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Nab-paclitaxel plus capecitabine as first-line treatment for advanced biliary tract cancers:An open-label,non-randomized,phase II clinical trial

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World Journal of Gastroenterology 2024年第30期30卷 3564-3573页

作者： Ling-Xiao Xu jia-jia yuan Ran Xue Jun Zhou Department of Gastrointestinal Oncology Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Peking University Cancer Hospital and InstituteBeijing 100142China

BACKGROUND Biliary tract cancers(BTCs)are a heterogeneous group of tumors with high malignancy,poor prognosis,and limited treatment *** To explore the efficacy and safety of nab-paclitaxel plus capecitabine as first-line treatment for advanced and metastatic *** This open-label,non-randomized,double-center,phase II clinical trial recruited systemic therapy-naive patients with unresectable or metastatic BTCs between April 2019 and June 2022 at Beijing Cancer Hospital and the First Hospital of China Medical *** patients were administered nab-paclitaxel(150 mg/m^(2),day 1)and capecitabine(2000 mg/m^(2),twice daily,days 1-7)in 14-day cycles until experiencing intolerable toxicity or disease *** primary outcome was the objective response rate(ORR).The secondary outcomes included the disease control rate(DCR),overall survival(OS),progression-free survival(PFS),and *** A total of 44 patients successfully completed the trial,with a median age of 64.00 years(interquartile range,35.00-76.00),and 26(59.09%)were *** response assessment was impeded for one patient due to premature demise from tumor *** the remaining 43 patients undergoing at least one imaging assessment,the ORR was 23.26%[95%confidence interval(CI):11.80%-38.60%],and the DCR was 69.77%(95%CI:53.90%-82.80%).The median OS was 14.1 months(95%CI:8.3-19.9),and the median PFS was 4.4 months(95%CI:2.5-6.3).A total of 41 patients(93.18%)experienced at least one adverse event(AE),with 10 patients(22.73%)encountering grade≥3 AEs,and the most frequent AEs of any grade were alopecia(79.50%),leukopenia(54.55%),neutropenia(52.27%),and liver dysfunction(40.91%),and no treatment-related deaths were *** Nab-paclitaxel plus capecitabine may be an effective and safe first-line treatment strategy for patients with advanced or metastatic BTCs.

关键词： Nab-paclitaxel Capecitabine Biliary tract cancer Objective response rate Phase II clinical trial

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Effects of acupuncture on hypothalamic–pituitary–adrenal axis:Current status and future perspectives

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Journal of Integrative Medicine 2024年第4期22卷 445-458页

作者： jia-yuan Zheng Jing Zhu Yu Wang Zhan-zhuang Tian Department of Integrative Medicine and Neurobiology School of Basic Medical SciencesState Key Laboratory of Medical Neurobiology and Ministry of Education Frontiers Center for Brain ScienceInstitutes of Brain ScienceInstitute of Acupuncture ResearchAcademy of Integrative MedicineShanghai Key Laboratory for Acupuncture Mechanism and Acupoint FunctionShanghai Medical CollegeFudan UniversityShanghai 200032China Department of Human Anatomy School of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghai 201203China

The hypothalamic–pituitary–adrenal(HPA) axis is a critical component of the neuroendocrine system,playing a central role in regulating the body's stress response and modulating various physiological processes. Dysregulation of HPA axis function disrupts the neuroendocrine equilibrium, resulting in impaired physiological functions. Acupuncture is recognized as a non-pharmacological type of therapy which has been confirmed to play an important role in modulating the HPA axis and thus favorably targets diseases with abnormal activation of the HPA axis. With numerous studies reporting the promising efficacy of acupuncture for neuroendocrine disorders, a comprehensive review in terms of the underlying molecular mechanism for acupuncture, especially in regulating the HPA axis, is currently in need. This review fills the need and summarizes recent breakthroughs, from the basic principles and the pathological changes of HPA axis dysfunction, to the molecular mechanisms by which acupuncture regulates the HPA axis. These mechanisms include the modulation of multiple neurotransmitters and their receptors, neuropeptides and their receptors, and microRNAs in the paraventricular nucleus,hippocampus, amygdala and pituitary gland, which alleviate the hyperfunctioning of the HPA *** review comprehensively summarizes the mechanism of acupuncture in regulating HPA axis dysfunction for the first time, providing new targets and prospects for further exploration of acupuncture.

关键词： Acupuncture Electroacupuncture Hypothalamic-pituitary-adrenal axis Mechanism Neurotransmitter microRNA

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Comparison of inebilizumab or rituximab in addition to glucocorticoid therapy for neuromyelitis optica spectrum disorders

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1073-1078页

作者： Chu-yuan Lou Yong Wang jia-yuan Xing Teng Ma Lei Tao Xiao-Tang Wang Run-Sheng Wang Neuroophthalmic Center Xi’an People’s Hospital(Xi’an Fourth Hospital)Xi’an 710004Shaanxi ProvinceChina

AIM:To investigate the short-term efficacy and safety of inebilizumab for neuromyelitis optica spectrum disorders(NMOSD).METHODS:A total of 33 patients with NMOSD treated with inebilizumab(Group INB,n=15)or rituximab(Group RTX,n=18)in addition to high-dose glucocorticoids were *** groups underwent hormone shock therapy during the acute ***,Group INB received inebilizumab injections during the remission phase,while Group RTX received rituximab injections.A comparison of aquaporins 4(AQP4)titer values,peripheral blood B lymphocyte counts,and visual function recovery was conducted before and 8wk after ***,adverse reactions and patient tolerability were analyzed after using inebilizumab treatment ***:Following inebilizumab treatment,there was a significantly improvement in the visual acuity of NMOSD patients(P0.05).Furthermore,inebilizumab exhibited higher safety levels than that of rituximab ***:The combination of inebilizumab and high-dose glucocorticoids proves to be *** comparison to rituximab injections,inebilizumab displays better tolerance and ***,it demonstrates a partial effect in preventing optic nerve ***,it stands as an effective method to reduce the disability rates and improve the daily living ability of patients with NMOSD.

关键词： neuromyelitis optica spectrum disorders inebilizumab rituximab glucocorticoids

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Early colorectal cancer screening–no time to lose

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World Journal of Gastroenterology 2024年第23期30卷 2959-2963页

作者： Ying Wang Zheng-Long Wu Yi-Gang Wang Hui Wang Xiao-yuan jia College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018Zhejiang ProvinceChina Department of Oncology Zhejiang Xiaoshan HospitalHangzhou 310018Zhejiang ProvinceChina

In this editorial,we comment on the article entitled“Stage at diagnosis of colorectal cancer through diagnostic route:Who should be screened?”by Agatsuma et *** cancer(CRC)is emerging as an important health issue as its incidence continues to rise globally,adversely affecting the quality of *** the public has become more aware of CRC prevention,most patients lack screening *** poor lifestyle practices can lead to CRC and symptoms can appear in the early stages of ***,due to the lack of awareness of the disease,most of the CRC patients are diagnosed already at an advanced stage and have a poor prognosis.

关键词： Colorectal cancer The immunochemical fecal occult blood test Diagnostic route Cancer screening Stage at diagnosis

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Middle Devonian ostracods from Jiwozhai patch reef(Dushan,Guizhou Province,South China):Biostratigraphic and palaeoecological implication

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Journal of Palaeogeography 2024年第3期13卷 581-593页

作者： Jun-Jun Song jia-yuan Huang Wen Guo Kun Liang Yu-Cong Sun Zhi-Hong Wang Wen-Kun Qie State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008Jiangsu ProvinceChina Hubei Key Laboratory of Paleontology and Geological Environment Evolution Wuhan Center of China Geological SurveyWuhan 430205Hubei ProvinceChina University of Chinese Academy of Sciences NanjingNanjing 211135Jiangsu ProvinceChina

The Middle Devonian ostracods from the Jiwozhai patch reef in Dushan, Guizhou Province, South China were described for the first time in this study. Twenty-nine species belonging to 20 genera were identified and figured, including a new species named Wangshangkia jiwozhaiensis sp. nov. The ostracod fauna in the Jiwozhai patch reef represents a Givetian age. The ostracod assemblage belongs to the smooth-podocopid association, which is also ecologically equivalent to the Eifelian Mega-Assemblage Ⅲ. This association is indicative of shallow open-marine environments. The Jiwozhai patch reef fauna is primarily comprised of suspension feeders, including filter-feeding ostracods, corals, brachiopods and bryozoans. Ostracods from the Jiwozhai patch reef were compared to the ostracod faunas from Laurentia-Baltica at generic level, which reveals limited faunal exchanges between South China and Laurentia-Baltica during the Middle Devonian.

关键词： Ostracods Givetian Jiwozhai patch reef Dushan Palaeoecology

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Epidemiology of congenital diaphragmatic hernia among 24 million Chinese births:a hospital-based surveillance study

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World Journal of Pediatrics 2024年第7期20卷 712-722页

作者： Zhi-Yu Chen Jing Tao Wen-Li Xu Yu-Yang Gao Wen-Yan Li Zhen Liu jia-yuan Zhou Li Dai National Center for Birth Defects Monitoring West China Second University HospitalSichuan UniversityNo.17 Section 3 RenminnanluChengdu 610041China The Joint Laboratory for Pulmonary Development and Related Diseases West China Institute of Women and Children’s HealthWest China Second University HospitalSichuan UniversityChengduChina Key Laboratory of Birth Defects and Related Diseases of Women and Children Ministry of EducationSichuan UniversityChengduChina NHC Key Laboratory of Chronobology Sichuan UniversityChengduChina Med‑X Center for Informatics Sichuan UniversityChengduChina

Background The prevalence of congenital diaphragmatic hernia(CDH)varies across countries,with limited information available on its epidemiology in *** study aimed to investigate the prevalence,time trends,and perinatal outcomes of CDH in China,as well as its associated malformations and potential associations with maternal and infant *** This study included all birth and CDH cases from the Chinese Birth Defects Monitoring Network between 2007 and 2019,with CDH cases classified as either isolated or *** employed the joinpoint regression model to calculate the trends of prevalence and the annual percent change,with Poisson regression used for adjusted prevalence rate ratios.A P value≤0.05 was considered statistically *** A total of 4397 CDH cases were identified among 24,158,029 births in the study period,yielding prevalence rates of 1.82,1.13 and 0.69 per 10,000 for overall,isolated,and associated CDH,*** prevalence of each type of CDH increased over *** prevalence of overall CDH varied significantly by infant sex(male ***,1.91/10,000 vs.1.63/10,000),maternal residence(urban ***,2.13/10,000 vs.1.45/10,000),maternal age(<20 years,1.31/10,000;20-24 years,1.63/10,000;25-29 years,1.80/10,000;30-34 years,1.87/10,000;≥35 years,2.22/10,000),and geographic region(central,1.64/10,000;east,2.45/10,000;west,1.37/10,000).Cardiovascular anomalies were the most common malformations associated with *** with associated CDH had a higher risk of premature birth and perinatal death than those with isolated *** The increasing prevalence and high perinatal mortality rate of CDH highlight the need for further etiological,epidemiological,and clinical studies among the Chinese population.

关键词： China Congenital diaphragmatic hernia Epidemiology Prevalence

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基因技术利用行为的刑法规制

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法学 2024年第4期 77-94页

作者：贾元中国社会科学院法学研究所中国社会科学院大学法学院

基因技术利用行为在给人类社会带来福祉的同时,也引发了一系列伦理和安全问题,需要刑法对之加以回应。现有刑法对基因技术利用行为规制的不足主要有两方面原因:一是我国的刑事立法具有滞后性,并在生物科技利用行为规制方面呈现被动性特... 详细信息

基因技术利用行为在给人类社会带来福祉的同时,也引发了一系列伦理和安全问题,需要刑法对之加以回应。现有刑法对基因技术利用行为规制的不足主要有两方面原因:一是我国的刑事立法具有滞后性,并在生物科技利用行为规制方面呈现被动性特点;二是现有罪名存在一定的局限性,虽然我国刑法已经设立了非法植入基因编辑、克隆胚胎罪和非法采集人类遗传资源、走私人类遗传资源材料罪等罪名,但尚不足以应对可能出现的新基因技术利用行为的规制需求。由于基因技术利用行为具有强烈的风险不确定性以及强伦理性,对这类行为的规制应当以风险预防原则为基础展开。在现有刑法框架下,对相关行为可以通过对现有罪名,如以危险方法危害公共安全罪、故意伤害罪等罪名的解释适用进行规制,但这样仅能起到事后惩罚作用,而无法实现风险的提前预防。所以最有效方式是通过立法途径对风险进行溯源预防,即在基因开发利用行为的研究阶段就采取较为严格的规制措施,必要时设立新的罪名。

关键词：基因技术利用基因编辑生殖性克隆非法人体试验

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数据商业化利用的反不正当竞争法规制

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南京大学学报（哲学．人文科学．社会科学） 2024年第2期61卷 62-70页

作者：袁嘉四川大学法学院四川省成都市610207

数据权属不明晰、保护客体不确定和保护规则不统一等问题,制约了数据要素的流通共享与开发利用。相较于数据赋权保护思路,从数据商业化利用的视角切入,以反不正当竞争法为核心的行为规制思路能够有效平衡多元数据主体的利益,确立数据竞... 详细信息

数据权属不明晰、保护客体不确定和保护规则不统一等问题,制约了数据要素的流通共享与开发利用。相较于数据赋权保护思路,从数据商业化利用的视角切入,以反不正当竞争法为核心的行为规制思路能够有效平衡多元数据主体的利益,确立数据竞争规则,维护公平竞争的市场秩序。欲实现理想的规制,在宏观上应当坚持数据高效流通利用优先的原则,注重保障消费者等弱势群体的合法权益;在微观上应当以数据商业化利用的各个环节为切入点,通过类型化立法技术提炼出数据获取、数据使用和数据交易中不正当竞争行为的判定规则,并将其纳入新修订反不正当竞争法中。

关键词：数据商业化利用反不正当竞争法数据获取数据使用数据交易

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滥用数据优势行为的竞争法规制

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政法论丛 2024年第2期 75-85页

作者：袁嘉四川大学法学院四川成都610207

数字经济时代滥用数据优势行为不仅诱发了直接排斥效应、供给挤压效应和市场封锁效应等竞争损害,而且阻滞了创新要素流通利用,不利于数据要素价值充分释放。我国《反垄断法》与《反不正当竞争法》均已围绕新兴业态开展数字化变革,但如... 详细信息

数字经济时代滥用数据优势行为不仅诱发了直接排斥效应、供给挤压效应和市场封锁效应等竞争损害,而且阻滞了创新要素流通利用,不利于数据要素价值充分释放。我国《反垄断法》与《反不正当竞争法》均已围绕新兴业态开展数字化变革,但如何协调两者关系以塑造体系化数据竞争规则,迄今尚缺乏定论。我国宜以市场支配地位和相对交易优势地位的分层建构规制滥用数据优势行为,同时由反垄断法调整排他性滥用行为,并以保证特定数据的可获取性为重点;由反不正当竞争法调整剥削性滥用行为,以保障公平交易权为重点。

关键词：数据优势滥用行为垄断行为不正当竞争行为

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统而分殊:大数据时代中国式信用权益保护新模式

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行政法学研究 2024年第1期 40-51页

作者：贾媛媛桂林电子科技大学法学院广西桂林541004

受欧陆人格权学说和德国“主观公权利”理论影响,当前我国的信用权益保护呈现出仰赖民法逻辑的私权保护模式。然而,大数据不仅改变了国家与社会的权力格局,也抽离了公/私权利二元论的理论预设。社会权力与行政权力的双重叠加、大数据的... 详细信息

受欧陆人格权学说和德国“主观公权利”理论影响,当前我国的信用权益保护呈现出仰赖民法逻辑的私权保护模式。然而,大数据不仅改变了国家与社会的权力格局,也抽离了公/私权利二元论的理论预设。社会权力与行政权力的双重叠加、大数据的不反应性和算法干扰等特征已然使私权保护模式下信用权能的完整性成为镜花水月。“重民事轻行政”的“跛足”保护态势,不仅导致信用体系建设的公、私利益失衡,也难以弥合信用数据治理的法治客观需求。请求权架设下的权利结构新体系不仅可将民事与行政活动中多边法律主体间的动态活动纳入观察视野,而且可为信用权益保护提供层层递进的逻辑结构和内在一体化的规范供给。在信用权利新体系架构下,寻求部门法间“统而分殊”的体系性合作成为中国式信用权益保护的应有之义。在“统而分殊”的信用权益一体化保护新模式下,行政法应当从立法、执法与司法三个方面作出积极调整,实现与民法信用权益保护的合作与衔接。

关键词：大数据信用权保护主观公权利

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