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Epidemiology and outcome of individuals with intraductal papillary neoplasms of the bile duct

World Journal of Gastrointestinal Oncology 2023年第5期15卷 843-858页

作者： Rong-Shou Wu Wen-Jun Liao Jing-Sheng Ma jia-kun wang Lin-Quan Wu Ping Hou Department of Hepatobiliary and Pancreatic Surgery The Second Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of Organ Transplantation The Second Affiliated Hospital of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina Department of General Surgery The First Affiliated Hospital of Gannan Medical CollegeNo.23 Qingnian RoadZhanggong DistrictGanzhou 341000Jiangxi ProvinceChina

BACKGROUND Intraductal papillary neoplasm of the bile duct(IPNB)is a rare distinct subtype of precursor lesions of biliary *** is considered to originate from luminal biliary epithelial cells,typically displays mucin-hypersecretion or a papillary growth pattern,and results in cystic dilatation[1].IPNB develops anywhere in the intrahepatic and extrahepatic biliary tracts,and can occur in various pathological stages from low-grade dysplasia to invasive *** have similar phenotypic changes in the occurrence and development of all subtypes,and the prognosis is significantly better than that of traditional(nonpapillary)*** To evaluate the clinicopathological features of IPNB to provide evidence-based guidance for *** Invasive IPNB,invasive intraductal papillary mucinous neoplasm of the pancreas(IPMN),and traditional cholangiocarcinoma data for affected individuals from 1975 to 2016 were obtained from the Surveillance,Epidemiology,and End Results(SEER)*** percentage changes(APCs)in the incidence and incidence-based(IB)mortality were *** identified the independent predictors of overall survival(OS)and cancer-specific survival(CSS)in indivi duals with invasive *** The incidence and IB mortality of invasive IPNB showed sustained decreases,with an APC of-4.5%(95%CI:-5.1%to-3.8%)and-3.3%(95%CI:-4.1%to-2.6%)(P<0.001),*** decreases in incidence and IB mortality were seen for invasive IPMN but not for traditional *** OS and CSS for invasive IPNB were better than for invasive IPMN and traditional cholangiocarcinoma.A total of 1635 individuals with invasive IPNB were included in our prognosis *** most common tumor sites were the pancreaticobiliary ampulla(47.9%)and perihilar tract(36.7%),but the mucin-related subtype of invasive IPNB was the main type,intrahepatically(approximately 90%).In the univariate and multivariate Cox regression analysis,age,tum

关键词： Surveillance,Epidemiology,and End Results database Intraductal papillary neoplasms of the bile duct Subtype Annual percentage changes Prognosis

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Rumen fermentation and acetogen population changes in response to an exogenous acetogen TWA4 strain and Saccharomyces cerevisiae fermentation product

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2015年第8期16卷 709-719页

作者： Chun-lei YANG Le-luo GUAN jian-xin LIU jia-kun wang Institute of Dairy Science Mo E Key Laboratory of Molecular Animal Nutrition College of Animal SciencesZhejiang University Department of Agricultural Food & Nutritional Science Faculty of Agricultural Life & Environmental SciencesUniversity of Alberta

The presence of yeast cells could stimulate hydrogen utilization of acetogens and enhance acetogenesis. To understand the roles of acetogens in rumen fermentation, an in vitro rumen fermentation experiment was conducted with addition of acetogen strain （TWA4） and/or Saccharomyces cerevisiae fermentation product （XP）. A 2×2 factorial design with two levels of TWA4 （0 or 2×10^7 cells/ml） and XP （0 or 2 g/L） was performed. Volatile fatty acids （VFAs） were increased （P〈0.05） in XP and TWA4XP, while methane was increased only in TWA4XP （P〈0.05）. The increase rate of microorganisms with formyltetrahydrofolate synthetase, especially acetogens, was higher than that of methanogens under all treatments. Lachnospiraceae was predominant in all acetogen communities, but without close acetyI-CoA synthase （ACS） amino acid sequences from cultured isolates. Low-Acetitomaculum ruminis-like ACS was predominant in all acetogen communities, while four unique phylotypes in XP treatment were all amino acid identified Iow-Eubacterium limosum-like acetogens. It differs to XP treatment that more Iow-A. ruminis-like and less Iow- E. limosum-like sequences were identified in ＂I＇WA4 and TWA4XP treatments. Enhancing acetogenesis by supple- mentation with an acetogen strain and/or yeast cells may be an approach to mitigate methane, by targeting proper acetogens such as uncultured Iow-E. limosum-like acetogens.

关键词： Acetogen Saccharomyces cerevisiae fermentation product Rumen fermentation Methanogen

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RGS4 promotes the progression of gastric cancer through the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition

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World Journal of Gastroenterology 2025年第2期31卷 113-127页

作者： Peng-Yu Chen Pei-Yao wang Bang Liu Yang-Pu jia Zhao-Xiong Zhang Xin Liu Dao-Han wang Yong-jia Yan Wei-Hua Fu Feng Zhu Department of General Surgery Tianjin Medical University General HospitalTianjin Medical UniversityTianjin 300052China Department of General Surgery Jincheng People’s HospitalJincheng 048000Shanxi ProvinceChina

BACKGROUND Regulator of G protein signaling(RGS)proteins participate in tumor formation and metastasis by acting on theα-subunit of heterotrimeric G *** speci-fic effect of RGS,particularly RGS4,on the progression of gastric cancer(GC)is not yet *** To explore the role and underlying mechanisms of action of RGS4 in GC *** The prognostic significance of RGS4 in GC was analyzed using bioinformatics based public databases and verified by immunohistochemistry and quantitative polymerase chain reaction in 90 patients with *** assays were employed to assess the carcinogenic impact of RGS4,and the mechanism of its possible influence was detected by western blot analysis.A nude mouse xenograft model was established to study the effects of RGS4 on GC growth in *** RGS4 was highly expressed in GC tissues compared with matched adjacent normal *** RGS4 expression was correlated with increased tumor-node-metastasis stage,increased tumor grade as well as poorer overall survival in patients with *** experiments demonstrated that RGS4 knockdown suppressed GC cell proliferation,migration and ***,xenograft experiments confirmed that RGS4 silencing significantly inhibited tumor ***,RGS4 knockdown resulted in reduced phosphorylation levels of focal adhesion kinase,phosphatidyl-inositol-3-kinase,and protein kinase B,decreased vimentin and N-cadherin,and elevated *** High RGS4 expression in GC indicates a worse prognosis and RGS4 is a prognostic ***4 influences tumor progression via the focal adhesion kinase/phosphatidyl-inositol-3-kinase/protein kinase B pathway and epithelial-mesenchymal transition.

关键词： Gastric cancer Prognosis Regulator of G protein signaling 4 Focal adhesion kinase Epithelial-mesenchymal transition

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Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie wang Congrui Liu Chao Fang Qiuxia Peng Wen Qin Xuebing Yan kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

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Analysis of Electromagnetic Exposure in Wireless Power Transfer System for Endoscopic Micro-robot

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Chinese Journal of Biomedical Engineering(English Edition) 2008年第2期17卷 47-53,60页

作者： YE Dong-dong YAN Guo-zheng LI jia-jun wang kun-dong MA Guan-ying Institute of Precision Engineering and Intelligence Micro-system School of Electronics and Information Technology Shanghai Jiaotong University Shanghai 200240 China

A wireless power transfer system for endoscopic micro-robot operating at 36 kHz is presented in this paper. The issue of patient＇ s health and safety regarding exposure to the electromagnetic field is addressed. The specific absorption rate and current density can be used to investigate the electromagnetic influences on the biological tissues surrounded by the wireless power launching coil. In view of this purpose, the limited close-ound solenoid electromagnetic model is built, the relationship between the electric intensity and the specific absorption rate and current density is deduced, and the simulation experiments are done. Experimental results show that the values of SAR and current density related to different tissue catalogs are all very small and do not exceed their own limits respectively when the resonance frequency of operation is 36 kHz.

关键词： wireless power transfer endoscopic micro-robot specific absorptionrate current density solenoid

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Integration of Electrical Properties and Polarization Loss Modulation on Atomic Fe–N‑RGO for Boosting Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang Yuefeng Yan Zhen wang Guansheng Ma Dechang jia Xiaoxiao Huang Yu Zhou State Key Laboratory of Precision Welding&Joining of Materials and Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key Laboratory of Advanced Structural‑Functional Integration Materials&Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing effective strategies to regulate graphene’s conduction loss and polarization has become a key to expanding its application in the electromagnetic wave absorption(EMWA)*** on the unique energy band structure of graphene,regulating its bandgap and electrical properties by introducing heteroatoms is considered a feasible ***,metal-nitrogen doping reduced graphene oxide(M–N-RGO)was prepared by embedding a series of single metal atoms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd,and Sn)in RGO using an N-coordination atom-assisted *** composites had adjustable conductivity and polarization to optimize dielectric loss and impedance matching for efficient EMWA *** results showed that the minimum reflection loss(RL_(min))of Fe–N-RGO reaches−74.05 dB(2.0 mm)and the maximum effective absorption bandwidth(EAB_(max))is 7.05 GHz(1.89 mm)even with a low filler loading of only 1 wt%.Combined with X-ray absorption spectra(XAFS),atomic force microscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the polarization center to increase dipole polarization,interface polarization and defect-induced polarization due to d-p orbital hybridization and structural ***,electron migration within the Fe further leads to conduction loss,thereby synergistically promoting energy *** study demonstrates the effectiveness of metal-nitrogen doping in regulating the graphene′s dielectric properties,which provides an important basis for further investigation of the loss mechanism.

关键词： Electromagnetic wave absorption Fe-N-RGO Dipole polarization Conduction loss Impedance matching

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Global research status and trends of somatic symptom disorder: A bibliometric study

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World Journal of Psychiatry 2025年第1期15卷 168-178页

作者： Chao Yang kun Zhang Qian wang Shuai wang Huan Li Kai Zhang Department of Psychiatry Beijing Luhe HospitalCapital Medical UniversityBeijing 100001China Department of Psychiatry Chaohu Hospital of Anhui Medical UniversityHefei 238000Anhui ProvinceChina School of Medicine Jiangxi University of TechnologyNanchang 510001Jiangxi ProvinceChina School of Public Health Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND With the growing scholarly and clinical fascination with somatic symptom dis-order(SSD),a bibliometric analysis is *** To conduct a bibliometric analysis to investigate the current status and frontiers of *** The documents related to SSD are obtained from the web of science core collection database(WoSCC),and VOSviewer 1.6.16 from January 1,2000 to December 31,2023,and the WoSCC’s literature analysis wire were used to conduct the biblio-metric *** A total of 567 documents related to SSD were included,and 2325 authors across 947 institutions from 57 countries/regions have contributed to SSD research,published in 277 *** most productive author,institution,country and journal were Löwe B,University of Hamburg,Germany,and Journal of Psycho-somatic Research *** first high-cited document was published in the Journal of Psychosomatic Research in 2013 by Dimsdale JE and colleagues,which explored the rationale behind the SSD diagnosis introduction in diagnostic and statistical manual of mental *** In conclusion,the main research hotspots and frontiers in the field of SSD are validity and reliability of the SSD criteria,functional impairment of SSD,and the treatment for *** high-quality studies are needed to assess the diagnosis and treatment of SSD.

关键词： Somatic symptom disorder Validity and reliability Functional impairment Treatment Bibliometric analysis

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红细胞分布宽度和D-二聚体联合评估系统性红斑狼疮病情活动程度

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标记免疫分析与临床 2017年第2期24卷 130-132,149页

作者：王坤贾兴旺颜光涛解放军总医院生化科北京100853 火箭军总医院清河门诊部检验科北京100085

目的探讨RDW和DD在SLE病情活动中的监测价值。方法收集2015年10月至2016年9月在我院住院的确诊SLE患者123例,根据SLEDAI-2000评分规则对患者疾病活动程度进行评分,将SLEDAI评分<10分计为病情稳定,将SLEDAI评分≥10计为病情活动。收集同... 详细信息

目的探讨RDW和DD在SLE病情活动中的监测价值。方法收集2015年10月至2016年9月在我院住院的确诊SLE患者123例,根据SLEDAI-2000评分规则对患者疾病活动程度进行评分,将SLEDAI评分<10分计为病情稳定,将SLEDAI评分≥10计为病情活动。收集同期年龄性别匹配的100例健康体检人员作为对照组,比较各组RDW与DD水平,探讨RDW和DD在SLE病情活动程度上的评估价值。结果 SLE患者RDW与DD水平明显高于健康对照组,病情活动组SLE患者的RDW与DD水平显著高于稳定组,当取RDW≥14.65%,DD≥1.66μg/m L为阳性标准,并且采用RDW和DD并联方式作为诊断标准时可以在评估SLE活动程度上获得最好的评估效能。结论采用RDW、DD并联的标准在监测SLE患者的病情发展上有一定的应用价值。

关键词：红细胞分布宽度 D-二聚体系统性红斑狼疮

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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang Nan Mo Le Tong jianhong Dong Ziwei Fan Mengxian jia Juanqing Yue Ying wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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建设仿真技术强国的思考

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计算机仿真 2018年第5期35卷 9-12,26页

作者：陈佳玉王崑声胡良元徐源中国航天系统科学与工程研究院北京100048

当前全球仿真技术迅猛发展,新的增长点不断涌现,将深刻改变未来世界仿真技术发展的格局。本文提出我国仿真技术强国的内涵,从分析我国仿真技术发展现状出发,剖析在政策环境、核心技术、成果应用、体制机制等方面我国与仿真技术先进国家... 详细信息

当前全球仿真技术迅猛发展,新的增长点不断涌现,将深刻改变未来世界仿真技术发展的格局。本文提出我国仿真技术强国的内涵,从分析我国仿真技术发展现状出发,剖析在政策环境、核心技术、成果应用、体制机制等方面我国与仿真技术先进国家间存在的差距。在仿真技术需肩负起建设我国科技强国这一重要任务的新时期,以习近平新时代中国特色社会主义思想为指导,根据我国国情提出推动我国建设世界仿真技术强国的思路、重点和相关政策建议。

关键词：仿真技术强国发展战略政策建议

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