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Effects of 1-methylcyclopropene on skin greasiness and quality of'Yuluxiang'pear during storage at 20℃

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Journal of Integrative Agriculture 2024年第7期23卷 2476-2490页

作者： Wanting Yu Xinnan zhang Weiwei Yan Xiaonan Sun Yang Wang Xiaohui jia Research Institute of Pomology Chinese Academy of Agricultural SciencesXingcheng 125100China

During storage at 20℃,specific pear cultivars may exhibit a greasy texture and decline in quality due to fruit *** these varieties,‘Yuluxiang’is particularly susceptible to peel greasiness,resulting in significant economic ***,there is an urgent need for a preservative that can effectively inhibit the development of *** studies have demonstrated the efficacy of 1-methylcyclopropene(1-MCP)in extending the storage period of *** hypothesize that it may also influence the occurrence of postharvest peel greasiness in the‘Yuluxiang’*** this study,we treated‘Yuluxiang’pears with *** stored them at 20℃while analyzing the composition and morphology of the surface waxes,recording enzyme activities related to wax synthesis,and measuring indicators associated with fruit storage quality and physiological *** results demonstrate that prolonged storage at 20℃leads to a rapid increase in skin greasiness,consistent with the observed elevations in L^(*),greasiness score,and the content of total wax and greasy wax ***,there were indications that cuticular waxes underwent melting,resulting in the formation of an amorphous *** comparison to controls,the application of 1-MCP significantly inhibited increments in L^(*) values as well as grease scores while also reducing accumulation rates for oily waxes throughout most stages over its shelf period,additionally delaying transitions from flaky-wax structures towards their amorphous *** the initial 7 d of storage,several enzymes involved in the biosynthesis and metabolism of greasy wax components,including lipoxygenase(LOX),phospholipase D(PLD),andβ-ketoacyl-CoA synthase(KCS),exhibited an increase followed by a subsequent *** activity of LOX during early shelf life(0–7 d)and the KCS activity during middle to late shelf life(14–21 d)were significantly suppressed by ***,1-MCP effectively maintained firmness,

关键词： ‘Yuluxiang’pear skin greasiness 1-methylcyclopropene storage quality

Directional amine-based solvent extraction for simultaneous enhanced water recovery,salt separation and effective descaling from hypersaline brines

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Frontiers of Environmental Science & Engineering 2024年第3期18卷 83-92页

作者： Yuyao zhang Litao jia Jin Zhao Xuming Liu Shuyu Dong Chuanyang Liu Yuanyuan Cui Shougang Research Institute of Technology Beijing 100043China Research Center of Environmental Technology in Water Pollution Source Identification and Precise Supervision School of EnvironmentTsinghua UniversityBeijing 100084China

The feasibility of simultaneous water recovery,salt separation and effective descaling of hypersaline brine was investigated by diisopropylamine(DIPA)-based directional solvent extraction(DSE),using diluted/concentrated seawater with initial saline concentration range of 12–237 g/L at extraction temperatures of 5 and 15℃,*** water recovery shows an obvious boundary at saline concentration of 115 g/L under dual effect of specific water extraction efficiency and extraction *** Cl^(–) ion concentration in product water is in sharp contrast to the nearly complete removal of SO_(4)^(2–)and hardness ions,indicating that DIPA-based DSE process indeed achieved efficient separation and purification of Cl^(–) ion from hypersaline ***,the radical precipitation of Mg^(2+)and Ca^(2+)ions in form of Mg(OH)_(2)and CaCO_(3)demonstrates effective descaling potential,although it leads to more DIPA residues in dewatered raffinate than product ***,an exponential correlation between the Cl^(–) removal efficiency and specific water extraction efficiency further reveals the intrinsic relationship of water extraction process and transfer of Cl^(–) ion to the product ***,the study provides a novel approach for integrating the water recovery and separation of Cl^(–) ion from ultra-high-salinity brines with radical precipitation of Mg^(2+)and Ca^(2+) ions in one step.

关键词： Hypersaline brines Directional solvent extraction Salt separation Ca^(2+)and Mg^(2+)descaling

Therapeutic strategies of targeting nonapoptotic regulated cell death (RCD) with smallmolecule compounds in cancer

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Acta Pharmaceutica Sinica B 2024年第7期14卷 2815-2853页

作者： Xin Jin Wenke Jin Linlin Tong jia Zhao Lan zhang Na Lin Department of Ultrasound Department of Medical Oncology and Department of Hematologythe First Hospital of China Medical UniversityChina Medical UniversityShenyang 110001China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Regulated cell death(RCD)is a controlled form of cell death orchestrated by one or more cascading signaling pathways,making it amenable to pharmacological *** subroutines can be categorized as apoptotic or non-apoptotic and play essential roles in maintaining homeostasis,facilitating development,and modulating *** evidence has recently revealed that RCD evasion is frequently the primary cause of tumor *** non-apoptotic RCD subroutines have garnered attention as promising cancer therapies due to their ability to induce tumor regression and prevent relapse,comparable to ***,they offer potential solutions for overcoming the acquired resistance of tumors toward apoptotic *** an increasing understanding of the underlying mechanisms governing these non-apoptotic RCD subroutines,a growing number of small-molecule compounds targeting single or multiple pathways have been discovered,providing novel strategies for current cancer *** this review,we comprehensively summarized the current regulatory mechanisms of the emerging non-apoptotic RCD subroutines,mainly including autophagy-dependent cell death,ferroptosis,cuproptosis,disulfidptosis,necroptosis,pyroptosis,alkaliptosis,oxeiptosis,parthanatos,mitochondrial permeability transition(MPT)-driven necrosis,entotic cell death,NETotic cell death,lysosome-dependent cell death,and immunogenic cell death(ICD).Furthermore,we focused on discussing the pharmacological regulatory mechanisms of related small-molecule *** brief,these insightful findings may provide valuable guidance for investigating individual or collaborative targeting approaches towards different RCD subroutines,ultimately driving the discovery of novel small-molecule compounds that target RCD and significantly enhance future cancer therapeutics.

关键词： Regulated cell death(RCD) Non-apoptotic RCD subroutine Autophagy Ferroptosis Necroptosis Regulatory mechanism Small-molecule compound Cancer therapy

Lanthanum promoting bone formation by regulating osteogenesis,osteoclastogenesis and angiogenesis

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Journal of Rare Earths 2024年第3期42卷 621-628,I0007页

作者： Dandan Zou Runlian Lin Yu Han Juan jia Guoqiang Zhou Haisong zhang Kun Ge Hebei Key Laboratory of Chronic Kidney Diseases and Bone Metabolism Affiliated Hospital of Hebei UniversityBaoding071000China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Key Laboratory of Chemical Biology of Hebei ProvinceCollege of Chemistry and Environmental ScienceHebei UniversityBaoding071002China

With lanthanum(La) in agriculture, medicine, and the chemical industry, La shows accumulation in the body, especially in the bone, because of its similar structure to calcium. Moreover, La has a direct role in bone formation regulating osteoblasts and osteoclasts. Nevertheless, bone formation is complex under the regulation of osteogenesis, osteoclastogenesis, and angiogenesis in the bone microenvironment. It is difficult to comprehensively understand the regulation of bone homeostasis from a single kind of ***, some bone microenvironment-related cells and mouse calvaria culture models were used to study the regulatory effect of La-based compound-lanthanum nitrate(La(NO_(3))_(3)) on bone ***(NO_(3))_(3) has good biological safety, and the osteogenic differentiation is significantly increased under La(NO_(3))_(3) treatment for bone marrow mesenchymal stem cells(BMMSC). In contrast, the differentiation,maturation, and bone erosion ability of osteoclasts are significantly decreased. Meanwhile, the angiogenesis ability of human umbilical vein endothelial cells(HUVEC) is significantly promoted when treated with La(NO_(3))_(3). Furthermore, bone metabolism and angiogenesis are improved under La(NO_(3))_(3) treatment in the calvaria ex vivo culture model and BMMSC-HUVEC co-culture system. These results suggest that La has the beneficial effect of promoting bone metabolism and improving bone formation in the bone microenvironment.

关键词： Lanthanum Bone microenvironment Osteogenic differentiation Angiogenesis Rare earths

Establishment and transcriptome analysis of single blastomerederived cell lines from zebrafish

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Journal of Genetics and Genomics 2024年第9期51卷 957-969页

作者： jia Xu Siqi Liu Yirui Ai Yunbin zhang Shifeng Li Yiping Li Key Laboratory of Multi-Cell Systems Shanghai Key Laboratory of Molecular AndrologyShanghai Institute of Biochemistry and Cell BiologyCenter for Excellence in Molecular Cell ScienceUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

Maintaining chromosome euploidy in zebrafish embryonic cells is challenging because of the degradation of genomic integrity during cell *** this study,we report the derivation of zebrafish cell lines from single *** cell lines have a stable chromosome status attributed to BMP4 and exhibit continuous proliferation in *** zebrafish cell lines are successfully established from single ***-cell transcriptome sequencing analysis confirms the fidelity of gene expression profiles throughout long-term culturing of at least 45 *** long-term cultured cells are specialized into epithelial cells,exhibiting similar expression patterns validated by integrative transcriptomic ***,this work provides a protocol for establishing zebrafish cell lines from single blastomeres,which can serve as valuable tools for in vitro investigations of epithelial cell dynamics in terms of lifeedeath balance and cell fate determination during normal homeostasis.

关键词： Zebrafish Single embryo Cell lines Sngle-cell RNA sequencing(scRNA-Seq) Embryonic epidermis Epithelium

Effects of Acupotomy on Immobilization-Induced Gastrocnemius Contracture and Fibrosis in Rats via Wnt/β-Catenin Signaling

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Chinese Journal of Integrative Medicine 2024年第7期30卷 633-642页

作者： HU Rui PAN Jun-kang LI jia-hui zhang Han LI Shao-rong zhang Yi School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing100029China Acupuncture Department Kunming Municipal Hospital of Traditional Chinese MedicineKunming650500China

Objective To determine whether acupotomy ameliorates immobilization-induced muscle contracture and fibrosis via Wnt/β-catenin signaling *** Thirty Wistar rats were randomly divided into 5 groups(n=6)by a random number table,including control,immobilization,passive stretching,acupotomy,and acupotomy 3 weeks(3-w)*** rat model of gastrocnemius contracture was established by immobilizing the right hind limb in plantar flexion for 4 *** in the passive stretching group received passive stretching at gastrocnemius,a daily series of 10 repetitions for 30 s each at 30-s intervals for 10 consecutive *** in the acupotomy and acupotomy 3-w groups received acupotomy once and combined with passive stretching at gastrocnemius a daily series of 10 repetitions for 30 s each at 30-s intervals for 10 consecutive ***,rats in the acupotomy 3-w group were allowed to walk freely for 3 weeks after 10-day *** treatment,range of motion(ROM),gait analysis[i.e.,paw area,stance/swing and maximum ratio of paw area to paw area duration(Max dA/dT)],gastrocnemius wet weight and the ratio of muscle wet weight to body weight(MWW/BW)were *** morphometric and muscle fiber cross-sectional area(CSA)were assessed by hematoxylin-eosin ***-related mRNA expressions(i.e.,Wnt 1,β-catenin,axin-2,α-smooth muscle actin,fibronectin,and types I and III collagen)were measured using real-time quantitative polymerase chain *** 1,β-catenin and fibronectin concentrations were measured by enzyme-linked immunosorbent *** I and III collagen in the perimysium and endomysium were analyzed using *** Compared with the control group,ROM,gait function,muscle weight,MWW/BW and CSA were significantly decreased in the immobilization group(all P<0.01),while protein levels of types I and III collagen,Wnt 1,β-catenin,fibronectin and mRNA levels of fibrosis-related genes were obviously increased(all P<0.01).Tr

关键词： acupotomy immobilization muscle contracture muscle fibrosis Wnt/β-catenin signaling

Tailored ionically conductive graphene oxide-encased metal ions for ultrasensitive cadaverine sensor

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Chinese Chemical Letters 2024年第8期35卷 508-513页

作者： Ying Chen Li Li Junyao zhang Tongrui Sun Xuan zhang Shiqi zhang jia Huang Yidong Zou School of Materials Science and Engineering Tongji UniversityShanghai 201804China Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Translational Research Institute of Brain and Brain-Like IntelligenceShanghai Fourth People’s Hospital Affiliated to Tongji UniversityTongji UniversityShanghai 200434China School of Mechanical Engineering Nantong UniversityNantong 226019China

Intelligent chemical sensors have been extensively used in food safety and environmental assessment,while limited sensitivity and homogeneity bring about huge obstacles to their practical ***,novel ionically conductive sensitive materials were elaborately designed based on metal ion decorated graphene oxide(GO)via a facile and general in-situ spin-coating strategy,where the abundant functional groups(-OH and-COOH)of GO layer could provide natural binding sites for various bivalent metal cations(such as Cu^(2+),Ni^(2+),Zn^(2+),Co^(2+),and Mg^(2+))through coordination and electrostatic *** intercalated metal cations on the layered GO nanosheets can be regarded as charge carriers and complexation with targeted gas(cadaverine,Cad),which is a typical metabolites production and food *** contrast,the designed GO@Cu(Ⅱ)sensor exhibited the optimal sensing performance toward Cad molecules at room temperature,including ultra-low detection limit(ca.3 nL),excellent sensitivity,and rapid low concentration detection rate(only 16 s).Interestingly,the sensor exhibited an irreversible and specific response toward Cad,while it showed a transient and reversible response to other interfering gases,implying its outstanding *** addition,the GO@Cu(Ⅱ)sensor enabled real-time monitoring of the decay progression of cheese,and it exhibited great potential for large-scale production via its excellent *** provides an efficient approach to tailoring intelligent chemical sensors for real-time food safety monitoring and human health warning.

关键词： Graphene oxide Cadaverine monitoring Chemical sensor Ionically conductive Homogeneity

Renal Extramedullary Plasmacytoma--One Case Report

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Clinical oncology and cancer researeh 2010年第6期7卷 380-382页

作者： Yu-ping ZHONG Shi-lun CHEN Xiao-hui LIU Ying HU Xin LI jia-jia zhang Na AN Department of Hematology and Oncology Chaoyang Hospital Capital Medical University Research Center of Multiple Myeloma Beijing 100043. China.

Extramedullary plasmacytoma （EMP） is rare in multiple myeloma, especially kidneys are involved. We report one case, including diagnosis and treatment. The purpose of this paper is to provide an attention on the extr... 详细信息

关键词： extramedullary plasmacytoma renal myeloma.

A new study on formation mechanism of ordered porous anodized metal oxides

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Rare Metals 2024年第10期43卷 5410-5418页

作者： Xi-Di Sun Xin Guo jia-Han zhang Jing Wu Yi Shi Hui-Yuan Sun Cao-Feng Pan Li-jia Pan Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and EngineeringNanjing University College of Physics and Hebei Advanced Thin Film Laboratory Hebei Normal University Institute of Atomic Manufacturing Beihang University

The preparation of ordered porous metal oxide films by anodic oxidation is an efficient and simple preparation ***,there has been no unified explanation about the formation mechanism of the porous structure for many *** this paper,the relationship between the crystal structure of metals and the morphology of ordered porous metal oxide films is *** influence of the crystal structures of different metals on the optimal morphology of porous films is discussed.

关键词： Anodic oxidation