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Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer‑like social memory loss

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Military Medical Research 2025年第1期12卷 48-71页

作者： Hui-Yang lei Gui-Lin Pi Ting He Rui Xiong Jing-Ru Lv jia-le liu Dong-Qin Wu Meng-Zhu Li Kun Shi Shi-Hong Li Na-Na Yu Yang Gao Hui-Ling Yu Lin-Yu Wei Xin Wang Qiu-Zhi Zhou Pei-Lin Zou jia-Yang Zhou Ying-Zhou liu Nai-Ting Shen Jie Yang Dan Ke Qun Wang Gong-Ping liu Xi-Fei Yang jian-Zhi Wang Ying Yang Department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Traditional Chinese Medicine the Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014China Key Laboratory of Modern Toxicology of Shenzhen Shenzhen Center for Disease Control and PreventionShenzhen 518055GuangdongChina Co‑Innovation Center of Neuroregeneration Nantong UniversityNantong 226000JiangsuChina

Background:Episodic memory loss is a prominent clinical manifestation of Alzheimer’s disease(AD),which is closely related to tau pathology and hippocampal *** to the heterogeneity of brain neurons,the specific roles of different brain neurons in terms of their sensitivity to tau accumulation and their contribution to AD-like social memory loss remain ***,further investigation is ***:We investigated the effects of AD-like tau pathology by Tandem mass tag proteomic and phosphoproteomic analysis,social behavioural tests,hippocampal electrophysiology,immunofluorescence staining and in vivo optical fibre recording of GCaMP6f and ***,we utilized optogenetics and administered ursolic acid(UA)via oral gavage to examine the effects of these agents on social memory in ***:The results of proteomic and phosphoproteomic analyses revealed the characteristics of ventral hippocampal CA1(vCA1)under both physiological conditions and AD-like tau *** tau progressively accumulated,vCA1,especially its excitatory and parvalbumin(PV)neurons,were fully filled with mislocated and phosphorylated tau(p-Tau).This finding was not observed for dorsal hippocampal CA1(dCA1).The overexpression of human tau(hTau)in excitatory and PV neurons mimicked AD-like tau accumulation,significantly inhibited neuronal excitability and suppressed distinct discrimination-associated firings of these neurons within *** excitatory and PV neurons in vCA1 at specific rhythms and time windows efficiently ameliorated tau-impaired social ***,1 month of UA administration efficiently decreased tau accumulation via autophagy in a transcription factor EB(TFEB)-dependent manner and restored the vCA1 microcircuit to ameliorate tau-impaired social ***:This study elucidated distinct protein and phosphoprotein networks between dCA1 and vCA1 and highlighted the susceptibility of the vCA1 microcircuit to AD-like tau

关键词： Alzheimer’s disease Tau protein Ventral hippocampus Social memory Ursolic acid Transcription factor EB(TFEB)

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Analysis of vibration response characteristics of subway station and superstructure with hard combination

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Earthquake Engineering and Engineering Vibration 2025年第1期24卷 271-281页

作者： jia Jinglong Xu Weiping liu Xu Wei Yong Key Laboratory of Transportation Tunnel Engineering Ministry of EducationSchool of Civil EngineeringSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Intelligent Geotechnics and Tunnelling Chengdu 610031China China Railway Eryuan Chongqing Survey and Design Institute Co.Ltd. Chongqing 400023China

The vibration response and noise caused by subway trains can affect the safety and comfort of *** study the dynamic response characteristics of subway stations and superstructures under train loads with a hard combination,a numerical model is developed in this *** indoor model test verified the accuracy of the numerical *** influence laws of different hard combinations,train operating speeds and modes were studied and evaluated *** results show that the frequency corresponding to the peak vibration acceleration level of each floor of the superstructure property is concentrated at 10–20 *** vibration response decreases in the high-frequency parts and increases in the lowfrequency parts with increasing distance from the ***,the factors,such as train operating speed,operating mode,and hard combination type,will affect the vibration of the *** vibration response under the reversible operation of the train is greater than that of the unidirectional *** operating speed of the train is proportional to its vibration *** vibration amplification area appears between the middle and the top of the superstructure at a higher train *** vibration acceleration level will exceed the limit value of relevant regulations,and vibration-damping measures are *** the scope of application,this study provides some suggestions for constructing subway stations and superstructures.

关键词： subway station superstructure vibration response hard combination

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Upcycling of polyphenylene oxide into 2,6-dimethyl aniline via depolymerization and amination over a Pt/CeO_(2) catalyst

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Science China Chemistry 2025年第2期68卷 520-525页

作者： Shengchao jia Wenke Zhao Xiaohui liu Yong Guo Yanqin Wang State Key Laboratory of Green Chemical Engineering and Industrial Catalysis Research Institute of Industrial CatalysisSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China Shanghai Key Laboratory of Functional Materials Chemistry School of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

Upcycling of plastic waste into N-containing compound is a novel and attractive strategy for its disposal and will opens up a promising direction for the production of value-added ***,an efficient strategy for the depolymerization-amination of polyphenylene oxide(PPO)into 2,6-dimethyl aniline is developed over a simple Pt/CeO_(2) *** C–O linkages of PPO can be selectively broken,producing 2,6-dimethyl phenol and then hydrogenated and aminated to 2,6-dimethyl cyclohexylamine over the Pt/CeO_(2) ***,2,6-dimethyl aniline was produced with high selectivity through the dehydrogenation of 2,6-dimethyl cyclohexylamine in the same *** can be used as the hydrogen-acceptor in the dehydrogenation step and enhance the selectivity of target *** N-containing compound,2,6-dimethyl aniline,is obtained and separated after HCl ***,the Pt/CeO_(2) catalyst exhibit remarkable stability and can sustainably catalyze the synthesis of 2,6-dimethyl aniline in several cycles.

关键词： PPO depolymerization-amination 2,6-dimethyl aniline Pt/CeO_(2)

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Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 144-151页

作者： Yunhan Yang Han jia Tuo liu Yuzhen Yang Jun Yang Key Laboratory of Noise and Vibration Research Institute of AcousticsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of SciencesBeijing 100190China

The phenomenon of induced transparency,characterized by a high quality(Q)factor,holds significant importance in the fields of high-precision sensing,energy storage and wave *** transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters,thereby hindering advanced research on high-Q *** we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection *** virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom,we achieve the manipulation of induced transparency in a decoupled,wide-ranging,and elaborate *** the diverse evolutions across the intrinsic parameter space,we show experimentally a counter-intuitive increase in the Q-factor of the transparency window,which is attributed to the enhanced dissipation of the bright ***,a constant group delay at the center frequency is observed accompanying this *** work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon,and paves the way towards applications in programmable acoustic sensors,filters and slow-wave devices.

关键词： induced transparency acoustic meta-atom high quality-factor scattering programmable intrinsic parameter

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Assessing microcatheter-assisted 360-degree trabeculotomy combined with trabeculectomy for refractory glaucoma:1-year results

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 94-102页

作者： jia-Yin Qin Yan liu Tao Wang Department of Ophthalmology Peking University International HospitalBeijing 102206China Beijing Key Laboratory of Ophthalmology and Visual Science Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To evaluate the efficacy and safety of microcatheterassisted 360-degree trabeculotomy combined with trabeculectomy(MATT-Trab)for treating refractory ***:Patients with refractory glaucoma who underwent MATT-Trab were retrospectively *** indicators for research statistics included the intraocular pressure(IOP)level,degree of decrease,changes in medication dosage,and success *** indicators included the best-corrected visual acuity and incidence of ***:This study comprised 31 patients,including 11 males and 20 females,with ages ranging from 8mo to 67y(mean age:29.40±22.10y).The average postoperative IOP at 1d,1wk,1mo,3mo,6mo,1y,and the last followup was significantly lower than the average preoperative IOP(31.33±9.24 mm Hg,P<0.05).The average number of postoperative medications at 1y was 0.48±1.51,which was significantly reduced compared to that used preoperatively(3.77±0.99,P=0.00).The absolute and qualified success rates were 45.16% and 83.87%,*** acuity exhibited no statistically significant difference between the postoperative and preoperative follow-up time points,except for the first day after *** most common postoperative complications were anterior chamber hemorrhage(25 cases,86.21%)and high IOP(10 cases,34.48%).CONCLUSION:Our results indicate that MATT-Trab is effective and safe for treating refractory glaucoma.

关键词： glaucoma refractor y glaucoma trabeculotomy trabeculectomy microcatheter

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Histopathological diagnosis of microvascular invasion in hepatocellular carcinoma:Is it reliable?

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World Journal of Gastroenterology 2025年第5期31卷 105-116页

作者： liu-Jun Li Chao-Qun Wu Fei-le Ye Zhou Xuan Xiao-Li Zhang jian-Ping Li jia Zhou Zhong-Zhen Su Department of Ultrasound The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina Department of Ultrasound The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Guangdong Provincial Key Laboratory of Biomedical Imaging and Guangdong Provincial Engineering Research Center of Molecular Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Pathology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000Guangdong ProvinceChina Department of Pathology The First Affiliated HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Microvascular invasion(MVI)is a critical prognostic factor for postoperative hepatocellular carcinoma recurrence,but the reliability of its current pathological diagnosis remains *** To evaluate the accuracy of current 7-point sampling methods and propose an optimal pathological protocol using whole-mount slide imaging(WSI)for better MVI *** We utilized 40 New Zealand white rabbits to establish VX2 liver tumor *** entire tumor-containing liver lobe was subsequently obtained,following which five different sampling protocols(A-E)were employed to evaluate the detection rate,accuracy,quantity,and distribution of MVI,with the aim of identifying the optimal sampling *** VX2 liver tumor models were successfully established in 37 rabbits,with an incidence of MVI of 81.1%(30/37).The detection rates[27%(10/37),43%(16/37),62%(23/37),68%(25/37),and 93%(14/15)]and quantity(15,36,107,125,and 395)of MVI increased significantly from protocols A to *** distribution of MVI showed fewer MVIs farther away from the tumor,but the percentage of MVI detected quantity gradually increased from 6.7%to 48.3%in the distant nonneoplastic liver tissue from protocols A to *** C was identified as the optimal sampling method by comparing them in *** sampling protocol of three consecutive interval WSIs at the tumor center(WSI3)was further screened to determine the optimal number of *** A(7-point sampling method)exhibited only 46%accuracy and a high false-negative rate of 67%.Notably,the WSI3 protocol improved the accuracy to 78%and decreased the false-negative rate to 27%.CONCLUSION The current 7-point sampling method has a high false-negative rate in MVI *** contrast,the WSI3 protocol provides a practical and effective approach to improve MVI diagnostic accuracy,which is crucial for hepatocellular carcinoma diagnosis and treatment planning.

关键词： Hepatocellular carcinoma Microvascular invasion Histopathological diagnosis Whole-mount slide imaging Sampling protocol

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Alumina supported platinum-ceria catalyst for reverse water gas shift reaction

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Journal of Rare Earths 2025年第2期43卷 284-294,I0002页

作者： Na jiang Weiwei Wang Haoxin liu Meiyao Wu Chunjiang jia Key Laboratory for Colloid and Interface Chemistry Key Laboratory of Special Aggregated MaterialsSchool of Chemistry and Chemical EngineeringShandong UniversityJinan 250100China

The activation of CO_(2)molecules is a fundamental step for their effective *** highdensity oxygen vacancies on the surface of reducible oxides is pivotal for the activation of CO_(2).In this work,we prepared a series of 0.5PtxCe/Al_(2)O_(3)(x=1,5,10,or 20)catalysts with varying Ce loading and 0.5 wt%of Pt for the reverse water gas shift(RWGS)*** size of CeO_(2)particle increases with Ce ***,the 0.5Pt5Ce/Al_(2)O_(3) catalyst with an average CeO_(2)particle size of 5.5 nm exhibits a very high CO_(2)conversion rate(116.4×10^(-5)mol_(CO_(2))/(g_(cat)·s))and CO selectivity(96.1%)at 600℃.Our experimental findings reveal that the small-size CeO_(2)in 0.5Pt5Ce/Al_(2)O_(3) possesses a greater capacity to generate reactive oxygen vacancies,promoting the adsorption and activation of CO_(2).In addition,the oxygen vacancies are cyclically generated and consumed during the reaction,which contributes to the elevated catalytic performance of the *** work provides a general strategy to construct rich oxygen vacancies on CeO_(2)for designing high-performance catalysts in C_(1) chemistry.

关键词： CO_(2)activation Ceria Oxygen vacancies Size-effect Reverse water gas shift reaction Rare earths

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Outcomes of a non-diffractive extended depth of focus intraocular lens in patients with well-controlled glaucoma and ocular hypertension

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International Journal of Ophthalmology(English edition) 2025年第1期18卷 79-85页

作者： jia-Ru liu Andrei-Alexandru Szigiato Paul Harasymowycz Department of Ophthalmology University of MontrealQuebec H3T 1J4Canada Department of Ophthalmology Hôpital Sacré-CoeurQuebec H4J 1C5Canada Department of Ophthalmology Hôpital Maisonneuve-RosemontQuebec H1T 2M4Canada Bellevue Ophthalmology Clinics Quebec H1V 1G5Canada

AIM:To assess visual outcomes and satisfaction of a non-diffractive extended depth of focus(EDOF)intraocular lens(IOL)in individuals with ocular hypertension(OHT)and well-controlled mild glaucoma undergoing cataract ***:An investigator-initiated,single-center,prospective,interventional,noncomparative study conducted in Montreal,*** study enrolled 31 patients(55 eyes)with OHT or mild glaucoma who received a non-diffractive EDOF IOL(Acrysof IQ Vivity).Participants underwent sequential cataract surgery with the Vivity ***-up evaluations occurred at 1d,1,and 3mo postoperatively,assessing uncorrected distance,intermediate,and near visual ***(QUVID:Questionnaire for visual disturbances and IOLSAT:Intraocular lens satisfaction)were administered pre and post-operatively to measure visual disturbances and spectacle independence in various *** parameters included intraocular pressure(IOP),glaucoma medications,spherical equivalence,mean deviation and pattern standard deviation or square root of lost variance on Octopus visual ***:At 1 and 3mo postoperatively,significant improvements were observed in uncorrected distance and intermediate visual *** independence was enhanced for distance and intermediate vision,especially in bright light ***-free intermediate vision was improved even in dim *** disturbances,particularly glare symptoms,were reduced,and there was a notable decrease in IOP and glaucoma medication burden at *** was more hazy vision postoperatively with no impact on visual acuity and visual ***:The non-diffractive EDOF lens improves distance and intermediate spectacle-free visual function in patients with OHT and well-controlled *** findings highlight significant improvements in visual acuity,reduced glare,enhanced spectacle independence,and improved visual performance in different lighting conditions.

关键词： extended depth of focus refractive glaucoma ocular hypertension cataract intraocular lens

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Enhanced post-combustion CO_(2) capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu Wang Xiao Ding Huang Yunyi Yiyu liu jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and TechnologyJiangmen 529100GuangdongChina Guangzhou HKUST Fok Ying Tung Research Institute Guangzhou 511458GuangdongChina The Hong Kong University of Science and Technology(Guangzhou) Guangzhou 511453GuangdongChina Stoddart Institute of Molecular Science Department of ChemistryZhejiang UniversityHangzhou 310058ZhejiangChina Carbon Neutrality and Climate Change Thrust Society HubThe Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511453GuangdongChina

Graphene has enormous potential to capture CO_(2)due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO_(2)adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N_(2)/H_(2)plasma treatment process to prepare graphene-based sorbent material with enhanced CO_(2)adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO_(2)adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture (DAC).Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N_(2)/H_(2)plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO_(2)capture Climate change Plasma treatment Graphene aerogel

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Integrating well logs, 3D seismic, and earthquake data for comprehensive prediction of 3D in-situ stress orientations: A case study from the Weiyuan area in the Sichuan Basin, China

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Petroleum Science 2025年第1期22卷 210-221页

作者： Huan Cao Yang Zhao Hai-Chao Chen le-le Zhang Cheng-Gang Xian Ji-Dong Yang Lu liu State Key Laboratory of Petroleum Resources and Engineering and Unconventional Petroleum Research Institute China University of Petroleum (Beijing) Department of Geophysics China University of Petroleum (East China) Aramco Beijing Research Center Aramco Asia

Determining the orientation of in-situ stresses is crucial for various geoscience and engineering applications. Conventional methods for estimating these stress orientations often depend on focal mechanism solutions(FMSs) derived from earthquake data and formation micro-imager(FMI) data from well ***, these techniques can be costly, depth-inaccurate, and may lack spatial coverage. To address this issue, we introduce the use of three-dimensional(3D) seismic data(active sources) as a lateral constraint to approximate the 3D stress orientation field. Recognizing that both stress and fracture patterns are closely related to seismic velocity anisotropy, we derive the orientation of azimuthal anisotropy from multi-azimuth 3D seismic data to compensate for the lack of spatial stress orientation information. We apply our proposed workflow to a case study in the Weiyuan area of the Sichuan Basin, China, a region targeted for shale gas production. By integrating diverse datasets, including 3D seismic, earthquakes, and well logs, we develop a comprehensive 3D model of in-situ stress(orientations and magnitudes). Our results demonstrate that the estimated anisotropy orientations from 3D seismic data are consistent with the direction of maximum horizontal principal stress(SHmax) obtained from FMIs. We analyzed 12earthquakes(magnitude > 3) recorded between 2016 and 2020 for their FMSs and compressional axis(Paxis) orientations. The derived SHmax direction from our 3D stress model is 110°ES(East-South), which shows excellent agreement with the FMSs(within 3.96°). This close alignment validates the reliability and precision of our integrated method for predicting 3D SHmax orientations.

关键词： In-situ stress orientation SHmax Azimuthal velocity anisotropy Focal source mechanism Formation micro-imager

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