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Systems Theory-Driven Framework for AI Integration into the Holistic Material Basis Research of Traditional Chinese Medicine

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Engineering 2024年第9期40卷 28-50页

作者： Jingqi Zeng Xiaobin jia School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Natural Medicines China Pharmaceutical UniversityNanjing 210009China

This paper introduces a systems theory-driven framework to integration artificial intelligence(AI)into traditional Chinese medicine(TCM)research,enhancing the understanding of TCM’s holistic material basis while adhering to evidence-based *** the System Function Decoding Model(SFDM),the research progresses through define,quantify,infer,and validate phases to systematically explore TCM’s material *** employs a dual analytical approach that combines top-down,systems theory-guided perspectives with bottom-up,elements-structure-function methodologies,provides comprehensive insights into TCM’s holistic material ***,the research examines AI’s role in quantitative assessment and predictive analysis of TCM’s material components,proposing two specific AIdriven technical *** interdisciplinary effort underscores AI’s potential to enhance our understanding of TCM’s holistic material basis and establishes a foundation for future research at the intersection of traditional wisdom and modern technology.

关键词： Artificial intelligence Systems theory Traditional Chinese medicine Material basis Bottom-up

Study of inter-well interference in shale gas reservoirs by a robust production data analysis method based on deconvolution

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Petroleum Science 2024年第4期21卷 2502-2519页

作者： Wen-Chao Liu Cheng-Cheng Qiao Ping Wang Wen-Song Huang Xiang-Wen Kong Yu-Ping Sun He-dong Sun Yue-Peng {1. School of Civil and Resource Engineering University of Science and Technology Beijing PetroChina Research Institute of Petroleum Exploration and Development

In order to overcome the defects that the analysis of multi-well typical curves of shale gas reservoirs is rarely applied to engineering, this study proposes a robust production data analysis method based on deconvolution, which is used for multi-well inter-well interference research. In this study, a multi-well conceptual trilinear seepage model for multi-stage fractured horizontal wells was established, and its Laplace solutions under two different outer boundary conditions were obtained. Then, an improved pressure deconvolution algorithm was used to normalize the scattered production data. Furthermore, the typical curve fitting was carried out using the production data and the seepage model solution. Finally,some reservoir parameters and fracturing parameters were interpreted, and the intensity of inter-well interference was compared. The effectiveness of the method was verified by analyzing the production dynamic data of six shale gas wells in Duvernay area. The results showed that the fitting effect of typical curves was greatly improved due to the mutual restriction between deconvolution calculation parameter debugging and seepage model parameter debugging. Besides, by using the morphological characteristics of the log-log typical curves and the time corresponding to the intersection point of the log-log typical curves of two models under different outer boundary conditions, the strength of the interference between wells on the same well platform was well judged. This work can provide a reference for the optimization of well spacing and hydraulic fracturing measures for shale gas wells.

关键词： Shale gas Inter-well interference Deconvolution Production data analysis Typical curves Multi-stage fractured horizontal well

N6-methyladenosine methylation regulates the tumor microenvironment of Epstein-Barr virus-associated gastric cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2555-2570页

作者： Yu Zhang Fang Zhou Ming-Yu Zhang Li-Na Feng jia-Lun Guan Ruo-Nan {1. Yu-Jie Huang Su-Hong Xia jia-Zhi Liao Kai Zhao Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Institute of Liver and Gastrointestinal Diseases Hubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina Department of Pharmacy Wuhan Fourth HospitalWuhan 430030Hubei ProvinceChina

BACKGROUND N6-methyladenosine(m6A)methylation modification exists in Epstein-Barr virus(EBV)primary infection,latency,and lytic *** also modifies EBV latent genes and lytic ***-associated gastric cancer(EBVaGC)is a distinctive molecular subtype of *** hypothesized EBV and m6A methylation regulators interact with each other in EBVaGC to differentiate it from other types of *** To investigate the mechanisms of m6A methylation regulators in EBVaGC to determine the differentiating factors from other types of *** First,The Cancer Gene Atlas and Gene Expression Omnibus databases were used to analyze the expression pattern of m6A methylation regulators between EBVaGC and EBV-negative GC(EBVnGC).Second,we identified Gene Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)functional enrichment of m6A-related differentially expressed *** quantified the relative abundance of immune cells and inflammatory factors in the tumor microenvironment(TME).Finally,cell counting kit-8 cell proliferation test,transwell test,and flow cytometry were used to verify the effect of insulin-like growth factor binding protein 1.IGFBP1.in EBVaGC cell *** m6A methylation regulators were involved in the occurrence and development of *** with EBVnGC,the expression levels of m6A methylation regulators Wilms tumor 1.associated protein,RNA binding motif protein 1.B,CBL proto-oncogene like 1.leucine rich pentatricopeptide repeat containing,heterogeneous nuclear ribonucleoprotein A2B1.IGFBP1.and insulin-like growth factor 2 binding protein 1.were significantly downregulated in EBVaGC(P1.was significantly higher(P=0.046).GO and KEGG functional enrichment analyses showed that the immunity pathways were significantly activated and rich in immune cell infiltration in *** with EBVnGC,the infiltration of activated CD4+T cells,activated CD8+T cel

关键词： N6-methyladenosine methylation Tumor microenvironment Epstein-Barr virus Gastric cancer Insulin-like growth factor binding protein 1

Oleanolic acid improved intestinal immune function by activating and potentiating bile acids receptor signaling in E. coli-challenged piglets

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2137-2155页

作者： Chenyu Xue Hongpeng jia Rujing Cao Wenjie Cai Weichen Hong jianing Tu Songtao Wang Qianzhi jiang Chongpeng Bi Anshan Shan Na dong The Laboratory of Molecular Nutrition and Immunity College of Animal Science and TechnologyNortheast Agricultural UniversityHarbinP.R.China

Background Infection with pathogenic bacteria during nonantibiotic breeding is one of the main causes of animal intestinal *** acid(OA)is a pentacyclic triterpene that is ubiquitous in *** previous work demonstrated the protective effect of OA on intestinal health,but the underlying molecular mechanisms remain *** study investigated whether dietary supplementation with OA can prevent diarrhea and intestinal immune dysregulation caused by enterotoxigenic Escherichia coli(ETEC)in *** key molecular role of bile acid receptor signaling in this process has also been *** Our results demonstrated that OA supplementation alleviated the disturbance of bile acid metabolism in ETEC-infected piglets(P<0.05).OA supplementation stabilized the composition of the bile acid pool in piglets by regulating the enterohepatic circulation of bile acids and significantly increased the contents of UDCA and CDCA in the ileum and cecum(P<0.05).This may also explain why OA can maintain the stability of the intestinal microbiota structure in ETEC-challenged *** addition,as a natural ligand of bile acid receptors,OA can reduce the severity of intestinal inflammation and enhance the strength of intestinal epithelial cell antimicrobial programs through the bile acid receptors TGR5 and FXR(P<0.05).Specifically,OA inhibited NF-κB-mediated intestinal inflammation by directly activating TGR5 and its downstream c AMP-PKA-CREB signaling pathway(P<0.05).Furthermore,OA enhanced CDCA-mediated MEK-ERK signaling in intestinal epithelial cells by upregulating the expression of FXR(P<0.05),thereby upregulating the expression of endogenous defense molecules in intestinal epithelial *** In conclusion,our findings suggest that OA-mediated regulation of bile acid metabolism plays an important role in the innate immune response,which provides a new diet-based intervention for intestinal diseases caused by pathogenic bacterial infections in pig

关键词： Bile acid receptors Enterotoxigenic Escherichia coli Intestinal innate immunity Oleanolic acid

A modified transformer and adapter-based transfer learning for fault detection and diagnosis in HVAC systems

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Energy Storage and Saving 2024年第2期3卷 96-105页

作者： Zi-Cheng Wang dong Li Zhan-Wei Cao Feng Gao Ming-{1. Li Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an710049China Science and Technology on Space Physics Laboratory China Academy of Launch Vehicle TechnologyBeijing100076China School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China

Fault detection and diagnosis(FDD)of heating,ventilation,and air conditioning(HVAC)systems can help to improve the energy saving in building energy ***,most data-driven trained FDD models have limited generalizability and can only be applied to specific *** diversity of HVAC systems and the high cost of data acquisition present challenges for the practical application of *** learning technology can be employed to mitigate this problem by training a model on systems with sufficient data and then transfer it to other systems with limited *** this study,a novel transfer learning approach for HVAC FDD is ***,the transformer model is modified to incorporate one encoder and two decoders connected,enabling two *** modified transformer model accommodates absent features in the target domain and serves as a robust foundation for transfer *** has effective performance in complex systems and achieves an accuracy of 91.38%for a system with 1. faults and multiple fault severity ***,the adapter-based parameter-efficient transfer learning method,facilitating the transfer of trained models simply by inserting small adapter modules,is investigated as the transfer learning *** demonstrate that this adapter-based transfer learning approach achieves satisfactory performance similar to full fine-tuning with fewer trainable *** works well with limited data amount in target ***,the findings highlight the significance of adapters positioned near the bottom and top layers,emphasizing their critical role in facilitating successful transfer learning.

关键词： Fault detection and diagnosis Transfer learning HVAC system Energy saving Transformer model

Mechanical characteristics and reservoir stimulation mechanisms of the Gulong shale oil reservoirs, the northern Songliao Basin

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Petroleum Science 2024年第3期21卷 2023-2036页

作者： Si-Wei Meng jia-Ping Tao Tian-jiao Li dong-Xu Li Su-Ling Wang Liu Yang Xin Liu Li-Hao Liang He Liu PetroChina Research Institute of Petroleum Exploration Development Beijing100083China National Key Laboratory of Continental Shale Oil Daqing 163002HeilongjiangChina Dalian University of Technology Dalian116024LiaoningChina PetroChina Daqing Oilfield Co.Ltd. Daqing163002HeilongjiangChina Northeast Petroleum University Daqing163002HeilongjiangChina China University of Mining and Technology(Beijing) Beijing100083China

Shale oil of the Qingshankou Formation of the Gulong Sag,the northern Songliao Basin,represents the first attempt at large-scale development of pure-shale-type shale oil in *** integrating the multiscale refined reservoir characterization with macro-micro-scale mechanical testing,it is clarified that the Gulong shale is characterized by high clay mineral content,high rock plasticity,highly-developed bedding,and prominent mechanical anisotropy.A three-dimensional(3D)fracture propagation model of hydraulic fracturing was built for the Gulong shale,which fully captures the hydraulic fracture distribution pattern affected by the high bedding density,in-situ stress,and fracturing treatment *** research showed that due to influences of bedding,hydraulic fracturing in the Gulong shale forms a complex fracture morphology featuring the main fracture with multiple perpendicular branches that have different lengths(like the outdoor directional TV antenna);however,the vertical propagation of fractures is inhibited,and the fracture height is commonly less than 1. *** limited stimulated reservoir volume(SRV)is the main problem facing the fracturing stimulation of the Gulong shale *** density has vital effects on fracture morphology,so case-specific fracturing designs shall be developed for shale intervals with different bedding development *** reservoirs with welldeveloped bedding,it is suggested to properly increase the perforation cluster spacing and raise the volume and proportions of viscous fluids of the pad,so as to effectively promote vertical fracture propagation and improve reservoir stimulation *** study integrates multi-scale fine reservoir characterization and macro-micro-scale mechanical testing,as well as the construction and numerical simulation of hydraulic fracturing models for high-density layered shale reservoirs,providing a new approach and methodological framework for the fracturing research of high-density layer

关键词： Shale oil Hydraulic fracturing High bedding density Fracture propagation model

The hard X-ray nanoprobe beamline at the SSRF

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Nuclear Science and Techniques 2024年第7期35卷 79-88页

作者： Yan He Hui jiang {1.-Xu Liang Zhi-Sen jiang Huai-Na Yu Hua Wang Cheng-Wen Mao jia-Nan Xie Ai-Guo Li Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai201210China

The hard X-ray nanoprobe beamline BL1.U is a phase-Ⅱ beamline project at the Shanghai Synchrotron Radiation *** beamline aims to enable comprehensive experiments at high spatial resolutions ranging from 50 to 1. nm. The X-ray energy range of the beamline, 5–25 keV, can detect most elements in the periodic table. Two operating modes were designed to accommodate the experimental requirements of high-energy resolution or high photon flux, respectively. X-ray nanofluorescence, nanodiffraction, and coherent diffraction imaging are developed as the main experimental techniques for BL1.U. This paper describes the beamline optics, end station configurations, experimental methods under development, and preliminary test results. This comprehensive overview aims to provide a clear understanding of the beamline capabilities and potential applications.

关键词： Shanghai synchrotron radiation facility Hard X-ray nanoprobe X-ray nanofocusing

Super-resolution Imaging of Telescopic Systems based on Optical-neural Network Joint Optimization

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Research in Astronomy and Astrophysics 2024年第9期24卷 167-177页

作者： You-Hong Sun Tao Zhang Hao-dong Shi Qiang Fu {1.-Nan Liu Kai-Kai Wang Chao Wang Research Institute of Chongqing Changchun University of Science and TechnologyChangchun 130022China National and Local Joint Engineering Research Center for Space Photoelectric Technology Changchun University of Science and TechnologyChangchun 130022China The Institute of Remote Sensing Satellites China Academy of Space Technology(CAST)Beijing 100094China

Optical telescopes are an important tool for acquiring optical information about distant objects,and resolution is an important indicator that measures the ability to observe object ***,due to the effects of system aberration,atmospheric seeing,and other factors,the observed image of ground-based telescopes is often degraded,resulting in reduced *** paper proposes an optical-neural network joint optimization method to improve the resolution of the observed image by co-optimizing the point-spread function(PSF)of the telescopic system and the image super-resolution(SR)*** improve the speed of image reconstruction,we designed a generative adversarial net(LCR-GAN)with light parameters,which is much faster than the latest unsupervised *** reconstruct the PSF trained by the network in the optical path,a phase mask is *** improves the image reconstruction effect of LCR-GAN by reconstructing the PSF that best matches the *** results of simulation and verification experiments show that compared with the pure deep learning method,the SR image reconstructed by this method is rich in detail and it is easier to distinguish stars or stripes.

关键词： Techniques:image processing Telescopes Stars:imaging

Enhanced cycling stability and rate performance of Co-doped and La_(2)O_(3)-coated LiNi_(0.9)Mn_(0.1.O_(2) toward power battery

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Rare Metals 2024年第2期43卷 658-670页

作者： jia-Qi Peng Yuan-Yuan Wei {1.-Ming Liu Yun Li Bin Hu Bin Huang jian-Wen Yang Shun-Hua Xiao Ren-Heng Wang Guangxi Key Laboratory of Electrochemical and Magneto-Chemical Functional Materials College of Chemistry and BioengineeringGuilin University of TechnologyGuilin541004China Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province College of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

Ultra-high nickel layered oxide cathode material with high energy density is the most promising material to improve the electrochemical performance of lithium-ion batteries(LIBs).However,the poor structural stability and severe surface/interface side reactions of the material lead to poor rate performance and cyclic stability,which limits its application in *** this paper,the dual-modification strategy of Co doping and La_(2)O_(3) coating is used to meet the above *** doping can effectively widen layer spacing and reduce Li^(+)/Ni^(2+) mixing,and La_(2)O_(3) coating can effectively eliminate the residual alkali on the surface of active material,inhibit the thickening of cathode electrolyte interphase(CEI)film and reduce surface/interface side ***,the modified material(NM90-CL)with excellent electrochemical properties is achieved through the synergistic enhancement of Co doping and La_(2)O_(3) *** capacity retention rate can reach 77.9%after 200 cycles at 1.0℃ and 75.7%after 200 cycles at 5.0℃.Its reversible capacity can up to 1.3.5 mAh·g^(–1. at 1..0℃.This dual-modification strategy will provide theoretical guidance and technical support for the synthesis of other high-performance electrode materials.

关键词： High nickel cathode material Co doping La_(2)O_(3) coating Electrochemical performance Electrochemical mechanism