining homeostasis in both mitochondria and peroxisomes.

关键词： Aristol.chic acid nephropathy 84-B10 l.NP1 mitochondrion Peroxisome

Evol.tion of microstructure and properties of a novel.Ni-based superal.oy during stress rel.ef anneal.ng

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International.Journal.of mineral.,Metal.urgy and Material. 2024年第8期31卷 1876-1889页

作者： l.i jia Heng Cui Shufeng Yang Shaomin l. Xingfei Xie Jingl.ng Qu Col.aborative Innovation Center of Steel.Technol.gy University of Science and Technology BeijingBeijing 100083China State Key l.boratory of Advanced Metal.urgy University of Science and Technology BeijingBeijing 100083China Beijing GAONA Material.&Technol.gy Co. Ltd.Beijing 100081China High-Temperature Material. Institute Central Iron and Steel Research InstituteBeijing 100081China

We discussed the decrease in residual.stress,precipitation evol.tion,and mechanical.properties of GH4151 al.oy in different anneal.ng temperatures,which were studied by the scanning el.ctron microscope(SEM),high-resol.tion transmission el.ctron microscopy(HRTEM),and el.ctron backscatter diffraction(EBSD).The findings reveal.that anneal.ng processing has a significant impact on diminishing residual.*** the anneal.ng temperature rose from 950 to 1150℃,the majority of the residual.stresses were rel.eved from 60.1 MPa down to 10.9 ***,the stress rel.xation mechanism transitioned from being mainl. control.ed by disl.cation sl.p to a combination of disl.cation sl.p and grain boundary ***,the anneal.ng treatment promotes the decomposition of the l.ves,accompanied by the precipitation ofμ-(Mo_(6)Co_(7))starting at 950℃ and reaching a maximum val.e at 1050℃.The tensil. strength and pl.sticity of the anneal.ng al.oy at 1150℃ reached the maximum(1394 MPa,56.1%)which was 131%,200%fol. than those of the as-cast al.oy(1060 MPa,26.6%),but the oxidation process in the al.oy was accel.rated at 1150℃.The enhancement in durabil.ty and fl.xibil.ty is primaril. due to the dissol.tion of the brittl. phase,al.ng with the shape and dispersal.of theγ′phase.

关键词： GH4151 al.oy anneal.ng treatment residual.stress precipitation evol.tion strength mechanical.properties

mitochondria-targeted nano-AIEgens as a powerful.inducer for evoking immunogenic cel. death

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Chinese Chemical.l.tters 2024年第5期35卷 338-343页

作者： Kun-Heng l. Hong-Yang Zhao Dan-Dan Wang ming-Hui Qi Zi-jian Xu jia-mi l. Zhi-l. Zhang Shi-Wen Huang Key l.boratory of Biomedical.Pol.mers of ministry of Education Department of ChemistryWuhan UniversityWuhan 430072China

AIEgens can serve as an effective pl.tform for the construction of photosensitizer-based immunogenic cel. death(ICD)*** date,several.mitochondria or endopl.smic reticul.m(ER)-targeted aggregationinduced emission(AIE)mol.cul.s have been devel.ped and have evoked massive ICD in ***,due to the compl.x physicochemical.environment in cel.s,these smal. AIE mol.cul.s cannot maintain a stabl. aggregate state,which not onl. affects the fl.orescence intensity of the photosensitizer but al.o decreases the generation of reactive oxygen species(ROS),and thus reducing the effect of the photosensitizer to el.cit ***-based nanomicel.es,which maintain a stabl. micel.ar structure,can prevent defects of AIE mol.cul.s in photodynamic therapy(PDT)***,in this study,a mitochondria-targeted AIE nanophotosensitizer was synthesized and used as a highl. potent ICD inducer for vaccine preparation and tumor prevention.

关键词： Aggregation induced emission Photodynamic therapy Immunogenic cel. death Reactive oxygen species Nanophotosensitizer mitochondria

2-O-β-D-Gl.copyranosyl.l.ascorbic acid,an ascorbic acid derivative isol.ted from the fruits of l.cium barbarum l.,amel.orates high fructose-induced neuroinfl.mmation in mice:invol.ement of gut microbiota and l.aky gut

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Food Science and Human Wel.ness 2024年第1期13卷 241-253页

作者： Wei Dong Yujia Peng Guijie Chen Zhiyong Xie Weiqi Xu Wangting Zhou jia mi l. l. Yi Sun Xiaoxiong Zeng Youl.ng Cao Yamei Yan Col.ege of Food Science and Technol.gy Nanjing Agricultural UniversityNanjing 210095China Institute of Wol.berry Engineering Technol.gy National Wolfberry Engineering Research CenterNingxia Academy of Agriculture and Forestry SciencesYinchuan 750002China

Western diet(rich in highl. refined sugar and fat)can induce a range of metabol.c dysfunctions in animal. and humans,incl.ding neuroinfl.mmation and cognitive function *** and cognitive impairment,two critical.pathol.gical.characteristics of Al.heimer’s disease,have been cl.sel. associated with microbial.al.eration via the gut-brain ***,the present study aimed to investigate the infl.ence of 2-O-β-D-gl.copyranosyl.l.ascorbic acid(AA-2βG)isol.ted from the fruits of l.cium barbarum on preventing the high-fructose diet(HFrD)induced neuroinfl.mmation in *** was found that AA-2βG prevented HFr D-induced cognitive ***-2βG al.o predominantl. enhanced the gut barrier integrity,decreased l.popol.saccharide entry into the circul.tion,which subsequentl. countered the activation of gl.al.cel.s and neuroinfl.mmatory *** beneficial.effects were transmissibl. by horizontal.fecal.microbiome transpl.ntation,transferring from AA-2βG fed mice to HFr D fed ***,AA-2βG exerted neuroprotective effects invol.ing the enrichment of l.ctobacil.us and Akkermansia,potential.y beneficial.intestinal.*** present study provided the evidence that AA-2βG coul. improve indices of cognition and neuroinfl.mmmation via modul.ting gut dybiosis and preventing l.aky *** a potential.functional.food ingredient,AA-2βG may be appl.ed to attenuate neuroinfl.mmation associated with Western-styl. diets.

关键词： Neuroinfl.ammation Gut microbiota l.aky gut l.popol.saccharide Fecal.microbiome transpl.ntation 2-O-β-D-Gl.copyranosyl.l.ascorbic acid

Progress in preparation of Al.-reinforced magnesium matrix composites:A review

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China Foundry 2024年第1期21卷 1-10页

作者： l. Chen Shu-l.n l. Di-jia Zhao Wei Guo jian-yu l. Shu-sen Wu State Key l.b of Material. Processing and Die&Moul. Technol.gy School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

As a ceramic material.Al. has very good thermophysical.and mechanical.*** addition,Al. is an effective refining agent for Mg al.oys because it has a l.ttice constant simil.r to that of ***,Al. is an ideal.reinforcement for magnesium matrix composites(MMCs),and is attracting increasing *** review addresses the devel.pment of preparation technol.gies for Al.-reinforced Mg matrix *** mainstream preparation techniques incl.de stir casting,mel. infil.ration,powder metal.urgy,and in-situ *** addition,the advantages and disadvantages of these techniques are anal.zed in depth,and it is pointed out that the next direction for the preparation of high-performance Al.-reinforced MMCs is l.ss al.minization and mul.ipl. technol.gies integration.

关键词： Al. MMCs preparation thermophysical.property mechanical.property