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Teicoplanin combined with conventional vancomycin therapy for the treatment of pulmonary methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis infections

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World Journal of Clinical Cases 2021年第34期9卷 10549-10556页

作者： Wei Wu min liu jia-Jing Geng Mei Wang Laboratory Medicine Bejing Tongren HospitalCapital Medical UniversityBeijing 100176China Department of General Practice The Community Health Services Center in LumenBeijing 100080China

BACKGROUND Vancomycin and teicoplanin are both antibiotics that have significant antimicrobial effects on Gram-positive *** To explore the value of teicoplanin combined with conventional(vancomycin only)anti-infective therapy for the treatment of methicillin-resistant Staphylococcus aureus and Staphylococcus epidermidis pulmonary *** A total of 86 patients with methicillin-resistant Staphylococcus aureus or methicillin-resistant Staphylococcus epidermidis pulmonary infections,treated in our hospital between January 2018 and February 2020,were assigned to the study and control groups using a random number table method,with 43 patients in each *** control group received conventional treatment(vancomycin),and the study group received both teicoplanin and conventional *** following indicators were assessed in both groups:the time required for symptom relief,treatment effectiveness,serum levels of inflammatory factors(procalcitonin,interleukin-1β,tumor necrosis factor-α,C-reactive protein),clinical pulmonary infection scores before and after treatment,and the incidence of adverse *** Patients in the study group were observed to have faster cough and expectoration resolution,white blood cell count normalization,body temperature normalization,and rales disappearance than patients in the control group(all P<0.05);the total rate of effectiveness was 93.02%in the study group,higher than the 76.74%in the control group(P<0.05).The pre-treatment serum levels of procalcitonin,interleukin-1β,tumor necrosis factor-α,and C-reactive protein as well as the clinical pulmonary infection scores were similar among the patients in both ***,the post-treatment serum levels of procalcitonin,interleukin-1β,tumor necrosis factor-α,and C-reactive protein as well as the clinical pulmonary infection scores were significantly lower in the study group than in the control group(P<0.05).There was no significant difference in the incidence o

关键词： Vancomycin Teicoplanin Methicillin-resistant Staphylococcus aureus Methicillin-resistant Staphylococcus epidermidis Lung infection

Electrical Characteristics of Metal Contacts to Boron Doped Polycrystalline Semiconducting Diamond Thin Films

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Chinese Physics Letters 1996年第7期13卷 541-544页

作者： liu Xing-zhao YANG Bang-chao jia Yu-min LI Yan-rong University of Electronic Science and Technology of China Chengdu 610054

Low resistance ohmic contacts have been fabricated on chemical vapor deposition grown polycrystalline B doped semiconducting diamond thin films by thermally activated solid state reaction process.A bilayer metallization of Ti/Au was *** annealing at 820℃ for 10min in Ar atmosphere,the specific contact resistance of 2 × 10^(-4)Ω.cm2 has been *** properties of the diamond/Ti interfaces have been characterized by using x-rays diffraction and scanning electron *** performance of semiconducting diamond thin film thermistors has been reported.

关键词： resistance process Diamond

Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3287-3301页

作者： Ziwei Fan Mengxian jia jian Zhou Zhoule Zhu Yumin Wu Xiaowu Lin Yiming Qian jiashu Lian Xin Hua jianhong Dong Zheyu Fang Yuqing liu Sibing Chen Xiumin Xue Juanqing Yue minyu Zhu Ying Wang Zhihui Huang Honglin Teng Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Neurology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalSchool of MedicineWestlake UniversityHangzhouZhejiang ProvinceChina

The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord *** of shifting microglia polarization from M1(neurotoxic and proinflammatory type)to M2(neuroprotective and anti-inflammatory type)after spinal cord injury appears to be *** possesses an anti-inflammatory biological ***,its roles and the underlying molecular mechanisms in spinal cord injury remain *** this study,we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in *** promoted M2 polarization through inactivating the cGAS/STING/NF-κB ***,we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury,inhibited neuronal loss,and promoted tissue repair and functional recovery in a mouse model of spinal cord ***,using a conditional co-culture system,we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal *** together,these results suggest that by targeting the cGAS/STING/NF-κB axis,tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype.

关键词： cGAS/STING functional recovery microglia neuroinflammation neuroprotection nuclear factor-κB polarization spinal cord injury tryptanthrin

Heparanase expression,degradation of basement membrane and low degree of infi ltration by immunocytes correlate with invasion and progression of human gastric cancer

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World Journal of Gastroenterology 2008年第24期14卷 3812-3818页

作者： Zun-jiang Xie Ying liu Li-min jia Ye-Chun He Departmentof Anatomy Harbin Medical University Harbin 150081Heilongjiang Province China

AIM： To disclose the mechanisms that accelerate or limit tumor invasion and metastasis in gastric cancer patients. METHODS： The heparanase expression, continuity of basement, degree of infiltration by dendritic cells and lymphocytes in gastric cancer tissues from 33 the early and late stage patients were examined by immunohistochemistry, in situ hybridization and transmission electron microscopy. RESULTS： Heparanase mRNA expression in the late stage patients with gastric cancer was stronger than that in the early stage gastric cancer patients. In the early stage gastric cancer tissues, basement membrane （BM） appeared intact, whereas in the late stage, discontinuous BM was often present. The density of Sl00 protein positive tumor infiltrating dendritic cells （TIDC） in the early stage gastric cancer tissues was higher than that in the late stage. The infiltrating degree of tumor infiltrating lymphocytes （TIL） in the early stage patients whose tumor tissues contained a high density of TIDC was significantly higher than that in the late stage gastric cancer tissues patients with a low density of TIDC. There were few cancer cells penetrated through the continuous BM of cancer nests in the early stage gastric cancers, but many cancer cells were found outside of the defective BM of cancer nests in the late stage. CONCLUSION： Our results suggest that strongheparanase expression is related with the degradation of BM which allows or accelerates tumor invasion and metastasis. However, high density of TIDC and degree of infiltration by TIL are associated with tumor progression in human gastric cancers.

关键词： Heparanase Basement membrane Tumorinfiltrating dendritic cell Tumor infiltrating lymphocyte Gastric cancer

Spreading Speeds of Time-Dependent Partially Degenerate Reaction-Diffusion Systems

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Chinese Annals of Mathematics,Series B 2022年第1期43卷 79-94页

作者： jia liu School of Science Chang'an UniversityXi'an 710064China

This paper is concerned with the spreading speeds of time dependent partially degenerate reaction-diffusion systems with monostable *** using the principal Lyapunov exponent theory,the author first proves the existence,uniqueness and stability of spatially homogeneous entire positive solution for time dependent partially degenerate reaction-diffusion *** the author shows that such system has a finite spreading speed interval in any direction and there is a spreading speed for the partially degenerate system under certain *** author also applies these results to a time dependent partially degenerate epidemic model.

关键词： Partially degenerate Reaction-diffusion system Time dependent Spreading speed

Retromer-Mediated Protein Sorting and Vesicular Trafficking

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Journal of Genetics and Genomics 2016年第4期43卷 165-177页

作者： jia-jia liu State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyChinese Academy of Sciences CAS Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences

Retromer is an evolutionarily conserved multimeric protein complex that mediates intracellular transport of various vesicular cargoes and functions in a wide variety of cellular processes including polarized trafficking,developmental signaling and lysosome *** its interaction with the Rab GTPases and their effectors,membrane lipids,molecular motors,the endocytic machinery and actin nucleation promoting factors,retromer regulates sorting and trafficking of transmembrane proteins from endosomes to the trans-Golgi network（TGN） and the plasma *** this review.I highlight recent progress in the understanding of relromer-medialed protein sorting and vesicle trafficking and discuss how retromer contributes to a diverse set of developmental,physiological and pathological processes.

关键词： Retromer Sorting nexin Endosome Protein sorting and trafficking Neurodegeneration

Catalytic performance improvement of volatile organic compounds oxidation over MnO_(x) and GdMnO_(3) composite oxides from spent lithium-ion batteries:Effect of acid treatment

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Chinese Journal of Chemical Engineering 2021年第6期34卷 278-288页

作者： mingming Guo Lizhong liu jia-nan Gu Hongbo Zhang Xin min jianxing Liang Jinping jia Kan Li Tonghua Sun School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China School of Chemistry and Chemical Engineering Nantong UniversityNantong 226019China School of Chemical and Environmental Engineering Shanghai Institute of TechnologyShanghai 201418China Shanghai Institute of Pollution Control and Ecology Security Shanghai 200092China Shanghai Engineering Research Center of SolidWaste Treatment and Resource Recovery Shanghai 200240China

In this work,cathode materials of spent lithium-ion ternary batteries are recovered and used as metal precursor to prepare multi-metal oxides MnO_(x)(SY)and GdMnO_(3)(SY)via combustion method and sol-gel method,***,a series of MnO_(x)(SY)-n and GdMnO_(3)(SY)-n(n=0.05,0.10,1.00,4.00,n represents the dilute HNO_(3) concentration)catalysts are fabricated by acid treatment of MnO_(x)(SY)and GdMnO_(3)(SY)samples and catalytic activities of oxygenated VOCs oxidation over all the prepared catalysts are *** evaluation results show that acid-treated MnO_(x)(SY)-0.10 and GdMnO_(3)(SY)-0.05 samples perform the optimum VOCs removal efficiency respectively,which may be attributed to their obvious enhancement of physicochemical *** detail,Mn O_(x)(SY)-0.10 and GdMnO_(3)(SY)-0.05 samples exhibit the larger specific surface area,bigger amount of surface high-valence metal ions(Mn^(4+),Co^(3+),Ni^(3+)),more abundant adsorbed oxygen species and better low-temperature reducibility,which can play a crucial role in the significant improvement of VOCs *** situ DRIFTS results imply that the possible main intermediates are-OCO,-COO and-C-O species produced during VOCs *** by-products are further determined via TD/GC-MS analysis.

关键词： Spent lithium-ions batteries Acid treatment Multi manganese-based oxides and perovskite VOCs oxidation

Multi-dimensional classification via stacked dependency exploitation

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Science China(Information Sciences) 2020年第12期63卷 104-117页

作者： Bin-Bin jia min-Ling ZHANG School of Computer Science and Engineering Southeast University College of Electrical and Information Engineering Lanzhou University of Technology Key Laboratory of Computer Network and Information Integration (Southeast University) Ministry of EducationChina Collaborative Innovation Center of Wireless Communications Technology

Multi-dimensional classification(MDC) aims to build classification models for multiple heterogenous class spaces simultaneously, where each class space characterizes the semantics of an object w.r.t. one specific dimension. Modeling dependencies among class spaces plays a key role in solving MDC tasks, where most approaches work by assuming directed acyclic graph(DAG) structure or random chaining structure over class spaces. Different from existing probabilistic strategies, a deterministic strategy named Seem for dependency modeling is proposed in this paper via stacked dependency exploitation. In the first-level, pairwise dependencies are considered which can be modeled more reliably than modeling full dependencies among all class spaces by DAG or chaining structure. In the second-level, the class label of unseen instance *** class space is determined by adaptively stacking predictive outputs from first-level pairwise *** results show that stacked dependency exploitation leads to superior performance against stateof-the-art MDC approaches.

关键词： machine learning multi-dimensional classification class dependencies deterministic strategy stacked dependency exploitation

“Light” of the spinach major light-harvester structure

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Protein & Cell 2010年第2期1卷 115-116页

作者： min-Ze jia Institute of Biophysics Chinese Academy of SciencesBeijing 100101China

In 2004,Wenrui Chang and his colleagues determined for the first time the atomic structure of the spinach major lightharvesting complex of photosystem II(LHC-II)and published their results in the journal Nature as a full article(liu et al.,2004).A figure showing the structural model of spinach major LHC-II in a sophisticated and elegant assembly of icosahedral proteoliposome was selected for the cover of that issue of Nature(Fig.1).Publication of this article immediately drew great attentions from related academe,both domestic and overseas.

关键词： spinach structure journal