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Long non-coding RNA NONMMUG014387 promotes Schwann cell proliferation after peripheral nerve injury

Neural Regeneration Research 2017年第12期12卷 2084-2091页

作者： Bin Pan Zhong-ju Shi jia-yin Yan jia-he li Shi-qing Feng Department of Orthopedics Tianjin Medical University General Hospital Tianjin China

Schwann cells play a critical role in peripheral nerve regeneration through dedifferentiation and proliferation. In a previous study, we performed microarray analysis of the sciatic nerve after injury. Accordingly, we predicted that long non-coding RNA NONMMUG014387 may promote Schwann cell proliferation after peripheral nerve injury, as bioinformatic analysis revealed that the target gene of NONMMUG014387 was collagen triple helix repeat containing 1（Cthrc1）. Cthrc1 may promote cell proliferation in a variety of cells by activating Wnt/PCP signaling. Nonetheless, bioinformatic analysis still needs to be verified by biological experiment. In this study, the candidate long non-coding RNA, NONMMUG014387, was overexpressed in mouse Schwann cells by recombinant adenovirus transfection. Plasmid p HBAd-MCMV-GFP-NONMMUG014387 and p HBAd-MCMV-GFP were transfected into Schwann cells. Schwann cells were divided into three groups： control（Schwann cells without intervention）, Ad-GFP（Schwann cells with GFP overexpression）, and Ad-NONMMUGO148387（Schwann cells with GFP and NONMMUGO148387 overexpression）. Cell Counting Kit-8 assay was used to evaluate proliferative capability of mouse Schwann cells after NONMMUG014387 overexpression. Polymerase chain reaction and western blot assay were performed to investigate target genes and downstream pathways of NONMMUG014387. Cell proliferation was significantly increased in Schwann cells overexpressing lnc RNA NONMMUG014387 compared with the other two groups. Further, compared with the control group, m RNA and protein levels of Cthrc1, Wnt5 a, ROR2, Rho A, Rac1, JNK, and ROCK were visibly up-regulated in the Ad-NONMMUGO148387 group. Our findings confirm that long non-coding RNA NONMMUG014387 can promote proliferation of Schwann cells surrounding the injury site through targeting Cthrc1 and activating the Wnt/PCP pathway.

关键词： nerve regeneration peripheral nerve injury Schwann cells long non-coding RNAs proliferation Wnt/PCP pathway Cell CountingKit-8 assay adenovirus overexpression sciatic nerve Cthrcl neural regeneration

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A study of economic development in Tibet of China based on the ecological economic mode

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Ecological Economy 2006年第3期2卷 235-244页

作者： Zhao Xiaohong he jia jiang li Neijiang Teachers＇ College Neijiang 641112 P. R. China

The purpose of this paper is to study the issues on keeping the continuous development of Tibetan economy and the relative stability of its ecosystem. hence, in order to achieve the object, the study analyzes the status quo of economic development in Tibet and the problems of resource exploitation. It especially discusses frailty of Tibetan eco-environment, and evaluates the contradictions between the traditional economic developing mode and the safety of plateau＇s ecosystem. It concludes that there is an inevitable clash between the development of Tibetan economy and the safety of plateau＇s eco-system; this problem cannot be avoided by any decision maker, Therefore, the character of Tibetan econvironment and the requirement of its economic development strategy determine that ecological economy developing mode is the only choice for Tibet. This paper suggests that it should be compensated by the national government to assure that Tibetan economy can keep a higher developing speed. In accordance with the feature of plateau eco-economy system and demand of Tibetan economic development, this paper also suggests several methods to apply the ecoeconomy developing strategy of Tibet.

关键词： Tibet Ethnic group areas Ecological economy Developing mode

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Clinical features and risk factors of acute hepatitis E with severe jaundice

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World Journal of Gastroenterology 2012年第48期18卷 7279-7284页

作者： Bin Xu Hai-Bin Yu Wei Hui jia-li he lin-lin Wei Zheng Wang Xin-Hui Guo liver and Endocrine Diseases Ward of Beijing Youan Hospital Capital Medical University

AIM:To compares the clinical features of patients infected with hepatitis E virus(heV) with or without severe *** addition,the risk factors for heV infection with severe jaundice were ***:We enrolled 235 patients with heV into a cross-sectional study using multi-stage sampling to select the study *** with possible acute hepatitis E showing elevated liver enzyme levels were screened for heV infection using serologic and molecular *** infection was documented by heV antibodies and by the detection of heV-RNA in *** used χ2 analysis,Fisher's exact test,and Student's t test where appropriate in this *** predictors in the univariate analysis were then included in a forward,stepwise multiple logistic regression ***:No significant differences in symptoms,alanine aminotransferase,aspartate aminotransferase,al-kaline phosphatase,or hepatitis B virus surface antigen between the two groups were *** infected patients with severe jaundice had significantly lower peak serum levels of γ-glutamyl-transpeptidase(GGT)(median:170.31 U/L vs 237.96 U/L,P = 0.007),significantly lower ALB levels(33.84 g/L vs 36.89 g/L,P = 0.000),significantly lower acetylcholine esterase(Che) levels(4500.93 U/L vs 5815.28 U/L,P = 0.000) and significantly higher total bile acid(TBA) levels(275.56 μmol/L vs 147.03 μmol/L,P = 0.000) than those without severe *** median of the lowest point time tended to be lower in patients with severe jaundice(81.64% vs 96.12%,P = 0.000).heV infected patients with severe jaundice had a significantly higher viral load(median:134 vs 112,P = 0.025) than those without severe *** infected patients with severe jaundice showed a trend toward longer median hospital stay(38.17 d vs 18.36 d,P = 0.073).Multivariate logistic regression indicated that there were significant differences in age,sex,viral load,GGT,albumin,TBA,Che,prothrombin index,alcohol overconsumption,and duration of admiss

关键词： hepatitis E virus Acute hepatitis E Clinical features Severe jaundice Risk factor

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Bioinformatic identification of key candidate genes and pathways in axon regeneration after spinal cord injury in zebrafish

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Neural Regeneration Research 2020年第1期15卷 103-111页

作者： jia-he li Zhong-Ju Shi Yan li Bin Pan Shi-Yang Yuan lin-lin Shi Yan Hao Fu-jiang Cao Shi-Qing Feng Department of Orthopedics Tianjin Medical University General HospitalTianjinChina Department of Orthopedics the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Tianjin Neurological Institute Key Laboratory of Post-Neuroinjury Neurorepair and Regeneration in Central Nervous SystemMinistry of Education and Tianjin CityTianjinChina

Zebrafish and human genomes are highly homologous;however,despite this genomic similarity,adult zebrafish can achieve neuronal proliferation,regeneration and functional restoration within 6–8 weeks after spinal cord injury,whereas humans *** analyze differentially expressed zebrafish genes between axon-regenerated neurons and axon-non-regenerated neurons after spinal cord injury,and to explore the key genes and pathways of axonal regeneration after spinal cord injury,microarray GSE56842 was analyzed using the online tool,GEO2R,in the Gene Expression Omnibus *** ontology and protein-protein interaction networks were used to analyze the identified differentially expressed ***,we screened for genes and pathways that may play a role in spinal cord injury repair in zebrafish and mammals.A total of 636 differentially expressed genes were obtained,including 255 up-regulated and 381 down-regulated differentially expressed genes in axon-regenerated *** Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment results were also obtained.A protein-protein interaction network contained 480 node genes and 1976 node *** also obtained the 10 hub genes with the highest correlation and the two modules with the highest *** results showed that spectrin may promote axonal regeneration after spinal cord injury in *** growth factor beta signaling may inhibit repair after spinal cord injury in *** adhesion or tight junctions may play an important role in the migration and proliferation of some cells,such as Schwann cells or neural progenitor cells,after spinal cord injury in *** analysis identified key candidate genes and pathways in axonal regeneration after spinal cord injury in zebrafish,providing targets for treatment of spinal cord injury in mammals.

关键词： axonal regeneration differentially expressed genes focal adhesions Gene Ontology Kyoto Encyclopedia of Genes and Genomes neural regeneration protein-protein interaction network signaling pathway spectrin tight junctions transforming growth factor beta Wnt signaling pathway

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有串补电容输电线纵联差动保护原理

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天津大学学报（自然科学与工程技术版） 2005年第3期38卷 195-200页

作者：郭征贺家李天津大学电气与自动化工程学院天津300072

传统电流差动保护应用到超高压和特高压长线路时,线路分布电容电流对其影响很大.目前电容电流补偿的方法和故障分量的方法都不能取得很好的效果.为此,提出一种应用贝瑞隆模型实现纵联差动保护的原理,该原理也可用在有串补电容的输电线路... 详细信息

传统电流差动保护应用到超高压和特高压长线路时,线路分布电容电流对其影响很大.目前电容电流补偿的方法和故障分量的方法都不能取得很好的效果.为此,提出一种应用贝瑞隆模型实现纵联差动保护的原理,该原理也可用在有串补电容的输电线路上.实现方法是用贝瑞隆模型计算线路中选定的参考点两侧的电流并进行比较,当线路安装有串补电容时,可将参考点选在串补电容安装处.理论分析和仿真结果显示该原理是正确的.该原理不受分布电容电流的影响,在灵敏度和可靠性上都优于传统的分相电流差动保护.

关键词：差动保护串补电容贝瑞隆模型

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Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang jia Zeng Donglin Gan Kun ling Mingfang he jianshu li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

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Passive activity enhances residual control ability in patients with complete spinal cord injury

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Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia he jia Zheng Hongming Bai jia-Sheng Rao Guiyun Song Wei Song Xiaoguang li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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一种提取基波分量的高精度快速滤波算法

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电力系统自动化 2006年第10期30卷 39-43,74页

作者：李斌李永丽贺家李天津大学电气与自动化工程学院天津市300072

为满足微机继电保护速动性的要求,短数据窗傅里叶算法得到了广泛应用。在系统发生故障期间,电压电流信号中包含大量的非周期分量与谐波分量,这将极大地延迟传统半波傅里叶算法的收敛速度。为此提出了基于狭窄带通滤波与半波傅里叶算法... 详细信息

为满足微机继电保护速动性的要求,短数据窗傅里叶算法得到了广泛应用。在系统发生故障期间,电压电流信号中包含大量的非周期分量与谐波分量,这将极大地延迟传统半波傅里叶算法的收敛速度。为此提出了基于狭窄带通滤波与半波傅里叶算法相结合的快速滤波算法,该算法充分利用了狭窄带通滤波算法对低频和高次谐波良好的抑制作用,同时结合了半波傅里叶算法计算实部受衰减直流分量影响小的特点,计算速度快,且滤波效果明显优于传统算法。

关键词：微机保护半波傅里叶算法狭窄带通滤波衰减直流分量谐波

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750 kV线路保护与并联电抗器动作的研究

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电力系统自动化 2005年第11期29卷 40-44页

作者：李斌李永丽贺家李天津大学电气与自动化工程学院天津市300072

分析了并联电抗器在750kV输电线路单端电源供电与双端电源供电情况下抑制过电压的作用;同时分析了当750kV线路输送大功率时,由于并联电抗器的接入又导致线路电压显著降低,线路的传输能力受到限制,因此应当考虑在传输大功率的运行方式下... 详细信息

分析了并联电抗器在750kV输电线路单端电源供电与双端电源供电情况下抑制过电压的作用;同时分析了当750kV线路输送大功率时,由于并联电抗器的接入又导致线路电压显著降低,线路的传输能力受到限制,因此应当考虑在传输大功率的运行方式下切除并联电抗器。为解决线路传输能力与抑制过电压的矛盾,分析研究了并联电抗器在抑制750kV线路跳闸过电压、加速潜供电弧熄灭以及抑制合闸过电压等方面的作用,并由此提出了750kV线路保护与并联电抗器之间动作配合关系。理论分析与仿真研究表明,所提出的线路保护与并联电抗器之间的动作逻辑关系不仅保证了750kV输电线路正常经济运行,又达到了并联电抗器抑制过电压等方面的作用。

关键词： 750 kV输电线路线路保护并联电抗器过电压并联电阻

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我国西部生态环境建设绩效评价体系研究

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生态经济 2006年第10期22卷 130-132页

作者：何家理安康学院政史系陕西安康725000

“局部改善,整体恶化”是我国西部地区生态环境状况的真实概括。为了治理西部地区的生态环境,党中央于1999年6月确定了西部大开发战略,将能源开发同生态环境治理并举。6年来,中央财政性建设资金投向西部地区4600亿元,转移支付和专项补助... 详细信息

“局部改善,整体恶化”是我国西部地区生态环境状况的真实概括。为了治理西部地区的生态环境,党中央于1999年6月确定了西部大开发战略,将能源开发同生态环境治理并举。6年来,中央财政性建设资金投向西部地区4600亿元,转移支付和专项补助5000多亿元。国家计划在10年间退耕还林2．2亿亩,投资3600亿元。由于生态环境建设的绩效是一个漫长的量变累积过程,通过确定我国西部地区生态环境状况四大特征,建立“常态、一般、差”三级评价指标体系,对西部地区生态环境建设的绩效做出客观评价,有利于坚定人们对西部地区生态环境建设的信心。

关键词：西部地区生态环境建设绩效评价体系

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