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基于VEGF/PI3K/Akt通路基因表达探讨骨坏死康复丸对激素性股骨头坏死大鼠血管新生的影响

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广州中医药大学学报 2024年第8期41卷 2127-2135页

作者：李文茜田亮玉张谨沈彩红杨志敏冯小艳郭家巧曹玉举郑州中医骨伤病医院河南郑州450016 河南省骨坏死研究中医药重点实验室河南郑州450016 河南省骨伤病中医诊疗工程技术研究中心河南郑州450016

【目的】观察骨坏死康复丸对激素性股骨头坏死(SONFH)大鼠的治疗作用及机制。【方法】将60只大鼠随机分为空白组,模型组,仙灵骨葆胶囊组及骨坏死康复丸低、中、高剂量组,每组10只。除空白组,其他各组大鼠采用脂多糖联合糖皮质激素诱导... 详细信息

【目的】观察骨坏死康复丸对激素性股骨头坏死(SONFH)大鼠的治疗作用及机制。【方法】将60只大鼠随机分为空白组,模型组,仙灵骨葆胶囊组及骨坏死康复丸低、中、高剂量组,每组10只。除空白组,其他各组大鼠采用脂多糖联合糖皮质激素诱导法建立SONFH模型。干预结束后,分别进行股骨头的血管造影观察骨髓内微血管变化、苏木素-伊红(HE)染色并计算空骨陷窝率、Micro-CT扫描分析、压缩实验,采用实时定量聚合酶链反应(RT-qPCR)法检测全血磷脂酰肌醇3-激酶(PI3K)、蛋白激酶B(Akt)1、血管内皮生长因子(VEGF)、血小板内皮细胞黏附分子1(CD31)基因表达。【结果】与空白组比较,模型组股骨头髓腔内血供差,空骨陷窝率增加(P0.05)。【结论】骨坏死康复丸可改善大鼠激素性股骨头坏死,其机制与促进VEGF/PI3K/Akt通路基因表达,进而促进血管新生有关。

关键词：骨坏死康复丸激素性股骨头坏死血管新生磷脂酰肌醇3-激酶(PI3K) 蛋白激酶B(Akt)1 血管内皮生长因子(VEGF) 血小板内皮细胞黏附分子1(CD31) 大鼠

采用MapReduce模型的甚长基线干涉测量并行处理方法

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西安交通大学学报 2015年第4期49卷 61-66页

作者：田斌何强王佳郑雨西西安交通大学电子与信息工程学院西安710049 西安卫星测控中心西安710043

针对传统甚长基线干涉测量(very long baseline interferometry,VLBI)并行处理方法存在逻辑复杂、数据存储和计算扩展性较差等缺点,基于MapReduce模型设计了一种VLBI观测数据相关的并行处理方法。该方法采用模型周期作为数据并行处理基... 详细信息

针对传统甚长基线干涉测量(very long baseline interferometry,VLBI)并行处理方法存在逻辑复杂、数据存储和计算扩展性较差等缺点,基于MapReduce模型设计了一种VLBI观测数据相关的并行处理方法。该方法采用模型周期作为数据并行处理基本单元,构建数据关联算法分割观测数据使各台站同一模型周期数据对齐到同一波前,设计实现数据相关计算的Map过程,使用Reduce对各模型周期结果进行综合处理以得到最终结果。实验结果表明:该方法在积分周期包含的模型周期数量大于节点CPU核数时性能比传统方式低25%左右,在积分周期包含的模型周期数量小于节点CPU核数时通常能提供更高的计算效率,并且能简化VLBI并行相关处理的复杂度,具有更好的数据存储和计算可扩展性。

关键词：甚长基线干涉测量数据相关处理并行处理 MapReduce模型

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隔墙隔音效果的计算机仿真实验

系统仿真学报 2005年第10期17卷 2564-2566,2570页

作者：田力余嘉顺唐红重庆邮电学院重庆400065 新西兰皇家地质与核科学研究所

利用对时间二阶导数的二阶中心差分和空间二阶导数的四阶中心差分将二维声波方程离散化,形成一个模拟声音传播过程的计算方案,并在Windows2000平台上用C++开发程序予以实现。通过对无阻隔的空气模型,空气中的砖墙模型以及空气中的双层... 详细信息

利用对时间二阶导数的二阶中心差分和空间二阶导数的四阶中心差分将二维声波方程离散化,形成一个模拟声音传播过程的计算方案,并在Windows2000平台上用C++开发程序予以实现。通过对无阻隔的空气模型,空气中的砖墙模型以及空气中的双层木板隔墙模型上的声传播过程的数字仿真模拟,验证了软件的可行性,同时了解到声音在这三个模型所代表的建筑环境中的传播特点,此实验证实了砖墙隔音效果优于木板墙的直觉体验。

关键词：隔墙隔音声传播计算机仿真

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单核细胞增生李斯特菌脑膜炎1例

中国感染与化疗杂志 2018年第2期18卷 206-208页

作者：李佳田卓民天津南开医院中西医结合医院脑病科天津300100 天津市人民医院

1临床资料患者男，8 0岁，退休干部。既往体健，于2015年6月7日因剧烈头痛，神志恍惚入院。入院前1 d，开始发热伴头痛，自以为“感冒”，服“布洛芬”，体温暂时降至正常后复升达40.5℃。入院当天查体：T 39.0℃，P 100次/min，R 20次/... 详细信息

1临床资料患者男，8 0岁，退休干部。既往体健，于2015年6月7日因剧烈头痛，神志恍惚入院。入院前1 d，开始发热伴头痛，自以为“感冒”，服“布洛芬”，体温暂时降至正常后复升达40.5℃。入院当天查体：T 39.0℃，P 100次/min，R 20次/min，BP 150/90 mmHg，神志恍惚，言语欠流利，颈项强直，四肢肌力Ⅳ级，肌张力正常，腱反射（++），Kernig征（+），双侧巴氏征（-），双侧指鼻试验、轮替试验及跟膝胫试验欠合作。外周血白细胞14.0×109/L，中性粒细胞比例0.925；血沉24.0 mm/h，肝肾功能正常。

关键词：单核细胞增生李斯特菌脑膜炎感染

松辽盆地海力锦铀矿床黄铁矿微量元素、硫同位素特征及其对成矿流体性质的指示

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铀矿地质 2024年第1期40卷 119-128页

作者：田明明李子颖张云龙贾立城邱林飞邢作昌宁君李继木唐国龙林效宾核工业北京地质研究院北京100029 核工业二四三大队内蒙古赤峰024000

海力锦铀矿床控矿灰色砂岩垂向上具有“两红夹一灰”特征,铀矿体呈多层板状,与传统的层间氧化带砂岩型铀矿明显不同。文章通过对赋矿灰色砂岩中黄铁矿微区微量元素和硫同位素特征研究,反演海力锦铀矿床成矿流体性质及来源,主要获得了以... 详细信息

海力锦铀矿床控矿灰色砂岩垂向上具有“两红夹一灰”特征,铀矿体呈多层板状,与传统的层间氧化带砂岩型铀矿明显不同。文章通过对赋矿灰色砂岩中黄铁矿微区微量元素和硫同位素特征研究,反演海力锦铀矿床成矿流体性质及来源,主要获得了以下几点认识:(1)海力锦铀矿床含矿层黄铁矿赋存形式包括胶状、草莓状,铀矿物常与草莓状或胶状黄铁矿共伴生于有机质胞腔内或矿物粒间孔隙。(2)黄铁矿微量元素特征显示,As、Mo、Sb等亲硫性元素从核部到边部含量增高,Mo、Ni、Zn、Cu、Ba等元素与U具有较好的正相关性,这些元素在大气降水中难以沉淀和富集,往往富集于深部还原性流体中。硫同位素δ34SV-CDT值显示从核部到边部明显降低的特征,表明黄铁矿形成环境发生了较大改变,指示海力锦铀矿床成矿流体可能为深部具有一定温度的还原性流体。(3)松辽盆地西南部深部发育厚度大且面积广的富铀烃源岩,海力锦铀矿床东南部F1断裂为沟通深部富铀烃源岩和含矿层的深大断裂,据此认为海力锦铀矿床成矿流体可能来自深部还原性流体(富铀烃源岩),控矿灰色砂岩为还原性流体对原生氧化沉积建造的还原改造。

关键词：黄铁矿原位硫同位素成矿流体海力锦铀矿床松辽盆地

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TACR非能动慢化剂余热排出系统消除不稳定性研究

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核动力工程 2010年第3期31卷 40-44页

作者：田野贾宝山阎林清华大学工程物理系北京100084

为了解决非能动慢化剂余热排出系统的不稳定性,本文对原系统结构设计进行了更改,并采用CATHENA程序模拟了在失流事故工况下改进后的系统排热能力。对模拟计算的结果分析表明,改进后的非能动慢化剂余热排出系统能够保证反应堆安全,并且... 详细信息

为了解决非能动慢化剂余热排出系统的不稳定性,本文对原系统结构设计进行了更改,并采用CATHENA程序模拟了在失流事故工况下改进后的系统排热能力。对模拟计算的结果分析表明,改进后的非能动慢化剂余热排出系统能够保证反应堆安全,并且消除了系统中的不稳定性。

关键词：慢化剂余热排出系统 CATHENA

Artificial intelligence promotes shared decision-making through recommending tests to febrile pediatric outpatients

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World Journal of Emergency Medicine 2023年第2期14卷 106-111页

作者： Wei-hua Li Bin Dong Han-song Wang jia-jun Yuan Han Qian Ling-ling Zheng Xu-lin Lin Zhao Wang Shi-jian Liu Bo-tao Ning Dan tian Lie-bin Zhao Pediatric AI Clinical Application and Research Center Shanghai Children’s Medical CenterShanghai 200127China Shanghai Engineering Research Center of Intelligence Pediatrics(SERCIP) Shanghai 200127China Child Health Advocacy Institute China Hospital Development Institute of Shanghai Jiao Tong UniversityShanghai 200127China Pediatric Intensive Care Unit Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Hangzhou YITU Healthcare Technology Co.Ltd. Hangzhou 310000China

BACKGROUND:To promote the shared decision-making(SDM)between patients and doctors in pediatric outpatient departments,this study was designed to validate artificial intelligence(AI)-initiated medical tests for children with ***:We designed an AI model,named Xiaoyi,to suggest necessary tests for a febrile child before visiting a pediatric outpatient *** calculated the sensitivity,specificity,and F1 score to evaluate the efficacy of Xiaoyi’s *** patients were divided into the rejection and acceptance *** we analyzed the rejected examination items in order to obtain the corresponding ***:We recruited a total of 11,867 children with fever who had used Xiaoyi in outpatient *** recommended examinations given by Xiaoyi for 10,636(89.6%)patients were *** average F1 score reached 0.94.A total of 58.4%of the patients accepted Xiaoyi’s suggestions(acceptance group),and 41.6%refused(rejection group).Imaging examinations were rejected by most patients(46.7%).The tests being time-consuming were rejected by 2,133 patients(43.2%),including rejecting pathogen studies in 1,347 patients(68.5%)and image studies in 732 patients(31.8%).The difficulty of sampling was the main reason for rejecting routine tests(41.9%).CONCLUSION:Our model has high accuracy and acceptability in recommending medical tests to febrile pediatric patients,and is worth promoting in facilitating SDM.

关键词： Artificial intelligence Pediatric outpatient Medical examinations Shared decision-making

Who are more at risk for acute mountain sickness： a prospective study in Qinghai-Tibet railroad construction workers on Mt. Tanggula

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Chinese Medical Journal 2012年第8期125卷 1393-1400页

作者： WU tian-yi DING Shou-quan LIU Jin-liang jia jian-hou CHAI Zuo-chun DAI Rui-chen Physiological Research Group of the Ministry of Railway High Altitude Medical Research Institute Xining Qinghai 810012 China Qinghai-Tibet Railroad Hospital at Fenghuoshan Golmud Qinghai 816000 China Qinghai-Tibet Railroad Hospital at Kekexili Golmud Qinghai 816000 China Qinghai-Tibet Railroad Hospital at Dangxiong Lhasa Tibet 851500 China Qinghai-Tibetan Railway Construction Company Golmud Qinghai 816000 China

Background It is important to determine the incidence of acute mountain sickness （AMS） among workers at altitudes between 3500 m and 5000 m on Mt. Tanggula during the construction of the Qinghai-Tibet railroad. This study explored the risk factors predisposing workers to developing AMS and attempted to develop more effective ways of preventing and treating AMS. Methods A total of 11 182 workers were surveyed by completing twice daily a Lake Louise questionnaire, and a score 〉3 indicated AMS. The contributing risk factors were assessed for at least 2 months for the duration of the study in the years from 2001 to 2003. A risk model was developed by multiple Logistic regression. Standard statistica~ methods were used to analyze data. Results AMS occurred in 56% of workers working at high altitudes on Mt. Tanggula. The incidence of AMS increased with increasing altitude. Rapid ascent to an altitude above 3500 m, sea-level or lowland newcomers, young people under 25 years of age, heavy physical exertion, obese person, and arterial oxygen saturation （SaO2） below 80% were independent AMS risk factors. No significant association was found between AMS and sex or taking Rhodiola. Medical education contributed to an early diagnosis of AMS. Conclusions This study used the Lake Louise scoring system suggesting that it is a well-validated standard for field evaluation of AMS and for making an early diagnosis. These studies have described many variables regarding risk factors for the development of AMS. Risk factors which can be modified should be attended to, and the physicians should carry out check-ups and tests to identify subjects who are more at risk. Prevention consists in continuous gradual ascent, medical education, and prompt descent to avoid progression in patients with serious AMS. It is most important to effectively control the risk factors of AMS.

关键词： acute mountain sickness incidence risk factors Qinghai-Tibet railway

Synthesis of size-controllable Fe3O4 magnetic submicroparticles and its biocompatible evaluation in vitro

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Journal of Central South University 2016年第11期23卷 2784-2791页

作者：田庆华宁文博王惟嘉袁秀洪白志明 School of Metallurgy and Enviroment Cental South University Changsha 410083 China Haikou Municipal People's Hospital Haikou 570100 China

Large scaled uniform and size-controllable magnetic submicroparticles(MSPs) were synthesized via solvothermal method with ferric chloride as iron source and sodium acetate as trapping agent. The influence of Fe^(3+) and Na Ac contents on the size distribution of MSPs was investigated. The structural and morphological properties of the synthesized particles were studied by scanning electron microscopy(SEM), X-ray power diffraction(XRD) and vibrating sample magnetometer(VSM). The well-dispersed MSPs with size of 100-1000 nm were obtained by simply adjusting the contents of Fe^(3+) and NaA c. In addition, the hemolysis and cytotoxicity of Fe_3O_4 MSPs, and their ability to case arrest in cell life-cycles were studied. The results indicate that larger size could lead to lower hemolysis. From MTT(3-(4,5-dimethylthuazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the interactions between MSPs and adhesive mouse fibroblast cell line(L929) were probed. Larger size of Fe_3O_4 MSPs demonstrates lower cell viability following an exposure to the cells.

关键词： magnetite submicroparticles biocompatibility hemolysis cytotoxicity