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具抗菌及乙酰胆碱酯酶抑制活性珊瑚真菌的筛选

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微生物学杂志 2015年第5期35卷 23-27页

作者：班海侠钟敏雷晓凌陈芳蔡加怡广东海洋大学食品科技学院广东省水产品加工与安全重点实验室水产品深加工广东普通高等学校重点实验室广东湛江524088

为开发利用珊瑚真菌资源,以徐闻珊瑚保护区珊瑚样品中分离鉴定的43株海洋真菌为研究对象,采用双层平板法和Ellman法分别对其进行抗菌和乙酰胆碱酯酶(AChE)抑制活性筛选。结果显示,43株菌株至少对一种指示菌有抑制作用,且有12株菌株对革... 详细信息

为开发利用珊瑚真菌资源,以徐闻珊瑚保护区珊瑚样品中分离鉴定的43株海洋真菌为研究对象,采用双层平板法和Ellman法分别对其进行抗菌和乙酰胆碱酯酶(AChE)抑制活性筛选。结果显示,43株菌株至少对一种指示菌有抑制作用,且有12株菌株对革兰阳性菌和革兰阴性菌均表现出不同程度的抗菌活性,抗菌谱较广;当浓度为1 mg/m L时,有8株菌株的发酵液提取物对乙酰胆碱酯酶的抑制率达到50%以上。其活性菌株中曲霉属(Aspergillus)为优势属。

关键词：珊瑚真菌抗菌活性乙酰胆碱酯酶(AChE)抑制活性筛选

基于网络药理学对桂枝茯苓丸治疗放射性肺炎的潜在作用机制初探

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海南医学 2022年第8期33卷 953-958页

作者：邹航李淼何嘉宁朱诗雨翁文浩赵春阳蔡佳怡中国医科大学药学院辽宁沈阳110122 中国医科大学临床一系辽宁沈阳110122 中国医科大学附属第一医院辽宁沈阳110001

目的运用网络药理学初步探索经典名方桂枝茯苓丸治疗放射性肺炎的潜在机制。方法通过利用中药系统药理学数据库与分析平台(TCMSP)数据库筛选桂枝茯苓丸的活性成分和作用靶点,检索GeneCard和OMIM数据库收集放射性肺炎靶点(2021年5月31日... 详细信息

目的运用网络药理学初步探索经典名方桂枝茯苓丸治疗放射性肺炎的潜在机制。方法通过利用中药系统药理学数据库与分析平台(TCMSP)数据库筛选桂枝茯苓丸的活性成分和作用靶点,检索GeneCard和OMIM数据库收集放射性肺炎靶点(2021年5月31日更新检索)。应用Cytoscape构建网络关系图,通过String数据库进行蛋白-蛋白互作网络分析。运用R软件对相关基因进行KEGG和GO富集,应用AutoDock对活性成分和蛋白靶标进行对接。结果桂枝茯苓丸作用于放射性肺炎的潜在靶点共计85个,存在90个潜在生理功能,136条相关通路,8个亲和性较好的小分子。结论桂枝茯苓丸治疗放射性肺损伤是多靶点作用,潜在靶点可为后续的药理学研究提供依据。

关键词：放射性肺炎桂枝茯苓丸网络药理学活性成分作用靶点机制

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Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan Zhang yi Yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

Wave function collapses and 1/n energy spectrum induced by a Coulomb potential in a one-dimensional flat band system

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Chinese Physics B 2022年第5期31卷 173-179页

作者： yi-cai Zhang School of Physics and Materials Science Guangzhou UniversityGuangzhou 510006China

We investigate the bound state problem in a one-dimensional flat band system with a Coulomb *** is found that,in the presence of a Coulomb potential of type I(with three equal diagonal elements),similarly to that in the twodimensional case,the flat band could not *** the same time,the flat band states are transformed into localized states with a logarithmic singularity near the center *** addition,the wave function near the origin would collapse for an arbitrarily weak Coulomb *** to the wave function collapses,the eigen-energies for a shifted Coulomb potential depend sensitively on the cut-off *** a Coulomb potential of type II,there exist infinite bound states that are generated from the flat ***,when the bound state energy is very near the flat band,the energy is inversely proportional to the natural number,e.g.,E_(n)∝1/n,n=1,2,3,...It is expected that the 1/n energy spectrum could be observed experimentally in the near future.

关键词： wave function collapses flat band infinite bound states

Radiomics in the diagnosis and treatment of hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 346-351页

作者： Chun jiang yi-Qi cai jia-jia Yang Can-Yu Ma jia-Xi Chen Lan Huang Ze Xiang jian Wu Department of Clinical Laboratory The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China Zhejiang University School of Medicine Hangzhou 310030China Department of Infection Management The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215008China

Hepatocellular carcinoma(HCC)is a common malignant *** present,early diagnosis of HCC is dif-ficult and therapeutic methods are *** can achieve accurate quantitative evaluation of the lesions without invasion,and has important value in the diagnosis and treatment of *** fea-tures can predict the development of cancer in patients,serve as the basis for risk stratification of HCC patients,and help clinicians distinguish similar diseases,thus improving the diagnostic ***-more,the prediction of the treatment outcomes helps determine the treatment *** is also helpful in predicting the HCC recurrence,disease-free survival and overall *** review summa-rized the role of radiomics in the diagnosis,treatment and prognosis of HCC.

关键词： Hepatocellular carcinoma Radiomics Diagnosis Prognosis Treatment

Tuning the interfacial reaction environment via pH-dependent and induced ions to understand C–N bonds coupling performance in NO3- integrated CO2 reduction to carbon and nitrogen compounds over dual Cu-based N-doped carbon catalyst

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Journal of Energy Chemistry 2025年第1期100卷 273-285页

作者： Tianhang Zhou Chen Shen Zhenghao Wu Xingying Lan yi Xiao College of Carbon Neutrality Future Technology State Key Laboratory of Heavy Oil Processing China University of Petroleum (Beijing) Institute of Materials Science TU Darmstadt Department of Chemistry Xi'an Jiaotong-Liverpool University Department of Mechanical and Mechatronics Engineering and Waterloo Institute of Nanotechnology University of Waterloo Waterloo

Dual atomic catalysts （DAC）,particularly copper （Cu2）-based nitrogen （N） doped graphene,show great potential to effectively convert CO2and nitrate （NO3-） into important industrial chemicals such as ethylene,glycol,acetamide,and urea through an efficient catalytical process that involves C–C and C–N ***,the origin of the coupling activity remained unclear,which substantially hinders the rational design of Cu-based catalysts for the N-integrated CO2reduction reaction （CO2RR）.To address this challenge,this work performed advanced density functional theory calculations incorporating explicit solvation based on a Cu2-based N-doped carbon (Cu2N6C10) catalyst for *** calculations are aimed to gain insight into the reaction mechanisms for the synthesis of ethylene,acetamide,and urea via coupling in the interfacial reaction *** to the sluggishness of CO2,the formation of a solvation electric layer by anions （F-,Cl-,Br-,and I-） and cations (Na+,Mg2+,K+,and Ca2+) leads to electron transfer towards the Cu *** process significantly accelerates the reduction of *** results reveal that*CO intermediates play a pivotal role in N-integrated ***,the Cu2-based N-doped carbon catalyst examined in this study has demonstrated the most potential for C–N coupling to *** findings reveal that through the process of a condensation reaction between*CO and NH2OH for urea synthesis,*NO3-is reduced to*NH3,and*CO2to*CCO at dual Cu atom *** dual-site reduction facilitates the synthesis of acetamide through a nucleophilic reaction between NH3and the ketene ***,we found that the I-and Mg2+ions,influenced by pH,were highly effective for acetamide and ammonia synthesis,except when F-and Ca2+were ***,the mechanisms of C–N bond formation were investigated via ab-initio molecular dynamics simulations,and we found that adjusting the micro-environment can change the dominant side reaction,shift

关键词： pH-dependent micro-environments C–N coupling Dual Cu-based nitrogen carbon catalysts Explicit solvation model Ion stabilizer AIMD

Exploring bouncing cosmologies with cosmological surveys

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Science China(Physics,Mechanics & Astronomy) 2014年第8期57卷 1414-1430页

作者： cai yi-Fu Department of Physics McGill UniversityMontréal QC H3A 2T8 Canada

From recent observational data two significant directions have been made in the field of theoretical cosmology recently. First, we are now able to make use of present observations, such as the Planck and BICEP2 data, to examine theoretical predictions from the standard inflationary ACDM which were made decades of years ago. Second, we can search for new cosmological signatures as a way to explore physics beyond the standard cosmic paradigm. In particular, a subset of early universe models admit a nonsingular bouncing solution that attempts to address the issue of the big bang singularity. These models have achieved a series of considerable developments in recent years, in particular in their perturbative frameworks, which made brand-new predictions of cosmological signatures that could be visible in current and forthcoming observations. Herein we present two representative paradigms of early universe physics. The first is the reputed new matter （or matter-ekpyrotic） bounce scenario in which the universe starts with a matter-dominated contraction phase and transitions into an ekpyrotic phase. In the setting of this paradigm, we have proposed some possible mechanisms of generating a red tilt for primordial curvature perturbations and confront the general predictions with recent cosmological observations. The second is the matter-bounce inflation scenario which can be viewed as an extension of inflationary cosmology with a matter contraction before inflation. We present a class of possible model constructions and review the implications on the current CMB experiments. Lastly a review of significant achievements of these paradigms beyond the inflationary ACDM model is made, which is expected to shed new light on the future direction of observational cosmology.

关键词： bouncing cosmology big bang singularity CMB observations

植物源外泌体样纳米囊泡刺激成骨细胞、抑制破骨细胞并促进成骨

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中国组织工程研究 2025年第31期29卷 6765-6771页

作者：药文鑫王毅蔡林冯晓波武汉大学中南医院疼痛科湖北省武汉市430071 武汉大学中南医院脊柱与骨肿瘤科湖北省武汉市430071

背景:骨质疏松症易引发病理性骨折且严重影响患者的生活质量,植物源外泌体样纳米囊泡在调节骨质疏松症骨平衡方面发挥着重要作用。目的:综述不同植物源外泌体样纳米囊泡在骨质疏松症治疗中的研究现状与展望。方法:通过计算机在PubMed、W... 详细信息

背景:骨质疏松症易引发病理性骨折且严重影响患者的生活质量,植物源外泌体样纳米囊泡在调节骨质疏松症骨平衡方面发挥着重要作用。目的:综述不同植物源外泌体样纳米囊泡在骨质疏松症治疗中的研究现状与展望。方法:通过计算机在PubMed、Web of Science、中国知网中检索1995年1月至2024年3月发表的相关文献,以“osteoporosis,plant-derived exosome-like nanovesicles,exosomes,osteoblasts,osteoclasts”为英文检索词,以“骨质疏松症,植物源外泌体样纳米囊泡,外泌体,成骨细胞,破骨细胞”为中文检索词,最终纳入53篇文献进行分析。结果与结论:植物源外泌体样纳米囊泡具有生物相容性、低毒性和天然靶向性等优点,这些特性不仅确保了其在体内的稳定存在与有效作用,还避免了不必要的免疫反应,为长期治疗策略的设计奠定了基础。植物源外泌体样纳米囊泡可以通过刺激成骨细胞增殖、抑制破骨细胞分化以及促进成骨-抑制破骨双重作用抗骨质疏松症;此外,部分植物源外泌体样纳米囊泡因具有骨靶向性,未来或将成为新型示踪靶标和治疗方案广泛应用于骨质疏松症治疗过程中。

关键词：骨质疏松症植物源性外泌体样纳米囊泡外泌体成骨细胞破骨细胞工程化外泌体

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A computational cognition model of perception,memory,and judgment

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Science China(Information Sciences) 2014年第3期57卷 154-168页

作者： FU XiaoLan cai LianHong LIU Ye jia jia CHEN WenFeng yi Zhang ZHAO GuoZhen LIU YongJin WU ChangXu State Key Laboratory of Brain and Cognitive Science Institute of PsychologyChinese Academy of Sciences TNLIST Department of Computer Science and TechnologyTsinghua University College of Computer Science Sichuan University Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of Sciences

The mechanism of human cognition and its computability provide an important theoretical foundation to intelligent computation of visual *** paper focuses on the intelligent processing of massive data of visual media and its corresponding processes of perception,memory,and judgment in *** particular,both the human cognitive mechanism and cognitive computability of visual media are investigated in this paper at the following three levels:neurophysiology,cognitive psychology,and computational modeling.A computational cognition model of Perception,Memory,and Judgment(PMJ model for short)is proposed,which consists of three stages and three pathways by integrating the cognitive mechanism and computability aspects in a unified ***,this paper illustrates the applications of the proposed PMJ model in five visual media research *** demonstrated by these applications,the PMJ model sheds some light on the intelligent processing of visual media,and it would be innovative for researchers to apply human cognitive mechanism to computer science.

关键词： perception memory judgment computational cognition model