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FREE VIBRATION ANALYSIS OF LATTICE SANDWICH BEAMS UNDER SEVERAL TYPICAL BOUNDARY CONDITIONS

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Acta Mechanica Solida Sinica 2013年第5期26卷 458-467页

作者： jia lou Bing Wang Li Ma Linzhi Wu Center for Composite Materials and Structures Harbin Institute of Technology

Free vibration problems of lattice sandwich beams under several typical boundary conditions are investigated in the present paper. The lattice sandwich beam is transformed to an equivalent homogeneous three-layered sandwich beam. Unlike the traditional analytical model in which the rotation angles of the face sheets and the core are assumed the same, different rotation angles are considered in this paper to characterize the real response of sandwich beams. The analytical solutions of the natural frequencies for several typical boundary conditions are obtained. The effects of material properties and geometric parameters on the natural frequencies are also investigated.

关键词： vibration composites lattice materials beam analytical method

Throughput analysis for relay-aided interference channel in cognitive radio networks

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High Technology Letters 2011年第4期17卷 344-349页

作者： lou jia Luo Tao Yue Guangxin School of Information and Communication Engineering Beijing University of Posts and Telecommunications Beijing 100876 P.R. China

This paper considers a two-user Gaussian interference channel aided by a single relay. Two source-destination pairs and the relay share a single common chaunel, and the relay assists both sources in communicating the messages to their respective destinations. This paper mainly focuses on the ＂amplify-and-forward＂（AF） relaying strategy for relay, and derives upper bound and lower bound on achievable sum rate accordingly. Next, the application of the above model in cognitive radio （CR） networks is considered. The schemes that can ensure the coexistence of the secondary user with the primary user are proposed, in the sense that there is no rate degradation for the primary user due to sharing of the channel. Further, the throughput of the secondary user in different communication scenarios is investigated.

关键词： interference channel relay achievable sum rate cognitive radio(CR) throughput

Contragestazol (DL111-IT) inhibits proliferation of human androgen-independent prostate cancer cell line PC3 in vitro and in vivo

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Asian Journal of Andrology 2005年第4期7卷 389-393,页

作者： Qiao-Jun He Bo Yang Yi-jia lou Rui-Ying Fang Department of Pharmacology College of Pharmaceutical Science Zhejiang University Hangzhou 310031 China

Aim： To evaluate the antiproliferative activity of contragestazol （DL111-IT） on the human prostate cancer cell line PC3 in vitro and in vivo and to elucidate its potential molecular mechanisms. Methods： The cell killing ability of DL111-IT was measured by the 3-（4,5-dimethylthia-zol,2-yl）-2,5-diphenyltetrazolium bromide （MTT） reagent assay method and the tumor xenograft model. The cell cycle was analyzed by flow cytometry and protein expression, including retinoblastoma （pRb）, cyclin-dependent kinase 4 （CDK4） and cyclin D 1, was detected by Western blotting. Results： DL111-IT exhibited high efficiency on cell growth inhibition of the human androgen-independent prostate cancer cell line PC3. The drug concentration that yielded 50 % cell inhibition （IC50 value） was 9.9 mg/mL. In the PC3 tumor xenograft study, DL111-IT （1.25 mg/kg-20.0 mg/kg） given once a day for 10 days significantly inhibited tumor growth, with the inhibition rate ranging from 21% to 50 %. Flow cytometric analysis indicated that DL111-IT could cause GI arrest in the PC3 cell line, but not apoptosis. DL111-IT enhanced pRb expression and down-regulated CDK4 and cyclin D 1 expression, suggesting that cell cycle regulation might contribute to the anticancer property of DL 111- IT. Conclusion： DL111-1T inhibits the proliferation of human androgen-independent prostate cancer cell line PC3 in vitro and in vivo by a cell cycle regulation pathway.

关键词： DL111-IT prostate cancer pRb cyclin-dependent kinase 4 cyclin D 1 PC3 cell line

Analysis and evaluation of effects of processing steps on dimensional tolerance of PIM parts

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Journal of Central South University of Technology 2005年第Z1期12卷 33-38页

作者： LI Yi-min lou jia YUE jian-ling State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China

The factors affecting the dimensional tolerance of powder injection molding (PIM), such as the selection of the powder and binder, the feedstock homogeneity, the feedstock thermal properties, the feedstock rheologic behavior, the debinding schedule and atmosphere and sintering temperature gradient were discussed. An attempt was made to develop a model to estimate the influence of important variables. The results show that a better understanding of these factors can provide some useful theoretical instructions for large scale production.

关键词： powder injection molding dimensional tolerance processing step

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新课改下化学教育的优化与调整

湖北科技学院学报 2025年第1期45卷 116-124页

作者：杨小洁王云婷娄佳蕙黄亚琼湖北科技学院核技术与化学生物学院湖北咸宁437100

新课标为化学教学提供了依据,本研究基于化学教学现状分析,以化学新课程标准为调整教学依据。教师通过创设生活和实验情境,设置探究活动提高学生的兴趣。教师除了用教学方法提高学生兴趣外,还需注重知识之间融合,帮助学生形成知识网络... 详细信息

新课标为化学教学提供了依据,本研究基于化学教学现状分析,以化学新课程标准为调整教学依据。教师通过创设生活和实验情境,设置探究活动提高学生的兴趣。教师除了用教学方法提高学生兴趣外,还需注重知识之间融合,帮助学生形成知识网络。教学既包含教师的教也包含学生的学,因此教师应该帮助学生选择合适的学习策略。教师是学生学习的榜样,教师需要提升个人素养以适应教育事业的发展,教师需要提升创新能力、专业能力并与时俱进。

关键词：新课标化学教学学习策略教学策略优化

Diagnosis of poorly differentiated adenocarcinoma of the stomach by confocal laser endomicroscopy:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1481-1486页

作者： jia-Xin lou Yong Wu Muren Huhe Jing-Jie Zhang Dong-Wu jia Zhen-Yu jiang Department of Gastroenterology The Second Affiliated Hospital of Baotou Medical CollegeInner Mongolia University of Science and TechnologyBaotou 014030Inner Mongolia Autonomous RegionChina Medical Innovation Center The Fourth Military Medical UniversityXi'an 710000Shaanxi ProvinceChina

BACKGROUND In recent years,confocal laser endomicroscopy(CLE)has become a new endoscopic imaging technology at the microscopic level,which is extensively performed for real-time in vivo histological *** can be performed to distinguish benign from malignant *** this study,we diagnosed using CLE an asymptomatic patient with poorly differentiated gastric *** SUMMARY A 63-year-old woman was diagnosed with gastric mucosal lesions,which may be gastric cancer,in the small curvature of the stomach by *** consented to undergo CLE for morphological observation of the gastric *** the combination of CLE diagnosis and postoperative pathology,the intraoperative CLE diagnosis was considered to be *** to our experience,CLE can be performed as the first choice for the diagnosis of gastric *** CLE has several advantages over pathological *** believe that CLE has great potential in the diagnosis of benign and malignant gastric lesions.

关键词： Confocal laser endomicroscopy Poorly differentiated gastric adenocarcinoma Diagnosis Early stage Case report

Increased CMTM4 mRNA expression predicts a poor prognosis in patients with hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 596-601页

作者： He-Qi Zhou jian-Hao Li Li-Wen Liu jia-Min lou Zhi-Gang Ren Department of Infectious Diseases the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China Key Laboratory of Clinical Medicine the First Affiliated Hospital of Zhengzhou UniversityZhengzhou450052China

Hepatocellular carcinoma(HCC)is one of the most common human malignancies and main cause of cancer mortality worldwide[1].Conventional treatment for HCC consists of hepatic resection,liver transplantation and radiofrequency ablation[2,3].Despite improvements in clinical treatment,the 5-year survival rate of advanced HCC patients remains *** exploration of novel therapeutic targets and the identification of prognostic biomarkers for HCC are vital and essential to improve clinical ***-like MARVEL transmembrane domaincontaining member 4(CMTM4),mapped to chromosome 16q22.1,is the most conserved member of the CMTM *** CMTM family comprises 9 genes:CMTM 1-8 and *** from CMTM family are involved in the immune system[4],the male reproductive system[5],angiogenesis regulation,and tumorigenesis.

关键词： patients clinical mortality

Fecal microbiota transplantation has therapeutic effects on chronic hepatits B patients via altering composition of gut microbiota

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 486-487页

作者： jia-Min lou Zhi-Gang Ren Ang Li Ben-Chen Rao Zu-jiang Yu Department of Infectious Diseases the First Affiliated Hospital of Zhengzhou UniversityNo.1 Jianshe East RoadZhengzhou 450052China Gene Hospital of Henan Province Precision Medicine Centerthe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

Chronic hepatits B(CHB)is an increasingly disturbing public health issue ***,interferon and oral antiviral drugs such as entecavir(ETV)or tenofovir disoproxil fumarate(TDF)are two internationally recognized drugs for the treatment of ***,the HBeAg clearance or seroconversion rate is low even in patients with long-term antiviral *** patients have to increase the dosage of antiviral therapy drugs[1].Intestinal microorganisms are confirmed to play an important role in the pathogenesis of different chronic liver diseases including CHB,and fecal microbiota transplantation(FMT)may be a novel treatment strategy for CHB.

关键词： drugs patients dosage

Enhanced expressions and activations of leukotriene C4synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model

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World Journal of Gastroenterology 2008年第17期14卷 2748-2756页

作者： Kui-Fen Ma Hong-Yu Yang Zhe Chen Luo-Yang Qi Dan-Yan Zhu Yi-jia lou Institute of Pharmacology & Toxicology andBiochemical Pharmaceutics College of Pharmaceutical SciencesZlaejiang University Hangzhou 310058 Zhejiang Province China

AIM： To investigate the expression and activity of leukotriene C4 （LTC4） synthesis enzymes and their underlying relationship with cysteinyl leukotriene （cys-LT） generation in a rat fulminant hepatic failure （FHF） model induced by D-galactosamine/lipopolysaccharide （D-GaIN/ LPS）. METHODS： Rats were treated with D-GaIN （300 mg/kg） plus LPS （0.1 mg/kg） for 1, 3, 6, and 12 h. Enzyme immunoassay was used to determine the hepatic cys-LT content. Reverse transcription-polymerase chain reaction （RT-PCR）, Western blot or immunohistochemical assay were employed to assess the expression or location of LTC4 synthesis enzymes, which belong to membrane associated proteins in eicosanoid and glutathione （MAPEG） metabolism superfamily. Activity of LTC4 synthesis enzymes was evaluated by determination of the products of LTA4 after incubation with liver microsomes using high performance liquid chromatography （HPLC）. RESULTS： Livers were injured after treatment with D-GaIN/LPS, accompanied by cys-LT accumulation at the prophase of liver injury. Both LTC4 synthase （LTC4S） and microsomal glutathione-S-transferase （mGST） 2 were expressed in the rat liver, while the latter was specifically located in hepatocytes. Their mRNA and protein expressions were up-regulated at an earlier phase after treatment with D-GaIN/LPS. Meantime, a higher activity of LTC4 synthesis enzymes was detected, although theactivity of LTC4S played the main role in this case. CONCLUSION： The expression and activity of both LTC4S and mGST2 are up regulated in a rat FHF model, which are, at least, partly responsible for cys-LT hepatic accumulation.

关键词： Cysteinyl leukotriene Micmsomal glutathioneS-transferase 2 Leukotriene C4 synthase D-galacto-samine/lipopolysaccharide Fulminant hepatic failure