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Mesenchymal stromal cell-dependent immunoregulation in chemically-induced acute liver failure

World Journal of Stem Cells 2021年第3期13卷 208-220页

作者： jia-hang zhou Xuan Lu Cui-Lin Yan Xin-Yu Sheng Hong-Cui Cao State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Zhejiang Provincial Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

Drug-induced liver injury(DILI),which refers to liver damage caused by a drug or its metabolites,has emerged as an important cause of acute liver failure(ALF)in recent ***-induced ALF in animal models mimics the pathology of DILI in humans;thus,these models are used to study the mechanism of potentially effective treatment *** stromal cells(MSCs)possess immunomodulatory properties,and they alleviate acute liver injury and decrease the mortality of animals with chemically-induced ***,we summarize some of the existing research on the interaction between MSCs and immune cells,and discuss the possible mechanisms underlying the immunomodulatory activity of MSCs in chemically-induced *** conclude that MSCs can impact the phenotype and function of macrophages,as well as the differentiation and maturation of dendritic cells,and inhibit the proliferation and activation of T lymphocytes or B *** also have immunomodulatory effects on the production of cytokines,such as prostaglandin E2 and tumor necrosis factor-alpha-stimulated gene 6,in animal ***,MSCs have significant benefits in the treatment of chemically-induced ALF by interacting with immune cells and they may be applied to DILI in humans in the near future.

关键词： Mesenchymal stromal cell Immune response Drug-induced liver injury Acute liver failure Dendritic cell

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Hypoxia-inducible factor-1α–mediated upregulation of CD99 promotes the proliferation of placental mesenchymal stem cells by regulating ERK1/2

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World Journal of Stem Cells 2021年第4期13卷 317-330页

作者： Xu-Dong Feng jia-Qi Zhu jia-hang zhou Fei-Yan Lin Bing Feng Xiao-Wei Shi Qiao-Ling Pan Jiong Yu Lan-Juan Li Hong-Cui Cao State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND As human placenta-derived mesenchymal stem cells(hP-MSCs)exist in a physiologically hypoxic microenvironment,various studies have focused on the influence of ***,the underlying mechanisms remain to be further *** The aim was to reveal the possible mechanisms by which hypoxia enhances the proliferation of *** A hypoxic cell incubator(2.5%O2)was used to mimic a hypoxic *** counting kit-8 and 5-ethynyl-20-deoxyuridine incorporation assays were used to assay the proliferation of *** cell cycle was profiled by flow *** profiling of hP-MSCs under hypoxia was performed by RNA ***99 mRNA expression was assayed by reverse transcription-polymerase chain *** interfering RNA-mediated hypoxia-inducible factor 1α(HIF-1α)or CD99 knockdown of hP-MSCs,luciferase reporter assays,and the ERK1/2 signaling inhibitor PD98059 were used in the mechanistic *** expression was assayed by western blotting;immunofluorescence assays were conducted to evaluate changes in expression *** Hypoxia enhanced hP-MSC proliferation,increased the expression of cyclin E1,cyclin-dependent kinase 2,and cyclin A2,and decreased the expression of *** hypoxia,CD99 expression was increased by HIF-1α.CD99-specific small interfering RNA or the ERK1/2 signaling inhibitor PD98059 abrogated the hypoxia-induced increase in cell *** Hypoxia promoted hP-MSCs proliferation in a manner dependent on CD99 regulation of the MAPK/ERK signaling pathway in vitro.

关键词： Hypoxia-inducible factor 1α Hypoxia Mesenchymal stem cells Proliferation CD99 RNA sequencing assay MAPK/ERK signaling pathway

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Long non-coding RNA SNHG16 promotes human placenta-derived mesenchymal stem cell proliferation capacity through the PI3K/AKT pathway under hypoxia

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World Journal of Stem Cells 2022年第9期14卷 714-728页

作者： Xu-Dong Feng jia-hang zhou Jun-Yao Chen Bing Feng Rui-Tian Hu jian Wu Qiao-Ling Pan Jin-Feng Yang Jiong Yu Hong-Cui Cao State Key Laboratory for The Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Chemistry Duke UniversityDurhamNC 27708United States Jinan Microecological Biomedicine Shandong Laboratory Jinan 250117Shandong ProvinceChina Key Laboratory of Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND The effect of hypoxia on mesenchymal stem cells(MSCs)is an emerging topic in MSC *** long non-coding RNAs(lncRNAs)and messenger RNAs(mRNAs)are reported to play a critical role in regulating the biological characteristics of MSCs,their specific expression and co-expression profiles in human placenta-derived MSCs(hP-MSCs)under hypoxia and the underlying mechanisms of lncRNAs in hP-MSC biology are *** To reveal the specific expression profiles of lncRNAs in hP-MSCs under hypoxia and initially explored the possible mechanism of lncRNAs on hP-MSC *** Here,we used a multigas incubator(92.5%N_(2),5%CO_(2),and 2.5%O_(2))to mimic the potential of *** sequencing technology was applied to identify the exact expression profiles of lncRNAs and mRNAs under *** We identified 289 differentially expressed lncRNAs and 240 differentially expressed mRNAs between the hypoxia and normoxia *** them,the lncRNA SNHG16 was upregulated under hypoxia,which was also validated by reverse transcription-polymerase chain ***16 was confirmed to affect hP-MSC proliferation rates using a SNHG16 knockdown ***16 overexpression could significantly enhance the proliferation capacity of hP-MSCs,activate the PI3K/AKT pathway,and upregulate the expression of cell cycle-related *** Our results revealed the specific expression characteristics of lncRNAs and mRNAs in hypoxiacultured hP-MSCs and that lncRNA SNHG16 can promote hP-MSC proliferation through the PI3K/AKT pathway.

关键词： Human placenta-derived mesenchymal stem cell Hypoxia Long non-coding RNAs Proliferation Mesenchymal stem cell

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产GL-7-ACA酰化酶重组大肠杆菌的构建和表达

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微生物学通报 2004年第4期31卷 38-42页

作者：罗晖胡晓佳周航童忆舟于慧敏李强沈忠耀清华大学化工系生物化学研究所北京100084

为了实现GL 7 ACA酰化酶在大肠杆菌中的成功表达 ,将GL 7 ACA酰化酶基因用PCR的方法去除其信号肽序列 ,并将其连接到质粒pET 2 8a ,通过筛选得到了表达GL 7 ACA酰化酶的重组菌BL2 1 (DE3) /pET ACY。分别考察了诱导温度、菌浓 (OD60 0 ... 详细信息

为了实现GL 7 ACA酰化酶在大肠杆菌中的成功表达 ,将GL 7 ACA酰化酶基因用PCR的方法去除其信号肽序列 ,并将其连接到质粒pET 2 8a ,通过筛选得到了表达GL 7 ACA酰化酶的重组菌BL2 1 (DE3) /pET ACY。分别考察了诱导温度、菌浓 (OD60 0 )、诱导剂IPTG的用量等因素对重组菌表达GL 7 ACA酰化酶的影响。在优化条件下 ,GL 7 ACA酰化酶酶活可达 2 66U/L。GL 7 ACA酰化酶经一步DEAE Sepharose纯化即可达到 80 %的纯度 ,酶活收率为 5 0 %。

关键词： GL-7-ACA酰化酶大肠杆菌表达

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Energy-resolved spin filtering effect and thermoelectric effect in topological-insulator junctions with anisotropic chiral edge states

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Frontiers of physics 2022年第6期17卷 85-93页

作者： jia-En Yang hang Xie School of Electronics and IoT Chongqing College of Electronic EngineeringChongqing 401331China College of Physics Chongqing UniversityChongqing 401331China Chongqing Key Laboratory for Strongly-Coupled Physics Chongqing UniversityChongqing 401331China

Topological edge states have crucial applications in the future nano spintronics *** this work,circularly polarized light is applied on the zigzag silicene-like nanoribbons resulting in the anisotropic chiral edge *** energy-dependent spin filter is designed based on the topological-insulator(TI)junctions with anisotropic chiral edge *** resonance transmission has been observed in the TI junctions by calculating the local current *** some strong Fabry–Perot resonances are found leading to the sharp transmission ***,the weak and asymmetric resonance corresponds to the broad transmission *** addition,a qualitative relation between the resonant energy separation TR and group velocity vf is derived:TR=πhvf n/L,that indicated TR is proportional to vf and inversely proportional to the length L of the *** different TR between the spin-up and spin-down cases results in the energyresolved spin filtering ***,the intensity of the circularly polarized light can modulate the group velocity ***,the intensity of circularly polarized light,as well as the conductor-length,play very vital roles in designing the energy-dependent spin *** the transmission gap root in the Fabry–Perot resonances,the thermoelectric(TE)property can be enhanced by adjusting the gap.A schedule to enhance the TE performance in the TI-junction is proposed by modulating the electric field(Ez).The TE dependence on Ez in the nanojunction is investigated,where the appropriate Ez leads to a very high spin thermopower and spin figure of *** TI junctions have potential usages in the nano spintronics and thermoelectric devices.

关键词： electron transport topological edge states 2D materials spintronics thermoelectric effects

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Lanthanide-containing persistent luminescence materials with superbright red afterglow and excellent solution processability

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Science China Chemistry 2021年第12期64卷 2125-2133页

作者： Ming Xu jia Liu Xianlong Su Qianwen zhou hang Yuan Yue Wen Yihang Cheng Fuyou Li Department of Chemistry&State Key Laboratory of Molecular Engineering of Polymers Fudan UniversityShanghai200433China Shanghai Taywell Biotechnology Co. Ltd.Shanghai200438China

Lanthanide-containing persistent luminescence materials are promising candidates for a wide range of applications by virtue of splendid superiorities in afterglow ***,it is a crucial challenge to achieve high-quality afterglow materials at the attractive nanoscale,with uniform size,controllable morphology,and satisfying ***,a bottom-up approach was developed to construct the high-quality afterglow nanoparticles,incorporating luminescent lanthanide complex and organic molecular ingredients under mild *** nanoparticles exhibited intrinsic lanthanide luminescence with superbright red afterglow(>10 cd m^(−2))in a homogeneous *** afterglow solution with excellent processability can serve as ideal building blocks for the on-demand fabrication of functional ***-dispersible afterglow nanoparticles with state-of-the-art high brightness were uniformly constructed to perform whole-blood lateral flow assay of procalcitonin with a naked-eye detection limit of 0.5 ng mL^(−1),promoting the point-of-care testing development.

关键词： persistent luminescence lanthanide photochemical afterglow solution processing point-of-care testing

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Application of waste frying oils in the biosynthesis of biodemulsifier by a demulsifying strain Alcaligenes sp.S-XJ-1

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Journal of Environmental Sciences 2011年第6期23卷 1020-1026页

作者： jia Liu Kaiming Peng Xiangfeng Huang Lijun Lu hang Cheng Dianhai Yang Qi zhou Huiping Deng Tongji University Shanghai 200092 China College of Environmental Science & Engineering State Key Laboratory of Pollution Control and Resource Reuse Tongji University Shanghai 200092 China

Exploration of biodemulsifiers has become a new research *** waste frying oils（WFOs） as carbon source to synthesize biodemulsifiers has a potential prospect to decrease production cost and to improve the application of biodemulsifiers in the *** this study,a demulsifying strain,Alcaligenes sp.S-XJ-1,was investigated to synthesize a biodemulsifier using waste frying oils as carbon *** was found that the increase of initial pH of culture medium could increase the biodemulsifier yield but decrease the demulsification ratio compared to that using paraffin as carbon *** addition,a biodemulsifier produced by waste frying oils and paraffin as mixed carbon source had a lower demulsification capability compared with that produced by paraffin or waste frying oil as sole carbon ***-batch fermentation of biodemulsifier using waste frying oils as supplementary carbon source was found to be a suitable *** of waste frying oils utilization was studied by using tripalmitin,olein and tristearin as sole carbon sources to synthesize *** results showed saturated long-chain fatty acid was diffcult for S-XJ-1 to utilize but could effectively enhance the demulsification ability of the produced ***,FT-IR result showed that the demulsification capability of biodemulsifiers was associated with the content of C=O group and nitrogen element.

关键词： waste frying oils biodemulsifier fatty acid glyceride Alcaligenes sp.

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Threat Model and Defense Scheme for Side-Channel Attacks in Client-Side Deduplication

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Tsinghua Science and Technology 2023年第1期28卷 1-12页

作者： Guanxiong Ha hang Chen Chunfu jia Mingyue Li College of Cyber Science Nankai UniversityTianjin 300350China Tianjin Key Laboratory of Network and Data Security Technology Tianjin 300350China

In cloud storage,client-side deduplication is widely used to reduce storage and communication *** client-side deduplication,if the cloud server detects that the user’s outsourced data have been stored,then clients will not need to reupload the ***,the information on whether data need to be uploaded can be used as a side-channel,which can consequently be exploited by adversaries to compromise data *** this paper,we propose a new threat model against side-channel *** from existing schemes,the adversary could learn the approximate ratio of stored chunks to unstored chunks in outsourced files,and this ratio will affect the probability that the adversary compromises the data privacy through side-channel *** this threat model,we design two defense schemes to minimize privacy leakage,both of which design interaction protocols between clients and the server during deduplication checks to reduce the probability that the adversary compromises data *** analyze the security of our schemes,and evaluate their performances based on a real-world *** with existing schemes,our schemes can better mitigate data privacy leakage and have a slightly lower communication cost.

关键词： cloud storage deduplication side-channel privacy

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Tectonics-palaeogeomorphology in rift basins: controlling effect on the sequence architecture

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Petroleum Science 2013年第4期10卷 458-465页

作者： Ji Hancheng jia Haibo Sun Simin Chen Liang Tang Yang Chen Wei Geng Yikai zhou hang State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum Geological Research Institute of jiangsu Oilfield Branch Company SINOPEC

The relationship between deposition and tectonics of sedimentary basins has been a significant subject in recent *** typical rift basins such as the Nanpu Sag as an example,combined with the analysis of the tectonics-palaeogeomorphology of basins,we undertook a detailed study of the differences of the third-order sequences in different basins,the combination of depositional systems within the sequence framework and the distribution of depocenters and subsidence *** results revealed a significant relationship between the tectonics-palaeogeomorphology of rift basins and the filling styles of sedimentary *** basin structure plays a primary role in controlling the development of the third-order sequences and the boundary of these sequences is easily formed in basins with gentle slopes,shallow water and a small *** characteristics of the tectonics-palaeogeomorphology of rift basins are dominated by half-grabens of extensional faults,which affect the temporal and spatial combination of sedimentary systems within the sequences as well as the distribution of depocenters and subsidence *** on the development rules of the faults dominating the half-grabens of extensional faults,rift basins are classified into two types： the single fault segmented-linkage type and the multi-fault combination *** main controlling factors of the temporal and spatial combination of sedimentary systems and the distribution of depocenters and subsidence centers in different basins are *** characteristics of early segmentation and later linkage of the faults play a critical role in controlling the sedimentary system combination within the sequence framework and the temporal and spatial differences of depocenters and subsidence centers of the single fault segmented-linkage rift basins,while the differences in fault activities are the dominating factors of the multi-fault combination rift basins.

关键词： Tectonics-palaeogeomorphology sequence architecture extensional half-graben Nanpu Sag

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Dynamic behaviors of the lump solutions and mixed solutions to a(2+1)-dimensional nonlinear model

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Communications in Theoretical Physics 2023年第5期75卷 52-61页

作者： Si-jia Chen Xing Lü Yu-hang Yin Department of Mathematics Beijing Jiaotong UniversityBeijing 100044China Beijing Laboratory of National Economic Security Early-warning Engineering Beijing Jiaotong UniversityBeijing 100044China

In this paper,we propose a combined form of the bilinear Kadomtsev-Petviashvili equation and the bilinear extended(2+1)-dimensional shallow water wave equation,which is linked with a novel(2+1)-dimensional nonlinear *** model might be applied to describe the evolution of nonlinear waves in the *** the effect of a novel combination of nonlinearity and dispersion terms,two cases of lump solutions to the(2+1)-dimensional nonlinear model are derived by searching for the quadratic function solutions to the bilinear ***,the one-lump-multi-stripe solutions are constructed by the test function combining quadratic functions and multiple exponential *** one-lump-multi-soliton solutions are derived by the test function combining quadratic functions and multiple hyperbolic cosine *** behaviors of the lump solutions and mixed solutions are analyzed via numerical *** result is of importance to provide efficient expressions to model nonlinear waves and explain some interaction mechanism of nonlinear waves in physics.

关键词： bilinear form test function mixed solutions dynamic behaviors

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