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Tetrahedral framework nucleic acids promote cognitive impairment recovery post traumatic brain injury

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Chinese Chemical Letters 2023年第4期34卷 141-147页

作者： Yangyang Wang Weiqiang jia jianwei zhu Ruxiang Xu Yunfeng lin Department of Neurosurgery Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengdu 611731China Department of Neurosurgery The First People’s Hospital in Shuangliu District/West China Airport HospitalSichuan UniversityChengdu 610299China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Disease West China Hospital of StomatologySichuan UniversityChengdu 610041China

Cognitive impairment often occurs after post traumatic brain injury. In addition, recovery of cognitive impairment is largely dependent on spontaneous repair and the severity of secondary insult. The tetrahedral framework nucleic acid is a novel nanostructure has been shown to have a positive biological effect in promoting regeneration and anti-inflammation. To explore the treatment effect of tetrahedral framework nucleic acids for cognitive impairment recovery post traumatic brain injury, we established a mouse model of traumatic brain injury and verified the efficacy of tetrahedral framework nucleic acids in promoting cognitive impairment recovery post traumatic brain injury. The results show that the tetrahedral framework nucleic acids promoted the recovery of post-traumatic cognitive function by enhancing the proliferation of endogenous neural stem cells. Besides, tetrahedral framework nucleic acids modulated the neuroinflammatory response in the acute phase by inhibiting excessive astrocyte and microglial activation. Taken together, the results of the study indicate tetrahedral framework nucleic acids for treatment of cognitive impairment post traumatic brain injury.

关键词： Tetrahedral framework nucleic acids Traumatic brain injury Cognitive impairment Neural stem cell Neuroinflammation

Novel Photodetectors Based on Double-Walled Carbon Nanotube Film/TiO2 Nanotube Array Heterodimensional Contacts

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Nano Research 2011年第9期4卷 901-907页

作者： Mingjie Yang Jia-Lin Zhu Wei Liu jia-lin Sun Department of Physics and State Key Lab of Low-Dimensional Quantum Physics Tsinghua University Beijing 100084 China Laboratory of Advanced Materials Department of Material Science and Engineering Tsinghua University Beijing 100084 China

基于双 walled 碳 nanotube (DWCNT ) ，电影和 TiO2 nanotube 与 hetrodimensional 穿的光电探测器的一种新类型非欧姆的接触被制作了。由于维数差别效果， DWCNT film/TiO2 nanotube 数组光电探测器相对一台 Au film/TiO2 nanotube ... 详细信息

基于双 walled 碳 nanotube (DWCNT ) ，电影和 TiO2 nanotube 与 hetrodimensional 穿的光电探测器的一种新类型非欧姆的接触被制作了。由于维数差别效果， DWCNT film/TiO2 nanotube 数组光电探测器相对一台 Au film/TiO2 nanotube 数组设备展出高得多的 photocurrent-to-dark 电流比率和 photoresponse，甚至在小偏爱电压。photocurrent-to-dark 电流比率到达了四个数量级， 2467 A/W 的高 photoresponse 在 340 nm 在照耀之上被发现。而且，感光性的区域能被扩大到可见范围。photocurrent-to-dark 电流比率在 532 nm 在照耀之上到达了约三个数量级，在光子精力比 TiO2 的乐队差距低得多的地方。

关键词：双壁碳纳米管碳纳米管阵列阵列探测器非欧姆接触 TiO2 偏置电压二氧化钛光响应

Fabrication of double-walled carbon nanotube film/TiO_2 nanotube array heterojunctions with length-dependent photoresponse for broad band photodetectors

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International Journal of Minerals,Metallurgy and Materials 2013年第3期20卷 307-312页

作者： Ming-jie Yang Wei Liu jia-lin Sun Jin-quan Wei Jia-Lin Zhu Laboratory of Advanced Materials Department of Material Science and Engineering Tsinghua University State Key Laboratory of Low-Dimensional Quantum Physics Department of Physics Tsinghua University Key Laboratory for Advanced Materials Processing Technology of Education Ministry Department of Mechanical Engineering Tsinghua University

A novel photodetector based on double-walled carbon nanotube （DWCNT） film/TiO2 nanotube array （TNA） heterojunctions was fabricated, which exhibited high photoresponse in a broad spectral range. The photoresponse of the detector was dramatically dependent on the length of the TNAs. High photocurrent-to-dark current ratio with a value of 3360 was observed in the visible range by optimizing the lengths of the TNAs. The photosensitive regions could be extended into the near-infrared range. These results reveal that DWCNT film/TNA heterojunctions show potential applications for broad band photodetectors.

关键词： photodetectors titanium dioxide carbon nanotubes heterojunctions

A phenomenological model for plastic flow behavior of rotating band material with a large temperature range

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Defence Technology（防务技术） 2023年第7期25卷 121-133页

作者： Yi-cheng zhu jia-wei Fu lin-fang Qian Jing-hua Cao School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094JiangsuChina Northwest Institute of Mechanical and Electrical Engineering Xianyang712099ShaanxiChina School of Materials Science and Engineering Nanjing University of Science and TechnologyNanjing210094China

The plastic flow behavior of the rotating band material is investigated in this paper. The rotating band material is processed from H96 brass alloy, which is hardened to a much higher yield strength compared to the annealed one. The dynamically uniaxial compression behavior of the material is tested using the split Hopkinson pressure bar(SHPB) with temperature and strain rate ranging from 297 to 1073 K and500 to 3000 s^(-1), respectively, and a phenomenological plastic flow stress model is developed to describe the mechanical behavior of the material. The material is found to present noticeable temperature sensitivity and weak strain-rate sensitivity. The construction of the plastic flow stress model has two steps. Firstly, three univariate stress functions, taking plastic strain, plastic strain rate and temperature as independent variable, respectively, are proposed by fixing the other two variables. Then, as the three univariate functions describe the special cases of flow stress behavior under various conditions, the principle of stress compatibility is adopted to obtain the complete flow stress function. The numerical results show that the proposed plastic flow stress model is more suitable for the rotating band material than the existing well-known models.

关键词： Rotating band Plastic flow behavior Large temperature range Phenomenological model

The revival of thermal utilization from the Sun: interfacial solar vapor generation

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National Science Review 2019年第3期6卷 562-578页

作者： lin Zhou Xiuqiang Li George W.Ni Shining zhu jia zhu National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences School of Physics Key Laboratory of Intelligent Optical Sensing and Manipulation Ministry of Education Collaborative Innovation Center of Advanced Microstructures Nanjing University Department of Mechanical Engineering Massachusetts Institute of Technology

Since solar energy is the ultimate energy resource and a significant amount of global energy utilization goes through heat, there have been persistent efforts for centuries to develop devices and systems for solar–thermal conversion. Most recently, interfacial solar vapor generation, as an emerging concept of solar–thermal conversion, has gained significant attention for its great potentials in various fields such as desalination, sterilization, catalysis, etc. With the advances of rationally designed materials and structures and photon and thermal management at the nanoscale, interfacial solar vapor generation has demonstrated both thermodynamic and kinetical advantages over conventional strategies. In this review, we aim to illustrate the definition, mechanism and figures of merit of interfacial solar vapor generation, and to summarize the development progress of relevant materials and applications, as well as to provide a prospective view of the future.

关键词： solar vapor generation solar absorber solar evaporator interfacial heating

Hepatic perivascular epithelioid cell tumors:The importance of preoperative diagnosis

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World Journal of Gastroenterology 2024年第13期30卷 1926-1933页

作者： Shuai Yan jia-Jie Lu lin Chen Wei-Hua Cai Jin-zhu Wu Department of Medical School Nantong UniversityNantong 226300Jiangsu ProvinceChina Department of Hepatobiliary Surgery Affiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina Nantong Institute of Liver Disease Affiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina

Accurate preoperative diagnosis is highly important for the treatment of perivascular epithelioid cell tumors(PEComas)because PEComas are mainly benign tumors and may not require surgical intervention.By analyzing the causes,properties and clinical manifestations of PEComas,we summarize the challenges and solutions in the diagnosis of PEComas.

关键词： Hepatic perivascular epithelioid cell tumors Liver Preoperative diagnosis Angiomyolipomas Mesenchymal tissue-derived tumors

Residual-stress relaxation mechanism and model description of 5052H32 Al alloy spun ellipsoidal heads during annealing treatment

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Advances in Manufacturing 2022年第1期10卷 87-100页

作者： Yong-Cheng lin jiang-Shan zhu jia-Yang Chen Jun-Quan Wang School of Mechanical and Electrical Engineering Central South UniversityChangsha 410083People’s Republic of China

Marginal-restraint mandrel-free spinning is an advanced technology for manufacturing ellipsoidal heads with large diameter-thickness ratios.Nevertheless,the spinning-induced residual stress,which greatly influences the in-service performance of spun heads,should be removed.In this study,the effects of annealing on the residual-stress relaxation behavior of 5052H32 aluminum alloy spun heads were investigated.It is found that the residual stress first rapidly decreases and then remains steady with the increase in annealing time at the tested annealing temperatures.The relaxation of the residual stress becomes increasingly obvious with the increase in annealing temperature.When the annealing temperature is less than 220℃,there are no obvious changes in grain size.Moreover,the spinning-induced dislocations are consumed by the static recovery behavior,which decreases the residual stress during annealing.When the annealing temperature is approximately 300℃,the broken grains transform into equiaxed grains.In addition,static recrystallization and recovery behaviors occur simultaneously to promote the relaxation of the residual stress.Considering the different stress relaxation mechanisms,a model based on the Zener-Wert-Avrami equation was established to predict the residual-stress relaxation behavior.Finally,the optimized annealing temperature and time were approximately 300C and 30 min,respectively.

关键词： Spinning Residual stress Annealing treatment Microstructure evolution Relaxation mechanism

Identification of temperature anomaly RR Lyrae stars in LAMOST survey,misclassification and binarities

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Research in Astronomy and Astrophysics 2020年第6期20卷 239-252页

作者： lin-jia Li Sheng-Bang Qian jia Zhang jia-jia He Li-Ying zhu Yunnan Observatories Chinese Academy of SciencesKunming 650216China Key laboratory of the structure and evolution of celestial objects Chinese Academy of SciencesKunming 650216China Center for Astronomical Mega-Science Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

RR Lyrae stars,a well-known type of pulsating variable stars,have been known about for more than a century.A large amount of photometric data on RR Lyrae stars has been accumulated by space-and ground-based sky surveys,but the spectral data are relatively poor.Fortunately,the LAMOST sky survey project provides an opportunity to view them from the point of view of spectra.We collect the atmospheric parameters of 1685 RR Lyrae stars provided by the LAMOST catalog,and carry out research by using the reliable Teff.We find that there is a clear correlation between their Teff and pulsation periods,which is consistent with the pulsation and evolution theories of RR Lyrae stars.In addition,we focus on those RR Lyrae stars with abnormal temperatures.After analyzing the data from several photometric surveys,we find that some of these temperature anomalies are misclassified variable stars(e.g.,eclipsing binaries,pulsating stars on main sequence),and some are RR Lyrae binary candidates.For the latter,the temperatures of potential companions should be lower and their luminosities should not be neglected(e.g.,red giant stars).We obtain that the ratio of temperature anomaly stars to all the sample stars is 4%,which means that the impact on the further analysis(e.g.,kinematics analysis)is low.We also present the catalogs of spectral anomaly RR Lyrae stars.

关键词： techniques spectroscopic-techniques photometric-stars fundamental parameters-stars variables RR Lyrae

RNA-based nanomedicines and their clinical applications

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Nano Research 2023年第12期16卷 13182-13204页

作者： lin-jia Su Zi-Han Ji Mo-Xi Xu jia-Qing zhu Yi-Hai Chen Jun-Fei Qiao Yi Wang Yao-Xin lin CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology(NCNST)Beijing 100190China University of Chinese Academy of Sciences(UCAS) Beijing 100149China Department of Breast Surgery Harbin Medical University Cancer HospitalHarbin 150081China School of Chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China Institute of Bioengineering and Institute of Materials Science&Engineering École Polytechnique Fédérale de Lausanne(EPFL)Lausanne1015Switzerland

RNA-based nanomedicines encompass a range of therapeutic approaches that utilize RNA molecules or molecules that target RNAs for the treatment or prevention of diseases.These include antisense oligonucleotides(ASOs),small interfering RNAs(siRNAs),endogenous microRNAs(miRNAs),messenger RNAs(mRNAs),clustered regularly interspersed short palindromic repeats-associated protein 9(CRISPR/Cas9),single guide RNAs(sgRNAs),as well as RNA aptamers.These therapeutic agents exert their effects through various mechanisms such as gene inhibition,addition,replacement,and editing.The advancement of RNA biology and the field of RNA therapy has paved the way for the development and utilization of RNA-based nanomedicine in human healthcare.One remarkable example of RNA-based nanomedicine is the mRNA-based vaccines including mRNA-1273(Moderna)and BNT162b2(Pfizer/BioNTech)that have been successfully employed in response to the coronavirus disease 2019(COVID-19)pandemic.This review aims to highlight the advantages of RNA-based nanomedicines,provides an overview of significant developments in delivery systems,elucidates the molecular mechanisms of action underlying RNA-based nanomedicines,and discusses their clinical applications.Additionally,the review will address the existing challenges and innovations in delivery platforms while exploring the future possibilities for these promising RNA-based nanomedicines.

关键词： RNA-based nanomedicine conjugate-based delivery system nanoparticle-based delivery system clinical trial