检索结果-南通市图书馆

Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma

引用

World Journal of Gastroenterology 2024年第8期30卷 919-942页

作者： Ren-Yong Wang jia-Ling Yang Ning Xu jia Xu Shao-hua Yang Dao-Ming Liang Jin-Ze Li Hong Zhu Second Affiliated Hospital of Kunming Medical University Kunming 650106Yunnan ProvinceChina School of Basic Medical Sciences Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina Wuhan Blood Center Wuhan 430030Hubei ProvinceChina Department of Gastrointestinal Surgery The Third People's Hospital of Hubei ProvinceWuhan 430071Hubei ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common types of *** influence of lipid metabolism disruption on the development of HCC has been demonstrated in published *** To establish an HCC prognostic model for lipid metabolism-related long non-coding RNAs(LMR-lncRNAs)and conduct in-depth research on the specific role of novel LMR-lncRNAs in *** Correlation and differential expression analyses of The Cancer Genome Atlas data were used to identify differentially expressed *** real-time polymerase chain reaction analysis was used to evaluate the expression of *** red staining was employed to observe intracellular lipid *** interaction between RP11-817I4.1,miR-3120-3p,and ATP citrate lyase(ACLY)was validated through the performance of dual-luciferase reporter gene and RIP *** Three LMR-lncRNAs(negative regulator of antiviral response,RNA transmembrane and coiled-coil domain family 1 antisense RNA 1,and RP11-817I4.1)were identified as predictive markers for HCC patients and were utilized in the construction of risk ***,proliferation,migration,and invasion were reduced by RP11-817I4.1 *** increase in lipid levels in HCC cells was significantly induced by RP11-817I4.1 through the miR-3120-3p/ACLY *** LMR-lncRNAs have the capacity to predict the clinical characteristics and prognoses of HCC patients,and the discovery of a novel LMR-lncRNAs,RP11-817I4.1,revealed its role in promoting lipid accumulation,thereby accelerating the onset and progression of HCC.

关键词： Hepatocellular carcinoma Lipid metabolism Immune microenvironment Prognostic markers Metabolic reprogramming

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Challenging anticoagulation therapy for multiple primary malignant tumors combined with thrombosis:A case report and review of literature

引用

World Journal of Clinical Cases 2024年第9期12卷 1704-1711页

作者： jia-Xin Chen Ling-Ling Xu Jing-Ping Cheng Xun-hua Xu Department of Gerontology China Resources and Wisco General HospitalWuhan University of Science and TechnologyWuhan 430080Hubei ProvinceChina Medical College Wuhan University of Science and TechnologyWuhan 430065Hubei ProvinceChina Department of Gerontology China Resources and Wisco General HospitalWuhan 430080Hubei ProvinceChina Department of Radiology China Resources and Wisco General HospitalWuhan 430080Hubei ProvinceChina

BACKGROUND Venous thromboembolism significantly contributes to patient deterioration and *** of its etiology and anticoagulation treatment is intricate,necessitating a comprehensive consideration of various factors,including the bleeding risk,dosage,specific anticoagulant medications,and duration of ***,a case of lower extremity thrombosis with multiple primary malignant tumors and high risk of bleeding was reviewed to summarize the shortcomings of treatment and prudent anticoagulation *** SUMMARY An 83-year-old female patient was admitted to the hospital due to a 2-wk history of left lower extremity edema that had worsened over 2 *** her medical history and relevant post-admission investigations,it was determined that the development of left lower extremity venous thrombosis and pulmonary embolism in this case could be attributed to a combination of factors,including multiple primary malignant tumors,iliac venous compression syndrome,previous novel coronavirus infection,and inadequate treatment for prior thrombotic ***,the selection of appropriate anticoagulant medications,determination of optimal drug dosages,and establishment of an appropriate duration of anticoagulation therapy were important because of concurrent thrombocytopenia,decreased quantitative fibrinogen levels,and renal *** Anticoagulant prophylaxis should be promptly initiated in cases of high-risk *** anticoagulation therapy is required for complex thrombosis.

关键词： Venous thromboembolism Cancer-associated thrombosis Anticoagulation therapy iliac vein compression syndrome COVID-19 Thrombocytopenia Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High-Performanceα-Diimine Nickel Complexes for Facile Access of PE Elastomers with Exceptional Material Properties

引用

Chinese Journal of Polymer Science 2024年第5期42卷 620-635,I0008页

作者： Li-Dong Qin Xin-yu Wang Qaiser Mahmood Zhi-Xin yu Yi-Zhou Wang Song Zou Tong-Ling Liang Wen-hua Sun School of Pharmaceutical Sciences Changchun University of Chinese MedicineChangchun130117China Chemistry and Chemical Engineering Guangdong Laboratory Shantou515031China Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Science Institute of ChemistryChinese Academy of SciencesBeijing100190China

For practicable elastomeric polyethylene,achieving high catalyst thermal stability and activity,along with precise control of polymer properties such as branching density,molecular weights,and distribution,is crucial but *** this study,two sets of symmetricalα-diimine nickel complexes,each comprising four nickel bromide or chloride complexes,were synthesized and investigated their performance for ethylene polymerization under various reaction *** activation with either Et2AlCl or MMAO cocatalysts,these complexes displayed not only high activity but also generated high molecular weight polyethylenes with controlled polydispersity and a substantial number of *** catalyst with the least steric hindrance displayed the remarkable high activity(up to 1.2×10^(7) g·mol^(-1)·h^(-1)).Notably,nickel bromides demonstrated higher activity compared to their chloride *** investigation into the effect of reaction temperature on catalytic performance revealed that NiBrMe-MMAO system displayed high thermal stability(activity up to 2.51×10^(6) g·mol^(-1)·h^(-1) at 100℃)and consistently yielded high polymer molecular weights with narrow polydispersity over a broad temperature range of 30-100℃.Of significant note,mechanical analysis of the resulting polyethylene demonstrated excellent ultimate tensile strength and high strain at ***,the polyethylene sample prepared at 100℃exhibited ultimate tensile strength up to 10 MPa with 1863%maximum strain at break and a strain recovery of up to 54.9%after ten cycles at a fixed strain of 300%,indicating excellent material properties of prepared thermoplastic polyethylene elastomers(TPE).

关键词： Thermoplastic polyethylene elastomers α-Diimine nickel pre-catalysts Ethylene polymerization Mechanical properties Highly branched polyethylene

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dissolution kinetics and reaction mechanism of Al_(2)O_(3) in molten CaF_(2)-CaO-Al_(2)O_(3) slag

引用

Journal of Iron and Steel Research International 2024年第4期31卷 861-869页

作者： Yao-xin Du Yan-wu Dong Zhou-hua jiang Ganna Stovpchenko yu-shuo Li Jun huang Xin-wei Wang yu-xiao Liu School of Metallurgy Northeastern UniversityShenyang 110819LiaoningChina Key Laboratory of Ecological Metallurgy of Multimetallic Mineral Northeastern UniversityShenyang 110819LiaoningChina State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina E.O.Paton Electric Welding Institute of the National Academy of Science of Ukraine Kiev 03115Ukraine

The dissolution behavior of Al_(2)O_(3) in molten CaF_(2)-CaO-Al_(2)O_(3) slag,a basic slag system of electroslag remelting process,was investigated by rotating cylinder method using corundum rods to simulate Al_(2)O_(3) inclusions in *** experimental results show that the dissolution rate of Al_(2)O_(3);rods in CaF_(2)-CaO-Al_(2)O_(3) slag increases with the increase in rotating speed and temperature,and the rate-controlling step is the mass transfer in the *** dissolution rate of Al_(2)O,in CaF_(2)-CaO-Al_(2)O_(3) slag increases with the increase in the ratio of CaO to Al_(2)O_(3),which is due to the increase in dissolution driving force and the decrease in slag *** apparent activation energy of the mass transfer of AlOs in slag C is calculated to be 222.86 kJ mol^(-1).During the dissolution of Al_(2)0,inclusions in the slag,it reacts with F in liquid slag at first,then reacts with CaO to form the intermediate compounds of xCaO-yAl_(2)O_(3) system,and finally dissolves in molten *** dissolution rate of Al_(2)O_(3) inclusions in CaF_(2)-CaO-Al_(2)O_(3) slag for electroslag remelting is positively correlated with the ratio of the dissolution driving force and slag viscosity,and the correlation coeficient is 2.487×10^(-11).

关键词： Inclusion Electroslag remelting Mass transfer:Dissolution rate-Dissolution driving force

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of Sc on Al_(3)Fe phase and mechanical properties of as-cast AA5052 aluminum alloy

引用

China Foundry 2024年第3期21卷 257-264页

作者： Yang Li Qing yu Feng-feng Chen jia-wen He Hong-mei Yang Meng-nie Li Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China

The AA5052 aluminum alloy is widely used in automobile and aerospace manufacturing,and with the development of light-weight alloys,it is required that these materials exhibit better mechanical *** studies have demonstrated that the addition of Sc to aluminum alloys can improve both the microstructure and properties of the *** this study,the effect of Sc on the Fe-rich phase and properties of the AA5052 aluminum alloy was studied by adding 0%,0.05%,0.2%,and 0.3%*** results show that with the increase of Sc,the coarse needle-like Fe-rich phase gradually transforms into Chinese-script and then nearly spherical particles,reduce the size of Fe-rich phase,and refine the grain with increase of high angle grain boundaries(HAGBs).These microstructure changes enhance the strength of the AA5052 alloy through Sc *** ductility of the alloy is obviously improved because the addition of a lower amount of Sc changes the morphology of Fe-rich phase from needle-like into a Chinese-script,and it is subsequently reduced as a result of significant increase in HAGBs with increasing Sc content.

关键词： AA5052 aluminum alloy Al3Fe phase mechanical properties grain boundary

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Changes in microstructure and properties of weld heat-affected zone of high-strength low-alloy steel

引用

Journal of Iron and Steel Research International 2024年第8期31卷 2041-2052页

作者： Shu-jun jia Qi-lin Ma yu Hou Ba Li He-song Zhang Qing-you Liu Central Iron and Steel Research Institute Co. Ltd.Beijing 100081China Collaborative Innovation Center for Steel Commonality University of Science and Technology BeijingBeijing 100083China Construction Project Management Branch of China National Petroleum Pipeline Network Group Co. Ltd.Langfang 065000HebeiChina

The evolution of the microstructure and toughness of APL5L X80 pipeline steel after thermal welding simulation was investigated by X-ray diffraction,electron backscatter diffraction,and transmission electron *** results indicated that primary heat-affected zones can be divided into weld,coarse-grained,fine-grained,intercritical,and sub-critical *** microstructure of the weld zone is mainly composed of bainitic ferrite and a small amount of granular bainite;however,the original austenite grains are distributed in the columnar *** structure of the coarse-grained zone is similar to that of the weld zone,but the original austenite grains are *** contrast,the microstructure in the fine-grained zone is dominated by fine granular bainite,and the effective grain size is only 8.15μm,thus providing the highest toughness in the entire heat-affected *** intercritical and subcritical zones were brittle valley regions,and the microstructure was dominated by granular ***,the martensite-austenite(M/A)constituents are present in island chains along the grain boundaries,and the coarse size of the M/A constituents seriously reduces the *** results of the crack propagation analyzes revealed that high-angle grain boundaries can significantly slow down crack growth and change the crack direction,thereby increasing the material *** impact toughness of the low-temperature tempering zone was equivalent to that of the columnar grain zone,and the impact toughness was between those of the critical and fine-grained zones.

关键词： Welding thermal simulation Impact toughness Crack propagation Martensite-austenite constituent High-strength low-alloy steel weld Heat-affected zone

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progress in preparation of AlN-reinforced magnesium matrix composites:A review

引用

China Foundry 2024年第1期21卷 1-10页

作者： Lu Chen Shu-lin Lü Di-jia Zhao Wei Guo jian-yu Li Shu-sen Wu State Key Lab of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China

As a ceramic material,AlN has very good thermophysical and mechanical *** addition,AlN is an effective refining agent for Mg alloys because it has a lattice constant similar to that of ***,AlN is an ideal reinforcement for magnesium matrix composites(MMCs),and is attracting increasing *** review addresses the development of preparation technologies for AlN-reinforced Mg matrix *** mainstream preparation techniques include stir casting,melt infiltration,powder metallurgy,and in-situ *** addition,the advantages and disadvantages of these techniques are analyzed in depth,and it is pointed out that the next direction for the preparation of high-performance AlN-reinforced MMCs is less aluminization and multiple technologies integration.

关键词： AlN MMCs preparation thermophysical property mechanical property

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Engineering molecular regulation for SiO_(x) with long-term stable cycle and high Coulombic efficiency as lithium-ion battery anodes

引用

Rare Metals 2024年第2期43卷 588-598页

作者： Fei Wang Han Gao Zhao-yu Niu Yao-Peng Zheng Ming-Yan Chuai jia-Nan Xu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China University of Science and Technology of China Hefei230026China

In the current situation where the practical application of silicon anode materials encounters great challenges,silicon oxide(SiO_(x),0≤x≤2)has attracted the attention of researchers due to its relatively small volume expansion,stable cycling performance,and low cost,which is possible to realize commercial applications earlier than silicon ***,it remains a challenge to prepare SiO_(x)materials with long-term stable cycling performance and high Coulombic efficiency using low-cost *** this work,SiO_(x)anode material with high Coulombic efficiency and good long-term cycling stability was prepared at a low cost by hydrolysis of siloxane and in situ polymerization of phenolic *** hydrolysis of siloxane was further regulated by different silane coupling agents to regulate the size and microstructure of prepared SiO_(x)materials,which displayed the substantially improved electrochemical *** excellent electrochemical performance of SiO_(x)prepared by regulated hydrolysis of siloxane with silane coupling agents is attributed to the effect of silane coupling agent on size and microstructure of SiO_(x),revealing that the strategy of modulating the hydrolysis of siloxane by silane coupling agent is a potential method to prepare high-performance SiO_(x)materials.

关键词： Hydrolysis Silane coupling agent Long cycle SiO_(x) anode Lithium-ion battery(LIB)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preliminary study of metabonomic changes during the progression of atherosclerosis in miniature pigs

引用

Animal Models and Experimental Medicine 2024年第4期7卷 419-432页

作者： yunxiao jia yuqiong Zhao Miaomiao Niu Changqi Zhao Xuezhuang Li hua Chen Laboratory Animal Center Chinese PLA General HospitalBeijingPeople's Republic of China

Background:To explore potential biomarkers for early diagnosis of atherosclerosis(AS)and provide basic data for further research on AS,the characteristics of serum metabolomics during the progression of AS in mini-pigs were observed ***:An AS model in Bama miniature pigs was established by a high-cholesterol and high-fat *** serum samples were collected monthly for metabolomics and serum lipid *** the end of the treatment period,pathological analysis of the abdominal aorta and coronary artery was performed to evaluate the lesions of AS,thereby distinguishing the susceptibility of mini-pigs to *** metabolomics was de-tected using a high-resolution untargeted metabolomic *** analysis was used to identify metabolites associated with AS ***:Based on pathological analysis,mini-pigs were divided into two groups:a susceptible group(n=3)and a non-susceptible group(n=6).A total of 1318 metabo-lites were identified,with significant shifting of metabolic profiles over time in both *** monitoring analysis highlighted 57 metabolites that exhibited an ob-vious trend of differential changes between two groups with the advance of *** KEGG(Kyoto Encyclopedia of Genes and Genomes)pathway enrichment analysis in-dicated significant disorders in cholesterol metabolism,primary bile acid metabolism,histidine metabolism,as well as taurine and hypotaurine ***:During the progression of AS in mini-pigs induced by high-cholesterol/high-fat diet,the alterations in serum metabolic profile exhibited a time-dependent pattern,accompanied by notable disturbances in lipid metabolism,cholesterol me-tabolism,and amino acid *** metabolites may become potential bio-markers for early diagnosis of AS.

关键词： atherosclerosis metabolomics miniature pig susceptibility

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DsS-inducedcolitis

引用

Precision Clinical Medicine 2024年第2期7卷 146-158页

作者： Jun-hua Li yu Chen Zheng-hao Ye Li-ping Chen jia-xin Xu jian Han Lin Xie Shuai Xing De-an Tian Ursula Seidler jia-zhi Liao Fang Xiao Department of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gastroenterology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Organ Transplantation Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolHannover 30625Germany

Background:Myeloid differentiation factor 88(MyD88)is the core adaptor for Toll-like receptors defending against microbial invasion and initiating a downstream immune response during microbiota-host ***,the role of MyD88 in the pathogenesis of inflammatory bowel disease is *** study aims to investigate the impact of MyD88 on intestinal inflammation and ***:MyD88 knockout(MyD88^(-/-))mice and the MyD88 inhibitor(TJ-M2010-5)were used to investigate the impact of MyD88 on acute dextran sodium sulfate(Dss)-induced *** activity index,colon length,histological score,and inflammatory cytokines were examined to evaluate the severity of *** transcriptome analysis and 16S rDNA sequencing were used to detect the potential ***:In an acute DSS-colitis model,the severity of colitis was not alleviated in MyD88^(-/-)mice and TJ-M2010-5-treated mice,despite significantly lower levels of NF-kB activation being exhibited compared to control ***,16S rDNA sequencing and RNA transcriptome analysis revealed a higher abundance of intestinal Proteobacteria and an up-regulation of the nucleotide oligomerization domain-like receptors(NLRs)signaling pathway in colitis mice following MyD88 *** blockade of the NLRs signaling pathway or elimination of gut microbiota with broad-spectrum antibiotics in DsS-induced colitis mice treated with TJ-M2010-5 ameiorated the disease severity,which was not improved solely by MyD88 *** treatment with broad-spectrum antibiotics,downregulation of the NLR signaling pathway was ***:Our study suggests that the suppression of MyD88 might be associated with unfavorable changes in the composition of gut microbiota,leading to NLR-mediated immune activation and intestinal inflammation.

关键词： microbiota innate immunity myeloid differentiation factor 88,MyD88 inhibitor NOD-like receptor inflammatory bowel disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：