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A novel Fe(OH)3/TiO2 nanoparticles and its high photocatalytic activity

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Chinese Chemical Letters 2007年第10期18卷 1261-1264页

作者： Nan wang li hua zhu jing li he qing tang Department of Chemistry and Chemical Engineering Hubei Key Lab of Bioinorganic Chemistry and Materia Medica Huazhong University of Science and Technology Wuhan 430074 China

A very simple and controllable approach was proposed to synthesize novel Fe（OH）3/TiO2 nanoparticles. Compared with neat TiO2, the Fe（OH）3/TiO2 increased the rate of the photocatalytic degradation of methyl orange at pH 6.0 by more than five times, showing photocatalytic activity as excellent as P25. This enhancing effect is mainly attributed to the ferric hydroxide deposits as the electron scavenger and the enriched surface hydroxyl groups.

关键词： Titanium dioxide Surface modification Ferric hydroxide Photocatalysis

Partitioning of nitrogen atoms and its effect on retained austenite content in an ultra-low-carbon Cr-Mn-N stainless steel

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Journal of Iron and Steel Research International 2021年第8期28卷 1030-1036页

作者： Zhe zhu Wan-tang Fu Rong-bin li Qi-wei Chen Ze-an Zhou Zhen-hua wang jia-qing liu Shu-hua Sun State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004HebeiChina Shanghai Engineering Research Center of Hot Manufacturing Shanghai Dianji UniversityShanghai 201306China School of Science Yanshan UniversityQinhuangdao 066004HebeiChina

The partitioning of nitrogen atoms and its effect on the retained austenite content(RAC)during quenching and partitioning(Q&P)process were investigated by dilatometry,X-ray diffraction,and field emission transmission electron microscopy with energy-dispersive spectrometer mapping in a 00Cr13Mn8N *** partitioning by diffusion of N atoms from martensite to austenite occurred at 400℃after quenching.N atoms are enriched in austenite after partitioning,and the stability of these N-rich austenite is improved and retained at room temperature during subsequent *** different quenching temperatures(QTs)result in different phase fractions after *** the increase in QT,RAC first increases and then decreases,and the maximum RAC is 28.5 vol.%after quenching at 80℃.A mathematical model was developed to rapidly and accurately characterize the phase fraction in Q&P process based on the relative length change of the samples partitioned after quenching at different QTs.

关键词： Nitrogen partitioning Quenching and partitioning Retained austenite Energy-dispersive spectrometer mapping Dilatometry Ultra-low-carbon stainless steel

Elucidating the interaction of kansui and licorice by comparative plasma/tissue metabolomics and a heatmap with relative fold change

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Journal of Pharmaceutical Analysis 2019年第5期9卷 312-323页

作者： Yan-Yan Chen Juan Shen Yu-Ping tang Jin-Gao Yu jing wang Shi-Jun Yue Jie Yang jia-Qian Chen li-Mei Feng Zhen-hua zhu Wei-Wei Tao li Zhang Jin-Ao Duan Key Laboratory of Shaanxi Administration of Traditional Chinese Medicine for TCM Compatibility State Key Laboratory of Research&Development of Characteristic Qin Medicine Resources(Cultivation)Shaanxi Key Laboratory of Chinese Medicine Fundamentals and New Drugs Researchand Shaanxi Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationShaanxi University of Chinese MedicineXi’an 712046Shaanxi ProvinceChina jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicineand Jiangsu Key Laboratory for High Technology Research of TCM FormulaeNanjing University of Chinese MedicineNanjing 210023Jiangsu ProvinceChina

Although compatibility is highly advocated in traditional Chinese medicine (TCM), inappropriate combination of some herbs may reduce the therapeutic action and even produce toxic effects. Kansui and licorice, one of TCM “Eighteen Incompatible Medicaments”, are the most representative cases of improper herbal combination, which may still be applied simultaneously under given conditions. However, the potential mechanism of their compatibility and incompatibility is unclear. In the present study, two different ratios of kansui and licorice, representing their compatibility and incompatibility respectively, were designed to elucidate their interaction by comparative plasma/tissue metabolomics and a heatmap with relative fold change. As a result, glycocholic acid, prostaglandin F2a, dihydroceramide and sphinganine were screened out as the principal alternative biomarkers of compatibility group;sphinganine, dihydroceramide, arachidonic acid, leukotriene B4, acetoacetic acid and linoleic acid were those of incompatibility group. Based on the values of biomarkers in each tissue, the liver was identified as the compatible target organ, while the heart, liver, and kidney were the incompatible target organs. Furthermore, important pathways for compatibility and incompatibility were also constructed. These results help us to better understand and utilize the two herbs, and the study was the first to reveal some innate characters of herbs related to TCM “Eighteen Incompatible Medicaments”.

关键词： Comparative metabolomics Kansui licorice Incompatibility heatmap

Prospective study of light dark matter search with a newly proposed DarkSHINE experiment

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Science China(Physics,Mechanics & Astronomy) 2023年第1期66卷 124-138页

作者： jing Chen Ji-Yuan Chen Jun-Feng Chen Xiang Chen Chang-Bo Fu Jun Guo Le he Zheng-Ting he Kim Siang Khaw jia-lin li liang li Shu li Meng Lv Dan-Ning liu Han-qing liu Kun liu Qi-Bin liu Yang liu Ze-jia Lu Cen Mo Si-Yuan Song Xiao-Long wang Yu-Feng wang Zhen wang Zi-Rui wang Wei-Hao Wu Dao Xiang Hai-Jun Yang Jun-hua Zhang Yu-Lei Zhang Zhi-Yu Zhao Xu-liang zhu Chun-Xiang zhu Yi-Fan zhu Tsung-DaoLee Institute Shanghai Jiao Tong UniversityShanghai 201210China Institute of Nuclear and Particle Physics School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Key Laboratory for Particle Astrophysics and Cosmology(MOE) Shanghai Key Laboratory for Particle Physics and Cosmology(SKLPPC)Shanghai 200240China Center for High Energy Physics Peking UniversityBeijing 10087lChina School of Mechanical and Electronic Engineering Suzhou UniversitySuzhou 234000China School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai 200240China School of Electronics Information and Electrical EngineeringShanghai Jiao Tong UniversityShanghai 200240China R&D Center Shanghai Instituteof CeramicsChinese Academyof SciencesShanghai 20189China Key Laboratory of Nuclear Physics and lon-beam Application(MOE) Fudan UniversityShanghai 200443China Institute of Modern Physics Fudan UniversityShanghai 200443China IKey Laboratory for Laser Plasmas(MOE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Zhangjiang Institute for Advanced Study Shanghai JiaoTong UniversityShanghai 200240.China College of literature Scienceand the ArtsUniversity of MichiganAnn Arbor MI 48109-1040USA Deparment of Physics Swiss Federal Institnute of Technology ZurichZurich 8093Swizerland

Dark photons have been well motivated as strong candidates for dark force carriers and light dark matter in the sub-GeV mass *** with collider experiments,fixed-target experiments provide a complementary approach to searching for dark photons,particularly in the lower mass *** have studied the physics potential of the electron-on-target experiment based on the Shanghai SHINE facility,which provides 10 MHz single electron beam at 8 GeV *** analysis focuses on dark photons being produced via electron and nucleon interaction and then decays to dark matter candidates,which escape detection as missing momentum in the *** experiment takes advantage of using missing momentum to enhance signal versus background separation *** this study,signal samples as a function of dark photon mass and an inclusive background sample with 2.5 billion events are simulated with *** better background estimates,major rare background processes have also been *** paper presents the experiment and detector design,signal and background simulations,analysis strategy,and the prospective study of the experiment *** 9×10^(14) electron-on-target events(about three years running),this experiment is expected to rule out most of the sensitive regions predicted by popular dark photon models.

关键词： dark matter dark photon electron-on-target experiment

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TAX1BP1 and FIP200 orchestrate non-canonical autophagy of p62 aggregates for mouse neural stem cell maintenance

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Zoological Research 2024年第4期45卷 937-950页

作者： Yi-Fu zhu Rong-hua Yu Shuai Zhou Pei-Pei tang Rui Zhang Yu-Xin Wu Ran Xu jia-Ming Wei Ying-Ying wang jia-li Zhang Meng-Ke li Xiao-jing Shi Yu-Wei Zhang Guang-Zhi liu Rick FThorne Xu Dong Zhang Mian Wu Song Chen School of life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Translational Research Institute of henan Provincial People’s Hospital and People'’s Hospital of Zhengzhou University Tianjian Laboratory of Advanced Biomedical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan 450053China Institute of Medicinal Biotechnology Jiangsu College of NursingHuai’anJiangsu 223300China Laboratory Animal Center Academy of Medical ScienceZhengzhou UniversityZhengzhouHenan 450052China henan Key Laboratory of Stem cell Differentiation and Modification Henan Provincial People’s HospitalHenan UniversityZhengzhouHenan 450053China School of Biomedical Sciences and Pharmacy The University of NewcastleNSW 2308Australia

Autophagy plays a pivotal role in diverse biological processes,including the maintenance and differentiation of neural stem cells(NSCs).Interestingly,while complete deletion of Fip200 severely impairs NSC maintenance and differentiation,inhibiting canonical autophagy via deletion of core genes,such as Atg5,Atg16l1,and Atg7,or blockade of canonical interactions between FIP200 and ATG13(designated as FIP200-4A mutant or FIP200 KI)does not produce comparable detrimental *** highlights the likely critical involvement of the non-canonical functions of FIP200,the mechanisms of which have remained ***,utilizing genetic mouse models,we demonstrated that FIP200 mediates non-canonical autophagic degradation of p62/sequestome1,primarily via TAX1BP1 in *** deletion of Tax1bp1 in fip200hGFAP conditional knock-in(cKI)mice led to NSC deficiency,resembling the fip200hGFAP conditional knockout(cKO)mouse ***,reintroducing wild-type TAX1BP1 not only restored the maintenance of NSCs derived from tax1bp1-knockout fip200hGFAP cKI mice but also led to a marked reduction in p62 aggregate ***,a TAX1BP1 mutant incapable of binding to FIP200 or NBR1/p62 failed to achieve this ***,conditional deletion of Tax1bp1 in fip200hGFAP cKO mice exacerbated NSC deficiency and p62 aggregate accumulation compared to fip200hGFAP cKO ***,these findings illustrate the essential role of the FIP200-TAX1BP1 axis in mediating the non-canonical autophagic degradation of p62 aggregates towards NSC maintenance and function,presenting novel therapeutic targets for neurodegenerative diseases.

关键词： Non-canonical autophagy TAX1BP1 FIP200 p62 Aggregates Neural stem cell

Effect and Safety of herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy:A Multicenter Double-Blind Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： huaNG Hao-yue liN Yu-ping WEI hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang wang Mei li qing-bo li Shan-shan wang Shi-dong DAI Fang liU Zhen-jie ZHAO ling WEN jian-xuan WU li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun he liu SONG Wei SUN Lu LUO Lu-lu he jia-li XIE Wen-wen liANG qing-shun huaNG Yuan zhu Sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai li Chun-ji OUYANG Wen-wei li Geng WU Ming-hui li An-xiang huaNG Jin-zhu Sanjoy K Paul tang Xian-yu FAN Guan-jie Department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou University of Chinese Medicine Guangzhou510120China Department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong Provincial Academy of Chinese Medical Sciences Guangzhou510120China Department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China Department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China Department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China Department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China Department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China Department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China Department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China Department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DPN).Methods:It is a multicenter double-blinded randomized controlled *** with DPN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(Phe reduction of TCSS-TS score at 12 weeks and the increase of SNCV of median nerve at 24 weeks in the control group were greater than those in the intervention group(Phe number of adverse events did not differ significantly between groups(P>0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DPN.A low dose of TW appeared to be more effective than a high dose.(Registry *** CTR-IOR-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial tangbi Waixi Decoction

CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44/c-MYC/LDHA axis

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Journal of Molecular Cell Biology 2023年第10期15卷 10-25页

作者： Haixia Cheng lingyang hua Hailiang tang Zhongyuan Bao Xiupeng Xu Hongguang zhu Shuyang wang Zeyidan jiapaer Roma Bhatia Ian FDunn jiaojiao Deng Daĳun wang Shuchen Sun Shihai Luan jing Ji qing Xie Xinyu Yang Ji Lei Guoping li Xianli wang Ye Gong Department of Pathology School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Department of Neurosurgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210000China Xinjiang Key Laboratory of Biology Resources and Genetic Engineering College of Life Science and TechnologyXinjiang UniversityUrumqi 830046China Beth Israel Deaconess Medical Center Harvard Medical SchoolBostonMA 02215USA Department of Neurosurgery University of Oklahoma Health Sciences CenterOklahoma CityOK 73117USA Fangshan Hospital of Beĳing University of Traditional Chinese MedicineBeĳing 102400China Center for Transplantation Science Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Cardiovascular Research Center Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA School of Public health Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Critical Care Medicine Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200032China

Meningioma is one of the most common primary neoplasms in the central nervous system,but no specific molecularly targeted therapy has been approved for the clinical treatment of aggressive *** is hence an urgent demand to decrypt the biological and molecular landscape of malignant ***,through the in-silica prescreening and 10-year follow-up studies of 445 meningioma patients,we uncovered that CBX7 expression progressively decreases with malignancy grade and neoplasia stage in meningioma,and a high CBX7 expression level predicts a favorable prognosis in meningioma ***7 restoration significantly induces cell cycle arrest and inhibits meningioma cell ***-based proteomics analysis indicated that CBX7 restoration triggers the metabolic shift from glycolysis to oxidative *** mechanistic study demonstrated that CBX7 promotes the proteasome-dependent degradation of c-MYC protein by transcriptionally inhibiting the expression of a c-MYC deubiquitinase,USP44,consequently attenuates c-MYC-mediated transactivation of LDHA transcripts,and further inhibits glycolysis and subsequent cell *** importantly,the functional role of CBX7 was further confirmed in subcutaneous and orthotopic meningioma xenograft mouse models and meningioma ***,our results shed light on the critical role of CBX7 in meningioma malignancy progression and identify the CBX7/USP44/c-MYC/LDHA axis as a promising therapeutic target against meningioma progression.

关键词： CBX7 meningioma glycolysis USP44 c-MYC LDHA malignancy glucose metabolism

Genetic dissection of the grain-filling rate and related traits through linkage analysis and genome-wide association study in bread wheat

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Journal of Integrative Agriculture 2022年第10期21卷 2805-2817页

作者： YU Hai-xia DUAN Xi-xian SUN Ai-qing SUN Xiao-xiao ZHANG jing-juan SUN hua-qing SUN Yan-yan NING tang-yuan TIAN Ji-chun wang Dong-xue li Hao FAN Ke-xin wang Ai-ping MA Wu-jun CheN jian-sheng State Key Laboratory of Crop Biology/Key Laboratory of Crop Water Physiology and Drought-tolerance Germplasm Improvement Minstry of Agriculture and Rural Affairs/Group of Wheat Quality BreedingCollege of AgronomyShandong Agricultural UniversityTai’an 271018P.R.China Dezhou Agricultural Protection and Technological Extension Center Dezhou 253000P.R.China Zhongnong Tiantai Seed Co. Ltd.Pingyi 273300P.R.China School of Veterinary and life Sciences Murdoch UniversityMurdochWA 6150Australia

Wheat grain yield is generally sink-limited during grain *** grain-filling rate(GFR)plays a vital role but is poorly studied due to the difficulty of phenotype *** study explored the grain-filling traits in a recombinant inbred population and wheat collection using two highly saturated genetic maps for linkage analysis and genome-wide association study(GWAS).Seventeen stable additive quantitative trait loci(QTLs)were identified on chromosomes 1B,4B,and *** linkage interval between IWB19555 and IWB56078 showed pleiotropic effects on GFR_(1),GFR_(max),kernel length(KL),kernel width(KW),kernel thickness(KT),and thousand kernel weight(TKW),with the phenotypic variation explained(PVE)ranging from 13.38%(KW)to 33.69%(TKW).198 significant marker-trait associations(MTAs)were distributed across most chromosomes except for 3D and *** major associated sites for GFR included IWB44469(11.27%),IWB8156(12.56%)and IWB24812(14.46%).linkage analysis suggested that IWB35850,identified through GWAS,was located in approximately the same region as QGFR_(max)2B.3-11,where two high-confidence candidate genes were *** important grain weight(GW)-related QTLs colocalized with grain-filling *** findings contribute to understanding the genetic architecture of the GFR and provide a basic approach to predict candidate genes for grain yield trait QTLs.

关键词： wheat grain-filling rate linkage analysis genome-wide association study

Measurement of the neutron total cross section of carbon at the Back-n white neutron beam of CSNS

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Nuclear Science and Techniques 2019年第9期30卷 73-82页

作者： Xing-Yan liu Yi-Wei Yang Rong liu Jie Wen Zhong-Wei Wen Zi-Jie Han Zhi-Zhou Ren Qi An huai-Yong Bai Jie Bao Ping Cao Qi-Ping Chen Yong-Hao Chen Pin-jing Cheng Zeng-Qi Cui Rui-Rui Fan Chang-qing Feng Min-Hao Gu Feng-Qin Guo Chang-Cai Han Guo-zhu he Yong-Cheng he Yue-Feng he Han-Xiong huang Wei-ling huang Xi-Ru huang Xiao-Lu Ji Xu-Yang Ji Hao-Yu jiang Wei jiang Han-Tao jing ling Kang Ming-Tao Kang Bo li Lun li Qiang li Xiao li Yang li Yang li Shu-Bin liu Guang-Yuan Luan Ying-lin Ma Chang-Jun Ning Bin-Bin Qi Jie Ren Xi-Chao Ruan Zhao-Hui Song Hong Sun Xiao-Yang Sun Zhi-jia Sun Zhi-Xin Tan Hong-qing tang jing-Yu tang Peng-Cheng wang Qi wang Tao-Feng wang Yan-Feng wang Zhao-Hui wang Zheng wang qing-Biao Wu Xiao-Guang Wu Xuan Wu li-Kun Xie Han Yi li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang jing Zhang lin-Hao Zhang li-Ying Zhang qing-Min Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-liang Zhang Zhi-Yong Zhang Ying-Tan Zhao liang Zhou Zu-Ying Zhou Dan-Yang zhu Ke-Jun zhu Peng zhu Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics State Key Laboratory of Particle Detection and Electronics Chinese Academy of Sciences(CAS) Department of Modern Physics University of Science and Technology of China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking University Key Laboratory of Nuclear Data China Institute of Atomic Energy Institute of High Energy Physics Chinese Academy of Sciences(CAS) Spallation Neutron Source Science Center University of South China Northwest Institute of Nuclear Technology Department of Engineering and Applied Physics University of Science and Technology of China Beihang University Xi’an jiaotong University

To verify the performance of the neutron total cross-sectional spectrometer, the neutron total cross section of carbon is initially measured in the energy range of 1 eV to 20 MeV using the time-of-flight method. The measurement is performed at the Back-n white neutron source with a 76-m time-of-flight path using the China Spallation Neutron Source. A multilayer fast fission chamber with 235U and 238U is employed as the neutron detector. The diameter and thickness of the natural graphite sample are 70 mm and 40 mm, respectively. Signal waveforms are collected using a data acquisition system. Off-line data processing was used to obtain the neutron time-of-flight spectra and transmissions. The uncertainty of the counting statistics is generally approximately 3% for each bin in the energy range of 1–20 MeV. It is determined that the results for the neutron total cross section of carbon obtained using ^235U cells are in good agreement with the results obtained using 238U cells within limits of statistical uncertainty. Moreover, the measured total cross sections show good agreement with the broadening evaluated data.

关键词： CSNS Back-n white neutron source NTOX Neutron total cross section Carbon Multilayer fast fission chamber