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Therapeutic Effect of First-line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR-TKI)Combined with Whole Brain Radiotherapy on Patients with EGFR Mutation-positive Lung Adenocarcinoma and Brain Metastases

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Current Medical Science 2018年第6期38卷 1062-1068页

作者： Shao-bo KE Hu QIU jia-mei chen Wei SHI Yong-shun chen Cancer Center Renmin Hospital of Wuhan UniversityWuhan 430060China

This study compared the therapeutic effect of first-line epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI)with that of EGFR-TKI plus whole brain radiotherapy(WBRT)on patients with EGFR mutation-positive lung adenocarcinoma and brain metastases.A total of 139 patients with lung adenocarcinoma and brain metastases treated with first-line EGFR-TK1therapy from September 2008 to December 2017 were enrolled in this *** study endpoints were intracranial time to progression(TTP)and overall survival(OS).The effects of clinical pathological parameters and EGFR gene status on the study endpoints were *** results showed that the intracranial TTP was significantly longer in EGFR-TKI plus WBRT group than in EGFR-TKI group (median 30.0 vs.18.2 months,χ2=10.824,P=0.001),but no significant difference in the OS was noted between the two groups (median 48.0 vs.41.1 months,χ2=0.012, P=0.912).Also,there was no statistically significant difference in the OS between patients treated with early and late radiotherapy (P=0.849)and between those with asymptomatic and those with symptomatic intracranial metastases (P=0.189).The OS and intracranial TTP of patients with intracranial oligometastases (≤3metastatic sites)were not significantly different from those of patients with multiple intracranial metastases (P=0.104 and P=0.357,respectively),and exon 19 and exon 21 mutations didn't show significant effects on the OS and intracranial TTP of patients (P=0.418 and P=0.386,respectively).In conclusion,there was no statistically significant difference in the OS between the EGFR-TKI alone group and EGFR-TK1 plus WBRT ***, simultaneous use of WBRT was found to significantly prolong intracranial TTP and improve cerebral symptoms,and thus EGFR-TKI and WBRT combined may be clinically beneficial for patients with EGFR mutation-positive lung adenocarcinoma and brain metastases.

关键词： lung adenocarcinoma brain metastases epidermal growth factor receptor tyrosine kinase inhibitor whole brain radiotherapy

Effectiveness of family psychosocial intervention on mental health and family function of caregivers of children with cancer:a meta-analysis

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Frontiers of Nursing 2023年第2期10卷 135-144页

作者： Li-Ya Ren Yu-Xin Wang Hao jiang mei-jia chen Chao-Qun Dong School of Nursing Wenzhou Medical UniversityWenzhouZhejiang 325035China

Objective:To evaluate the effect of family psychosocial intervention on the mental health and family function of caregivers of children with ***:A comprehensive literature search of CNKI,Wanfang,VIP,CMB,PubMed,Web of Science,MEDLINE,Embase,Cochrane Library,and PsycARTICLES was conducted to retrieve randomized controlled trials of family psychosocial intervention from database inception until 19 September ***(version 5.4.1)was used to analyze the ***:A total of 894 caregivers participated in 11 *** analysis showed that anxiety(standardized mean difference[SMD]=−0.22,95%confidence interval[CI]=−0.37 to−0.07,P=0.004)and depression(SMD=−0.33,95%CI=−0.57 to−0.08,P=0.01)were significantly reduced,while family function(SMD=−0.86,95%CI=−1.28 to−0.45,P1 month(SMD=−0.48,95%CI=0.68 to−0.27,P<0.00001).Conclusions:Current evidence supports the use of family psychological intervention to reduce depression and anxiety and improve family ***,its effect on PTSD symptoms requires further *** studies should further identify the role of specific family psychosocial interventions on families and caregivers of children with cancer.

关键词： anxiety cancer caregivers depression family function family psychosocial intervention meta-analysis

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Yiguanjian decoction enhances fetal liver stem/progenitor cell-mediated repair of liver cirrhosis through regulation of macrophage activation state

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World Journal of Gastroenterology 2018年第42期24卷 4759-4772页

作者： Ying Xu Wei-Wei Fan Wen Xu Shi-Li jiang Gao-Feng chen cheng Liu jia-mei chen Hua Zhang Ping Liu Yong-Ping Mu Department of Hepatology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Institute of Liver Diseases Shanghai University of Traditional Chinese MedicineShanghai 201203China Key Laboratory of Liver and Kidney Disease of the Ministry of Education Shanghai 201203China Clinical Key Laboratory of TCM of Shanghai Shanghai 201203China

AIM To investigate whether Yiguanjian decoction(YGJ) has an anti-liver cirrhotic effect and whether it regulates hepatic stem cell *** A rat model of liver cirrhosis was established via subcutaneous injection of carbon tetrachloride(CCl4) for8 wk. From the beginning of the ninth week, the rats received 2-acetylaminofluorene(2-AAF) by oral gavage and a DLK-1+ fetal liver stem/progenitor cell(FLSPC)transplant or an FLSPC transplant in combination with YGJ treatment for 4 wk. In vitro, lipopolysaccharide(LPS)-activated macrophages were co-cultured with WB-F344 cells, and the differentiation of WB-F344 cells was observed in the presence and absence of YGJ *** FLSPC transplantation improved liver function and histopathology, and inhibited the activation of the noncanonical Wnt signaling pathway, while activating the canonical Wnt signaling pathway. YGJ enhanced the therapeutic effects of FLSPCs and also promoted the liver regeneration differentiation of FLSPCs into *** vitro, LPS-activated macrophages promoted the differentiation of WB-F344 cells into myofibroblasts, and the canonical Wnt signaling was inhibited while the noncanonical Wnt signaling was activated in WB-F344 *** suppressed the activation of macrophages and then inhibited non-canonical Wnt signaling and promoted canonical Wnt *** YGJ enhances FLSPC-mediated repair of liver cirrhosis through regulation of macrophage activation state, and YGJ in combination with stem cell transplantation may be a suitable treatment for end-stage liver cirrhosis.

关键词： Cirrhosis Hepatic progenitor cells Wnt signaling pathway Macrophage 2-acetylaminofluorene Carbon tetrachloride Yiguanjian decoction

Imprvoing the solubility of Rivaroxaban via nanocrystallizion

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Imprvoing the solubility of Rivaroxaban via nanocrystallizio...

中国晶体学会第六届学术年会暨会员代表大会——第六届全国晶型药物研发技术学术研讨会

作者： Jin-mei Li jia-mei chen Tong-Bu Lu School of Pharmaceutical Sciences Sun Yat-Sen University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry and Chemical EngineeringSun Yat-Sen University

we described a Rivaroxaban(RIV) nanocrystal for overcoming poor solubility here. The results showed that using dissocubes method with polxamer 188、Hydroxy Propyl Methyl Cellulose(HPMC) E9 and Sodium Dodecyl Sulfonate(SDS) as stabilizers, mannitol as freeze-drying protective additive, RIV nanocrystal was produced quickly, the average size of nanocrystal was 186.6±10.0 nm and the zeta potential was 27.03±2.33 mV. The X-ray powder diffraction(XRPD) and differential scanning calorimetry(DSC) analysis verified that the crystalline state of RIV was not transformed after nanocrystallizion. In simulated intestinal fluid(pH 6.8) and simulated gastric fluid(pH 1.2), apparent solubility values of rivaroxaban both are higher than those of the physical mixture and rivaroxaban powder, indicating the solubility of rivaroxaban can be improved by nanocrystallization. It was stable for at least 1 month at 4℃. The pharmacokinetic test in rats indicated that the area under plasma concentration-time curve(AUC) value of RIV nanosuspension(0.552 mg/L·h) was about 4.8-fold higher than that of RIV solution(0.113 mg/L·h). In summary, rivaroxaban nanocrystals are a potential oral delivery system to improve rivaroxaban’s poor dissolution and its oral bioavailability.

关键词： Nanocrystal Rivaroxaban Dissolution Bioavailability

Preparation of Low Ratio Magnesium Ccement by Acid Leaching Treatment of Boron Mud

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 120-129页

作者： YANG mei ZHANG Mingzhe chen Hao School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China School of Physical Science and Technology Shenyang Normal UniversityShenyang 110168China

The effects of liquid-solid ratio and reaction time on the leaching rate of magnesium at room temperature were investigated,as well as the effects of the molar ratio of MgO/MgCl_(2),the amount of water added,and the amount of acid-impregnated slag dosed on the compressive strength and water resistance of *** results showed that the magnesium element in the boron mud could be maximally leached under the conditions of 1:1 concentration of hydrochloric acid at room temperature,liquid-solid ratio of 2.5 mL·g^(-1),and reaction time of 5 h,and the main products were amorphous SiO_(2) as well as a small amount of magnesium olivine which had not been completely *** LR-MOC prepared using the acid-soaked mixture could reach a softening coefficient of 0.85 for 28 d of water immersion when the molar ratio of MgO/MgCl_(2) was 2.2,the amount of water added was 0 g,and the acid-soaked slag dosing was 40 wt%,which also led to an appreciable late-strength,with an increase of 19.4%in compressive strength at 28 d compared to that at 7 *** previous studies,LR-MOC prepared in this way has a final strength phase that is not the more easily hydrolysed 3-phase but the lath-like *** this phenomenon,we analyzed the mechanism and found that,during the acid leaching process,a part of amorphous SiO_(2) dissolved in the acid leaching solution formed a silica sol,in which Mg^(2+)played a bridging role to make the silica sol more *** the addition and hydrolysis of MgO,the silica sol gel coagulation slows down,providing a capping layer to inhibit the hydrolysis of the 5-phase crystals and providing some strength after *** amorphous SiO_(2) in the other part of the acid-impregnated slag generated M-S-H gel with Mg^(2+)and OH-,which synergised with the dense structure composed of interlocking crystals to improve the water resistance of LR-MOC.

关键词： boron mud magnesium chloride-oxygen cement acid immersion water resistance silica sol

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Phenazopyridine/Phthalimide Nano-Cocrystals: Preparation and Pharmacokinetic evaluation

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Phenazopyridine/Phthalimide Nano-Cocrystals: Preparation and...

中国晶体学会第六届学术年会暨会员代表大会——第六届全国晶型药物研发技术学术研讨会

作者： Yu Huang jia-mei chen Tong-Bu Lu School of Pharmaceutical Sciences Sun Yat-Sen University

This study intended to fabricate phenazopyridine/phthalimide(PAP/PIMD) nano-cocrystal to improve dissolution and oral bioavailability. PAP/PIMD nano-cocrystal is prepared by sonochemical synthesis, using SDS as the stabilizers. The fabricated nano-cocrystal is nearly spherical with the particle size from 30.0 nm to 50.0 nm. Apparent solubility values of PAP/PIMD nano-cocrystal are higher than those of the cocrystal and phenazopyridine hydrochloride(PAP·HCl) in simulated intestinal fluid(PBS of pH 6.8), indicating the solubility of PAP/PIMD cocrystal can be improved by nanocrystallization. In vivo pharmacokinetic study suggested that PAP/PIMD nano-cocrystal was absorbed quickly with significantly higher Cmax and AUC compared to those of the cocrystal and PAP·HCl. In summary, PAP/PIMD nano-cocrystal is a potential oral delivery system to improve poor dissolution of phenazopyridine and its oral bioavailability.

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Cocrystal of Dapagliflozin with Citric Acid: Enhanced Hygroscopic and Thermal Stability

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Cocrystal of Dapagliflozin with Citric Acid: Enhanced Hygros...

中国晶体学会第六届学术年会暨会员代表大会——第六届全国晶型药物研发技术学术研讨会

作者： Jun-Hui Deng jia-mei chen Tong-Bu Lu School of Pharmaceutical Sciences Sun Yat-Sen University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry and Chemical EngineeringSun Yat-Sen University

Dapagliflozin(DAP) is a potent and selective sodium-glucose contransporter-2(SGLT-2) inhibitor, and performed as an efficacious treatment for type 2 diabetes. Sever hygroscopicity of DAP hinder the usage of its free form during process of pharmaceutical production. A solvate form(dapagliflozin propanediol, DAP-PDO-HO) is used in the market, which, however, also faces problem of thermal instability as higher vapor pressure of solvent molecules in crystal lattice. The present study obtained a new cocrystal of DAP with citric acid(DAP-CA). DAP-CA cocrystal was identified and characterized by H nuclear magnetic resonance(H-NMR), Fourier transform infra-red spectroscopy(FTIR), powder X-ray diffraction(PXRD) and thermal analysis, It was also evaluated by dynamic vapor sorption(DVS) and accelerated stability test under 40 ℃/75% RH, as well as powder dissolution test. DAP-CA cocrystal showed enhanced stability against both humidity and high temperature compared to the market form without compromising the dissolution solubility.

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Improving the Membrane Permeability of 5-Fluorouracil via Cocrystallization

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Improving the Membrane Permeability of 5-Fluorouracil via Co...

中国晶体学会第六届学术年会暨会员代表大会——第六届全国晶型药物研发技术学术研讨会

作者： Xia-Lin Dai Song Li jia-mei chen Tong-Bu Lu School of Pharmaceutical Sciences Sun Yat-Sen University MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of Chemistry and Chemical Engineering Sun Yat-Sen University

Pharmaceutical cocrystallization is proposed as a new method to enhance membrane permeability of a BCS class Ⅲ model drug, 5-fluorouracil(5FU). Three cocrystals of 5FU, 5FU/3-hydroxybenzoic acid(1), 5FU/4-aminobenzoic acid(2) and 5FU/cinnamic acid(3), were successfully synthesized by a slurry method or a liquid-assisted grinding process. Spectroscopic methods, thermal analysis, and X-ray diffraction were used to characterize these new forms. The permeability was studied using a Franz diffusion cell and silicone membrane. All of the cocrystals showed improved membrane permeability compared to free 5FU. The cumulative amount per unit area of permeated 5FU in the first ten hours for 1-3 were increased by 41%, 70% and 83%, and the steady penetrate rate of 1-3 were increased by 38%, 66% and 79% respectively, as compared to pure drug. Structure-permeability correlation study finds a link between intermolecular interactions and molecular packing in cocrystals and their permeability behavior and has important implications for use of cocrystallization approach to improve drugs’ permeability in pharmaceutical field.

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A Review on Thermal Management of Li-ion Battery:from Small-Scale Battery Module to Large-Scale Electrochemical Energy Storage Power Station

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Journal of Thermal Science 2025年第1期34卷 1-23页

作者： chen Zhifeng jia Li YIN Liaofei DANG Chao REN Honglei ZHANG Zhiqiang Beijing Key Laboratory of Flow and Heat Transfer of Phase Changing in Micro and Small Scale School of MechanicalElectronic and Control EngineeringBeijing Jiaotong University

Li-ion battery is an essential component and energy storage unit for the evolution of electric vehicles and energy storage technology in the ***,in order to cope with the temperature sensitivity of Li-ion battery and maintain Li-ion battery safe operation,it is of great necessary to adopt an appropriate battery thermal management system(BTMS).In this paper,the current main BTM strategies and research hotspots were discussed from two aspects:small-scale battery module and large-scale electrochemical energy storage power station(EESPS).The practical application situation,advantages and disadvantages,and the future development trend of each heat dissipation method(air,liquid,PCM,heat pipe,hybrid cooling) were described in *** them,the air cooling and liquid cooling were reviewed in-depth based on the engineering *** PCM,heat pipe and hybrid cooling were reviewed extensively based on the latest *** research provides a comprehensive understanding for the BTMS in all scales.

关键词： battery thermal management cooling methods large-scale electrochemical energy storage power station small-scale battery module