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免疫介导的肝炎研究进展

中国医学创新 2024年第13期21卷 168-172页

作者：皮加曹冠柏刘先齐重庆市九龙坡区人民医院外科重庆400050

近年来,以程序性死亡受体1(PD-1)抗体、程序性死亡配体1(PD-L1)抗体和细胞毒性T淋巴细胞相关抗原4(CTLA-4)抗体为代表的免疫检查点抑制剂(ICIs)彻底改变了肿瘤治疗。然而,伴随着涉及多个器官的免疫相关不良反应。肝脏不断暴露于外来抗原... 详细信息

近年来,以程序性死亡受体1(PD-1)抗体、程序性死亡配体1(PD-L1)抗体和细胞毒性T淋巴细胞相关抗原4(CTLA-4)抗体为代表的免疫检查点抑制剂(ICIs)彻底改变了肿瘤治疗。然而,伴随着涉及多个器官的免疫相关不良反应。肝脏不断暴露于外来抗原,已经进化出很高的免疫耐受能力。本文主要综述与免疫介导的肝炎相关的CTLA-4、ICIs、肝脏免疫耐受及免疫介导的肝炎发生机制的研究进展。

关键词：免疫介导的肝炎免疫治疗免疫检查点抑制剂

Psoriasis treatment using minimally manipulated umbilical cordderived mesenchymal stem cells:A case report

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World Journal of Clinical Cases 2021年第23期9卷 6798-6803页

作者： Hyunjun Ahn Sang Yeon Lee Won-Ju Jung jia pi Kye-Ho Lee bio Beauty&Health Company(bBHC)-Stem Cell Treatment and Research Institute(STRI) Seoul 04420South Korea Department of Functional Genomics University of Science and Technology KRIBB SchoolDeajeon 34113South Korea Stem Cell Treatment 97.7 B&H ClinicSeoul 04420South Korea

BACKGROUND Psoriasis is a chronic autoimmune disease that usually manifests as a red scaly epidermis,induration,and hyperproliferation of basal *** 2%of the world’s population suffers from psoriasis but there are no clear therapeutics ***,mesenchymal stem cells(MSCs)have been regarded as a therapeutic alternative for autoimmune diseases,as they possess immunosuppressive effects without *** umbilical cord-derived MSCs effectively regulate immune cells and are characterized by low immunogenicity,which has many advantages in treating immune *** SUMMARY The patient was a 47-year-old male,diagnosed with psoriasis in *** had received various treatments for 25 years,but the psoriatic condition was not significantly *** was given three rounds of minimally manipulated umbilical cord-derived MSCs over 2 *** erythema gradually *** months after the 1st round,all erythema completely disappeared,and the psoriasis did not *** Minimally manipulated umbilical cord-derived MSC transplantation can potentially treat patients who suffer from psoriasis.

关键词： Psoriasis Umbilical cord-derived mesenchymal stem cells Allogenic Cell therapy Minimal manipulation Case report

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地下室外墙单侧支模应用关键技术

建筑技术开发 2024年第10期51卷 26-28页

作者：晏雄皮佳亮邹恩泽李世红刘禹中建二局第三建筑工程有限公司北京100070

现代城市的土地资源稀缺,施工场地狭小成为普遍性问题。地下室的外墙施工质量越来越受到参建单位的重视。在地下外墙结构边线距离基坑围护较小,依照传统方法对外墙进行双面支模并加固施工的情况下,防水在支护后狭窄的半封闭空间下施工... 详细信息

现代城市的土地资源稀缺,施工场地狭小成为普遍性问题。地下室的外墙施工质量越来越受到参建单位的重视。在地下外墙结构边线距离基坑围护较小,依照传统方法对外墙进行双面支模并加固施工的情况下,防水在支护后狭窄的半封闭空间下施工安全风险大且后期的回填土无法做到夯实。回填土下沉会导致防水层破坏,增加了外墙渗漏风险。钢框模板单侧支模体系可节约工期,具有安装简单、成本低、抗渗好等特点。结合单侧支模体系的特殊工况,本研究从技术质量和管理的角度分析了单侧支模管理的关键技术问题,提出施工中易出现的关键问题,进行详细分析,并给出了解决方法。

关键词：单侧支模关键技术地下室外墙

Chiral liquid crystals based on pillararene and supramolecular self-assembly-induced chirality amplification

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Science China Chemistry 2024年第10期67卷 3373-3381页

作者： Bicong Liang Yujie Cheng Xiong Liu Lan jia Xuehong Wei Qiang Zheng pi Wang Danyu Xia Xuzhou Yan College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Scientific Instrument Center Shanxi UniversityTaiyuan 030006China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative MoleculesShanghai Jiao Tong UniversityShanghai 200240China

Macrocyclic liquid crystals combine the unique property of liquid crystals and excellent supramolecular assembly ability of macrocyclic *** is a significant challenge to make rational use of the advantages of macrocyclic compounds to prepare new macrocyclic ***,a type of macrocycles with rigid pillar-shaped frameworks and easy-tofunctionalize property,are excellent building blocks to fabricate liquid crystal ***,the site-selective modification property of pillararene has been rarely exploited to tailor liquid crystal *** reported pillararene-based liquid crystal systems are almost prepared by per-functionalized ***,we report the regulation of chiral liquid crystal behaviors by different derivatization of *** and thermotropic liquid crystals with different chirality were obtained by self-assembly of pillararene with different numbers of cholesterol *** bridge between thermotropic liquid crystal and lyotropic liquid crystal based on pillararene is *** addition,the chirality of the mesogens can be amplified through supramolecular self-assembly driven by noncovalent *** on the different liquid crystal behaviors,the optical signal of the pillararene-based chiral liquid crystals was used to fabricate an information encryption *** work provides a simple strategy to regulate liquid crystal behaviors via pillararene-based mesogens and realizes information encryption through the combination of different types of liquid crystals.

关键词： chiral liquid crystal pillararene self-assembly cholesterol information encryption

马克思主义哲学中国化何以可能——兼论李达传播和研究马克思主义哲学的特点

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武汉大学学报（人文科学版） 2005年第2期58卷 156-160页

作者：皮家胜武汉大学哲学学院湖北武汉430072

回答马克思主义哲学中国化何以可能这一问题,需要从“人类总体精神”这一视角去进行,即从理解与解释何以可能这一视角去进行。同时,也需要总结和概括以往马克思主义者在努力使马克思主义哲学中国化过程中创造的丰富经验,并从中获取有益... 详细信息

回答马克思主义哲学中国化何以可能这一问题,需要从“人类总体精神”这一视角去进行,即从理解与解释何以可能这一视角去进行。同时,也需要总结和概括以往马克思主义者在努力使马克思主义哲学中国化过程中创造的丰富经验,并从中获取有益启示,以使马克思主义哲学中国化得以健康顺利进行下去并取得成效。

关键词：马克思主义哲学中国化解释学

Pharmacokinetic study of ginsenoside Re after vaginal administration in rabbits by UPLC-MS/MS determination

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Chinese Herbal Medicines 2018年第3期10卷 304-309页

作者： Xu Han Ying Zhang jia-xin pi Dereje Kebebe Bing Zhang Shu-ya Wang Bo-ying Liu Jing Ren Zhi-dong Liu Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine Engineering Research Center of Modern Chinese Medicine Discovery and Preparation Technique Ministry of EducationTianjin University of Traditional Chinese Medicine School of Pharmacy Institute of Health SciencesJimma University

Objective: A selective and sensitive ultra performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS) method was employed to study the pharmacokinetics of ginsenoside Re(GRe) in rabbits after vaginal administration of Xiaomi suppository to evaluate the systemic exposure of the suppository for the local ***: Chromatographic separation was on an ACQUITY UPLC?BEH C18 column, and acetonitrile-0.1%formic acid was used as mobile phase in gradient elution. The plasma samples were deproteinized by acetonitrile, and the pharmacokinetic parameters were calculated by Winnonlin ***: Calibration curve of GRe showed a good linearity over the concentration range from 5 ng/mL to500 ng/mL(r = 0.9999). The low limit of quantification of 5 ng/m L could satisfy the experimental requirement. The intra-day and inter-day precision of GRe at three concentrations were less than 1.96%, and the average recoveries of GRe were more than 64.0%. The pharmacokinetic parameters for vaginal administration were as follows: Tm ax, 0.5 h; C max, 20.88 ng/mL; AUC0-t, 64.71 h · ng/mL and the residence time was3.06 h. By using deconvolution calculation method, the cumulative absorption fraction of GRe was about0.89%.Conclusion: The systemic exposure of GRe was minimal after vaginal administration of Xiaomi suppository.

关键词： ginsenoside Re pharmacokinetics vaginal administration Xiaomi suppository

Multi-surrogate framework with an adaptive selection mechanism for production optimization

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Petroleum Science 2024年第1期21卷 366-383页

作者： jia-Lin Wang Li-Ming Zhang Kai Zhang jian Wang jian-ping Zhou Wen-Feng Peng Fa-Liang Yin Chao Zhong Xia Yan pi-Yang Liu Hua-Qing Zhang Yong-Fei Yang Hai Sun School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Qingdao University of Technology Qingdao266580ShandongChina College of Science China University of PetroleumQingdao266580ShandongChina Zepu Oil and Gas Development Department PetroChina Tarim Oilfield CompanyKorla841000XinjiangChina Hainan Branch of CNOOC Ltd Haikou70311HainanChina

Data-driven surrogate models that assist with efficient evolutionary algorithms to find the optimal development scheme have been widely used to solve reservoir production optimization ***,existing research suggests that the effectiveness of a surrogate model can vary depending on the complexity of the design problem.A surrogate model that has demonstrated success in one scenario may not perform as well in *** the absence of prior knowledge,finding a promising surrogate model that performs well for an unknown reservoir is ***,the optimization process often relies on a single evolutionary algorithm,which can yield varying results across different *** address these limitations,this paper introduces a novel approach called the multi-surrogate framework with an adaptive selection mechanism(MSFASM)to tackle production optimization *** consists of two *** the first stage,a reduced-dimensional broad learning system(BLS)is used to adaptively select the evolutionary algorithm with the best performance during the current optimization *** the second stage,the multi-objective algorithm,non-dominated sorting genetic algorithm II(NSGA-II),is used as an optimizer to find a set of Pareto solutions with good performance on multiple surrogate models.A novel optimal point criterion is utilized in this stage to select the Pareto solutions,thereby obtaining the desired development schemes without increasing the computational load of the numerical *** two stages are combined using sequential transfer *** the two most important perspectives of an evolutionary algorithm and a surrogate model,the proposed method improves adaptability to optimization problems of various reservoir *** verify the effectiveness of the proposed method,four 100-dimensional benchmark functions and two reservoir models are tested,and the results are compared with those obtained by six other surrogate-model-based *** res

关键词： Production optimization Multi-surrogate models Multi-evolutionary algorithms Dimension reduction Broad learning system

DNA Methylation Variation Is Identified in Monozygotic Twins Discordant for Congenital Heart Diseases

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Congenital Heart Disease 2024年第2期19卷 247-256页

作者： Shuliang Xia Huikang Tao Shixin Su Xinxin Chen Li Ma jianru Li Bei Gao Xumei Liu Lei pi Jinqing Feng Fengxiang Li jia Li Zhiwei Zhang Guangdong Provincial People’s Hospital Southern Medical UniversityGuangzhou510100China Department of Cardiovascular Surgery Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhou510623China Department of Pediatric Cardiology Guangdong Cardiovascular InstituteGuangdong Provincial Key Laboratory of South China Structural Heart DiseaseGuangzhou510100China Clinical Physiology Laboratory Institute of PediatricsGuangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Key Laboratory of Research in Structural Birth Defect DiseaseGuangzhou510623China Department of Echocardiogram Guangzhou Women and Children’s Medical CenterGuangzhou Medical UniversityGuangdong Provincial Clinical Research Center for Child HealthGuangzhou510623China Department of Pediatrics Washington University School of MedicineSt.LouisMO63130USA Clinical Biological Resource Bank of Guangzhou Women and Children’s Medical Center Guangzhou Medical UniversityGuangzhou510623China

Aims:Multiple genes and environmental factors are known to be involved in congenital heart disease(CHD),but epigenetic variation has received little ***(MZ)twins with CHD provide a unique model for exploring this *** order to investigate the potential role of Deoxyribonucleic Acid(DNA)methyla-tion in CHD pathogenesis,the present study examined DNA methylation variation in MZ twins discordant for CHD,especially ventricular septal defect(VSD).Methods and Results:Using genome-wide DNA methylation profiles,we identified 4004 differentially methylated regions(DMRs)in 18 MZ twin pairs discordant for CHD,and 2826 genes were *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis revealed a list of CHD-associated *** further investigate the role of DNA methylation in VSD,data from 7 pairs of MZ twins with VSD were *** identified 1614 DMRs corresponding to 1443 genes associated with arrhythmogenic right ventricular cardiomyopathy,cyclic guanosine monopho-sphate-protein kinase G(cGMP-PKG)signaling pathway by KEGG analysis,and cell-cell adhesion,calcium ion transmembrane transport by GO analysis.A proportion of DMR-associated genes were involved in calcium signaling *** methylation changes of calcium signaling genes might be related to VSD ***:CHD is associated with differential DNA methylation in MZ *** may be etiologically linked to DNA methylation,and methylation of calcium signaling genes may be involved in the development of VSD.

关键词： Congenital heart disease monozygotic twins methylation modification epigenetics

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马一浮“诗教主仁”美育思想及其现代启示

美育学刊 2022年第3期13卷 24-33页

作者：皮佳佳广州美术学院美育研究中心广东广州510006

马一浮以“诗以感为体”和“此心之能感”为基础提出“诗教主仁”思想,包含了丰富的美学和美育思想,也贯通了中国现代美育理论核心。其一,马一浮“仁”论内涵,是由“心之本体”和“德之全称”共同构成其“仁”论核心;其二,“诗教主仁”... 详细信息

马一浮以“诗以感为体”和“此心之能感”为基础提出“诗教主仁”思想,包含了丰富的美学和美育思想,也贯通了中国现代美育理论核心。其一,马一浮“仁”论内涵,是由“心之本体”和“德之全称”共同构成其“仁”论核心;其二,“诗教主仁”的内涵,是以《诗》为代表的文学艺术通过“感”的方式直接作用人心,使得自心识得仁体,变化气质,复归人的纯粹天性;其三,“诗教主仁”美育思想,具有“释回赠美”之功,打开了现代美育理论通往传统思想渊源的大门。“诗教主仁”既继承了中国传统文学艺术与世界的感通交互方式,又对接了现代美育的感性之思。

关键词：马一浮 “诗教主仁” 美育 “感”