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The comparison of survival between active surveillance or watchful waiting and focal therapy for low-risk prostate cancer:a real-world study from the SEER database

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Asian Journal of Andrology 2022年第3期24卷 305-310页

作者： Qi-Ming Yuan Tian-Hai lin kun Jin Shi Qiu Xiang-Hong Zhou Di Jin Jia-Kun Li Lu Yang Qiang Wei Department of Urology Institute of UrologyWest China Hospital of Sichuan UniversityChengdu 610041China

To reduce treatment-related side effects in low-risk prostate cancer(PCa),both focal therapy and deferred treatments,including active surveillance(AS)and watchful waiting(WW),are worth considering over radical prostatectomy(RP).Therefore,this study aimed to compare long-term survival outcomes between focal therapy and AS/WW.Data were obtained and analyzed from the Surveillance,Epidemiology,and End Results(SEER)database.Patients with low-risk PCa who received focal therapy or AS/WW from 2010 to 2016 were included.Focal therapy included cryotherapy and laser ablation.Multivariate Cox proportional hazards models were used to compare overall mortality(OM)and cancer-specific mortality(CSM)between AS/WW and focal therapy,and propensity score matching(PSM)was performed to reduce the influence of bias and unmeasured confounders.A total of 19292 patients with low-risk PCa were included in this study.In multivariate Cox proportional hazards model analysis,the risk of OM was higher in patients receiving focal therapy than those receiving AS/WW(hazard ratio[HR]=1.35,95%confidence interval[CI]:1.02–1.79,P=0.037),whereas no significant difference was found in CSM(HR=0.98,95%CI:0.23–4.11,P=0.977).After PSM,the OM and CSM of focal therapy and AS/WW showed no significant differences(HR=1.26,95%CI:0.92–1.74,P=0.149;and HR=1.26,95%CI:0.24–6.51,P=0.782,respectively).For patients with low-risk PCa,focal therapy was no match for AS/WW in decreasing OM,suggesting that AS/WW could bring more overall survival benefits.

关键词： active surveillance cancer-specific mortality focal therapy low-risk prostate cancer overall mortality watchful waiting

Hot spot temperature prediction and operating parameter estimation of racks in data center using machine learning algorithms based on simulation data

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Building Simulation 2023年第11期16卷 2159-2176页

作者： Xianzhong Chen Rang Tu Ming li Xu Yang kun jia School of Civil and Resources Engineering University of Science and Technology BeijingBeijing100083China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China China Electronics Engineering Design Institute CO. LTD.Beijing100142China

In this paper,models to predict hot spot temperature and to estimate cooling air’s working parameters of racks in data centers were established using machine learning algorithms based on simulation data.First,simulation models of typical racks were established in computational fluid dynamics(CFD).The model was validated with field test results and results in literature,error of which was less than 3%.Then,the CFD model was used to simulate thermal environments of a typical rack considering different factors,such as servers’power,which is from 3.3 kW to 20.1 kW,cooling air’s inlet velocity,which is from 1.0 m/s to 3.0 m/s,and cooling air’s inlet temperature,which is from 16℃ to 26℃ The highest temperature in the rack,also called hot spot temperature,was selected for each case.Next,a prediction model of hot spot temperature was built using machine learning algorithms,with servers’power,cooling air’s inlet velocity and cooling air’s inlet temperature as inputs,and the hot spot temperatures as outputs.Finally,based on the prediction model,an operating parameters estimation model was established to recommend cooling air’s inlet temperatures and velocities,which can not only keep the hot spot temperature at the safety value,but are also energy saving.

关键词： data center CFD simulation hot spot temperature machine learning algorithm prediction and estimation models

Wind farm active power dispatching algorithm based on Grey Incidence

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Global Energy Interconnection 2023年第2期6卷 175-183页

作者： Binbin Zhang Mengxin jia Chaobo Chen kun Wang Jichao li School of Electronic and Information Engineering Xi’an Technological UniversityXi’an 710021P.R.China

This study proposes a wind farm active power dispatching(WFAPD) algorithm based on the grey incidence method, which does not rely on an accurate mathematical model of wind turbines. Based on the wind turbine start-stop data at different wind speeds, the weighting coefficients, which are the participation degrees of a variable speed system and a variable pitch system in power regulation, are obtained using the grey incidence method. The incidence coefficient curve is fitted by the B-spline function at a full range of wind speeds, and the power regulation capacity of all wind turbines is obtained. Finally, the WFAPD algorithm, which is based on the regulating capacity of each wind turbine, is compared with the wind speed weighting power dispatching(WSWPD) algorithm in MATLAB. The simulation results show that the active power fluctuation of the wind farm is smaller, the rotating speed of wind turbines is smoother, and the fatigue load of highspeed turbines is effectively reduced.

关键词： Wind farm Active power dispatching Grey incidence B-spline function

Assessment of land degradation in Inner Mongolia between 2000 and 2020 based on remote sensing data

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Geography and Sustainability 2023年第2期4卷 100-111页

作者： linlin Zhao kun jia Xin liu Jie li Mu Xia State Key Laboratory of Remote Sensing Science Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Beijing Engineering Research Center for Global Land Remote Sensing Products Faculty of Geographical ScienceBeijing Normal UniversityBeijing 100875China Geological Survey of Inner Mongolia HohhotInner Mongolia 010020China

Achieving land degradation neutrality(LDN)worldwide is a significant target of the Sustainable Development Goal(SDG15.3).Inner Mongolia,as a typical dryland region in northern China,has carried out several large-scale ecological restoration programs to combat land degradation.However,there is a lack of comprehensive assess-ment of its land degradation situation after ecological programs implementation,which is of great significance to supporting SDG15.3 in China.This study analyzed the land degradation situation using the improved SDG15.3.1 calculation framework based on fine resolution data in Inner Mongolia from 2000 to 2020,and finally compre-hensively evaluated the land status of the whole region and those subject to ecological programs.The results show that net land restoration proportion of various ecological project regions and whole region continues to increase.The scope of the Grain for Green Program(GGP)had the largest proportion of net land restoration while the Natural Reserve Program(NRP)had the lowest proportion from 2000 to 2020.The net land restoration area of Inner Mongolia during 2000-2010 and 2010-2020 was 35,800 km 2 and 65,300 km 2,respectively.Overall,Inner Mongolia has achieved statistically zero growth in land degradation under the governance of ecological restora-tion programs.Therefore,reasonable planning,well monitoring,and timely assessment of ecological restoration programs are crucial to support SDG15.3.

关键词： SDG15.3 Land degradation neutrality(LDN) Land degradation Ecological programs Inner Mongolia

Facile fabrication of highly durable superhydrophobic strain sensors for subtle human motion detection

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Journal of Materials Science & Technology 2022年第15期110卷 35-42页

作者： li-Chuan jia Chang-Ge Zhou kun Dai Ding-Xiang Yan Zhong-Ming li College of Electrical Engineering Sichuan UniversityChengdu 610065China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China College of Materials Science and Engineering The Key Laboratory of Material Processing and Mold of Ministry of EducationZhengzhou UniversityZhengzhou 450001China School of Aeronautics and Astronautics Sichuan UniversityChengdu 610065China

Endowing strain sensors with superhydrophobicity is of great importance to guarantee their long-term service under harsh environments(such as wet,acid,alkali and salt atmospheres),whereas,the development of superhydrophobic strain sensors remains a great challenge.Herein,we realized a superhydrophobic and highly sensitive sensor for subtle human motion detection by designing a superhydrophobic and electrically conductive coating on cotton textile,via a facile drop-coating method.The resultant strain sensor showed a large water contact angle of 161.3°and a low sliding angle of 3.8°The superhydrophobic characteristics can keep almost unchanged even after undergoing 1000 peeling cycles,1000 stretchingrelease cycles,and 1000 bending-releasing cycles,revealing its excellent mechanical robustness.High sensitivity with the maximum gage factor of 169 was achieved for the strain sensor under a small strain of0–10%,and the sensing performance also showed well durability.Moreover,our sensor can effectively detect various subtle human physiological signals and body motions even under harsh conditions.These admirable features make the sensor promising applications in wearable electronics,personalized health monitoring,sound recognition,and so on.

关键词： Strain sensors Superhydrophobicity High sensitivity Drop coating Durable

Participation of the inositol 1,4,5-trisphosphategated calcium channel in the zona pellucida- and progesterone-induced acrosome reaction and calcium influx in human spermatozoa

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Asian Journal of Andrology 2020年第2期22卷 192-199页

作者： Ying-Ya li Yan-Ping jia li-Yan Duan kun-Ming li Center of Reproductive Medicine Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 201204China

The acrosome reaction is a prerequisite for fertilization,and its signaling pathway has been investigated for decades.Regardless of the type of inducers present,the acrosome reaction is ultimately mediated by the elevation of cytosolic calcium.Inositol 1,4,5-trisphosphate-gated calcium channels are important components of the acrosome reaction signaling pathway and have been confirmed by several researchers.In this study,we used a novel permeabilization tool BioPORTER?and first demonstrated its effectiveness in spermatozoa.The inositol 1,4,5-trisphosphate type-1 receptor antibody was introduced into spermatozoa by BioPORTER?and significantly reduced the calcium influx and acrosome reaction induced by progesterone,solubilized zona pellucida,and the calcium ionophore A23187.This finding indicates that the inositol 1,4,5-trisphosphate type-1 receptor antibody is a valid inositol 1,4,5-trisphosphate receptor inhibitor and provides evidence of inositol 1,4,5-trisphosphate-gated calcium channel involvement in the acrosome reaction in human spermatozoa.Moreover,we demonstrated that the transfer of 1,4,5-trisphosphate into spermatozoa induced acrosome reactions,which provides more reliable evidence for this process.In addition,by treating the spermatozoa with inositol 1,4,5-trisphosphate/BioPORTER?in the presence or absence of calcium in the culture medium,we showed that the opening of inositol 1,4,5-trisphosphate-gated calcium channels led to extracellular calcium influx.This particular extracellular calcium influx may be the major process of the final step of the acrosome reaction signaling pathway.

关键词： acrosome reaction human spermatozoa inositol 1,4,5-trisphosphate zona pellucida progesterone

Effects of water adsorption on active site-dependent H_(2)activation over MgO nanoflakes

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Nano Research 2023年第7期16卷 9059-9064页

作者： Aiyi Dong kun li Rentao Mu Conghui liu Rongtan li Haoran jia Le lin Qiang Fu School of Science Dalian Maritime UniversityDalian 116026China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China

Understanding the effect of H_(2)O adsorption on reactant activation is of great importance in heterogeneous catalysis,which remains a grand challenge particularly in oxide catalyst systems with structural complexity.Herein,the effect of D_(2)O adsorption on D_(2)activation over MgO nanocatalysts at different temperatures has been investigated by transmission Fourier transform infrared(FT-IR)and temperature-programmed desorption(TPD).Two sets of hydride and hydroxyl species produced from D_(2)dissociation at more active and less active Mg-O pairs can be observed by FT-IR,which all desorb via the product of D_(2)as confirmed by TPD experiments.We find that the physically adsorbed D_(2)O overlayer does not affect the dissociation of D_(2)since D_(2)may pass through the molecular layer and access the surface-active sites.When D_(2)O is partially dissociated on the MgO surface,D_(2)can only dissociate at the remaining active sites until that dissociated-ODw groups from D_(2)O occupy all active sites.These findings provide a fundamental understanding of the effect of water adsorption on D_(2)activation on oxide catalysts.

关键词： H_(2)activation MgO hydride hydroxyl H_(2)O

Mechanical properties and fracture mechanism of Fe/Cu composite sheets with Al interlayer after annealing treatment

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Journal of Iron and Steel Research(International) 2023年第9期30卷 1888-1895页

作者： Xiao-wei Feng jia-xin li Zhi-bin Zheng Bo Feng Hao-kun Yang Institute of New Materials Guangdong Academy of SciencesGuangdong Provincial Key Laboratory of Metal Toughening Technology and ApplicationGuangzhou 510000GuangdongChina Smart Manufacturing Division Hong Kong Productivity CouncilHong Kong 999077China

The feasibility of preparing Fe/Cu composite sheet was achieved by introducing submillimeter thickness Al sheet as an interlayer by rolling at room temperature.The shear test of the composite sheet supported that the metallurgical bonding strength between Fe/(Al)/Cu interface was stronger than that of Cu sheet at the initial state.With further 300 or 600℃ annealing treatments,the interlayer subsequently exhibited brittle shear fracture,and the shear strength significantly dropped under the shear test.Furthermore,the tensile test pointed out that the tensile fracture mechanism changed from fracture as a whole structure to interlayer-to-layer delamination mode after annealing treatment.The microstructure and X-ray diffraction observations proved that the formation of Cu–Al intermetallic compounds(IMCs)along the interlayer resulted in brittle fracture,rather than that of Fe–Al IMCs after annealing,especially under 600℃ annealing treatment.The investigation of the effect of the rolling process and annealing treatment on the mechanical properties of the Fe/(Al)/Cu composite sheet shall provide instruction for high-quality composite metallic sheet fabrication.

关键词： Composite sheet Fe/Cu Interlayer Intermetallic compound Fracture

Banded structure control of low carbon microalloyed steel based on oxide metallurgy

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Journal of Iron and Steel Research(International) 2023年第11期30卷 2242-2253页

作者： Yong-kun Yang jia-yu Zhu Xiao-ming li Yang Wang Dong-ping Zhan School of Metallurgical Engineering Xi’an University of Architecture and TechnologyXi’an710055ShaanxiChina School of Metallurgy Northeastern UniversityShenyang110819LiaoningChina

Banded structure is a common harmful microstructure for low carbon microalloyed steel,which seriously shortens the service life of processed parts.In order to study the effect of oxide metallurgy on improving banded structure,the Ti-Zr deoxidized low carbon microalloyed steel that can play the oxide metallurgical role of inclusion was chosen as the research object,and the inclusion characteristics,microstructure and transverse and longitudinal mechanical properties after hot rolling were analyzed.The results showed the inclusion number density increased in all experimental steels after hot rolling,and a large number of long strip inclusions with aspect ratio greater than 3 appeared along the rolling direction.In addition,after hot rolling,there were element segregation bands in the experimental steels,and granular bainite bands were formed in the element enrichment zone.However,the intragranular ferrite generated in the cooling process destroyed the continuity of granular bainite bands,so that the microstructure anisotropy indexes of experimental steels were small.The mechanical properties analysis showed that the anisotropy of performance was mainly reflected in plasticity and toughness in the experimental steels.Among them,the difference ratio of elongation,section shrinkage and impact energy of No.2 steel was 1.69%,3.87% and 1.69%,respectively,which were less than those of No.1 steel and No.3 steel.The anisotropy of microstructure and mechanical properties of No.2 steel that full played the role of oxide metallurgy were improved,and the banded structure control of low carbon microalloyed steel can be realized by oxide metallurgy technology.

关键词： Low carbon microalloyed steel Hot rolling Banded structure Oxide metallurgy Intragranular ferrite