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Nuclear Science and Techniques 2023年第10期34卷 20-35页

作者： He-Xing Yin Jia-Bao Guan Shun-Qiang Tian Ji-Ke Wang The Institute for Advanced Studies Wuhan UniversityWuhan 430072China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

Multi-objective evolutionary algorithms(MOEAs) are typically used to optimize two or three objectives in the accelerator field and perform well. However, the performance of these algorithms may severely deteriorate when the optimization objectives for an accelerator are equal to or greater than four. Recently, many-objective evolutionary algorithms(MaOEAs)that can solve problems with four or more optimization objectives have received extensive attention. In this study, two diffraction-limited storage ring(DLSR) lattices of the Extremely Brilliant Source(ESRF-EBS) type with different energies were designed and optimized using three MaOEAs and a widely used MOEA. The initial population was found to have a significant impact on the performance of the algorithms and was carefully studied. The performances of the four algorithms were compared, and the results demonstrated that the grid-based evolutionary algorithm(GrEA) had the best performance.Ma OEAs were applied in many-objective optimization of DLSR lattices for the first time, and lattices with natural emittances of 116 and 23 pm·rad were obtained at energies of 2 and 6 GeV, respectively, both with reasonable dynamic aperture and local momentum aperture(LMA). This work provides a valuable reference for future many-objective optimization of DLSRs.

关键词： Storage ring lattices Many-objective evolutionary algorithms GrEA algorithm NSGA

A series of stable, metastable and unstable salts of Imatinib with improved solubility

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Chinese Chemical Letters 2022年第4期33卷 2159-2164页

作者： Zheng-Yu Fang bao-Xi Zhang Wen-Hui Xing Hong-Li jia Xue Wang Ning-Bo Gong Yang Lu guan-Hua Du Beijing Key Laboratory of Polymorphic Drugs Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191 China Beijing City Key Laboratory of Drug Target Identification and Drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

Pharmaceutical salt formation is the most preferred and effective method to enhance the physicochemical properties of APIs. The aim of the study was to design and synthesize a series of new salts to improve the solubility of Imatinib(IM). Two stable salts with malonic acid(S1) and citric acid(S5), one metastable salt with fumaric acid(S2), two unstable salts with citric acid(S3, S4) were obtained for the first time.Single crystal and powder X-ray diffraction, Fourier transform infrared, differential scanning calorimetry,and thermogravimetric analysis were used to characterize the novel salts. The solubility and stability of the solid were also evaluated, and three salts(S1, S2, S5) had a more than 20 folds of solubility and a faster dissolution rate improved as compared to the pure drug in water and p H 6.8 buffer, respectively.

关键词： Imatinib Salt Characterization Stability Solubility

Design of S-band photoinjector with high bunch charge and low emittance based on multi-objective genetic algorithm

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Nuclear Science and Techniques 2023年第3期34卷 93-105页

作者： Ze-Yi Dai Yuan-Cun Nie Zi Hui Lan-Xin Liu Zi-Shuo Liu jian-Hua Zhong Jia-Bao Guan Ji-Ke Wang Yuan Chen Ye Zou Hao-Hu Li jian-Hua He The Institute for Advanced Studies Wuhan UniversityWuhan 430072China

High-brightness electron beams are required to drive LINAC-based free-electron lasers(FELs)and storage-ring-based synchrotron radiation light sources.The bunch charge and RMS bunch length at the exit of the LINAC play a crucial role in the peak current;the minimum transverse emittance is mainly determined by the injector of the LINAC.Thus,a photoin-jector with a high bunch charge and low emittance that can simultaneously provide high-quality beams for 4th generation synchrotron radiation sources and FELs is desirable.The design of a 1.6-cell S-band 2998-MHz RF gun and beam dynamics optimization of a relevant beamline are presented in this paper.Beam dynamics simulations were performed by combining ASTRA and the multi-objective genetic algorithm NSGA II.The effects of the laser pulse shape,half-cell length of the RF gun,and RF parameters on the output beam quality were analyzed and compared.The normalized transverse emittance was optimized to be as low as 0.65 and 0.92 mm·mrad when the bunch charge was as high as 1 and 2 nC,respectively.Finally,the beam stability properties of the photoinjector,considering misalignment and RF jitter,were simulated and analyzed.

关键词： Electron linear accelerator Photoinjector Beam dynamics Multi-objective genetic algorithm

Risk factors and the prognosis of sexual dysfunction in male patients with pituitary adenomas： a multivariate analysis

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Asian Journal of Andrology 2018年第1期20卷 43-49页

作者： Wen-jian-Long Zhou Shun-Chang Ma Min Zhao Chang Liu Xiu-Dong guan Zhao-Shi bao Gui-lun jia Wang jia Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing 100050 China Department of Neurosurgery Beijing Fuxing Hospital Capital Medical University Beijing 100045 China Department of Neurosurgery Peking University International Hospital Beijing 102206 China Department of Neurosurgery Beijing Huairou Hospital University of Chinese Academy of Sciences Beijing 101400 China

性机能障碍(SD ) 的影响对有影响物理、心理的健康的垂体腺瘤的许多男病人令人烦恼。研究探索了识别与垂体腺瘤影响性功能和男病人的预后的风险因素。254 个男病人，在 18 和 60 之间变老，意味着楶敤吗？

关键词：垂体腺瘤机能障碍预后睾丸激素冒险激素水平风险因素 NFPA

维普期刊数据库评论

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行政程序理性研究

求是学刊 2023年第2期50卷 92-107页

作者：关保英侯佳丽上海政法学院上海201701 上海财经大学上海200433

理性的行政程序要求其在制度设计及运行中必须遵循行政法治的精神,注重行政相对人权益保护,以追求效率作为内在价值等。实践中将行政程序虚无化、绝对化、脱节化和苛刻化都是非理性表现。为此,应当合理定位行政程序,把它作为工具性要素... 详细信息

理性的行政程序要求其在制度设计及运行中必须遵循行政法治的精神,注重行政相对人权益保护,以追求效率作为内在价值等。实践中将行政程序虚无化、绝对化、脱节化和苛刻化都是非理性表现。为此,应当合理定位行政程序,把它作为工具性要素附着于公平价值;通过行政程序典则化,对目前分散的行政程序规则予以整合并进一步规范;设计行政相对人及其他利害关系人深度参与的行政程序规则;建构行政程序运行的监督体制机制,以矫正非理性行政程序;将行政程序运行的效果和结论交于司法程序最终裁判。

关键词：行政程序非理性表现理性化要求法治推进

海洋文化自信视阈下海洋文化产业高质发展研究——以连云港为例

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民办高等教育研究 2019年第1期 75-77页

作者：包家官淮海工学院应用技术学院

海洋文化自信是加快建设海洋强国的重要保障,同时它也对海洋文化产业发展提出不断提升海洋文化资源开发能力、不断提升海洋文化产业发展水平、不断提升海洋文化生态建设成效三方面具体要求。结合连云港海洋文化产业发展现状、问题与机遇... 详细信息

海洋文化自信是加快建设海洋强国的重要保障,同时它也对海洋文化产业发展提出不断提升海洋文化资源开发能力、不断提升海洋文化产业发展水平、不断提升海洋文化生态建设成效三方面具体要求。结合连云港海洋文化产业发展现状、问题与机遇,应着力从以下五个层面促进其高质发展:一、以海兴市,培育符合沿海开放城市气质的海洋文化自信;二、产业强市,加快发展品牌特色明显的海洋文化产业;三、创新驱动,全面提升地方海洋文化产业竞争力;四、绿色发展,全力推进区域海洋生态文明建设;五、协调共进,努力构筑海洋文化产业展示平台。

关键词：海洋文化文化自信文化产业连云港

Network mechanism on effective constituents from Polygala Tenuifolia for anti-Alzheimer Disease

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中国药理学与毒理学杂志 2018年第4期32卷 287-288页

作者： Hao jia Xiao-cong PANG bao-yue ZHANG Zhe WANG Ai-lin LIU guan-hua DU Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050 China

OBJECTIVE To clarify out the network pharmacology mechanism of Polygala tenuifolia against Alzheimer disease(AD).METHODS Firstly,we collected the chemical constituents from Polygala tenuifolia and key targets toward AD.Machine learning algorithms were applied to construct classifi.ers for predicting the effective constituents.Secondly,docking models were utilized for further evalua.tion.Finally,we built constituent-target,target-target network and target-biology pathway network.RE.SULTS 104 chemical constituents Polygala tenuifolia from were collected.Through prediction of bloodbrain penetration and validation,36 chemical constituents were selected among 100 chemical constitu.ents,their action targets mainly focused on AChE,COX-2,TNF-α,insulin-degrading enzyme and APP.Their main structure types include Polygala saponins,Polygala glycosides,Polygala shrubby ketones,polygala xanthones and sterols,which acted on AchE,APP,M-TAU,GSK3β and 5 HT1A with high fre.quency.Gene-Ontology and KEGG enrichment analysis showed that the main pathways of these con.stituents involve in neurotransmitter release,synaptic conduction and synaptic plasticity,apoptosis reg.ulation,phosphorylation pathway,Ca^(2+) signaling pathway,and so on.CONCLUSION This study uncov.ered a network mechanism of Polygala tenuifolia against Alzheimer disease,which may provide impor.tant information for the further study and new drug development.

关键词：阿尔茨海默病中药治疗方法临床分析

L^(2) Extension and Effectiveness of L^(p) Strong Openness Property

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Acta Mathematica Sinica,English Series 2023年第5期39卷 814-826页

作者： Shi Jie bao Qi An guan School of Mathematical Sciences Peking UniversityBeijing 100871P.R.China

In this note,we present an L^(2) extension approach to the effectiveness result of L^(P) strong openness property of multiplier ideal sheaves.

关键词： Optimal L^(2)extension multiplier ideal sheaf L^(P)strong openness property

Improving inherent soil productivity underpins agricultural sustainability

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Pedosphere 2023年第1期33卷 3-5页

作者： jia bao ZHANG State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008(China)

There is now increasing attention to how to raise global food production and security due to the expanding population worldwide.Stable and high yield of crops depends on soil quality improvement,which relies on inherent soil productivity increase.Improvement in inherent soil productivity can provide a range of benefits for soil structure,microorganisms,nutrient cycling,and carbon sequestration.The underlying mechanisms related to inherent soil productivity improvement under different agricultural management practices on large scales need to be further clarified.Therefore,to achieve agricultural sustainability,efforts need to focus on developing technologies related to straw return,tillage management,and cover cropping and understanding their relationships with inherent soil productivity improvement.

关键词： soil crops return

L^(2)Extension and Effectiveness of Strong Openness Property

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Acta Mathematica Sinica,English Series 2022年第11期38卷 1949-1964页

作者： Shi Jie bao Qi An guan School of Mathematical Sciences Peking UniversityBeijing 100871P.R.China

In this note,we present an L^(2)extension approach to the effectiveness result of strong openness property of multiplier ideal sheaves.

关键词： Optimal L^(2)extension multiplier ideal sheaf strong openness property