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Impact of cognition-related single nucleotide polymorphisms on brain imaging phenotype in Parkinson’s disease

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Neural Regeneration Research 2023年第5期18卷 1154-1160页

作者： Ting Shen jia-li pu Ya-Si jiang Yu-Mei Yue Ting-Ting He Bo-Yi Qu Shuai Zhao Ya-Ping Yan Hsin-Yi Lai Bao-Rong Zhang Department of Neurology of the Second Affiliated Hospital Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Neurology of the Second Affiliated Hospital Interdisciplinary Institute of Neuroscience and TechnologyKey Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Neurology of Sir Run Run Shaw Hospital Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina College of Biomedical Engineering and Instrument Science Key Laboratory for Biomedical Engineering of Ministry of EducationZhejiang UniversityHangzhouZhejiang ProvinceChina

Multiple single nucleotide polymorphisms may contribute to cognitive decline in Parkinson’s disease. However, the mechanism by which these single nucleotide polymorphisms modify brain imaging phenotype remains unclear. The aim of this study was to investigate the potential effects of multiple single nucleotide polymorphisms on brain imaging phenotype in Parkinson’s disease. Forty-eight Parkinson’s disease patients and 39 matched healthy controls underwent genotyping and 7 T magnetic resonance imaging. A cognitive-weighted polygenic risk score model was designed, in which the effect sizes were determined individually for 36 single nucleotide polymorphisms. The correlations between polygenic risk score, neuroimaging features, and clinical data were analyzed. Furthermore, individual single nucleotide polymorphism analysis was performed to explore the main effects of genotypes and their interactive effects with Parkinson’s disease diagnosis. We found that, in Parkinson’s disease, the polygenic risk score was correlated with the neural activity of the hippocampus, parahippocampus, and fusiform gyrus, and with hippocampal-prefrontal and fusiform-temporal connectivity, as well as with gray matter alterations in the orbitofrontal cortex. In addition, we found that single nucleotide polymorphisms in α-synuclein(SNCA) were associated with white matter microstructural changes in the superior corona radiata, corpus callosum, and external capsule. A single nucleotide polymorphism in catechol-O-methyltransferase was associated with the neural activities of the lingual, fusiform, and occipital gyri, which are involved in visual cognitive dysfunction. Furthermore, DRD3 was associated with frontal and temporal lobe function and structure. In conclusion, imaging genetics is useful for providing a better understanding of the genetic pathways involved in the pathophysiologic processes underlying Parkinson’s disease. This study provides evidence of an association between genetic factors

关键词： cognition imaging genetics magnetic resonance imaging multi-modality Parkinson’s disease polygenic risk score single nucleotide polymorphism ultra-high field

A multiple-tissue-specific magnetic resonance imaging model for diagnosing Parkinson’s disease: a brain radiomics study

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Neural Regeneration Research 2022年第12期17卷 2743-2749页

作者： Xiao-Jun Guan Tao Guo Cheng Zhou Ting Gao Jing-Jing Wu Victor Han Steven Cao Hong-jiang Wei Yu-Yao Zhang Min Xuan Quan-Quan Gu Pei-Yu Huang Chun-Lei liu jia-li pu Bao-Rong Zhang Feng Cui Xiao-Jun Xu Min-Ming Zhang Department of Radiology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Neurology the Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeleyCAUSA Institute for Medical Imaging Technology School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghaiChina School of Information Science and Technology ShanghaiTech UniversityShanghaiChina Helen Wills Neuroscience Institute University of CaliforniaBerkeleyCAUSA Department of Radiology Hangzhou Hospital of Traditional Chinese MedicineHangzhouZhejiang ProvinceChina

Brain radiomics can reflect the characteristics of brain ***,the value of T1-weighted images,quantitative susceptibility mapping,and R2*mapping in the diagnosis of Parkinson’s disease(PD)was underestimated in previous *** this prospective study to establish a model for PD diagnosis based on brain imaging information,we collected high-resolution T1-weighted images,R2*mapping,and quantitative susceptibility imaging data from 171 patients with PD and 179 healthy controls recruited from August 2014 to August *** to the inclusion time,123 PD patients and 121 healthy controls were assigned to train the diagnostic model,while the remaining 106 subjects were assigned to the external validation *** extracted 1408 radiomics features,and then used data-driven feature selection to identify informative features that were significant for discriminating patients with PD from normal controls on the training *** informative features so identified were then used to construct a diagnostic model for *** constructed model contained 36 informative radiomics features,mainly representing abnormal subcortical iron distribution(especially in the substantia nigra),structural disorganization(e.g.,in the inferior temporal,paracentral,precuneus,insula,and precentral gyri),and texture misalignment in the subcortical nuclei(e.g.,caudate,globus pallidus,and thalamus).The predictive accuracy of the established model was 81.1±8.0%in the training *** the external validation dataset,the established model showed predictive accuracy of 78.5±2.1%.In the tests of identifying early and drug-naïve PD patients from healthy controls,the accuracies of the model constructed on the same 36 informative features were 80.3±7.1%and 79.1±6.5%,respectively,while the accuracies were 80.4±6.3%and 82.9±5.8%for diagnosing middle-to-late PD and those receiving drug management,*** accuracies for predicting tremor-dominant and non-tremor-dominant PD w

关键词： diagnosis imaging biomarker iron magnetic resonance imaging neuroimaging Parkinson’s disease quantitative susceptibility mapping R2*mapping radiomics T1-weighted imaging

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红曲红色素稳定性研究及光热降解动力学分析

食品与发酵科技 2017年第5期53卷 49-53,79页

作者：朱佳丽敬璞上海交通大学农业与生物学院上海闵行200240

红曲红色素是一种在食品行业应用广泛的天然色素。本文研究了pH、光照和温度对红曲红色素稳定性的影响,并建立光热降解动力学方程。结果表明,当溶液的pH9时,红色素稳定性降低,且pH升高至13时其溶液颜色由红色变为黄。红曲红色素的光稳... 详细信息

红曲红色素是一种在食品行业应用广泛的天然色素。本文研究了pH、光照和温度对红曲红色素稳定性的影响,并建立光热降解动力学方程。结果表明,当溶液的pH9时,红色素稳定性降低,且pH升高至13时其溶液颜色由红色变为黄。红曲红色素的光稳定性较差,随着光照时间的增加,色素保存率不断下降,经过6h的照射后,色素保存率降至77.4%。通过对数据进行零级、一级和二级线性动力学方程的拟合,发现红曲红色素光降解更符合二级动力学。温度对红曲红色素稳定性影响较大,随着温度的升高,红曲红热降解速率不断加快,热降解符合一级动力学方程,降解反应活化能Ea仅为43.5k J·mol^(-1)。

关键词：红曲红色素稳定性 pH 光照温度光热降解动力学方程

聚己内酯药物控释载体结构及制备方法研究进展

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高分子通报 2021年第9期 19-30页

作者：高扬陈磊杨来侠徐超李佳璞西安科技大学机械工程学院西安710045

聚己内酯作为一种无毒且分子量可控的合成高分子材料,由于自身具有良好的生物相容性、不同高聚物相容性以及生物降解性等优势被广泛应用于生物医疗、工业及生活日用等领域中,是一种非常有前景的高分子材料。随着精准医疗理念及现代制造... 详细信息

聚己内酯作为一种无毒且分子量可控的合成高分子材料,由于自身具有良好的生物相容性、不同高聚物相容性以及生物降解性等优势被广泛应用于生物医疗、工业及生活日用等领域中,是一种非常有前景的高分子材料。随着精准医疗理念及现代制造技术的不断融合发展,聚己内酯被制造成多种结构用于实现药物的控制释放,以提高药物在疾病治疗中的有效性及降低其副作用。本文综述了国内外关于聚己内酯在多种制备工艺的基础上被制备为微球、纤维、胶束及水凝胶药物载体的研究进展,分析了不同载体制备工艺的优缺点,展望了聚己内酯作为药物载体材料未来的发展方向,旨在为聚己内酯药物控释载体研究提供一定的参考。

关键词：药物控释聚己内酯制备工艺载体结构靶向给药

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基于可食用材料的3D打印技术应用进展

食品与机械 2018年第12期34卷 147-151页

作者：杨来侠杨繁荣桂玉莲李佳璞西安科技大学机械工程学院陕西西安710054

可食用材料范围的延伸加快了3D打印技术的发展。但与工程材料相比,针对可食用材料的3D打印技术仍然面临很多的挑战。文章介绍了目前较为成熟的3D打印技术和其应用领域,并阐述了食品3D打印机的结构构成,以及可食用材料3D打印的国内外研... 详细信息

可食用材料范围的延伸加快了3D打印技术的发展。但与工程材料相比,针对可食用材料的3D打印技术仍然面临很多的挑战。文章介绍了目前较为成熟的3D打印技术和其应用领域,并阐述了食品3D打印机的结构构成,以及可食用材料3D打印的国内外研究进展。总结分析了可食用材料应用于3D打印中存在的问题,并展望了未来会有更广泛的应用领域,将对3D打印技术发展产生深远的影响。

关键词： 3D打印可食用材料应用领域 3D打印机

一种小阳离子有机胺页岩抑制剂的合成及性能研究

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现代化工 2017年第1期37卷 128-131页

作者：李佳蒲晓林戎克生杨彦东都伟超西南石油大学化学化工学院四川成都610500 西南石油大学.石油与天然气工程学院四川成都610500 新疆油田公司工程技术研究院新疆克拉玛依834000

以N-甲基二乙醇胺和溴乙烷为原料合成了甲基乙基二羟乙基溴化铵小阳离子有机胺页岩抑制剂。采用单因素法考查了N-甲基二乙醇胺和溴乙烷的摩尔比、反应温度和反应时间对产率的影响,确立了最优反应条件:N-甲基二乙醇胺和溴乙烷摩尔比为1∶... 详细信息

以N-甲基二乙醇胺和溴乙烷为原料合成了甲基乙基二羟乙基溴化铵小阳离子有机胺页岩抑制剂。采用单因素法考查了N-甲基二乙醇胺和溴乙烷的摩尔比、反应温度和反应时间对产率的影响,确立了最优反应条件:N-甲基二乙醇胺和溴乙烷摩尔比为1∶1.4,反应温度为50℃,反应时间为22 h。产物经红外光谱表征为目标产物。采用线性膨胀率实验、粒度分布实验、页岩滚动回收实验、X射线衍射等方法对甲基乙基二羟乙基溴化铵进行了抑制性能评价,结果表明其抑制性能良好。

关键词：钻井液页岩抑制剂合成性能评价小阳离子

Social function scores and influencing factors in patients with residual depressive symptoms

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World Journal of Psychiatry 2025年第1期15卷 117-127页

作者： Zong-ling liao Xiao-li pu Zhi-Yi Zheng Jie Luo Department 1 of Psychiatry Gele Mountain Hospital of Chongqing Mental Health CenterChongqing 400030China Department of Psychology Chongqing Jiangjin District Psychiatric HospitalChongqing 402260China Department of Psychiatry Chongqing Third Social Welfare InstituteChongqing 400036China Women and Children’s Mental Health Center Affiliated Hospital of Chongqing Population and Family Planning Research InstituteChongqing 400020China

BACKGROUND At present,the influencing factors of social function in patients with residual depressive symptoms are still *** depressive symptoms are highly harmful,leading to low mood in patients,affecting work and interpersonal communication,increasing the risk of recurrence,and adding to the burden on *** the influencing factors of their social function is of great *** To explore the social function score and its influencing factors in patients with residual depressive *** This observational study surveyed patients with residual depressive symptoms(case group)and healthy patients undergoing physical examinations(control group).Participants were admitted between January 2022 and December *** functioning was assessed using the Sheehan Disability Scale(SDS),and scores were compared between *** influencing SDS scores in patients with residual depressive symptoms were analyzed by applying multiple linear regression while using the receiver operating characteristic curve,and these RESULTS The SDS scores of the 158 patients with depressive symptoms were 11.48±*** with the control group,the SDS scores and all items in the case group were *** scores were higher in patients with relapse,discon-tinuous medication,drug therapy alone,severe somatic symptoms,obvious residual symptoms,and anxiety scores≥*** history,medication compliance,therapy method,and residual symptoms correlated positively with SDS scores(r=0.354,0.414,0.602,and 0.456,respectively).Independent influencing factors included disease history,medication compliance,therapy method,somatic symptoms,residual symptoms,and anxiety scores(P<0.05).The areas under the curve for predicting social functional impairment using these factors were 0.713,0.559,0.684,0.729,0.668,and 0.628,respectively,with sensitivities of 79.2%,61.8%,76.8%,81.7%,63.6%,and 65.5%and specificities of 83.3%,87.5%,82.6%,83.3%,86.7%,and 92.1%,respectively.C

关键词： Depressive Residual symptoms Social function Influence factors

维普期刊数据库评论

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传统食品源乳酸菌对酸面团面包风味的影响

粮油食品科技 2024年第2期32卷 65-73页

作者：杨海莺卢玉张春强姚倩儒李佳璞牛兴和李慧中粮营养健康研究院有限公司老年营养食品研究北京市工程实验室营养健康与食品安全北京市重点实验室北京102209 南京财经大学食品科学与工程学院/江苏省现代粮食流通与安全协同创新中心江苏南京210023 中粮麦芽(大连)有限公司辽宁大连116200 北京农学院北京100020

乳酸菌在酸面团制作中扮演着重要角色,对其风味等品质有显著影响。不同种类的乳酸菌在性能上存在差异,为了选育特色酸面团用乳酸菌发酵剂,开发差异化酸面团面包,本研究对来自不同种类传统发酵食品中的乳酸菌,进行糖代谢能力、产有机酸... 详细信息

乳酸菌在酸面团制作中扮演着重要角色,对其风味等品质有显著影响。不同种类的乳酸菌在性能上存在差异,为了选育特色酸面团用乳酸菌发酵剂,开发差异化酸面团面包,本研究对来自不同种类传统发酵食品中的乳酸菌,进行糖代谢能力、产有机酸能力及风味特征评估,并验证其对酸面团和面包风味的影响。结果显示,有6株乳酸菌具有较强的糖代谢能力和产酸性能,风味特征优良。其产生的挥发性风味物质主要包括醇类、酯类、酮类、醛类、酸类和其他类化合物。其中有2株植物乳杆菌可为酸面团面包贡献酸味、果味和酒酿味等特殊风味。这些筛选出的菌株为开发具有特征性香气成分的酸面团发酵剂提供了资源,具有工业应用潜力。

关键词：乳酸菌酸面团风味物质糖代谢能力产有机酸能力面包

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可降解药物控释系统的药物扩散系数表征

西安科技大学学报 2018年第6期38卷 1021-1026页

作者：高扬李佳璞杨来侠徐超董贵荣西安科技大学机械工程学院陕西西安710054 西安理工大学高等技术学院陕西西安710082

为实现药物的长期稳定释放并提高药物利用率,提出了一种以聚乳酸-聚羟基乙酸(PLGA)为载药基体的新型植入式药物控释系统。该药物控释系统可埋植在病灶附近进行长期释药,在药物释放结束后药物载体自然降解。为研究该药物控释系统的释药性... 详细信息

为实现药物的长期稳定释放并提高药物利用率,提出了一种以聚乳酸-聚羟基乙酸(PLGA)为载药基体的新型植入式药物控释系统。该药物控释系统可埋植在病灶附近进行长期释药,在药物释放结束后药物载体自然降解。为研究该药物控释系统的释药性能,建立其药物释放模型、模拟释药过程是有效方法之一,但在建立药物释放模型过程中,不断降解的PLGA材料特性难以量化。文中提出了一种使用扩散系数来表征PLGA材料的降解溶蚀程度的方法,在37℃下使用生理盐水模拟体液,对50/50、65/35及75/25三种单体比例的PLGA材料进行吸水实验和降解实验,并制备全封装药物控释系统进行了体外释药实验。通过实验结果的对比并基于物质守恒与传递定理,推导了封装药物在PLGA载药基体中释放时扩散系数的分段表达函数。基于该扩散系数表达函数,建立了药物通过该给药系统释放的有限元模型;使用有限元模型模拟药物的释放过程,并将有限元模拟结果与该药物控释系统体外释药实验结果进行了对比。结果表明,药物控释系统累积释药量呈线性变化,有限元模型模拟结果与体外释药实验结果基本吻合,验证了药物在PLGA材料中扩散系数分段表达式及有限元释药模型的正确性。该研究为后期建立药物释放的解析模型提供了一定的理论基础。

关键词：机械工程可降解材料给药系统体外释药扩散系数