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P16 gene hypermethylation and hepatocellular carcinoma:A systematic review and meta-analysis

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World Journal of Gastroenterology 2011年第25期17卷 3043-3048页

作者： jia-Jie Zang Feng Xie Jin-Fang Xu Ying-Yi Qin Rong-Xi Shen jia-mei yang jia He Department of Health Statistics Second Military Medical Univer-sity Shanghai 200433 China Department of Special Treatment and Liver Transplantation Eastern HepatobiliarySurgery Hospital Second Military Medical University Shanghai200438 China

AIM:To quantitatively investigate the effect of p16 hypermethylation on hepatocellular carcinoma (HCC) and hepatocirrhosis using a meta-analysis of available casecontrol ***:Previous studies have primarily evaluated the incidence of p16 hypermethylation in HCC and corresponding control groups,and compared the incidence of p16 hypermethylation in tumor tissues,pericancer liver tissues,normal liver tissues and non-tumor liver tissues with that in other *** regarding publication information,study characteristics,and incidence of p16 hypermethylation in both groups were collected from these studies and ***:Fifteen studies,including 744 cases of HCC and 645 non-tumor cases,were identified for *** significant odds ratios (ORs) of p16 hypermethylation were obtained from tumor tissues and non-tumorous liver tissues of HCC patients (OR 7.04,95% CI:3.87%-12.78%,P < 0.0001),tumor tissues of HCC patients and healthy liver tissues of patients with other diseases (OR 12.17,95% CI:6.64%-22.31%,P < 0.0001),tumor tissues of HCC patients and liver tissues of patients with non-tumorous liver diseases (OR 6.82,95% CI:4.31%-10.79%,P < 0.0001),and cirrhotic liver tissues and non-cirrhotic liver tissues (OR 4.96,95% CI:1.45%-16.96%,P=0.01).The pooled analysis showed significantly increased ORs of p16 hypermethylation (OR 6.98,95% CI:4.64%-10.49%,P < 0.001) from HCC tissues and cirrhotic ***:P16 hypermethylation induces the inactivation of p16 gene,plays an important role in hepatocarcinogenesis,and is associated with an increased risk of HCC and liver cirrhosis.

关键词： P16 hypermethylation Hepatocellular carci-noma Liver cirrhosis Meta-analysis Odds ratio

Precautions in caudate lobe resection: Report of 11 cases

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World Journal of Gastroenterology 2008年第17期14卷 2767-2770页

作者： Zeng-Qing Wen Yi-Qun Yan jia-mei yang Meng-Chao Wu First Department of Hepatic Surgery Eastern HepatobiliarySurgery Hospital Second Military Medical University Shanghai200438 China

AIM： To find the precautions against the safety in caudate lobe resection. METHODS： The clinical data obtained from 11 cases of primary liver cancer in caudate lobe who received hepatectomy successfully were retrospectively analyzed. Four safe procedures were used in resection of primary liver cancer in caudate lobe：（1） selection of appropriate skin incision to obtain excellent exposure of operative field; （2） adequate mobilization of the liver to allow the liver to be displaced upwards to the left or to the right; （3） preparatory placement of tapes for total hepatic vascular exclusion, so that this procedure could be used to control the fatal bleeding of the liver when necessary; （4） selection of the ideal route for hepatectomy based on the condition of the tumor and the combined removal of multiple lobes if necessary. Among the 11 cases, simple occlusion of vessels of porta hepatis was used in caudate Iobectomy for 6 cases, while in the other cases, the vessels were intermittently occluded several times or total hepatic vascular isolation was used in the caudate Iobectomy. Combined partial right hepatectomy was done for 3 cases, combined left lateral Iobectomy for 2 cases and caudate Iobectomy alone for 6 cases. RESULTS： Operation was successful for all the 11 cases. Intermittent inflow occlusion was performed for all patients for 15 min at 5-min intervals. Blockade was performed twice in 3 patients and total hepatic vascular exclusion was performed in one of the three patients. Blockade was performed three times in one patient, including a total hepatic vascular exclusion. Total hepatic vascular exclusion was performed only in one patient. The mean blood loss was 300 mL. Ascites and pleural effusion occurred in 4 patients, jaundice in 1 patient. Six patients died of tumor recurrence in 6, 11, 12, 13, 15, 19 mo after operation, respectively. The other 5 patients have survived more than 16 mo since the operation. CONCLUSION： Caudate Iobectomy for liver cance

关键词： Caudate lobe Primary liver cancer Hepatectomy Porta hepatis Vascular exclusion

Risk factors for combined hepatocellular-cholangiocarcinoma:A hospital-based case-control study

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World Journal of Gastroenterology 2014年第35期20卷 12615-12620页

作者： Yan-Ming Zhou Xiao-Feng Zhang Lu-Peng Wu Cheng-Jun Sui jia-mei yang Department of Hepato-Biliary-Pancreato-Vascular Surgery the First Affiliated Hospital of Xiamen University Department of Special Treatment and Liver Transplantation Eastern Hepa-tobiliary Surgery HospitalSecond Military Medical University

AIM: To identify risk factors contributing to the development of combined hepatocellular-cholangiocarcinoma (CHC) in China.

关键词： Risk factors Combined hepatocellular-cholangiocarcinoma Hepatitis B virus Alcohol consumption Epidemiology

EXPERIMENTAL INVESTIGATION OF CHARACTERISTIC FREQUENCY IN UNSTEADY HYDRAULIC BEHAVIOUR OF A LARGE HYDRAULIC TURBINE

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Journal of Hydrodynamics 2009年第1期21卷 12-19页

作者： WANG Fu-jun LI Xiao-qin MA jia-mei yang Min ZHU Yu-liang College of Water Conservancy and Civil Engineering China Agricultural University Beijing 100083 China Beijing Huake Tongan Monitoring Technology Co. Ltd. Beijing 100037 China

The features of unsteady flow such as pressure variation and fluctuation in a large hydraulic turbine usually lead to the instability of operation. This article reports the recent in site investigation concerning the characteristic frequencies in pressure fluctuation, shaft torsional oscillation and structural vibration of a prototype 700 MW Francis turbine unit. The investigation was carried out for a wide load range of 200 MW-700 MW in the condition of water head 57 m-90 m. An extensive analysis of both time-history and frequency data of these unsteady hydraulic behaviours was conducted. It was observed that the pressure fluctuation in a draft tube is stronger than that in upstream flow passage. The low frequency with about one third of rotation frequency is dominative for the pressure fluctuation in part load range. Also the unsteady features of vibration of head cover and torsional oscillation of shaft exhibited the similar features. Numerical analysis showed that the vibration and oscillation are caused by vortex rope in the draft tube. In addition, a strong vibration with special characteristic frequency was observed for the head cover in middle load range. The pressure fluctuation in the draft tube with the same frequency was also recorded. Because this special vibration has appeared in the designed normal running condition, it should be avoided by carefully allocating power load in the future operation.

关键词： hydraulic turbine part load swirling flow unsteady behaviour characteristic frequency power load allocation

Troglitazone, a peroxisome proliferator-activated receptor γ ligand, induces growth inhibition and apoptosis of HepG2 human liver cancer cells

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World Journal of Gastroenterology 2008年第14期14卷 2168-2173页

作者： Yan-Ming Zhou Yin-Hao Wen Xiao-Yan Kang Hai-Hua Qian jia-mei yang Zheng-Feng Yin Department of Molecular Oncology Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

AIM: To examine the effect of troglitazone, a peroxisome proliferator-activated receptor γ (PPARγ) ligand, on the proliferation and apoptosis of human liver cancer cells. METHODS: Liver cancer cell line HepG2 was cultured and treated with troglitazone. Cell proliferation was detected by 3-(4-,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay; apoptosis was detected by flow cytometry and terminal deoxynucleotidyl transferase- mediated nick end labeling of DNA fragmentation sites (TUNEL) assay; and apoptosis-related protein was detected by immunocytochemistry and Western blotting. RESULTS: Troglitazone inhibited growth and induced apoptosis of HepG2 cells in a dose-dependent manner, and induced activation of caspase-3 expression. Troglitazone not only drove apoptosis-inhibiting factor survivin to translocate incompletely from the nucleus to the cytoplasm, but also inhibited expression of survivin, while it did not affect expression of apoptosis-promoting factor Bax. CONCLUSION: PPARγ ligands inhibit growth and induce apoptosis of liver cancer cells, and may have applications for the prevention and treatment of liver cancer.

关键词： Peroxisome proliferator-activated receptor γ Troglitazone Liver neoplasms Apoptosis

Clinicopathological and prognostic analysis of 429 patients with intrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2009年第47期15卷 5976-5982页

作者： Wei-Feng Shen Wei Zhong Feng Xu Tong Kan Li Geng Feng Xie Cheng-Jun Sui jia-mei yang Department of Special Treatment Eastern Hepatobiliary Surgery Hospital Second Military Medical University 225 Changhai Road Shanghai 200438 China Department of Gastroenterology Changzheng Hospital Second Military Medical University 415 Fengyang Road Shanghai 200003 China

AIM:To understand the clinicopathological characteristics and treatment selections and improve survival and provide valuable information for patients with intrahepatic cholangiocarcinoma(ICC). METHODS:We retrospectively evaluated 5311 liver cancer patients who received resection between October 1999 and December *** these,429(8.1%)patients were diagnosed with ICC,and their clinicopathological, surgical,and survival characteristics were analyzed. RESULTS:Upper abdominal discomfort or pain(65.0%), no symptoms(12.1%),and hypodynamia(8.2%)were the major causes for medical *** tests showed 198(46.4%)patients were HBsAg positive, 90(21.3%)hadα-fetoprotein>20μg/L,50(11.9%) carcinoembryonic antigen>10μg/L,and 242(57.5%) carbohydrate antigen 19-9(CA19-9)>37 U/*** data was available for 329(76.7%)patients and their mean survival time was 12.4 *** overall survival of the patients with R0,R1 resection and punching exploration were 18.3,6.6 and 5.6 mo,respectively. Additionally,CA19-9>37 U/mL was associated with lymph node metastases,but inversely associated *** analysis indicated that radical resection,lymph node metastases,macroscopic tumor thrombi and size,and CA19-9 were associated with prognosis. CONCLUSION:Surgical radical resection is still the most effective means to cure *** laboratory tests(such as CA19-9)can effectively predict the survival of the patients with ICC.

关键词： Intrahepatic cholangiocarcinoma Diagnosis Pathology Surgery Survival

Clinicopathologic characteristics of intrahepatic cholangiocarcinoma in patients with positive serum a-fetoprotein

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World Journal of Gastroenterology 2008年第14期14卷 2251-2254页

作者： Yan-Ming Zhou jia-mei yang Bin Li Zheng-Feng Yin Feng Xu Bin Wang Peng Liu Zhi-Min Li Department of Hepato- Biliary-Pancreato-Vascular Surgery The First Xiamen Hospital Fujian Medical University Xiamen 361003 Fujian Province China Department of Special Treatment Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China Molecular Oncology Research Laboratory Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai 200438 China

AIM:To explore clinicopathologic characteristics of intrahepatic cholangiocarcinoma (ICC) in patients with positive serum a-fetoprotein (AFP). METHODS:One hundred and thirty one patients who underwent surgical dissection for pathologically confirmed ICC were divided into a positive AFP (> 20 ng/mL) group (n = 32) and a negative AFP group (n = 99), whose clinicopathologic features were analyzed and compared. RESULTS:The positive rate of HBsAg and liver cirrhosis of the positive AFP group was higher than that of the negative AFP group, while the positive rate of CA19-9 (> 37 U/mL) and the lymph node metastasis rate was lower. CONCLUSION:ICC patients with positive AFP share many clinicopathologic similarities with hepatocellular carcinoma.

关键词： Intrahepatic cholangiocarcinoma A-fetopro tein Hepatitis B virus Liver cirrhosis Hepatic stem cells

Risk factors for intrahepatic cholangiocarcinoma:A case-control study in China

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World Journal of Gastroenterology 2008年第4期14卷 632-635页

作者： Yan-Ming Zhou Zheng-Feng Yin jia-mei yang Bin Li Wen-Yu Shao Feng Xu Yu-Lan Wang Dian-Qi Li Department of Hepato-Biliary-Pancreato-Vascular Surgery The First Xiamen Hospital FujianMedical University Xiamen 361003 Fujian Province China Molecular Oncology Research Laboratory Eastern Hepatobiliary Surgery Hospital SecondMilitary Medical University Shanghai 200438 China

AIM: To carry out a hospital-based case-control study to investigate risk factors for intrahepatic cholangiocarcinoma (ICC) in China. METHODS: A total of 312 ICC cases and 438 matched controls were included in the study. The presence of diabetes mellitus,hypertention,hepatolithiasis,primary sclerosing cholangitis,liver fluke infection (Clonorchis sinensis ),was investigated through clinical records. Blood from all participants was tested for hepatitis B surface antigen (HBsAg) and anti-HCV antibodies. Odds ratios (OR) and 95% confi dence intervals (95% CI) were estimated using conditional logistic regression. RESULTS: Compared with controls,ICC patients had a higher prevalence of HBsAg seropositivity (48.4% vs 9.6%,P < 0.000),and hepatolithiasis (5.4% vs 1.1%,P = 0.001). By multivariate analysis,the signif icant risk factors for development of ICC were HBsAg seropositivity (adjusted OR,8.876,95% CI,5.973-13.192),and hepatolithiasis (adjusted OR,5.765,95% CI,1.972-16.851). The prevalence of anti-HCV seropositivity,diabetes mellitus,hypertention,cigarette smoking,and alcohol consumption were not significantly different between cases and controls. CONCLUSION: These findings suggest that HBV infection and hepatolithiasis are strong risk factors for development of ICC in China.

关键词： Intrahepatic cholangiocarcinoma Hepatitis Bvirus Hepatitis C virus Risk factors

Intrahepatic cholestasis after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2002年第2期1卷 176-178页

作者： jia-mei yang Bin Zhu From the Department of Liver Transplantation, Eastern Hapatobiliary Surgery Hospital, the Second Military Medical University, Shanghai 200438, China Department of Liver Transplantation Eastern Hepatobiliary Surgery Hospital the Second Military Medical University Shanghai 200438 China. jmyang@***

Intrahepatic cholestasis occurs commonly after liver transplantation and may be caused by infections, drugs, and acute or chronic rejection. Some disor- ders may be managed medically, but others often re- quire re-tra... 详细信息

关键词： intrahepatic cholestasis liver transplantation