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Interplay between creeping fat and gut microbiota: A brand-new perspective on fecal microbiota transplantation in Crohn's disease

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World Journal of Gastroenterology 2025年第2期31卷 138-143页

作者： Ying Wang Jie liu Department of Life Sciences and Medicine South District of Endoscopic CenterThe First Affiliated Hospital of University of Science and Technology of ChinaUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Gastroenterology The First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

Inflammatory bowel disease,particularly Crohn's disease(CD),has been linked to modifications in mesenteric adipose tissue(MAT)and the phenomenon known as"creeping fat"(CrF).The presence of CrF is believed to serve as a predictor for early clinical recurrence following surgical intervention in patients with ***,the incorporation of the mesentery during ileocolic resection for CD has been correlated with a decrease in surgical recurrence,indicating the significant role of MAT in the pathogenesis of *** numerous studies have indicated that dysbiosis of the gut microbiota is a critical factor in the development of CD,the functional implications of translocated microbiota within the MAT of CD patients remain *** manuscript commentary discusses a recent basic research conducted by Wu et *** their study,intestinal bacteria from individuals were transplanted into CD model mice,revealing that fecal microbiota trans-plantation(FMT)from healthy donors alleviated CD symptoms,whereas FMT from CD patients exacerbated these ***,FMT was found to affect intestinal permeability,barrier function,and the levels of proinflammatory factors and ***,these findings suggest that targeting MAT and CrF may hold therapeutic potential for patients with ***,the study did not evaluate the composition of the intestinal microbiota of the donors or the subsequent alterations in the gut ***,the gut microbiota plays a crucial role in the histopathology of CD,and thus,targeting MAT and CrF may represent a promising avenue for treatment in this patient population.

关键词： Crohn's disease Mesenteric adipose tissue Creeping fat Fecal microbiota transplantation Gut microbiota

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Bullous pemphigoid associated with acquired hemophilia A: A case report

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World Journal of Clinical Cases 2025年第4期13卷 28-33页

作者： Su-Ye Hu Meng-Can Li Zi-jia Hao Xu-Ya Chai Pei-Sai Li Yang liu Li-Xia liu Ying Xu Pan-Pan Yang Ling-E Li Department of Dermatology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina Graduate School Hebei University of Traditional Chinese MedicineShijiazhuang 050051Hebei ProvinceChina Department of Pathology Shijiazhuang Traditional Chinese Medicine HospitalShijiazhuang 050051Hebei ProvinceChina

BACKGROUND Acquired hemophilia A (AHA) is a rare and potentially severe bleeding disordercaused by circulating autoantibodies against factor Ⅷ (FⅧ). In approximately50% of the patients, the condition is associated with autoimmune diseases,cancers, medication use, pregnancy, and the post-partum period. Bullous pemphigoid(BP) is a chronic autoimmune subepidermal blistering disease associatedwith tissue-bound and circulating autoantibodies against BP antigens 180 (BP180)and 230 (BP230). AHA-associated BP has a high mortality rate;hence, the understandingof this disease must *** SUMMARY A 69-year-old man presented with erythema, blisters, blood blisters, and crustsaccompanied by severe pruritus for more than 20 days, and ecchymosis andswelling on his left upper arm for 3 days. Pathological examination revealed asubepidermal blister that contained eosinophils. Laboratory tests showed that theBP180 autoantibody levels had increased, isolated activated partial thromboplastintime was notably prolonged (115.6 s), and coagulation FⅧ activity wasextremely low (< 1.0%). Furthermore, the FⅧ inhibitor titer had greatlyincreased (59.2 Bethesda units). Therefore, the patient was diagnosed as having BP associated with AHA, prescribed 0.05% topical halometasone cream, and transferred to a higher-level hospitalfor effective treatment;however, he died after 2 *** AHA associated BP is rare, dangerous, and has a high mortality rate. Therefore, its timely diagnosis and effectivetreatment are necessary.

关键词： Bullous pemphigoid Acquired hemophilia A Acquired hemophilia A FactorⅧ Case report

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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin Li Wen-Tao Kuai Lin Chen Ming-Hui Zeng Xue-Mei Tao jia-Xin Han Yue-Kui Wang Lian-Xin Xu Li-Ying Ge Yong-Gang liu Shuang Li Liang Xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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负载骨形态发生蛋白2水凝胶诱导牙髓干细胞的成骨分化

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中国组织工程研究 2025年第16期29卷 3301-3310页

作者：伊斯拉尔古丽·麦麦提贾森刘佳新疆医科大学第一附属医院(附属口腔医院)儿童口腔科-口腔预防科新疆维吾尔自治区乌鲁木齐市830054 西安医学院口腔医学院陕西省西安市710021 新疆维吾尔自治区口腔医学研究所新疆维吾尔自治区乌鲁木齐市830054

背景:前期研究证明,甲基丙烯酸酐改性明胶/经处理牙本质基质复合水凝胶支架可促进人牙髓干细胞的增殖及分化。水凝胶负载骨形态发生蛋白2被认为是骨修复中有前景的材料。目的:观察负载不同质量浓度骨形态发生蛋白2的甲基丙烯酸酐改性明... 详细信息

背景:前期研究证明,甲基丙烯酸酐改性明胶/经处理牙本质基质复合水凝胶支架可促进人牙髓干细胞的增殖及分化。水凝胶负载骨形态发生蛋白2被认为是骨修复中有前景的材料。目的:观察负载不同质量浓度骨形态发生蛋白2的甲基丙烯酸酐改性明胶/经处理牙本质基质复合水凝胶对人牙髓干细胞成骨向分化的诱导作用。方法:制备含0,50,100,200μg/mL骨形态发生蛋白2的甲基丙烯酸酐改性明胶/经处理牙本质基质复合水凝胶,分别记为GelMA/TDM、BMP-2(50 ng/mL)GelMA/TDM、BMP-2(100 ng/mL)GelMA/TDM、BMP-2(200 ng/mL)GelMA/TDM,检测复合水凝胶对骨形态发生蛋白2的体外缓释性能。采用改良组织块酶消化法提取人牙髓干细胞,分别接种于4种水凝胶表面,采用CCK-8法检测细胞增殖,DAPI染色检测细胞黏附;对各组水凝胶表面的人牙髓干细胞进行成骨诱导,进行碱性磷酸酶染色、碱性磷酸酶活性检测与茜素红染色,采用RT-PCR法检测相关成骨基因(Runx2、骨形态发生蛋白2、骨桥蛋白、骨钙素、Ⅰ型胶原)表达。结果与结论:①甲基丙烯酸酐改性明胶/经处理牙本质基质复合水凝胶可持续释放骨形态发生蛋白2长达21 d,在第3-6天释放较快,第6天之后释放趋于平稳;②4种水凝胶均可促进人牙髓干细胞的增殖,其中以BMP-2(100 ng/mL)-GelMA/TDM复合水凝胶的作用最明显;相较于GelMA/TDM复合水凝胶,BMP-2-GelMA/TDM复合水凝胶可促进人牙髓干细胞的黏附,其中以BMP-2(200 ng/mL)-GelMA/TDM复合水凝胶的作用最明显;③相较于GelMA/TDM复合水凝胶,BMP-2-GelMA/TDM复合水凝胶可提升碱性磷酸酶活性、钙结节含量与相关成骨基因表达,综合分析显示BMP-2(100 ng/mL)-GelMA/TDM复合水凝胶的作用更明显;④结果表明,BMP-2(100 ng/mL)-GelMA/TDM复合水凝胶促进牙髓干细胞成骨向分化的能力更明显。

关键词：人牙髓干细胞骨形态形成蛋白2 细胞增殖细胞分化组织工程牙髓-牙本质再生

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Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： Yunhan Yang Han jia Tuo liu Yuzhen Yang Jun Yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

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光交联复合水凝胶支架中人牙髓干细胞的成骨/成牙分化能力

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中国组织工程研究 2025年第19期29卷 4022-4028页

作者：杨杜娟程梦可刘佳新疆医科大学第一附属医院(附属口腔医院)儿童口腔科-口腔预防科新疆维吾尔自治区乌鲁木齐市830054 新疆维吾尔自治区口腔医学研究所新疆维吾尔自治区乌鲁木齐市830054

背景:甲基丙烯酸酐改性明胶(gelatin-methacryloyl,Gel-MA)与经处理牙本质基质(treated dentin matrix,TDM)在一定比例下经过紫外线交联后形成的复合水凝胶支架具有良好的孔隙率、机械性能、溶胀性能及生物降解率,这为临床上年轻恒牙的... 详细信息

背景:甲基丙烯酸酐改性明胶(gelatin-methacryloyl,Gel-MA)与经处理牙本质基质(treated dentin matrix,TDM)在一定比例下经过紫外线交联后形成的复合水凝胶支架具有良好的孔隙率、机械性能、溶胀性能及生物降解率,这为临床上年轻恒牙的牙髓再生提供了新的思路和方法。目的:探究1∶2质量比Gel-MA/TDM复合光交联水凝胶支架对人牙髓干细胞增殖能力及成骨/成牙本质分化能力的影响。方法:将第3代牙髓干细胞接种至1∶2质量比Gel-MA/TDM复合水凝胶支架中,采用CCK-8实验检测人牙髓干细胞在复合水凝胶支架中的增殖能力。将第3代牙髓干细胞接种至1∶2质量比Gel-MA/TDM复合水凝胶支架中并进行成骨诱导,采用碱性磷酸酶染色及茜素红染色观察矿化结节的形成情况,采用RT-PCR检测成牙相关因子(牙本质基质蛋白1、牙本质涎磷蛋白)和成骨相关因子(骨钙素、Runt相关转录因子2)的基因表达。结果与结论:①CCK-8检测结果显示,前7 d的牙髓干细胞增殖能力明显升高,第10天时速度减缓;②碱性磷酸酶染色及茜素红染色结果显示,Gel-MA/TDM复合水凝胶组牙髓干细胞的碱性磷酸酶活性及矿化结节生成强于单纯Gel-MA水凝胶组(P<0.05);③RT-PCR结果显示,Gel-MA/TDM复合水凝胶组牙髓干细胞中牙本质基质蛋白1、牙本质涎磷蛋白、骨钙素、Runt相关转录因子2的基因表达量明显高于单纯Gel-MA水凝胶组(P<0.05),且14 d基因表达量明显高于7 d(P<0.05)。结果表明,培养在1∶2 Gel-MA/TDM复合水凝胶支架上的牙髓干细胞表现出较好的增殖能力,能够强化牙髓干细胞的成骨、成牙本质分化能力。

关键词：牙髓再生甲基丙烯酸酐改性明胶牙本质基质复合支架牙髓干细胞成骨成牙本质

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Network pharmacology:Changes the treatment mode of"one disease-one target"in cancer treatment

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 268-271页

作者： Shuai liu Yong-Wei Yu Department of Cardiology The First People’s Hospital of JiashanJiaxing 314100Zhejiang ProvinceChina Department of Critical Care Medicine The First Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

The article concluded that network pharmacology provides new ideas and insights into the molecular mechanism of traditional Chinese medicine(TCM)treatment of *** is a new choice and hot spot in the field of cancer *** have also previously published studies on TCM and network *** this letter,we summarize the new paradigm of network pharmacology in cancer treatment mechanisms.

关键词： Network pharmacology Cancer Multicomponent Multitarget Therapy

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Double Roots of Mandibular Premolar in Full-mouth Periapical Films

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Chinese Medical Sciences Journal 2015年第3期30卷 174-178页

作者： Ling-jia Kong kuo Wan Deng-gao liu Department of Stomatology Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College Department of Radiology Peking University School of Stomatology

Objective To evaluate the incidence of two-rooted mandibular premolar morphology using full-mouth periapical film series in a Chinese population,with particular emphasis on bilateral incidence,so as to provide a clinical anatomical basis for root canal treatment in mandibular *** A total of 2015 patients who underwent dental treatment and had full mouth periapical radiographs at the Peking University School of Stomatology from April 2011 to April 2012 were enrolled in this *** experienced dentists reviewed the patients' periapical films and classified the root morphology of mandibular premolars *** incidence of unilateral and bilateral double roots were recorded and calculated,including confirmed and suspected bucco-lingual root *** In terms of the morphology of two-rooted mandibular first premolars,of the 2015 cases with complete root formation,two-rooted first premolars were detected in 120 cases,with a total number of 159 *** to the number of teeth,the overall incidence of double roots was 4.03%(159/3972).In terms of the morphology of two-rooted mandibular second premolars,of the 2015 cases with complete root formation,two-rooted second premolars were detected in 24 cases,with a total number of 33 *** to the number of teeth,the overall incidence of double roots was 0.85%(33/3880).Conclusions The roots of mandibular premolars display specific morphological *** on a large sample,we observed and calculated not only the occurrence rate of bucco-lingual and mesio-distal double roots in first and second mandibular premolars,but also the incidence of unilateral or bilateral double roots within the same *** findings could provide useful information on the anatomical structure of mandibular premolars for endodontic,prosthodontic and surgical procedures,and could improve the quality of treatment and reduce complications.

关键词： first mandibular premolar second mandibular premolar double roots full-mouth periapical film

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Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi Yu Faith Teo En Ning Chang liu Yu-Chi liu Tissue Engineering and Stem Cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina

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AlScN films prepared by alloy targets and SAW device characteristics

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Journal of Rare Earths 2023年第3期41卷 434-439,I0004页

作者： kuo Men Hao liu Xingquan Wang Qian jia Zhaochong Ding Huating Wu Daogao Wu Yuhua Xiong State Key Laboratory of Advanced Materials for Smart Sensing GRINM Group Co.Ltd.Beijing 100088China GRIMAT Engineering Institute Co. Ltd.Beijing 101402China State Key Laboratory of Non-ferrous Metals and Processes GRINM Group Co.Ltd.Beijing 100088China GRIKIN Advanced Material Co.Ltd. Beijing 100220China GRIREM Advanced Materials Co.Ltd. Beijing 100088China

In this paper,we reported a surface acoustic wave(SAW)device prepared and optimized by piezoelectric films containing AIN,AIScN(Sc-20 at%)and AIScN(Sc-30 at%)by reactive magnetron sputtering using Al and AISc alloy *** calculated the material intrinsic electromechanical coupling coefficient k_(t)^(2) of AlScN(Sc-20 at%)and AlScN(Sc-30 at%)which are much better than *** can be explained by the lattice ***,the results were confirmed by transmission electron microscopy(TEM)observation of the *** the SAW devices based on three thin films were tested by vector network analysis obtaining the device equivalent electro mechanical coupling coefficient k_(eff)^(2).The value of AIScN(Sc-20 at%)k_(eff)^(2),which equals to 1.94%,is higher than that of AIN and AIScN(Sc-30 at%)while the value of AIScN(Sc-30 at%)k_(t)^(2) is higher than that of *** is shown in our study that the crystallinity and orientation of the material still have a greater impact on k_(eff)^(2) but it does not have influence on k_(t)^(2) in the actual device preparation process.

关键词： AlScN film Alloy targets SAW Electromechanical coupling coefficient k_(t)^(2) Crystallinity Orientation

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