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Signal Transduction and Targeted Therapy 2024年第4期9卷 1625-1636页

作者： Qing zhang Mengen Xing Zhengkai Bao Lu xu Yang Bai Wanqi Chen Wenhao Pan Fang Cai Qunxian Wang Shipeng Guo Jing zhang Zhe Wang Yili Wu Yun zhang jia-Da li Weihong Song Oujiang Laboratory(zhejiang Lab for Regenerative Medicine Vision and Brain Health)Zhejiang Key Laboratory of Alzheimer's DiseaseZhejiang Provincial Clinical Research Center for Mental DisordersSchool of Mental Health and Wenzhou Kangning HospitalThe Second Affiliated Hospital and Yuying Children's HospitalInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang 325035China Townsend Family Laboratories Department of PsychiatryBrain Research CenterThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Chongqing Key Laboratory of Translational medical Research in Cognitive Development and Learning and Memory Disorders Ministry of Education Key Laboratory of Child Development and DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Center for medical Genetics Hunan Key Laboratory of Animal Models for Human DiseasesHunan Key Laboratory of Medical GeneticsHunan International Scientific and Technological Cooperation Base of Animal Models for Human DiseasesSchool of Life SciencesCentral South UniversityChangsha 410078 HunanChina The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijing 100053Chin

Mutations in the Contactin-associated protein-like 2(CNTNAP2)gene are associated with autism spectrum disorder(ASD),and ectodomain shedding of the CNTNAP2 protein plays a role in its ***,key enzymes involved in the C-terminal cleavage of CNTNAP2 remain largely unknown,and the effect of ASD-associated mutations on this process and its role in ASD pathogenesis remain *** this report we showed that CNTNAP2 undergoes sequential cleavages by furin,ADAM10/17-dependent a-secretase and presenilindependent *** identified that the cleavage sites of ADAM10 and ADAM17 in CNTNAP2 locate at its C-terminal residue I79 and L96,and the main a-cleavage product C79 by ADAM10 is required for the subsequent y-secretase cleavage to generate CNTNAP2 intracellular domain(CICD).ASD-associated CNTNAP2 mutations impair the a-cleavage to generate C79,and the inhibition leads to ASDIlike repetitive and social behavior abnormalties in the Cntnap2l1254T knock-in ***,exogenous expression of 79 improves autism-ike phenotypes in the Cntnap2^(11254T) knock-in and Cntnap2^(-/-)knockout *** data demonstrates that the a-secretase is essential for CNTNAP2 processing and its *** study indicates that inhibition of the cleavage by pathogenic mutations underlies ASD pathogenesis,and upregulation of its C-terminal fragments could have therapeutical potentials for ASD treatment.

关键词： NAP2 cleavage subsequent

Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

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World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-li zhang Xi zhang Wang Hua Zheng-De Xie Han-Min liu Hai-lin zhang Bi-Quan Chen Yuan Chen Xin Sun Yi xu Sai-Nan Shu Shun-Ying Zhao Yun-Xiao Shang ling Cao Yan-Hui jia Luo-Na lin Jiong li Chuang-li Hao Xiao-Yan Dong Dao-Jiong lin Hong-Mei xu De-Yu Zhao Mei Zeng Zhi-Min Chen li-Su Huang department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina department of Clinical Epidemiology Aarhus UniversityAarhusDenmark department of Respirology Children's Hospital of Soochow UniversitySuzhouChina department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

Current Mycoplasma pneumoniae epidemic among children in Shanghai:unusual pneumonia caused by usual pathogen

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World Journal of Pediatrics 2024年第1期20卷 5-10页

作者： Xiao-Bo zhang Wen He Yong-Hao Gui Quan Lu Yong Yin jian-Hua zhang Xiao-Yan Dong Ying-Wen Wang Ying-Zi Ye Hong xu jia-Yu Wang Bing Shen Dan-Ping Gu li-Bo Wang Yi Wang department of Respiratory Medicine Children's Hospital of Fudan University399 Wanyuan RoadShanghai 201102China State Key Laboratory of Genetic Engineering at School of life Sciences Institute of Reproduction&DevelopmentChildren's Hospital of Fudan UniversityShanghaiChina department of Respiratory Medicine Children's Hospital of Shanghai Jiao Tong UniversityShanghaiChina department of Respiratory Medicine Shanghai Children's Medical CenterAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina department of Pediatric Respiratory Xinhua HospitalAffiliated to Shanghai Jiaotong University School of MedicineShanghaiChina department of Nursing Children's Hospital of Fudan UniversityShanghaiChina department of Infectious Diseases Children's Hospital of Fudan UniversityShanghaiChina department of Nephrology Children's Hospital of Fudan UniversityShanghaiChina NHC Key Laboratory of Neonatal Diseases Children's Hospital of Fudan UniversityShanghaiChina Shanghai Shenkang hospital Development Center ShanghaiChina Center for medical Quality Control Management of Shanghai ShanghaiChina department of neurology Children's Hospital of Fudan University399Wanyuan RoadShanghai 201102China

Mycoplasma pneumoniae(***),primarily transmitted through respiratory droplets when infected individuals cough or sneeze,is a common cause of communityacquired pneumonia,especially among school-age children and *** infection occurs endemically with an epidemic peak every few *** worldwide incidence confirmed by direct test methods was reported to be 8.61%between 2017 and 2020 across all age groups[1].

关键词： pneumonia epidemic respiratory

Association of serum interleukin-6 with negative symptoms in stable early-onset schizophrenia

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World Journal of Psychiatry 2024年第6期14卷 794-803页

作者： Peng Chen Hai-Dong Yang Jun-Jie Wang Zhen-Hua Zhu Hui-Min Zhao xu-Yuan Yin Yuan Cai Hong-liangZhu jia-lin Fu Xin-Zhu zhang Wen-Xi Sun li Hui Xiao-Bin zhang Suzhou medical college of Soochow University Suzhou 215123Jiangsu ProvinceChina department of Psychiatry Suzhou Psychiatric HospitalInstitute of Mental HealthThe Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina department of Psychiatry The Fourth People’s Hospital of LianyungangThe Affiliated Kangda College of Nanjing Medical UniversityLianyungang 222003Jiangsu ProvinceChina Research Center of Biological Psychiatry Suzhou Psychiatric HospitalInstitute of Mental HealthThe Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina department of neurology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou Municipal HospitalGusu SchoolNanjing Medical UniversitySuzhou 215002Jiangsu ProvinceChina

BACKGROUND Accumulating evidence suggests that the inflammatory cytokine interleukin-6(IL-6)contributes to the pathophysiology of psychiatric ***,there was no study concerning the relationship between IL-6 concentrations and clinical features in the chronic phase of early-onset schizophrenia(EOS).AIM To investigate the relationship between serum IL-6 concentration and the clinical features of *** We measured serum IL-6 Levels from 74 patients with chronic schizophrenia,including 33 with age at onset0.05)after controlling for age,body mass index,and other *** symptom scores were higher in the EOS group than the AOS group(F=6.199,P=0.015).Serum IL-6 concentrations in the EOS group were negatively correlated with both total PANSS-negative symptom score(r=-0.389,P=0.032)and avolition/asociality subscore(r=-0.387,P=0.026).CONCLUSION Patients with EOS may have more severe negative symptoms than those with adult-onset schizophrenia during the chronic phase of the ***-6 signaling may regulate negative symptoms and its avolition/asociality subsymptoms among the early-onset chronic schizophrenic patients.

关键词： Early-onset schizophrenia Interleukin 6 Negative symptoms Avolition Asociality

Primary acinic cell carcinoma of the breast: A case report and review of literature

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World Journal of Clinical Cases 2024年第1期12卷 196-203页

作者： jia-Sheng Ding Min zhang Fang-Fang Zhou department of Intensive Care Unit Lishui Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina department of Pathology Lishui Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina department of Ultrasound Lishui Central HospitalThe Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000Zhejiang ProvinceChina

BACKGROUND In the current World Health Organization classification,acinic cell carcinoma(AcCC)of the breast is considered a rare histological subtype of triple-negative breast *** of the few reports in the literature,data concerning clinical outcomes are ***,we report a case of AcCC of the breast in a 48-year-old woman.A 48-year-old woman with a mass in her right breast came to our hospital for further *** and an ultrasound(US)scan showed a mass in the upper inner side of the right *** then underwent surgery to resect the mass in her right *** pathological examination revealed that the tumor had abundant acinar-like structures formed by tumor cells with prominent eosinophilic granules in the cytoplasm,consistent with acinar cell *** results of immunohistochemical analysis supported the diagnosis of breast acinar cell *** months later,she underwent breast-conserving surgery and sentinel lymph node *** pTNM stage was *** surgery,the patient received 30 radiotherapy *** patient was followed up for a period of one year,and no recurrence was *** of the breast is a rare type of malignant *** it is usually asym-ptomatic and can be detected by imaging studies,routine breast US or mamm-ograms are ***,there are no characteristic diagnostic imaging findings or clinical manifestations,so immunohistochemical examination is critical for an accurate diagnosis of AcCC of the breast.

关键词： Acinic cell carcinoma Breast Malignant tumor Immunohistochemical Surgery Case report

Non-contact wide-field viewing system-assisted scleral buckling surgery for retinal detachment in silicone oilfilled eyes

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 761-766页

作者： Su-Lan Wu Yi-Qi Chen li-Jun Shen jian-Bo Mao li lin Ji-Wei Tao Huan Chen Shi-An zhang jia-Feng Yu Chen-Xi Wang Center for Rehabilitation Medicine Department of OphthalmologyZhejiang Provincial People’s HospitalAffiliated People’s HospitalHangzhou Medical CollegeHangzhou 310000Zhejiang ProvinceChina The affiliated Eye hospital of wenzhou medical University in Hangzhou Hangzhou 310000Zhejiang ProvinceChina

AIM:To evaluate scleral buckling(SB)surgery using a noncontact wide-field viewing system and 23-gauge intraocular illumination for the treatment of rhegmatogenous retinal detachment in silicone oil(SO)-filled ***:Totally 9 patients(9 eyes)with retinal detachment in SO-filled eyes were retrospectively *** patients underwent non-contact wide-field viewing system-assisted buckling surgery with 23-gauge intraocular *** was removed at an appropriate time based on *** patients were followed up for at least 3mo after SO *** reattachment,complications,visual acuity and intraocular pressure(IOP)before and after surgery were ***:Patients were followed up for a mean of 8.22mo(3-22mo)after SO *** patients had retinal *** the final follow-up,visual acuity showed improvement for 8 patients,and no change for 1 *** IOP was high in 3 patients before surgery,but it stabilized after treatment;it was not affected in the other *** of the patients had infections,hemorrhage,anterior ischemia,or any other ***:This new non-contact wide-field viewing system-assisted SB surgery with 23-gauge intraocular illumination is effective and safe for retinal detachment in SO-filled eyes.

关键词： non-contact wide-field viewing system scleral buckling silicone oil-filled retinal detachment

Machine learning identifies the risk of complications after laparoscopic radical gastrectomy for gastric cancer

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World Journal of Gastroenterology 2024年第1期30卷 79-90页

作者： Qing-Qi Hong Su Yan Yong-liang Zhao lin Fan li Yang Wen-Bin zhang Hao liu He-Xin lin jian zhang Zhi-jian Ye Xian Shen li-Sheng Cai Guo-Wei zhang jia-Ming Zhu Gang Ji Jin-Ping Chen Wei Wang Zheng-Rong li Jing-Tao Zhu Guo-Xin li Jun You department of Gastrointestinal Oncology Surgery The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen 361001Fujian ProvinceChina department of Gastrointestinal Surgery Qinghai University Affiliated HospitalXining 810000Qinghai ProvinceChina department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery The First Hospital Affiliated to Army Medical UniversityChongqing 400038China department of General Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina department of General Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina department of Gastrointestinal Surgery The First Affiliated Hospital of Xinjiang Medical UniversityUrmuqi 830054Xinjiang Uygur Autonomous RegionChina department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina department of Gastrointestinal Surgery Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamen 361004Fujian ProvinceChina department of Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina department of General Surgery Unit 4 Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhou 363000Fujian ProvinceChina department of Gastrointestinal Surgery The Second Affiliated Hospital of Xiamen Medical CollegeXiamen 361021Fujian ProvinceChina department of Gastrointestinal Nutrition and Hernia Surgery The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina department of Digestive Diseases Xijing HospitalAir Force Military Medical UniversityXi'an 710032Shaanxi ProvinceChina department of Gastrointestinal Surgery Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362002Fujian Provin

BACKGROUND Laparoscopic radical gastrectomy is widely used,and perioperative complications have become a highly concerned *** To develop a predictive model for complications in laparoscopic radical gastrectomy for gastric cancer to better predict the likelihood of complications in gastric cancer patients within 30 days after surgery,guide perioperative treatment strategies for gastric cancer patients,and prevent serious *** In total,998 patients who underwent laparoscopic radical gastrectomy for gastric cancer at 16 Chinese medical centers were included in the training group for the complication model,and 398 patients were included in the validation *** clinicopathological data and 30-d postoperative complications of gastric cancer patients were *** machine learning methods,lasso regression,random forest,and artificial neural networks,were used to construct postoperative complication prediction models for laparoscopic distal gastrectomy and laparoscopic total gastrectomy,and their prediction efficacy and accuracy were *** The constructed complication model,particularly the random forest model,could better predict serious complications in gastric cancer patients undergoing laparoscopic radical *** exhibited stable performance in external validation and is worthy of further promotion in more *** Using the risk factors identified in multicenter datasets,highly sensitive risk prediction models for complications following laparoscopic radical gastrectomy were *** hope to facilitate the diagnosis and treatment of preoperative and postoperative decision-making by using these models.

关键词： Gastric cancer Laparoscopic radical gastrectomy Postoperative complications Laparoscopic total gastrectomy

Efficacy and safety of Tianqi Pingchan Granule,a compound Chinese herbal medicine,for levodopa-induced dyskinesia in Parkinson’s disease:A randomized double-blind placebo-controlled trial

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Journal of Integrative Medicine 2024年第5期22卷 545-551页

作者： Yu zhang Xiao-bo Zhu Yang Zhao Gui-yun Cui Wen-tao li Can-xing Yuan jian-ping Huang Ying Wan Na Wu Lu Song jia-hao Zhao Yan liang Chuan-ying xu Mei-juan liu Chen Gao Xin-xin Chen Zhen-guo liu department of neurology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China department of neurology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing 210022Jiangsu ProvinceChina Parkinson’s Disease Center the Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina department of neurology Shanghai Municipal Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200071China department of neurology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai 200032China department of neurology Wenzhou Central HospitalWenzhou 325000Zhejiang ProvinceChina

Background Patients with Parkinson’s disease(PD)undergoing long-term levodopa therapy are prone to develop levodopa-induced dyskinesia(liD).Amantadine is the main drug recommended for the treatment of liD by current guidelines,but it is far from meeting clinical *** Pingchan Granule(TPG),a compound Chinese herbal medicine,has been developed to relieve symptom of *** This randomized controlled trial evaluated the efficacy and safety of the combination of TPG and amantadine for ***,setting,participants and interventions This is a randomized double-blind placebo-controlled trial,conducted from January 2020 to August 2021 at 6 sites in jiangsu,zhejiang and Shanghai,*** hundred PD patients with≥0.5 h of liD were randomly assigned to either the TPG plus amantadine group(TPG group)or the placebo plus amantadine group(placebo group),and treated for a period of 12 *** ensure unbiased results,all study participants,investigators and sponsors were unaware of group ***,the data analysts remained blinded until the analysis was *** outcome measures The primary outcome was assessed using the Unified Dyskinesia Rating Scale(UDysRS)(Range 0–104).The key secondary end point was improvement of motor and non-motor *** analyses included all enrolled *** One hundred patients were enrolled and randomized into the two treatment *** changes in UDysRS at week 12 were–11.02 for the TPG group and–4.19 for the placebo group(treatment difference–6.83[–10.53 to–3.12];P=0.0004).Adverse events were reported for 2 of 50 patients(4.0%)in each of the *** This study indicated that a 12-week treatment of amantadine plus TPG effectively reduced UDysRS scores and was well tolerated,demonstrating the efficacy and safety of TPG for the treatment of liD in PD.

关键词： Parkinson’s disease Tianqi Pingchan Granule Levodopa-induced dyskinesia

Senktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer’s disease mice

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Protein & Cell 2024年第4期15卷 261-284页

作者： He-Zhou Huang Wen-Qing Ai Na Wei ling-Shuang Zhu Zhi-Qiang liu Chao-Wen Zhou Man-Fei Deng Wen-Tao zhang jia-Chen zhang Chun-Qing Yang Ya-Zhuo Hu Zhi-Tao Han Hong-Hong zhang jian-Jun jia Jing Wang Fang-Fang liu Ke li Qi xu Mei Yuan Hengye Man Ziyuan Guo Youming Lu Kai Shu ling-Qiang Zhu Dan liu department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of medical Genetics School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of Pathology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450002China department of Pathology School of Basic MedicineZhengzhou UniversityZhengzhou 450002China The Second affiliated hospital Department of NeurologyHengyang Medical SchoolUniversity of South ChinaHengyang 421001China Beijing Key Laboratory of Aging and Geriatrics National Clinical Research Center for Geriatric DiseaseInstitute of GeriatricsChinese PLA General Hospital and Chinese PLA Medical AcademyBeijing 100853China department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China department of neurology Union HospitalHuazhong University of Science and TechnologyWuhan 430022China department of Biology Boston UniversityBostonMA 02215USA Center for Stem Cell and Organoid Medicine(CuSTOM) Division of Developmental BiologyCincinnati Children’s Hospital Medical CenterCincinnatiOH 45229USA

Sporadic or late-onset Alzheimer’s disease(LOAD)accounts for more than 95%of Alzheimer’s disease(AD)cases without any family *** genome-wide association studies have identified associated risk genes and loci for LOAD,numerous studies suggest that many adverse environmental factors,such as social isolation,are associated with an increased risk of ***,the underlying mechanisms of social isolation in AD progression remain *** the current study,we found that 7 days of social isolation could trigger pattern separation impairments and presynaptic abnormalities of the mossy fibre-CA3 circuit in AD *** also revealed that social isolation disrupted histone acetylation and resulted in the downregulation of 2 dentate gyrus(DG)-enriched miRNAs,which simultaneously target reticulon 3(RTN3),an endoplasmic reticulum protein that aggregates in presynaptic regions to disturb the formation of functional mossy fibre boutons(MFBs)by recruiting multiple mitochondrial and vesicle-related ***,the aggregation of RTN3 also recruits the PP2A B subunits to suppress PP2A activity and induce tau hyperphosphorylation,which,in turn,further elevates RTN3 and forms a vicious ***,using an artificial intelligence-assisted molecular docking approach,we determined that senktide,a selective agonist of neurokinin3 receptors(NK3R),could reduce the binding of RTN3 with its ***,application of senktide in vivo effectively restored DG circuit disorders in socially isolated AD *** together,our findings not only demonstrate the epigenetic regulatory mechanism underlying mossy fibre synaptic disorders orchestrated by social isolation and tau pathology but also reveal a novel potential therapeutic strategy for AD.

关键词： Alzheimer’s disease memory impairment synaptic disorder tau pathology