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Electromagnetic Performance Analysis of Variable Flux Memory Machines with Series-magnetic-circuit and Different Rotor Topologies

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 3-11页

作者： Qiang Wei Z.Q.Zhu Yan jia jianghua Feng Shuying guo Yifeng Li Shouzhi Feng Department of Electronic and Electrical Engineering The University of SheffieldSheffield S13JDU.K. IEEE the CRRC Zhuzhou Institute Company Ltd. Zhuzhou 412001China

In this paper,the electromagnetic performance of variable flux memory(VFM)machines with series-magnetic-circuit is investigated and compared for different rotor *** on a V-type VFM machine,five topologies with different interior permanent magnet(IPM)arrangements are evolved and optimized under same *** on two-dimensional(2-D)finite element(FE)method,their electromagnetic performance at magnetization and demagnetization states is *** reveals that the iron bridge and rotor lamination region between constant PM(CPM)and variable PM(VPM)play an important role in torque density and flux regulation(FR)***,the global efficiency can be improved in VFM machines by adjusting magnetization state(MS)under different operating conditions.

关键词： Memory machine Permanent magnet Rotor topologies Series magnetic circuit Variable flux

Hexokinase 1 and 2 mediates glucose utilization to regulate the synthesis of kappa casein via ribosome protein subunit 6 kinase 1 in bovine mammary epithelial cells

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Animal Nutrition 2024年第1期16卷 338-349页

作者： Tianyu Yang jia guo Han Song Osmond Datsomor Yuhang Chen Maocheng jiang Kang Zhan guoqi Zhao Institute of Animal Culture Collection and Application College of Animal Science and Technology Yangzhou University

Glucose plays a vital part in milk protein synthesis through the mTOR signaling pathway in bovine mammary epithelial cells(BMEC). The objectives of this study were to determine how glucose affects hexokinase(HK) activity in BMEC and investigate the regulatory effect of HK in kappa casein(CSN3)synthesis via the mechanistic target of rapamycin complex 1(mTORC1) signaling pathway in BMEC. For this, HK1 and HK2 were knocked out in BMEC using the CRISPR/Cas9 system. The gene and protein expression, glucose uptake, and cell proliferation were measured. We found that glucose uptake, cell proliferation, CSN3 gene expression levels, and expression of HK1 and HK2 increased with increasing glucose concentrations. Notably, glucose uptake was significantly reduced in HK2 knockout(HK2KO)BMEC treated with 17.5 mM glucose. Moreover, under the same glucose treatment conditions, the proliferative ability and abundance of CSN3 were significantly diminished in both HK1 knockout(HK1KO)and HK2KO BMEC compared with that in wild-type BEMC. We further observed that the phosphorylation levels of ribosome protein subunit 6 kinase 1(S6K1) were reduced in HK1KO and HK2KO BMEC following treatment with 17.5 mM glucose. As expected, the levels of glucose-6-phosphate and the m RNA expression levels of glycolysis-related genes were decreased in both HK1KO and HK2KO BMEC following glucose treatment. These results indicated that the knockout of HK1 and HK2 inhibited cell proliferation and CSN3 expression in BMEC under glucose treatment, which may be associated with the inactivation of the S6K1 and inhibition of glycolysis.

关键词： Glucose Hexokinase Milk protein Mechanistic target of rapamycin complex 1 signaling pathway Bovine mammary epithelial cell Kappa casein

Combining network pharmacology， molecular docking， and experimental verification to investigate the anti-rheumatoid arthritis effect and mechanism of Baeckea frutescens leaves

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Food Science and Human Wellness 2024年

作者： Xueyang guo Mengyao Zhang Haixia Cai Xinyue jiang Siyuan zhou Wen Gong Zijiao Wei Weili Qiao Beixi jia Department of Pharmacognosy School of Pharmaceutical Science Zhengzhou University Department of Pharmacy Henan Provincial People's Hospital

The aromatic Baeckea frutescens leaves (BFL) known as “Gang-Song-Cha” is a popular drink (Tea) in South China. To explore the healthcare value， a systematic and in-depth study on BFL alleviating rheumatoid arthritis (RA) was carried out by integrating network pharmacology， molecular docking， and experimental verification. The efficacy was first evaluated， and the BFL extract could ameliorate RA by inhibiting articular swelling， lowering immune organ index， improving the ankle pathologies， and regulating serum levels of TNF-α， IL-6， and IL-10 in CIA rats. Then the anti-RA mechanism of BFL was investigated by leveraging the high-content and active component 5-hydroxy-7-methoxy-2-isopropylchromone (Chro.)， and the potential signaling pathway and related target proteins for Chro. acting on RA were analyzed by KEGG enrichment and docking simulation. Finally， the experimental validations were conducted on RA-FLS cells， and compound Chro. could inhibit cell invasion and migration， block cell cycle at G2/M phase and induce apoptosis， and reduce the secretion of inflammatory cytokines by suppressing the PI3K-Akt pathway. These results provided pharmacological basis for the folk usage of “Gang-Song-Cha (Tea)” for intervening RA.

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Preparation of single atom catalysts for high sensitive gas sensing

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International Journal of Extreme Manufacturing 2024年第3期6卷 216-248页

作者： Xinxin He Ping guo Xuyang An Yuyang Li jiatai Chen Xingyu Zhang Lifeng Wang Mingjin Dai Chaoliang Tan jia Zhang Key Laboratory of Microsystems and Microstructure Manufacturing Ministry of EducationHarbin Institute of TechnologyHarbin 150080People’s Republic of China Institute for Frontier Materials Deakin UniversityWaurn Ponds CampusLocked Bag 20000Victoria 3220Australia School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore Department of Electrical and Electronic Engineering The University of Hong KongPokfulam RoadHong Kong Special Administrative Region of China 999077People’s Republic of China Chongqing Research Institute Harbin Institute of TechnologyChongqing 401120People’s Republic of China

Single atom catalysts(SACs)have garnered significant attention in the field of catalysis over the past decade due to their exceptional atom utilization efficiency and distinct physical and chemical *** the semiconductor-based electrical gas sensor,the core is the catalysis process of target gas molecules on the sensitive *** this context,the SACs offer great potential for highly sensitive and selective gas sensing,however,only some of the bubbles come to the *** facilitate practical applications,we present a comprehensive review of the preparation strategies for SACs,with a focus on overcoming the challenges of aggregation and low *** research efforts have been devoted to investigating the gas sensing mechanism,exploring sensitive materials,optimizing device structures,and refining signal post-processing ***,the challenges and future perspectives on the SACs based gas sensing are presented.

关键词： single atom catalysts preparation sensing mechanism gas sensing

Nanocomposite: Keggin-type Co_(4)-polyoxometalate@cobaltporphyrin linked graphdiyne for hydrogen evolution in seawater

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Nano Research 2024年第3期17卷 1281-1287页

作者： Jiejie Ping Danyang He Fei Wang Nan Wang Yi-cheng Fu Zihao Xing Zhiyu jia guo-Yu Yang Key Laboratory of Cluster Science Ministry of EducationSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China Key Laboratory of Polyoxometalate and Reticular Material Chemistry of Ministry of Education Facluty of Chmeistry Northeast Normal UniversityChangchun 130024China Peking University Third Hospital Beijing 100190China

Polyoxometalate-based nanocomposites with electrocatalytic activity have been applied in hydrogen evolution reactions(HER).Seawater as the main water resource on the earth should be developed as the water electrolysis to prepare high-purity *** this paper,we used two synthesis strategies to prepare the nanocomposite Co_(4)-POM@Co-PGDY(Co_(4)-POM:the Kegging-type microcrystals of K_(10)[Co_(4)(PW_(9)O_(3)4)2]and Co-PGDY:cobalt-porphyrin linked graphdiyne)with excellent activity for ***-PGDY as the porous material is applied not only as the protection of microcrystals towards the metal ion in seawater but also as the co-electrocatalyst of Co_(4)-***_(4)-POM@Co-PGDY exhibits excellent HER performance in seawater electrolytes with low overpotential and high stability at high ***,we have observed a key H_(3)O+intermediate emergence on the surface of nanocomposite during hydrogen evolution process in seawater by Raman synchrotron radiation-based Fourier transform infrared(SR-FTIR).The results in this paper provide an effective strategy for preparing polyoxometalate-based electrocatalysts with high-performance toward hydrogen evolution reaction.

关键词： polyoxometalate graphdiyne seawater hydrogen evolution reaction

The response and anti-stress mechanisms of nitrifying sludge under long-term exposure to Cd Se quantum dots

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Journal of Environmental Sciences 2024年第1期135卷 174-184页

作者： Linkai guo Lei Yang Yongxiang Ren Shen Cui Xiaotong Li jia Wang Jun Lan Haoqi Lu Yuchao Wang Shaanxi Key Laboratory of Environmental Engineering Xi’an University of Architecture and TechnologyXi’an 710055China Key Lab of Northwest Water Resource Environment and EcologyMinistry of EducationXi’an University of Architecture and TechnologyXi’an 710055China

The wide application of CdSe quantum dots(QDs)increases its stress risk to sewage treatment *** study evaluated the response of nitrification performance,floc characteristics and microbial community of nitrifying sludge under long-term exposure to CdSe *** showed CdSe QDs(≥1 mg/L)would decrease the activity of ammonia monooxygenase(AMO).Under the stress of 30 mg/L CdSe QDs,the activity of AMO was reduced by 66%,while the activities of hydroxylamine oxidase and nitrite oxidoreductase were enhanced by 19.1%and 26%,***,the final nitrification effects were not adversely affected,and the production rates of NO_(2)^(-)-N and NO_(3)^(-)-N were ***,CdSe QDs improved biomass concentration in sludge and maintained the stability of sludge *** throughput sequencing analysis showed that CdSe QDs evidently reduced the abundance and diversity of microbial community in nitrifying *** abundances of amino acid metabolism and lipid metabolism were ***,CdSe QDs decreased the fluorescence intensity of tryptophan-like protein from 2,326 to 1,179 *** loosely bound extracellular polymeric substances(EPSs)and from 3,792 to 3,117 *** tightly bound *** relieve CdSe QD stress,the polysaccharide content increased from0.31 to 0.61 mg/g MLSS and intracellular antioxidant defense was *** CdSe QD level increasing to 30 mg/L,the total antioxygenic capacity and the activities of catalase were enhanced up to 411%and 143.2%,***,CdSe QDs had little adverse effects on cell membrane integrity,microbial metabolism and the abundance of Nitrospirae.

关键词： Quantum dots Activated sludge Extracellular polymeric substances Microbial community Antioxidant effect

Assessment of HER2 status in extramammary Paget disease and its implication for disitamab vedotin,a novel humanized anti-HER2 antibody-drug conjugate therapy

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Frontiers of Medicine 2024年第3期18卷 565-569页

作者： jia jia Lili Mao Jing Lin Wenyu Li Pei Yuan Lei guo Jie Dai Caili Li Xue Bai Zhongwu Li Yu Chen Jun guo jianming Ying Lu Si State Key Laboratory of Molecular Oncology Department of PathologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing100021China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Melanoma and SarcomaPeking University Cancer Hospital&InstituteBeijing100142China Department of Medical Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhou350014China Department of Pathology Peking University Cancer Hospital&InstituteBeijing100142China

Dear Editor,Extramammary Paget disease(EMPD)is a rare adenocarcinoma that originates in the apocrine gland-rich skin and usually affects the perineal skin(primary EMPD)or represents the intraepithelial spread of an underlying visceral carcinoma(secondary EMPD).Approximately half of EMPD cases are confined to the epidermis,which was defined as intraepithelial EMPD.

关键词： Paget HER2 adenocarcinoma

In situ observation of the electrochemical behavior of Li–CO_(2)/O_(2)batteries in an environmental transmission electron microscope

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Carbon Energy 2024年第4期6卷 244-255页

作者： Peng jia Yunna guo Dongliang Chen Jingming Yao Xuedong Zhang jianguo Lu Yuqing Qiao Liqiang Zhang Hebei Key Laboratory of Applied Chemistry College of Environmental and Chemical EngineeringYanshan UniversityQinhuangdaoChina State Key Laboratory of Metastable Materials Science and Technology Clean Nano Energy CenterYanshan UniversityQinhuangdaoChina State Key Laboratory of Silicon and Advanced Semiconductor Materials School of Materials Science and EngineeringZhejiang UniversityHangzhouChina Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education School of Materials Science and EngineeringXiangtan UniversityXiangtanChina

Li–CO_(2)/O_(2)batteries,a promising energy storage technology,not only provide ultrahigh discharge capacity but also capture CO_(2)and turn it into renewable *** electrochemical reaction pathways'ambiguity,however,creates a hurdle for their practical *** study used copper selenide(CuSe)nanosheets as the air cathode medium in an environmental transmission electron microscope to in situ study Li–CO_(2)/O_(2)(mix CO_(2)as well as O_(2)at a volume ratio of 1:1)and Li–O_(2)batteries as well as Li–CO_(2)*** discharge reactions take place successively in the Li–CO_(2)/O_(2)–CuSe nanobattery:(I)4Li^(+)+O_(2)+4e^(−)→2Li_(2)O;(II)Li_(2)O+CO_(2)→Li_(2)CO_(3).The charge reaction proceeded via(III)2Li_(2)CO_(3)→4Li^(+)+2CO_(2)+O_(2)+4e^(−).However,Li–O_(2)and Li–CO_(2)nanobatteries showed poor cycling stability,suggesting the difficulty in the direct decomposition of the discharge *** fluctuations of the Li–CO_(2)/O_(2)battery's electrochemistry were also shown to depend heavily on O_(2).The CuSe‐based Li–CO_(2)/O_(2)battery showed exceptional electrochemical *** Li^–CO_(2)/O_(2)battery offered a discharge capacity apex of 15,492 mAh g^(−1) and stable cycling 60 times at 100 mA g^(−1).Our research offers crucial insight into the electrochemical behavior of Li–CO_(2)/O_(2),Li–O_(2),and Li–CO_(2)nanobatteries,which may help the creation of high‐performance Li–CO_(2)/O_(2)batteries for energy storage applications.

关键词： CuSe nanosheets electrochemical reaction in situ environmental transmission electron microscopy Li-CO_(2)battery Li-CO_(2)/O_(2)battery Li-O_(2)battery

Endoscopic ultrasound-guided lauromacrogol injection for treatment of colorectal cavernous hemangioma:Two case reports

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 966-973页

作者： Hua-Tuo Zhu Wen-guo Chen Jing-Jie Wang jia-Nan guo Fen-Ming Zhang guo-Qiang Xu Hong-Tan Chen Department of Gastroenterology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Colorectal cavernous hemangioma is a rare vascular malformation resulting in recurrent lower gastrointestinal hemorrhage,and can be misinterpreted as *** resection is currently the mainstay of treatment,with an emphasis on sphincter *** SUMMARY We present details of two young patients with a history of persistent hematochezia diagnosed with colorectal cavernous hemangioma by endoscopic ultrasound(EUS).Cavernous hemangioma was relieved by several EUS-guided lauromacrogol injections and the patients achieved favorable clinical *** Multiple sequential EUS-guided injections of lauromacrogol is a safe,effective,cost-efficient,and minimally invasive alternative for colorectal cavernous hemangioma.

关键词： Endoscopic ultrasound Lauromacrogol injection Colorectal cavernous hemangioma Case report