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Study on the preservation effects of the amputated forelimb by machine p.r.usion at physiological temp.r.ture

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Chinese Journal of Traumatology 2024年第2期27卷 114-120页

作者： sheng-Feng Chen Bo-Yao Yang Tie-Yuan Zhang Xiang-Yu Song Zhi-Bo jia Lei-jia Chen Meng-yi Cui Wen-Jing xu jiang peng Guizhou Medical university Guiyang550025China Medical School of pLA Beijing100048 China beijing Key Lab of regenerative Medicine in Orthopedics Key Laboratory of Musculoskeletal Trauma and War Injuries PLADepartment of OrthopedicsThe Fourth Medical CenterChinese PLA General HospitalBeijing100048China Hebei North Universiy Zhangjiakou075000Hebei ProvinceChina

p.r.ose:Ischemia and hypoxia are the main factors limiting limb replantation and *** cold storage(SCS),a common preservation method for tissues and organs,can only prolong limb ischemia time to 4-6 *** normothermic machine p.r.usion(NMp)is a promising method for the preservation of tissues and organs,which can extend the preservation time in vitro by providing continuous oxygen and *** study aimed to evaluate the difference in the efficacy of the 2 limb preservation ***:The 6 forelimbs from beagle dogs were divided into 2 *** the SCS group(n=3),the limbs were preserved in a sterile refrigerator at 4°C for 24 h,and in the NMp group(n=3),the p.r.usate prep.r.d with autologous blood was used for the oxygenated machine p.r.usion at physiological temp.r.ture for 24 h,and the solution was changed every 6 *** effects of limb storage were evaluated by weight gain,p.r.usate biochemical analysis,enzyme-linked immunosorbent assay,and histological *** statistical analyses and graphs were p.r.ormed using Graphpad prism 9.0 one-way or two-way analysis of *** p value of less than 0.05 was considered to indicate statistical ***:In the NMp group,the weight gained p.r.entage was 11.72%±4.06%;the hypoxia-inducible factor-1αcontents showed no significant changes;the shape of muscle fibers was normal;the gap between muscle fibers slightly increased,showing the intercellular distance of(30.19±2.83)μm;and the vascularα-smooth muscle actin(α-SMA)contents were lower than those in the normal blood *** creatine kinase level in the p.r.usate of the NMp group increased from the beginning of p.r.usion,decreased after each p.r.usate change,and remained stable at the end of p.r.usion showing a peak level of 4097.6 U/*** lactate dehydrogenase level of the NMp group increased near the end of p.r.usion and reached the peak level of 374.4 U/*** the SCS group,the p.r.entage of weight gain was 0.18%±0.10%,a

关键词： Traumatic amputation Machine p.r.usion Static cold storage Limb replantation

promise and challenges of traditional Chinese medicine,specifically Calculus bovis,in liver cancer treatment

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World Journal of Gastroenterology 2024年第40期30卷 4380-4385页

作者： Ao-Xi xu Zhi-Feng Zhao Li Zhu yi-Heng Zhang Yan Li Yu-Fan Wei Bo-Ya Zhang Bin jiang Tian-Ze Gao Meng-Si Li jia-Yu Liu School of Medicine Nankai UniversityTianjin 300071China department of General Surgery The First Medical Center of Chinese People's Liberation Army General HospitalBeijing 100853China Medical School of Chinese people's Liberation Army Medical School of Chinese People's Liberation ArmyBeijing 100853China department of Hepatobiliary and pancreative Surgery The First Medical CenterChinese People's Liberation Army General HospitalBeijing 100853China department of Surgery Mancheng District People's HospitalBaoding 072150Hebei ProvinceChina department of Neurosurgery First Medical Centre of Chinese People's Liberation Army General HospitalBeijing 100853China

Liver cancer,one of the most common malignancies worldwide,ranks sixth in incidence and third in *** cancer treatment options are diverse,inclu-ding surgical resection,liver transplantation,p.r.utaneous ablation,transarterial chemoembolization,radiotherapy,chemotherapy,targeted therapy,immuno-therapy,and traditional Chinese medicine(TCM).A multidisciplinary team(MDT)is essential to customize treatment plans based on tumor staging,liver function,and p.r.ormance status(pS),ensuring individualized patient *** decisions require a MDT to tailor strategies based on tumor staging,liver function,and pS,ensuring p.r.onalized *** ap.r.val of new first-line and second-line drugs and the establishment of standard treatments based on immune checkpoint inhibitors have significantly expanded treatment options for advanced liver cancer,improving overall ***,many patients do not respond effectively to these treatments and ultimately succumb to the *** oncology treatments,while extending patient survival,often come with severe side effects,resistance,and damage to the body,negatively impacting quality of *** et al's study published at World Journal of Gastroenterology rigorously validates the anticancer prop.r.ies of Calculus bovis,enhancing our understanding of TCM and contributing to new liver cancer treatment *** over 5000 years,TCM has been used in East Asian countries like china to treat various diseases,including liver *** of real-world clinical data suggests that for patients with advanced-stage tumors lacking effective treatments,integrated TCM therapies could provide significant breakthroughs.

关键词： Traditional Chinese medicine Liver cancer Calculus bovis Treatment promise Challenges

Tislelizumab in previously treated,locally advanced unresectable/metastatic microsatellite instability-high/mismatch repair-deficient solid tumors

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Chinese Journal of Cancer research 2024年第3期36卷 257-269页

作者： jian Li Ye xu Aimin Zang Yunong Gao Quanli Gao Yanqiao Zhang Dong Wang jianming xu ying Yuan Haiping jiang Jieer ying Chunmei Shi Yanhong Deng Jing Wang Tianshu Liu yi Huang Xiaoping Qian Yueyin pan ying Cheng sheng Hu Jin Wang Mengyue Shi Ke Wang Han Hu Lin Shen State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China department of Oncology Fudan University Shanghai Cancer CenterShanghai 200032China department of Medical Oncology Affiliated Hospital of Hebei UniversityBaoding 071000China Key Laboratory of Carcinogenesis and Translational research(Ministry of Education/beijing) Department of GynecologyPeking University Cancer Hospital&InstituteBeijing 100142China department of Immunotherapy Henan Cancer HospitalZhengzhou 450001China department of Gastrointestinal Oncology Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150086China department of Gastrointestinal Oncology Chongqing University Cancer HospitalChongqing 400030China department of Gastrointestinal Oncology the Fifth Medical CenterChinese PLA General HospitalBeijing 100048China department of Medical Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China department of Medical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China department of Medical Oncology Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China department of Medical Oncology Fujian Medical University Union HospitalFuzhou 350001China department of Oncology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China department of Medical Oncology Hunan Cancer HospitalChangsha 410013China department of Medical Oncology Zhongshan HospitalFudan UniversityShanghai 200032China department of Immunotherapy Hubei Cancer HospitalWuhan 430079China department of Medical Oncology the Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China department of Medical Oncology Anhui Provincial HospitalHefei 230001China department of Medical Oncology Jilin Cancer Hospital

Objective:The open-label,phase II rATIONALE-209 study evaluated tislelizumab(anti-programmed cell death protein 1 antibody)as a tissue-agnostic monotherapy for microsatellite instability-high(MSI-H)/mismatch repair-deficient(dMMr)***:Adults with previously treated,locally advanced unresectable or metastatic MSI-H/dMMr solid tumors were *** received tislelizumab 200 mg intravenously every 3 *** response rate(Orr;primary endpoint),duration of response(Dor),and progression-free survival(pFS)were assessed by independent review committee(response Evaluation Criteria in Solid Tumors v1.1).results:Eighty patients were enrolled and treated;75(93.8%)patients had measurable disease at *** had metastatic disease and received at least one prior therapy for advanced/metastatic disease(n=79;98.8%).At primary analysis(data cutoff July 8,2021;median follow-up 15.2 months),overall Orr[46.7%;95%confidence interval(95%CI),35.1−58.6;one-sided prr across tumor-specific subgroups[colorectal(n=46):39.1%(95%CI,25.1–54.6);gastric/gastroesophageal junction(n=9):55.6%(95%CI,21.2−86.3);others(n=20):60.0%(95%CI,36.1−80.9)]were significantly greater with tislelizumab vs.a prespecified historical control Orr of 10%;five(6.7%)patients had complete *** Dor,pFS,and overall survival were not reached with long-term follow-up(data cutoff December 5,2022;median follow-up 28.9 months).Tislelizumab was well tolerated with no unexpected safety ***-related adverse events(TrAEs)of grade≥3 occurred in 53.8%of patients;7.5%of patients discontinued treatment due to ***:Tislelizumab demonstrated a significant Orr improvement in patients with previously treated,locally advanced unresectable or metastatic MSI-H/dMMr tumors and was generally well tolerated.

关键词： Biomarkers DNA mismatch repair immune checkpoint inhibitors microsatellite instability phase II clinical trials programmed cell death 1 receptor

Exp.r. consensus on the diagnosis and therapy of endo-p.r.odontal lesions

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International Journal of Oral Science 2024年第3期16卷 381-389页

作者： Bin Chen Yanan Zhu Minkui Lin Yangheng Zhang Yanfen Li Xiangying Ouyang Song Ge jiang Lin Yaping pan Yan xu yi ding Shaohua Ge Faming Chen Zhongchen Song Shaoyun jiang jiang Sun Lijun Luo Junqi Ling Zhi Chen Lin Yue xuedong Zhou Fuhua Yan department of p.r.odontology Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyNanjing UniversityNanjingChina department of Endodontics Nanjing Stomatological HospitalAffiliated Hospital of Medical SchoolInstitute of StomatologyNanjing UniversityNanjingChina Clinical research Center for Oral Tissue Deficiency diseases of Fujian province&Fujian Key Laboratory of Oral diseases&Fujian provincial Engineering research Center of Oral Biomaterial School and Hospital of StomatologyFujian Medical UniversityFuzhouChina department of p.r.odontology Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Research Center of Oral Biomaterials and Digital Medical DevicesBeijingChina School and Hospital of Stomatology Zunyi Medical UniversityZunyiChina department of Stomatology Beijing TongRen HospitalCapital Medical UniversityBeijingChina department of p.r.odontics School and Hospital of StomatologyChina Medical UniversityShenyangChina department of p.r.odontology The Affiliated Stomatological Hospital of Nanjing Medical UniversityJiangsu Key Laboratory of Oral DiseasesNanjing Medical UniversityNanjingChina State Key Laboratory of Oral diseases&National Center for Stomatology&National Clinical research Center for Oral diseases&department of p.r.odontics West China Hospital of StomatologySichuan UniversityChengduChina department of p.r.odontology School and Hospital of StomatologyShandong University&Shandong Key Laboratory of Oral Tissue Regeneration&Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration&Shandong Provincial Clinical Research Center for Oral Diseases JinanJinanChina State Key Laboratory of Oral&Maxillofacial reconstruction and regeneration National Clinical Research Center for Oral DiseasesShaanxi International Joint Research Center for Oral DiseasesDepartment of periodontologySchool of StomatologyThe Fou

Endo-p.r.odontal lesions (EpLs) involve both the p.r.odontium and pulp tissue and have complicated etiologies and pathogenic mechanisms,including unique anatomical and microbiological characteristics and multiple contributing *** etiological complexity leads to difficulties in determining patient prognosis,posing great challenges in clinical ***,EpL-affected teeth require multidisciplinary therapy,including p.r.odontal therapy,endodontic therapy and others,but there is still much debate about the ap.r.priate timing of p.r.odontal therapy and root canal *** compiling the most recent findings on the etiology,pathogenesis,clinical characteristics,diagnosis,therapy,and prognosis of EpL-affected teeth,this consensus sought to supp.r. clinicians in making the best possible treatment decisions based on both biological and clinical evidence.

关键词： diagnosis p.r.odontal lesions

Glioma-derived ANXA1 sup.r.sses the immune response to TLr3 ligands by promoting an anti-inflammatory tumor microenvironment

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Cellular & Molecular Immunology 2024年第1期21卷 47-59页

作者： Yu Zheng Haihui jiang Naixue Yang Shaoping Shen Daosheng Huang Lemei jia Jing Ling Longchen xu Mingxiao Li Kefu Yu Xiaohui ren Yong Cui xun Lan Song Lin Xin Lin Institute for Immunology and School of Medicine Tsinghua UniversityBeijing100084China department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityChina.National Clinical Research Center for Neurological DiseasesCenter of Brain TumorBeijing Institute for Brain Disorders and Beijing Key Laboratory of Brain TumorBeijing100070China department of Neurosurgery Peking University Third HospitalPeking UniversityBeijing100191China Tsinghua-peking Center for Life Sciences Beijing100084China

A highly immunosup.r.ssive tumor microenvironment(TME)and the presence of the blood‒brain barrier are the two major obstacles to eliciting an effective immune response in patients with high-grade glioma(HGG).Here,we tried to enhance the local innate immune response in relapsed HGG by intracranially injecting poly(I:C)to establish a robust antitumor immune response in this registered clinical trial(NCT03392545).During the follow-up,12/27(44.4%)patients who achieved tumor control concomitant with survival benefit were regarded as responders in our *** found that the T-cell receptor(TCr)rep.r.oire in the TME was reshaped after poly(I:C)*** on the rNA-seq analysis of tumor samples,the expression of annexin A1(ANXA1)was significantly upregulated in the tumor cells of nonresponders,which was further validated at the protein *** vitro and in vivo exp.r.ments showed that ANXA1 could induce the production of M2-like macrophages and microglia via its surface receptor formyl peptide receptor 1(Fpr1)to establish a Treg cell-driven immunosup.r.ssive TME and sup.r.ss the antitumor immune response facilitated by poly(I:C).The ANXA1/Fpr1 signaling axis can inhibit the innate immune response of glioma patients by promoting an anti-inflammatory and Treg-driven ***,ANXA1 could serve as a reliable predictor of response to poly(I:C),with a notable predictive accuracy rate of 92.3%.In light of these notable findings,this study unveils a new p.r.pective of immunotherapy for gliomas.

关键词： glioma ANXA1 TLr3 poly(I:C) immunotherapy

Scintillation Arc from FrB 20220912A

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Science china(physics,Mechanics & Astronomy) 2024年第1期67卷 134-142页

作者： Zi-Wei Wu robert AMain Wei-Wei Zhu Bing Zhang peng jiang jia-rui Niu Jin-Lin Han di Li Ke-jia Lee Dong-Zi Li Yuan-pei Yang Fa-yin Wang rui Luo pei Wang Chen-Hui Niu Heng xu Bo-Jun Wang Wei-Yang Wang Yong-Kun Zhang yi Feng De-jiang Zhou Yong-Hua xu Can-Min Deng Yu-Hao Zhu National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China Max-planck-Institut für radioastronomie Bonn 53121Germany Institute for Frontier in Astronomy and Astrophysics Beijing Normal UniversityBeijing 102206China Nevada Center for Astrophysics and department of physics and Astronomy University of NevadaLas VegasNV 89154USA CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy University of Chinese Academy of SciencesBeijing 100049China NAOC-UKZN Computational Astrophysics Centre University of KwaZulu-NatalDurban 4000South Africa department of Astronomy Peking UniversityBeijing 100871China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Cahill Center for Astronomy and Astrophysics California Institute of TechnologyPasadena 91125USA South-Western Institute For Astronomy research Yunnan UniversityKunming 650504China School of Astronomy and Space Science Nanjing UniversityNanjing 210093China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing university) Ministry of EducationNanjing 210023China CSIrO Space and Astronomy Epping 1710Australia department of Astronomy School of Physics and Materials ScienceGuangzhou UniversityGuangzhou 510006China research Center for Intelligent Computing platforms Zhejiang LaboratoryHangzhou 311100China Yunnan Observatories Chinese Academy of SciencesKunming 650011China Guangxi Key Laboratory for relativistic Astrophysics Department of PhysicsGuangxi UniversityNanning 530004China

We present the interstellar scintillation analysis of fast radio burst(FrB)20220912A during its extremely active episode in 2022using data from the Five-hundred-meter Ap.r.ure Spherical radio Telescope(FAST).We detect a scintillation arc in the FrB’s secondary spectrum,which describes the power in terms of the scattered FrB signals’time delay and Doppler *** arc indicates that the scintillation is caused by a highly localized *** analysis favors a Milky Way origin of the ionized interstellar medium(IISM)for the localized scattering medium but cannot rule out a host galaxy *** present our method for detecting the scintillation arc,which can be applied generally to sources with irregularly spaced bursts or *** methods could help shed light on the complex interstellar environment surrounding the FrBs and in our Galaxy.

关键词： fast radio burst scintillation FrB 20220912A

penpulimab,an anti-pD-1 antibody,for heavily pretreated metastatic nasopharyngeal carcinoma:a single-arm phase II study

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3056-3062页

作者： Xiaozhong Chen Wei Wang Qingfeng Zou Xiaodong Zhu Qin Lin yi jiang Yan Sun Liangfang Shen Lin Wang Guorong Zou Xiaoyan Lin Shaojun Lin Minying Li ying Wang ruilian xu rui Ao rensheng Wang Haifeng Lin Shuang Huang Tingting xu Wenting Li Mengying Xia Yu Xia Zhongmin Wang Baiyong Li Jingao Li Chaosu Hu department of radiation Oncology Cancer Hospital of the University of ChineseAcademy of Sciences(Zhejiang Cancer Hospital)HangzhouChina Gastroenterology and Urology department II Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaChina Clinical research Center for Gastrointestinal Cancer in Hunan province ChangshaChina department of Medical Oncology Affiliated Cancer Hospital&Institute of Guangzhou Medical UniversityGuangzhouChina department of radiation Oncology Guangxi Medical University Affiliated Tumor Hospital&Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor(Guangxi Medical University)Ministry of Education&Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanningChina department of radiation Oncology Cancer CenterThe First Affiliated Hospital of Xiamen UniversityXiamenChina department of Medical Oncology Cancer Hospital of Shantou University Medical CollegeShantouChina department of radiation Oncology Peking University Cancer Hospital&InstituteBeijingChina department of Oncology Xiangya Hospital Central South UniversityChangshaChina department of Medical Oncology Hainan General HospitalHainan Affiliated Hospital of Hainan Medical UniversityHaikouChina department of Oncology The Affiliated Panyu Central Hospital of Guangzhou Medical UniversityGuangzhouChina department of Medical Oncology Fujian Medical University Union HospitalFuzhouChina department of radiation Oncology Clinical Oncology School of Fujian Medical UniversityFujian Cancer HospitalFuzhouChina department of radiation Therapy for Thoracic Tumors Zhongshan City People’s HospitalZhongshanChina Tumor radiotherapy Center Chongqing University Cancer HospitalChongqing Cancer HospitalChongqing Cancer InstituteChongqingChina department of Oncology Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSo

penpulimab is an anti-programmed cell death-1(pD-1)IgG1 antibody with no Fc gamma receptor(Fcγr)binding activity,and thus theoretically reduced immune-related adverse events(irAEs)while maintaining *** single-arm,phase II trial conducted across 20 tertiary care centers in china enrolled adult patients with metastatic nasopharyngeal carcinoma(NpC)who had failed two or more lines of previous systemic *** received 200-mg penpulimab intravenously every 2 weeks(4 weeks p.r.cycle)until disease progression or intolerable *** primary endpoint was objective response rate(Orr)p.r.rECIST(version 1.1),as assessed by an independent radiological review *** secondary endpoints included progression-free survival(pFS)and overall survival(OS).One hundred thirty patients were enrolled and 125 were efficacy *** the data cutoff date(September 28,2022),1 patient achieved complete response and 34 patients attained p.r.ial *** Orr was 28.0%(95%CI 20.3–36.7%).The response was durable,with 66.8%still in response at 9 ***-three patients(26.4%)were still on *** median pFS and OS were 3.6 months(95%CI=1.9–7.3 months)and 22.8 months(95%CI=17.1 months to not reached),***(7.6%)patients exp.r.enced grade 3 or higher *** has promising anti-tumor activities and acceptable toxicities in heavily pretreated metastatic NpC patients,supp.r.ing further clinical development as third-line treatment of metastatic NpC.

关键词： metastatic nasopharyngeal supp.r.ing

Study of the response of 10B-doped MCp to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang Li Li‑jiao Wang Xiang‑Biao Qiu Jing‑Wen Li Wei xu Tao Li Ze‑Bin Lin Chang‑Jun Ning Yong‑Hao Chen rui‑rui Fan Kang Sun Jing‑Yu Tang rong Zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai jiang‑Bo Bai Jie Bao ping Cao Qi‑ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing Gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He Yang Hong yi‑Wei Hu Han‑Xiong Huang Wei‑Hua jia Hao‑Yu jiang Wei jiang Zhi‑Jie jiang Zheng‑Yao Jin Ling Kang Bo Li Chao Li Gong Li jia‑Wen Li Xiao Li Yang Li Jie Liu rong Liu Shu‑Bin Liu Guang‑Yuan Luan Bin‑Bin Qi Jie ren Zhi‑Zhou ren Xi‑Chao ruan Zhao‑Hui Song Zhi‑Xin Tan sheng‑Da Tang peng‑Cheng Wang Zhao‑Hui Wang Zhong‑Wei Wen Xiao‑Guang Wu xuan Wu Li‑Kun Xie yi‑Wei Yang Han yi Yong‑Ji Yu Guo‑Hui Zhang Lin‑Hao Zhang Mo‑Han Zhang Qi‑Wei Zhang Xian‑peng Zhang Yu‑Liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑ping Zhou Zhi‑Hao Zhou Ke‑Jun Zhu Institute of High Energy physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China State Key Laboratory of p.r.icle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China State Key Laboratory of p.r.icle Detection and Electronics University of Science and Technology of ChinaHefei 230026China department of Modern physics University of Science and Technology of ChinaHefei 230026China State Key Laboratory of Nuclear physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCps)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.10B-doped MCps(B-MCps)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temp.r.l resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCp with 10 mol%10B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the china Spallation Neutron *** neutron detection efficiency was calibrated at 1 eV,which is ap.r.ximately 300 times that of an ordinary MCp and indicates the success of 10 B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCp was comp.r.d with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCp gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCp for high-energy neutrons.

关键词： Neutron radiation image 10B-doped MCp Neutron response Wide-energy range neutrons

Frontiers in high entropy alloys and high entropy functional materials

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rare Metals 2024年第10期43卷 4639-4776页

作者： Wen-Tao Zhang Wen Huang Fu-Jie Yu Qi Zhao Xin-Dong Zhu Tao Feng Yao jiang Xiao-Ming Li xue-Fei Miao He Zhu Si Lan xue-Qian Wang Bao-Long Shen Zhe jia Feng-Qi Zhang Wei Wang Qi Liu Yang ren xun-Li Wang Xiao-Ya Cui Xiao-Yang Wang Ya-Nan Chen Bing-Bing Fan Meng-ru Li Qi-Long Gao jia-Ming Guo Zeng-Bao jiao Zhi-Min Guo Yu-ping Zhao Qian Yu rui Huang Ling-Kun Zhang yi-ping Lu xu-Bo Li Huai-Jun Lin Yan Ma Wei-Ming Yang Zhi-Hua Shen Hai-Yan He Yong-Gang Sun Yong-jiang Huang De-Zhuang Wang Qing-Feng Liu Fei-Yang Wang Hui Liu Hong-Hui Wu Li-Qiang Wang Yang Lu Nan Wang Tian-Li Wang Wei-Bing Liao yi-Han Wang Yuan Wu Yu-Zhen yin Jie pan yi Zhang Qing Wang jian-Yang Zhang Tao Yang Yasir Sohail Jin-Yu Zhang Hua Ji Qiang Li Wei-di Liu Zhi-Gang Chen Xiong-Jun Liu Wen Ma Liang Mao Zhen-Duo Wu School of Materials Science and Engineering Nanjing University of Science and Technology jiangsu Key Laboratory for Advanced Metallic Materials School of Materials Science and Engineering Southeast University department of physics City University of Hong Kong School of Materials Science and Engineering Tianjin University School of physics and Microelectronics Zhengzhou University department of Mechanical Engineering Research Institute for Advanced Manufacturing The Hong Kong Polytechnic University Center of Electron Microscopy and State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Key Laboratory of Solidification Control and digital prep.r.tion Technology (Liaoning province) School of Materials Science and Engineering Dalian University of Technology Institute of Advanced Wear & Corrosion resistance and Functional Materials Jinan University School of Mechanics and Civil Engineering China University of Mining and Technology School of physical Sciences Great Bay University School of Materials Science andEngineering Harbin Institute of Technology State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical Engineering Nanjing Tech University beijing Advanced Innovation Center for Materials Genome Engineering Research Institute for Carbon Neutrality University of Science and Technology Beijing department of Mechanical Engineering The University of Hong Kong School of Computing Macquarie University Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong province College of Physics and Optoelectronic Engineering Shenzhen University State Key Laboratory for Advanced Metals and Materials University of Science and Technology Beijing State Key Laboratory of Materials processing and die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Institute of materials Shanghai University department of Materials Science and Engineering C

Owing to their exceptional prop.r.ies, high-entropy alloys(HEAs) and high-entropy materials have emerged as promising research areas and shown diverse applications. Here,the recent advances in the field are comprehensively reviewed,organized into five sections. The first section introduces the background of HEAs, covering their definition, significance,application prospects, basic prop.r.ies, design principles, and microstructure. The subsequent section focuses on cutting-edge high-entropy structural materials, highlighting developments such as nanostructured alloys, grain boundary engineering,eutectic systems, cryogenic alloys, thin films, micro-nano-lattice structures, additive manufacturing, high entropy metallic glasses, nano-precipitate strengthened alloys, composition modulation, alloy fibers, and refractory systems. In the following section, the emphasis shifts to functional materials, exploring HEAs as catalysts, magneto-caloric materials, corrosion-resistant alloys, radiation-resistant alloys, hydrogen storage systems, and materials for biomedicine. Additionally, the review encompasses functional high-entropy materials outside the realm of alloys, including thermoelectric, quantum dots, nanooxide catalysts, energy storage materials, negative thermal expansion ceramics,and high-entropy wave absorption materials. The pap.r.concludes with an outlook, discussing future directions and potential growth areas in the field. Through this comprehensive review,researchers, engineers, and scientists may gain valuable insights into the recent progress and opp.r.unities for further exploration in the exciting domains of high-entropy alloys and functional materials.

关键词： Cutting-edge structural materials Cutting-edgefunctional materials High entropy alloys