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Journal of Iron and Steel Research International 2024年第8期31卷 1825-1839页

作者： Yun-qiang Zhao Hao-kun Yang Aloshyn Andriia Hong-hang Lo jia-xin Li Guangdong Provincial Key Laboratory of Advanced Welding Technology China-Ukraine Institute of WeldingGuangdong Academy of SciencesGuangzhou 510000GuangdongChina Smart Manufacturing Division Hong Kong Productivity CouncilHong Kong 999077China E.O.Paton Electric Welding Institute of National Academy of Sciences of Ukraine Kiev 01001KievanUkraine

Refill friction stir spot welding(RFSSW)provides a novel method to join similar and/or dissimilar metallic materials without a key-hole in the center of the *** the key-hole free characterization,the similar/dissimilar RFSSW joint exhibits remarkable and endurable characteristics,including high shear strength,long fatigue life,and strong corrosion *** the meanwhile,as the key-hole free joint has different microstructures compared with conventional friction stir spot welding,thus the RFSSW joint shall possess different shear and fatigue fracture mechanisms,which needs further *** explore the underlying failure mechanism,the similar/dissimilar metallic material joining parameters and pre-treatment,mechanical properties,as well as fracture mechanisms under this novel technology will be *** details,the welding tool design,welding parameters setting,and the influence of processing on the lap shear and fatigue properties,as well as the corrosion resistance will be mainly ***,the roadmap of RFFSW is also discussed.

关键词： Refill friction stir spot welding Processing Mechanism Similar materials joining Dissimilar materials joining Microstructure Mechanical property Fracture mechanism

Multiomics analyses unveil the involvement of microRNAs in pear fruit senescence under high-or low-temperature conditions

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Horticulture Research 2020年第1期7卷 153-164页

作者： Chao Gu Huan-Yu Xu Yu-hang zhou jia-Long Yao Zhi-Hua Xie Yang-Yang Chen Shao-Ling Zhang Centre of Pear Engineering Technology Research State Key Laboratory of Crop Genetics and Germplasm EnhancementNanjing Agricultural UniversityNanjing 210095China New Zealand Institute of Plant&Food Research Ltd. Private Bag 92169Auckland 1142New Zealand

Senescence leads to declines in fruit quality and shortening of shelf *** is known that low temperatures(LTs)efficiently delay fruit senescence and that high temperatures(HTs)accelerate ***,the molecular mechanism by which temperature affects senescence is ***,through multiomics analyses of fruits subjected to postharvest HT,LT,and room temperature treatments,a total of 56 metabolic compounds and 700 mRNAs were identified to be associated with fruit senescence under HT or LT *** compounds could be divided into antisenescent(I→III)and prosenescent(IV→VI)*** affected the expression of 202 mRNAs to enhance the biosynthesis of prosenescent compounds of types V and VI and to inhibit the accumulation of antisenescent compounds of types II and *** affected the expression of 530 mRNAs to promote the accumulation of antisenescent compounds of types I and II and to impede the biosynthesis of prosenescent compounds of types IV and ***,16 microRNAs were isolated in response to HT or LT conditions and interacted with the mRNAs associated with fruit senescence under HT or LT *** transformation of pear fruit showed that one of these microRNAs,Novel_188,can mediate fruit senescence by interacting with its target ***,both HT and LT conditions can affect fruit senescence by affecting microRNA–mRNA interactions,but the molecular networks are different in pear fruit.

关键词： involvement senescence conditions

Interactions of drug-metabolizing enzymes with the Chinese herb Psoraleae Fructus

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Chinese Journal of Natural Medicines 2019年第11期17卷 858-870页

作者： zhou Qi-hang ZHU Ya-Di Zhang Feng SONG Yun-Qing jia Shou-Ning ZHU Liang FANG Sheng-Quan GE Guang-Bo Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 200000China Translational Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200000China Qinghai Hospital of Traditional Chinese Medicine Xining 810000China

Psoraleae Fructus(the dried fruits of Psoralea corylifolia), one of the most frequently used Chinese herbs in Asian countries, has a variety of biological activities. In clinical settings, Psoraleae Fructus or Psoraleae Fructus-related herbal medicines frequently have been used in combination with a number of therapeutic drugs for the treatment of various human diseases, such as leukoderma, rheumatism and dysentery. The use of Psoraleae Fructus in combination with drugs has aroused concern of the potential risks of herb-drug interactions(HDI) or herb-endobiotic interactions(HEI). This article reviews the interactions between human drug-metabolizing enzymes and the constituents of Psoraleae Fructus;the major constituents in Psoraleae Fructus, along with their chemical structures and metabolic pathways are summarized, and the inhibitory and inductive effects of the constituents in Psoraleae Fructus on human drug-metabolizing enzymes(DMEs), including target enzyme(s), its modulatory potency, and mechanisms of action are presented. Collectively, this review summarizes current knowledge of the interactions between the Chinese herb Psoraleae Fructus and therapeutic drugs in an effort to facilitate its rational use in clinical settings, and especially to avoid the potential risks of HDI or HEI through human DMEs.

关键词： Psoraleae Fructus Cytochrome P450 enzymes(CYPs) Uridine diphosphate-glucuronosyltransferases(UGTs) Herb-drug interactions(HDI) Herb-endobiotic interactions(HEI)

Quantum interference enhanced thermopower in single-molecule thiophene junctions

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Chinese Chemical Letters 2022年第1期33卷 523-526页

作者： hang Chen Yaorong Chen Hewei Zhang Wenqiang Cao Chao Fang Yicheng zhou Zongyuan Xiao jia Shi Wenbo Chen Junyang Liu Wenjing Hong State Key Laboratory of Physical Chemistry of Solid Surfaces iChEMCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power Shanghai University of Electric PowerShanghai 200090China Beijing National Laboratory for Molecular Sciences Beijing 100190China

Quantum interference(QI)effects,which offer unique opportunities to widely manipulate the charge transport properties in the molecular junctions,will have the potential for achieving high *** we developed a scanning tunneling microscope break junction technique to investigate the thermopower through single-molecule thiophene *** observed that the thermopower of 2,4-TPSAc with destructive quantum interference(DQI)was nearly twice of 2,5-TP-SAc without DQI,while the conductance of the 2,4-TP-SAc was two orders of magnitude lower than that of 2,***,we found the thermopower was almost the same by altering the anchoring group or thiophene core in the control experiments,suggesting that the QI effect is responsible for the increase of *** density functional theory(DFT)calculations are in quantitative agreement with the experimental *** results reveal that QI effects can provide a promising platform to enhance the thermopower of molecular junctions.

关键词： Quantum interference Thermopower Thermoelectric device Single-molecule electronics Single-molecule junctions

Microstructural evolution and constitutive models of 9CrMoCoB heatresistant steel during high-temperature deformation

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Journal of Iron and Steel Research International 2019年第11期26卷 1228-1239页

作者： Chao-hang jia Chen-xi Liu Yong-chang Liu Chong Li Hui-jun Li Key Lab of Hydraulic Engineering Simulation and Safety School of Materials Science and EngineeringTianjin UniversityTianjin 300354China

In order to research the hot deformation behavior of 9CrMoCoB heat-resistant steel,hot compression tests were performed over a wide range of temperatures from 850 to 1150℃ and strain rates from 0.01 to 10.00 s^-*** flow stress appears to increase with the decrease in deformation temperature and the increase in strain *** relationship between microstructural evolution and deformation parameters was studied,indicating that both low strain rate and high deformation temperature appear to promote the dynamic recrystallization,while excessively high temperature with low strain rate would result in the high non-uniformity of grain *** experimental stress-strain data was applied to calculate the material constants involved in the Arrhenius-type constitutive model and the modified Zerilli-Armstrong(MZA)model,and feasibility of these two models was *** results show that the MZA model is more accurate to predict the high-temperature flow behavior of the experimental steel than the Arrhenius-type constitutive equation.

关键词： 9CrMoCoB steel-Hot deformation behavior Dynamic recrystallization Arrhenius-type constitutive model Modified Zerilli-Armstrong model

Flow Behavior and Constitutive Modeling of Delta-processed Inconel 718 alloy

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Journal of Iron and Steel Research International 2015年第9期22卷 837-845页

作者： jia-yong SI Xiao-hang LIAO Li-qiang XIE Kai-rui LIN College of Mechanical and Electrical Engineering Central South University of Forestry and Technology State Key Laboratory of Powder Metallurgy Central South University

The flow behavior of delta-processed Inconel 718 was studied in temperature range of 900-1 060℃ and strain rate range of *** effects of friction and temperature on the compressive deformation behavior were investigated,and the flow stress-strain error caused by friction was *** results showed that the effect of the friction was obvious with increasing strain rate and decreasing deformation *** revised flow stress is decreased by increasing temperature and decreasing strain rate and exhibits a typical dynamic recrystallization *** constitutive model has been developed through a hyperbolic-sine Arrhenius type equation to relate the flow stress,strain rate and *** influence of strain has also been incorporated by considering the variation of material constants as a function of *** prediction accuracy of developed constitutive model has been assessed using standard statistical *** to the analysis results,the proposed deformation constitutive equation gives an accurate and precise estimate of flow stress of delta-processed Inconel 718 alloy.

关键词： Inconel 718 delta process flow behavior constitutive modeling

Effects of chitooligosaccharide-zinc on the ovarian function of mice with premature ovarian failure via the SESN2/NRF2 signaling pathway

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Chinese Journal of Natural Medicines 2021年第10期19卷 721-731页

作者： LI jia CHEN Yu-hang XU jia-Yu LIU jiang-Ying FU jia-Cheng CAO Xiu-Ping HUANG jian ZHENG Yue-Hui Medical Experimental Teaching Center Nanchang UniversityNanchang 330006China The Second Clinical Medical College Nanchang UniversityNanchang 330006China The First Clinical Medical College Nanchang UniversityNanchang 330006China School of Basic Medicine Nanchang UniversityNanchang 330006China Shenzhen Traditional Chinese Medicine Hospital Shenzhen 518000China Key Laboratory of Reproductive Physiology and Pathology of jiangxi Province Nanchang UniversityNanchang 330006China

Chitooligosaccharide-zinc(COS·Zn)is a powerful anti-oxidant and anti-aging scavenger,whose anti-oxidative ability immensely exceeds vitamin ***,this study was aimed to investigate the protective effects of COS·Zn against premature ovarian failure(POF)and potential *** KM adult mice were divided into the following groups:a treatment group(150 mg·kg^(−1)·d^(−1) COS·Zn),a treatment group(300 mg·kg^(−1)·d^(−1) COS·Zn),a prevention group,two control groups and two CY/BUS ***·Zn(150,300 mg·kg^(−1)·d^(−1))and COS·Zn(300 mg·kg^(−1)·d^(−1))were therapeutically and preventatively administered to POF mice in the treatment and prevention studies,*** the groups were administered for 21 *** primary and secondary follicles were observed in the COS·Zn-treated groups(including the treatment and prevention groups)than those of the control ***,the ovarian index and the levels of FSH and LH notably increased in the treatment and prevention groups compared with those in the CY/BUS *** levels of MVH,OCT4 and PCNA in the treatment group(300·kg^(−1)·d^(−1) COS·Zn)and MVH in the prevention group remarkably increased compared with those in the CY/BUS ***,the levels of P53 and P16 protein were down-regulated in the treatment and prevention groups compared with those in the CY/BUS ***,the amounts of Sestrin2(SESN2)and SOD2 protein were obviously higher in the treatment group(150 mg·kg^(−1)·d^(−1) COS·Zn)than those in the CY/BUS ***,the amounts of NRF2 and SESN2 protein were up-regulated in the prevention ***,an increased GSH level was observed in the two treatment groups,compared with that in the CY/BUS groups,and the same trend was also present in the prevention *** together,COS·Zn improves the ovarian and follicular development through regulating the SESN2/NRF2 signaling *** results suggest the role of COS·Zn as a novel agent for the treatment and preventi

关键词： Premature ovarian failure Chitooligosaccharide-zinc Sestrin2-nrf2 Ovarian function Aging

Steering structural mesoporosity and working microenvironment of Fe-N-C catalysts for boosting cathodic mass transport of zinc-air batteries

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Science China Chemistry 2022年第8期65卷 1670-1678页

作者： hang Shen Yanyan jia Yanbin Qi Sheng Dai Hongliang jiang Yihua Zhu Chunzhong Li Shanghai Engineering Research Center of Hierarchical Nanomaterials School of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China Key Laboratory for Ultrafine Materials of Ministry of Education School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Key Laboratory for Advanced Materials and Feringa Nobel Prize Scientist Joint Research Center Institute of Fine ChemicalsSchool of Chemistry&Molecular EngineeringEast China University of Science and TechnologyShanghai 200237China

Transition metal-N-C materials have considerably been demonstrated as promising catalysts for cathodic oxygen reduction reaction(ORR)in Zn-air *** efforts mainly focus on tailoring coordination structure and identifying active sites of metal-N-C materials for ORR,while the mass transport of metal-N-C employed in catalytic layers of working electrodes is seldom ***,a Fe-N-C single-atom catalyst featuring high mesoporosity and abundant electrochemically accessible active sites is developed through post-loading Fe species into defective N-doped carbon *** Fe-N-C single-atom catalyst serving as the air cathode of Zn-air battery delivers a peak power density of 189.9 mW cm^(−2),significantly larger than 114.2 mW cm^(−2) of commercial Pt/C and 162.9 mW cm^(−2) of the Fe-N-C contrast catalyst with low *** importantly,through adding hydrophobic polytetrafluoroethylene(PTFE)nanoparticles in the catalytic layer of air cathode,the peak power density of Fe-N-C single-atom catalyst is further increased to 212.3 mW cm^(−2).The increased peak power density is attributed to the enhancement of O_(2) mass transport,as evidenced by a substantially decreased diffusion layer thickness that is obtained from electrochemical impedance spectroscopy.

关键词： electrocatalysis oxygen reduction reaction single-atom catalyst mass transport Zn-air batteries

Some New Features of Linear Theory for Describing Non-linear Diffusion

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Communications in Theoretical Physics 2009年第8期52卷 269-273页

作者： LI hang ZHU Hua-Ling jia Ming-Yun WU Lao-Sheng College of Resources and Environment Southwest University Chongqing 400716 China Department of Environmental Sciences University of California Riverside CA 92507

The non-linear flux equation, the non-linear Fokker-Planck equation （or Smoluchowski equation）, and the non-linear Langiven equation are the basic equations for describing particle diffusion in non-ideal system subjected to time-dependent external fields. Nevertheless, the exact solution of those equations is still a challenge because of their inherent complexity of the non-linear mathematics. Li et al. found that, based on the defined apparent variables, the nonlinear Fokker-Planck equation and the non-linear flux equation could be transformed to linear forms under the condition of strong friction limit or loeal equilibrium assumption. In this paper, some new features of the theory were found：（i） The linear flux equation for describing non-linear diffusion can be obtained from the irreversible thermodynamic theory; （ii） The linear non-steady state diffusion equation for describing non-linear diffusion of the non-steady state, which was described by the non-linear Fokker-Planek equation, can be derived more consistently from the microscopic molecular statistical theory; （iii） In the theory, the non-linear Langiven equation also bears a linear form; （iv） For some special cases, e.g. diffusion in a periodic total potential system, the local equilibrium assumption or the strong friction limit is not required in establishing the linear theory for describing non-linear diffusion, so the linear theory may be important in the study of Brown motor.

关键词： non-linear diffusion linear theory

Denoised Internal Models:A Brain-inspired Autoencoder Against Adversarial Attacks

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Machine Intelligence Research 2022年第5期19卷 456-471页

作者： Kai-Yuan Liu Xing-Yu Li Yu-Rui Lai hang Su jia-Chen Wang Chun-Xu Guo Hong Xie Ji-Song Guan Yi zhou School of Life Sciences and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Center for Brain Science and Brain-inspired Technology Shanghai 201602China School of Life Sciences Tsinghua UniversityBeijing 100084China National Engineering Laboratory for Brain-inspired Intelligence Technology and Application School of Information Science and TechnologyUniversity of Science and Technology of ChinaHefei 230026China Institute of Photonic Chips University of Shanghai for Science and TechnologyShanghai 200093China Centre for Artificial-intelligence Nanophotonics School of Optical-electrical and Computer EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China

Despite its great success,deep learning severely suffers from robustness;i.e.,deep neural networks are very vulnerable to adversarial attacks,even the simplest *** by recent advances in brain science,we propose the denoised internal models(DIM),a novel generative autoencoder-based model to tackle this *** the pipeline in the human brain for visual signal processing,DIM adopts a two-stage *** the first stage,DIM uses a denoiser to reduce the noise and the dimensions of inputs,reflecting the information pre-processing in the *** by the sparse coding of memory-related traces in the primary visual cortex,the second stage produces a set of internal models,one for each *** evaluate DIM over 42 adversarial attacks,showing that DIM effectively defenses against all the attacks and outperforms the SOTA on the overall robustness on the MNIST(Modified National Institute of Standards and Technology)dataset.

关键词： Brain-inspired learning autoencoder robustness adversarial attack generative model