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矿粉改性高性能混凝土的力学性能和耐久性能研究

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功能材料 2024年第2期55卷 2187-2192页

作者：卢重阳王佳兰州工业学院土木工程学院兰州730050

以S115矿粉为掺和料,制备了矿粉改性高性能混凝土,通过XRD、SEM、复合盐溶液干湿循环测试等手段,分析了矿粉取代率对混凝土的晶格结构、微观形貌、力学性能和耐久性能的影响。结果表明,适量矿粉的掺入能够加速水泥的水化反应速率,增加... 详细信息

以S115矿粉为掺和料,制备了矿粉改性高性能混凝土,通过XRD、SEM、复合盐溶液干湿循环测试等手段,分析了矿粉取代率对混凝土的晶格结构、微观形貌、力学性能和耐久性能的影响。结果表明,适量矿粉的掺入能够加速水泥的水化反应速率,增加网格结构的致密度,从而改善混凝土的微观形貌,提高混凝土的强度。矿粉取代率的增大会降低水泥石前期的强度,显著提高水泥石后期的强度。当矿粉取代率为50%时,养护28 d的混凝土的抗压强度和抗折强度均达到了最大值,分别为52.5和7.4 MPa。矿粉取代水泥后,混凝土在复合盐溶液的侵蚀下相对动弹性模量和质量损失率的下降趋势变得平缓,在30次干湿循环后,矿粉取代率50%的混凝土的相对动弹性模量最高为88%,质量损失率最小为1.6%,抗盐溶液侵蚀性能最佳。混凝土的腐蚀产物主要是针状结构的钙矾石和块状的石膏,这些产物存在于混凝土的孔隙和裂纹中,多次干湿循环后体积膨胀产生了内部应力,生成了深裂纹,最终撑裂混凝土,使混凝土失效。综合可知,矿粉的最佳取代率为50%。

关键词：矿粉混凝土力学性能耐久性能干湿循环

Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye Tao Song Shuai Huang jia wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

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Military Medical Research 2024年第4期11卷 500-520页

作者： Kun Zhang Meng-Xia Zhang Xiao-Xiang Meng Jing Zhu jia-Jun wang Yi-Fan He Ye-Hua Li Si-Cong Zhao Zhe-Min Shi Li-Na Zheng Tao Han Wei Hong Department of Histology and Embryology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Department of Hepatology and Gastroenterology Tianjin Union Medical CenterTianjin Medical UniversityTianjin Union Medical Center Affiliated to Nankai UniversityTianjin 300000China

Background:G-protein coupled receptors(GPCRs)are recognized as attractive targets for drug ***,it remains poorly understood how GPCRs,except for a few chemokine receptors,regulate the progression of liver ***,we aimed to reveal the role of GPR65,a proton-sensing receptor,in liver fibrosis and to elucidate the underlying ***:The expression level of GPR65 was evaluated in both human and mouse fibrotic ***,Gpr65-deficient mice were treated with either bile duct ligation(BDL)for 21 d or carbon tetrachloride(CCl4)for 8 weeks to investigate the role of GPR65 in liver fibrosis.A combination of experimental approaches,including Western blotting,quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR),and enzyme-linked immunosorbent assay(ELISA),confocal microscopy and rescue studies,were used to explore the underlying mechanisms of GPR65’s action in liver ***,the therapeutic potential of GPR65 inhibitor in the development of liver fibrosis was ***:We found that hepatic macrophage(HM)-enriched GPR65 was upregulated in both human and mouse fibrotic ***,knockout of Gpr65 significantly alleviated BDL-and CCl4-induced liver inflammation,injury and fibrosis in vivo,and mouse bone marrow transplantation(BMT)experiments further demonstrated that the protective effect of Gpr65knockout is primarily mediated by bone marrow-derived macrophages(BMMs).Additionally,in vitro data demonstrated that Gpr65 silencing and GPR65 antagonist inhibited,while GPR65 overexpression and application of GPR65 endogenous and exogenous agonists enhanced the expression and release of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and transforming growth factor-β(TGF-β),all of which subsequently promoted the activation of hepatic stellate cells(HSCs)and the damage of hepatocytes(HCs).Mechanistically,GPR65 overexpression,the acidic pH and GPR65 exogenous agonist induced up-regulation of

关键词： GPR65 Hepatic fibrosis Hepatic macrophages Inflammation c-Jun N-terminal kinase Nuclear factorκB

基于核空间联合稀疏表示和指数平滑的多基地水下小目标识别

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电子学报 2024年第1期52卷 217-231页

作者：王佳维许枫杨娟中国科学院声学研究所北京100190 中国科学院大学北京100049

针对多基地水下小目标分类识别问题,本文提出了一种基于核空间联合稀疏表示和指数平滑的多基地水下小目标识别方法 .对水下目标多角度散射信号提取6种典型的具有信息互补性和关联性的特征,提出一种随机森林(Random Forest,RF)和最小冗... 详细信息

针对多基地水下小目标分类识别问题,本文提出了一种基于核空间联合稀疏表示和指数平滑的多基地水下小目标识别方法 .对水下目标多角度散射信号提取6种典型的具有信息互补性和关联性的特征,提出一种随机森林(Random Forest,RF)和最小冗余最大相关(minimum Redundancy and Maximum Relevance,mRMR)相结合的特征选择方法(RF-mRMR),得出综合的特征重要性排序结果 .通过实验得出分类模型所需的最优特征子集,达到降低数据处理复杂度和提高目标分类结果的目的 .为了捕捉到数据中的高阶结构,在联合稀疏表示模型的基础上,使用核函数将线性不可分的特征数据映射到高维核特征空间.为了充分挖掘稀疏重构后包含在残差波段中的有用信息,使用指数平滑公式对具有一定意义的残差信息进行再利用,最后由核特征空间下的最小误差准则判定目标的类别.应用本文提出的方法对4类目标的海试数据进行识别,结果表明,相较于其他7种对比算法,本文提出的改进方法具有更好的分类性能,而且大多数情况下,本文提出的算法在双基地声呐模式下具有比单基地声呐更高的识别准确率和更低的虚警率.

关键词：多基地水下小目标识别多特征融合特征选择核空间联合稀疏表示指数平滑

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Effect of inflammatory response on joint function after hip fracture in elderly patients:A clinical study

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World Journal of Orthopedics 2024年第4期15卷 337-345页

作者： jia-Ming wang Yu-Tao Pan Chen-Song Yang Ming-Chong Liu Sheng-Chao Ji Ning Han Fang Liu Gui-Xin Sun Department of Traumatic Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200092China

BACKGROUND Excellent hip joint function facilitates limb recovery and improves the quality of *** study aimed to investigate the potential risk factors affecting postoperative joint functional activity and outcomes in elderly hip fractures patients and to provide evidence for patient rehabilitation and clinical *** To explore the relationship between inflammatory factors and hip function and the interaction between inflammation and health after hip fracture in elderly *** The elderly patients who had hip fracture surgery at our hospital between January 1,2021,and December 31,2022 were chosen for this retrospective clinical *** with excellent and fair postoperative hip function had their clinical information and characteristics gathered and ***,gender,fracture site,surgical technique,laboratory indices,and other variables that could have an impact on postoperative joint function were all included in a univariate *** further identify independent risk factors affecting postoperative joint function in hip fractures,risk factors that showed statistical significance in the univariate analysis were then included in a multiple logistic regression *** addition to this,we also compared other outcome variables such as visual analogue scale and length of hospital stay between the two *** A total of 119 elderly patients with hip fractures were included in this study,of whom 37 were male and 82 were *** results of univariate logistic regression analysis after excluding the interaction of various factors showed that there was a statistically significant difference in interleukin(IL)-6,IL-8,IL-10,C-reactive protein(CRP),and complement C1q(C1q)between the fair and excellent joint function groups(P20 pg/mL[Odds ratio(OR)3.070,95%CI:1.243-7.579],IL-8>21.4 pg/mL(OR 3.827,95%CI:1.498-9.773),CRP>10 mg/L(OR 2.142,95%CI:1.

关键词： Hip function Fracture Inflammatory factors Risk factors Prevention

Pyroptosis:A promising biomarker for predicting colorectal cancer prognosis and enhancing immunotherapy efficacy

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World Journal of Clinical Oncology 2024年第8期15卷 968-974页

作者： jia-Yi wang Yu-Hao Lu Fang Li Mo-Li Huang School of Biology and Basic Medical Sciences Medical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina

In this editorial,we comment on the article by Zhu et al published in the recent issue of the World Journal of Clinical *** focus specifically on the characteristics and mechanisms of pyroptosis and the impact of changes in the tumor immune microenvironment(TIME)on cancer *** is a distinct form of programmed cell death;its occurrence can change the TIME and regulate the growth and spread of tumors and therefore is significantly correlated with cancer *** research has demonstrated that pyroptosis-related genes can be used in prognostic models for various types of *** models enhance the mechanistic understanding of tumor evolution and serve as valuable guides for clinical treatment ***,further studies are required to thoroughly understand the function of pyroptosis within the TIME and to assess its mode of *** studies should reveal new tumor therapeutic targets and more successful tumor immunotherapy strategies.

关键词： Pyroptosis Colorectal cancer liver metastases Organoid model Immunotherapy Prognostic biomarker

High-frequency microwave cavity design for high-mass dark matter axion searches

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Chinese Physics B 2024年第5期33卷 87-94页

作者：张驰王佳李春光陈石广程航孙亮吴云 Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China Hefei National Laboratory Hefei 230088China

The haloscope based on the TM_(010)mode cavity is a well-established technique for detecting QCD ***,the method has limitations in detecting high-mass axion due to significant volume loss in the high-frequency *** a higher-order mode cavity can effectively reduce the volume loss of the high-frequency *** rotatable dielectric pieces as a tuning mechanism can compensate for the degradation of the form factor of the higher-order ***,the introduction of dielectric causes additional volume *** address these issues,this paper proposes a novel design scheme by adding a central metal rod to the higher-order mode cavity tuned by dielectrics,which improves the performance of the haloscope due to the increased effective volume of the cavity *** superiority of the novel design is demonstrated by comparing its simulated performance with previous ***,the feasibility of the scheme is verified by the full-wave simulation results of the mechanical design model.

关键词： axion haloscope microwave cavity

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我国增值税改革经验和进一步完善的制度设计

税务研究 2024年第8期 24-29页

作者：杨斌王佳厦门大学经济学院

经过40多年的改革,我国增值税日臻完善,并创立了中国模式,形成了中国经验:在改革战略选择上,遵循不增加纳税人负担原则;在制度设计上,采取增值税专用发票制度,通过销项税额减进项税额的方法计征增值税,同时通过征收率和差额计算方法计... 详细信息

经过40多年的改革,我国增值税日臻完善,并创立了中国模式,形成了中国经验:在改革战略选择上,遵循不增加纳税人负担原则;在制度设计上,采取增值税专用发票制度,通过销项税额减进项税额的方法计征增值税,同时通过征收率和差额计算方法计征增值税,解决了对小规模纳税人的增值税征收问题和对金融业征收增值税的世界性难题;在改革路径上,按照先试点后推广的路径推进。我国未来增值税改革应着力简并税率,优化减免税政策;对于小规模纳税人进项税额难以抵扣问题,应建立进项税额补偿机制;对于农产品免税形成的隐性税负问题,应建立农业生产者农产品进项税额补偿机制和专项退税机制。通过深化增值税改革,完善中国特色的增值税模式,进一步为世界增值税制度的发展贡献中国经验。

关键词：增值税税制改革营改增税率进项税额减免税

铁路及城市轨道交通环境振动影响评价标准分析

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噪声与振动控制 2024年第3期44卷 215-222页

作者：王嘉李莉同济大学铁道与城市轨道交通研究院上海201804 同济大学上海市轨道交通结构耐久与系统安全重点实验室上海201804

铁路及城市轨道交通在便民利民的同时,也对沿线周边环境产生振动影响。轨道交通环境振动影响评价标准是确定振动评价方法、指标和限值的关键,直接关系到振动传播对周边居民的影响。总结近年来轨道交通环境振动相关标准和规范,对轨道交... 详细信息

铁路及城市轨道交通在便民利民的同时,也对沿线周边环境产生振动影响。轨道交通环境振动影响评价标准是确定振动评价方法、指标和限值的关键,直接关系到振动传播对周边居民的影响。总结近年来轨道交通环境振动相关标准和规范,对轨道交通环境振动范畴、振动描述与测量基本参量和振动预测与控制方法进行梳理,提出现行标准中有待修正的内容,以期为治理轨道交通环境振动影响问题提供参考。

关键词：环境振动铁路及城市轨道交通振动标准振动评价振动控制