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Passive activity enhances residual control ability in patients with complete spinal cord injury

Neural Regeneration Research 2025年第8期20卷 2337-2347页

作者： Yanqing Xiao Mingming Gao Zejia He jia Zheng Hongming Bai jia-Sheng rao Guiyun Song Wei Song Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijingChina Department of Rehabilitation Evaluation China Rehabilitation Research CenterBeijingChina Cardiac Center Beijing Children’s HospitalCapital Medical UniversityBeijingChina The State Key Laboratory of Virtual Reality Technology and Systems Beihang UniversityBeijingChina Department of Rehabilitation Engineering China Rehabilitation Science InstituteBeijingChina

Patients with complete spinal cord injury retain the potential for volitional muscle activity in muscles located below the spinal injury ***,because of prolonged inactivity,initial attempts to activate these muscles may not effectively engage any of the remaining neurons in the descending pathway.A previous study unexpectedly found that a brief clinical round of passive activity significantly increased volitional muscle activation,as measured by surface *** this study,we further explored the effect of passive activity on surface electromyographic signals during volitional control tasks among individuals with complete spinal cord *** patients with chronic complete thoracic spinal cord injury were *** electromyography data from eight major leg muscles were acquired and compared before and after the passive activity *** results indicated that the passive activity led to an increased number of activated volitional muscles and an increased frequency of *** the cumulative root mean square of surface electromyography amplitude for volitional control of movement showed a slight increase after passive activity,the difference was not statistically *** findings suggest that brief passive activity may enhance the ability to initiate volitional muscle activity during surface electromyography tasks and underscore the potential of passive activity for improving residual motor control among patients with motor complete spinal cord injury.

关键词： complete spinal cord injury cycle training epidural electrical stimulation motor training passive activity physiological state spinal cord circuit surface electromyography volitional control task

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Machine Learning for Many-Body Localization Transition

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Chinese Physics Letters 2020年第8期37卷 12-18页

作者： Wen-jia rao School of Science Hangzhou Dianzi UniversityHangzhou 310027China

We employ the methods of machine learning to study the many-body localization(MBL)transition in a 1D random spin *** using the raw energy spectrum without pre-processing as training data,it is shown that the MBL transition point is correctly predicted by the *** structure of the neural network reveals the nature of this dynamical phase transition that involves all energy levels,while the bandwidth of the spectrum and nearest level spacing are the two dominant patterns and the latter stands out to classify *** further use a comparative unsupervised learning method,i.e.,principal component analysis,to confirm these results.

关键词： spectrum transition Transition

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中国男男性行为者HIV暴露后预防用药接受意愿相关因素的Meta分析

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现代预防医学 2025年第1期52卷 167-173页

作者：何艳楚鑫李娜娜郑敏瑶饶佳成都中医药大学护理学院成都中医药大学附属医院凉山彝族自治州第一人民医院

目的系统评价中国男男性行为（men who have sex with men, MSM）者HIV暴露后预防用药接受意愿的影响因素。方法在Pub Med、Web of Science、The Cochrane Library、EMbase、中国知网、维普、万方和CBM数据库中，检索2024年9月5日前MS... 详细信息

目的系统评价中国男男性行为（men who have sex with men, MSM）者HIV暴露后预防用药接受意愿的影响因素。方法在Pub Med、Web of Science、The Cochrane Library、EMbase、中国知网、维普、万方和CBM数据库中，检索2024年9月5日前MSM HIV暴露后预防用药接受意愿相关因素的研究，采用Rev Man 5.3软件分别对纳入的影响因素进行meta分析。结果共纳入26篇文献，调查人数31 600例，提取20个影响因素。Meta分析结果显示：年龄≤30岁（OR=1.65,95%CI:1.31～2.07）、月收入5 000～10 000元（OR=1.96,95%CI:1.51～2.55）、月收入>10 000元（OR=1.98,95%CI:1.03～3.80）、HIV阳性性伴侣（OR=2.47,95%CI:1.21～5.05）、多个性伴侣（OR=2.51,95%CI:1.90～3.32）、网约性伴侣（OR=2.03,95%CI:1.55～2.65）、知晓HIV相关知识（OR=2.33,95%CI:1.81～3.00）、知晓暴露后预防（post-exposure prevention,PEP）相关知识（OR=2.17,95%CI:1.33～3.54）、咨询过PEP(OR=26.09,95%CI:5.34～127.41)、使用性毒品（OR=2.01,95%CI:1.18～3.42）、使用安全套（OR=2.10,95%CI:1.66～2.66）、HIV检测≥2次/年（OR=2.33,95%CI:1.80～3.02）、性传播感染（OR=1.93,95%CI:1.52～2.45）、商业性行为（OR=3.21,95%CI:1.95～5.30）、同伴性教育（OR=1.60,95%CI:1.23～2.08）是MSM者HIV暴露后预防用药接受意愿的促进因素；同性恋（OR=0.34,95%CI:0.23～0.49）是其阻碍因素。结论我国MSM者HIV暴露后预防用药接受意愿的影响因素较多且复杂，未来应加强对HIV和PEP相关知识的宣传和推广，降低MSM人群中HIV发病率。

关键词：男男性行为暴露后预防影响因素中国 Meta分析

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电针“丰隆”“足三里”对非酒精性脂肪肝大鼠SIRT1/FOXO1信号通路的影响

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针刺研究 2025年第2期50卷 150-158页

作者：胡馨月罗亚祖芳张华雨甄文桧肖莎莎吴杰饶佳佳杨孝芳张宁贵州中医药大学针灸推拿学院贵州中医药大学第一附属医院

目的：观察电针对非酒精性脂肪肝（NAFLD）大鼠的肝功能、血脂代谢、肝脏病理形态及沉默信息调节因子1(SIRT1)/叉头框蛋白（O1FOXO1）信号通路分子表达的影响，探讨电针治疗NAFLD的潜在机制。方法：将13只SD大鼠作为空白组；43只SD大鼠... 详细信息

目的：观察电针对非酒精性脂肪肝（NAFLD）大鼠的肝功能、血脂代谢、肝脏病理形态及沉默信息调节因子1(SIRT1)/叉头框蛋白（O1FOXO1）信号通路分子表达的影响，探讨电针治疗NAFLD的潜在机制。方法：将13只SD大鼠作为空白组；43只SD大鼠以高脂饲料喂养12周建立NAFLD模型，造模成功后随机分为模型组、电针组、电针+抑制剂组及激动剂组，每组10只。空白组和模型组仅抓取固定；激动剂组腹腔注射SIRT1激动剂白藜芦醇（200 mg/kg）；电针组于“丰隆”和“足三里”进行电针治疗，每次30 min；电针+抑制剂组腹腔注射SIRT1抑制剂EX527(5 mg/kg)，其余治疗同电针组；以上治疗均每周3次，持续4周。干预结束后，比色法检测大鼠血清高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、甘油三酯（TG）含量及谷丙转氨酶（ALT）和谷草转氨酶（AST）活性；苏木精-伊红（HE）和油红O染色观察肝脏病理形态学变化；采用Western blot和实时荧光定量PCR法分别检测大鼠肝组织中SIRT1、FOXO1、ATP结合盒转运体A1(ABCA1)的蛋白与mRNA表达，以及乙酰化（AC）-FOXO1的蛋白表达。结果：与空白组比较，模型组大鼠血清HDL-C含量降低（P<0.05）,LDL-C、TC、TG含量及ALT、AST活性升高（P<0.01,P<0.05）,HE和油红O染色显示肝细胞排列紊乱、脂肪空泡化明显，肝脏SIRT1、FOXO1、ABCA1的蛋白和mRNA表达水平降低（P<0.05,P<0.01）,AC-FOXO1蛋白表达水平升高（P<0.05）。与模型组比较，电针组和激动剂组血清HDL-C含量升高（P<0.05）,LDL-C、TC、TG含量及ALT、AST活性降低（P<0.01,P<0.05）,HE和油红O染色结果显示肝组织形态改善，脂肪变性减轻，肝脏SIRT1、FOXO1、ABCA1的蛋白和mRNA表达水平升高（P<0.05,P<0.01）,AC-FOXO1蛋白表达水平降低（P<0.05）。与电针组比较，电针+抑制剂组血清HDL-C含量降低（P<0.05）,LDL-C、TC、TG含量及ALT、AST活性升高（P<0.01,P<0.05）,HE和油红O染色显示脂肪空泡较多，脂滴沉积明显，肝脏SIRT1、FOXO1、ABCA1蛋白和mRNA表达水平降低（P<0.05,P<0.01）,AC-FOXO1蛋白表达水平升高（P<0.05）。结论：电针可能通过激活SIRT1/FOXO1信号通路促进胆固醇流出减轻NAFLD大鼠的肝脏损伤。

关键词：非酒精性脂肪肝电针沉默信息调节因子1 叉头框蛋白O1

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Strong Convergence by the Shrinking Projection Method for a Generalized Equilibrium Problems and Hemi-Relatively Nonexpansive Mappings

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Journal of Mathematical Research and Exposition 2010年第6期30卷 1099-1107页

作者： Ruo Feng rao jia Lin HUANG Department of Mathematics Yibin UniversitySichuan 644007P.R.China

Motivated by the recent result obtained by Takahashi and Zembayashi in 2008,we prove a strong convergence theorem for finding a common element of the set of solutions of a generalized equilibrium problem and the set of fixed points of a hemi-relatively nonexpansive mapping in a Banach space by using the shrinking projection *** main results obtained in this paper extend some recent results.

关键词： hemi-relatively nonexpansive mapping generalized equilibrium problem α-inversestrongly monotone mapping.

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Imputing DNA Methylation by Transferred Learning Based Neural Network

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Journal of Computer Science & Technology 2022年第2期37卷 320-329页

作者： Xin-Feng Wang Xiang Zhou jia-Hua rao Zhu-Jin Zhang Yue-Dong Yang School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhou 510000China Key Laboratory of Machine Intelligence and Advanced Computing of Ministry of Education(Sun Yat-sen University)Guangzhou 510000 China

DNA methylation is one important epigenetic type to play a vital role in many diseases including *** the development of the high-throughput sequencing technology,there is much progress to disclose the relations of DNA methylation with ***,the analyses of DNA methylation data are challenging due to the missing values caused by the limitations of current *** many methods have been developed to impute the missing values,these methods are mostly based on the correlations between individual samples,and thus are limited for the abnormal samples in *** this study,we present a novel transfer learning based neural network to impute missing DNA methylation data,namely the TDimpute-DNAmeth *** method learns common relations between DNA methylation from pan-cancer samples,and then fine-tunes the learned relations over each specific cancer type for imputing the missing *** on 16 cancer datasets,our method was shown to outperform other commonly-used *** analyses indicated that DNA methylation is related to cancer survival and thus can be used as a biomarker of cancer prognosis.

关键词： neural network transfer learning DNA methylation data imputation survival analysis

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Efficacy of rituximab therapy in children with refractory nephrotic syndrome:a prospective observational study in Shanghai

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World Journal of Pediatrics 2014年第1期10卷 59-63页

作者： Li Sun Hong Xu Qian Shen Qi Cao jia rao Hai-Mei Liu Xiao-Yan Fang Li-Jun Zhou Department of Nephrology and Rheumatology Children's Hospital of Fudan UniversityShanghai 201102China

Background:Idiopathic nephrotic syndrome is the most common glomerular disease in *** study was undertaken to observe the efficacy and side-effects of rituximab(RTX)in treating children with different types of refractory primary nephrotic ***:Twelve patients with steroid dependent nephrotic syndrome(SDNS),frequently relapsing nephritic syndrome(FRNS),and steroid resistant nephrotic syndrome(SRNS)were enrolled in our *** were obvious drug side-effects,and proteinuria remained difficult to *** was administered at a dose of 375 mg/m2 body surface area,once or twice ***:The male to female ratio was 3:1,and the onset age was 1.6–8.9 *** were 9 patients with steroid sensitive nephrotic syndrome(SDNS or FRNS),and 3 patients with *** were 7 patients with minimal change disease(MCD),3 patients with focal segmental glomerular sclerosis(FSGS),1 with focal proliferative glomerulonephritis,and 1 without renal *** total effective treatment rate of RTX was 91.67%,and for 77.78%of the patients,steroid dosage could be *** months before and after RTX infusion,the mean steroid dosage was significantly decreased(P=0.014)and the recurrence number was significantly reduced(P<0.001).The results were better in MCD patients than in FSGS patients(P=0.045).There was no significant difference between FRNS/SDNS and SRNS patients(P=0.175).During RTX administration,3 patients developed skin rashes,1 developed hypotension,and 1 developed a *** patient experienced a persistent decrease in serum immunoglobulin level but without serious ***:RTX was effective in the treatment of refractory nephrotic syndrome,and it could significantly reduce the use of steroid and immunosuppressants.

关键词： refractory nephritic syndrome rituximab

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Maternal diseases and congenital anomalies of the kidney and urinary tract in offspring: a cohort study

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World Journal of Pediatrics 2024年第11期20卷 1168-1178页

作者： Qiang Ma Ya-Qi Li Qing-Tang Meng Bo Yang Hai-Tao Zhang Hua Shi Chang-You Liu Tian-Chao Xiang Na Zhao jia rao Department of Nephrology Tai’an Maternal and Child Health HospitalTai’anChina Department of Nephrology Children’s Hospital of Fudan UniversityNational Children’s Medical Center399 Wanyuan RoadShanghaiChina Department of Obstetrics Tai’an Maternal and Child Health HospitalTai’anChina Department of Color Ultrasound Tai’an Maternal and Child Health HospitalTai’anChina Department of Neonatology Tai’an Maternal and Child Health HospitalTai’anChina Shanghai Kidney Development and Pediatric Kidney Disease Research Center ShanghaiChina Shanghai Key Lab of Birth Defect Children’s Hospital of Fudan UniversityShanghaiChina National Key Laboratory of Kidney Diseases BeijingChina

Background Congenital anomalies of the kidneys and urinary tract(CAKUT)are the most common cause of prenatally diagnosed developmental *** study aimed to assess the relationship between maternal diseases and CAKUT in *** This retrospective study enrolled all pregnant women registered from January 2020 to December 2022 at one medical *** information on maternal noncommunicable diseases,including obesity,hypertension,diabetes mellitus,kidney disease,hyperthyroidism,hypothyroidism,psychiatric disease,epilepsy,cancer,and autoimmune disease was *** on the records of ultrasound scanning during the third trimester,the diagnosis was classified as isolated urinary tract dilation(UTD)or kidney *** logistic regression was performed to establish models to predict antenatal *** Among the 19,656 pregnant women,perinatal ultrasound detected suspicious CAKUT in 114(5.8/1000)fetuses,comprising 89 cases with isolated UTD and 25 cases with kidney *** risk of antenatal CAKUT was increased in the fetuses of mothers who experienced gestational diabetes,thyroid dysfunction,neuropsychiatric disease,anemia,ovarian and uterine disorders.A prediction model for isolated UTD was developed utilizing four confounding factors,namely gestational diabetes,gestational hypertension,maternal thyroid dysfunction,and hepatic ***,a separate prediction model for kidney anomalies was established based on four distinct confounding factors,namely maternal thyroid dysfunction,gestational diabetes,disorders of ovarian/uterine,and kidney *** Isolated UTD and kidney anomalies were associated with different maternal *** results may inform the clinical management of pregnancy and highlight potential differences in the genesis of various subtypes of CAKUT.

关键词： Congenital anomalies of the kidney and urinary tract(CAKUT) Kidney anomalies Predictive model Risk factors Urinary tract dilation(UTD)

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Chronic spinal cord injury repair by NT3-chitosan only occurs after clearance of the lesion scar

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2568-2580页

作者： Can Zhao jia-Sheng rao Hongmei Duan Peng Hao Junkui Shang Yubo Fan Wen Zhao Yudan Gao Zhaoyang Yang Yi Eve Sun Xiaoguang Li Beijing Key Laboratory for Biomaterials and Neural Regeneration Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100083China Institute of Rehabilitation Engineering China Rehabilitation Science InstituteBeijing 100068China Department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Beijing Advanced Innovation Centre for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Chinese Education MinistrySchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 10083China School of Engineering Medicine Beihang UniversityBeijing 10083China Shanghai Institute of Stem Cell Research and Clinical Translation Shanghai East HospitalTongji University School of MedicineShanghai 200120China Department of Psychiatry and Biobehavioral Sciences UCLA Medical SchoolLos AngelesCA 90095USA

Spinal cord injury(SCI)is a severe damage usually leading to limb dysesthesia,motor dysfunction,and other physiological *** have previously shown that NT3-chitosan could trigger an acute SCI repairment in rats and non-human *** to the negative effect of inhibitory molecules in glial scar on axonal regeneration,however,the role of NT3-chitosan in the treatment of chronic SCI remains *** with the fresh wound of acute SCI,how to handle the lesion core and glial scars is a major issue related to chronic-SCI *** we report,in a chronic complete SCI rat model,establishment of magnetic resonancediffusion tensor imaging(MR-DTI)methods to monitor spatial and temporal changes of the lesion area,which matched well with anatomical *** of the lesion core via suction of cystic tissues and trimming of solid scar tissues before introducing NT3-chitosan using either a rigid tubular scaffold or a soft gel form led to robust neural regeneration,which interconnected the severed ascending and descending axons and accompanied with electrophysiological and motor functional *** contrast,cystic tissue extraction without scar trimming followed by NT3-chitosan injection,resulted in little,if any *** together,after lesion core clearance,NT3-chitosan can be used to enable chronic-SCI repair and MR-DTI-based mapping of lesion area and monitoring of ongoing regeneration can potentially be implemented in clinical studies for subacute/chronic-SCI repair.

关键词： scar NT3 wound

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Strong Current-Polarization and Negative Differential Resistance in FeN3-Embedded Armchair Graphene Nanoribbons

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Chinese Journal of Chemical Physics 2018年第6期31卷 756-760,733页

作者： Ying-chao Wu jia-rui rao Xiao-fei Li School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China Chengdu 610054 China

Motivated by the recent advances of transition-metal-nitrogen-carbon (TM-N-C) materials in catalysis, we investigate the electronic structure and transport properties of FeN3-embedded armchair and zigzag graphene nanoribbons (FeN3@AGNRs, FeN3@ZGNRs) with different widths. The first-principles results indicate that the FeN3 induces significant changes on the band structures of both ZGNRs and AGNRs, making the resultant systems quite different from the pristine ones and own room-temperature stable ferromagnetic (FM) ground states. While only FeN3@AGNRs possess a significant spin-dependent negative differential resistance (NDR) and a striking current polarization (nearly 100%) behaviors, due to that FeN3 introduces two isolated spin-down states, which contribute current with different performances when they couple with different frontier orbits. It is suggested that by embedding FeN3 complexes, AGNRs can be used to build spin devices in spintronics.

关键词： Transition-metal-nitrogen-carbon Current polarization Electronic transport Non-equilibrium Green's function

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