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A prognostic four-gene signature and a therapeutic strategy for hepatocellular carcinoma:Construction and analysis of a circRNA-mediated competing endogenous RNA network

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 272-287页

作者： Hai-Yan Zhang jia-jie Zhu Zong-Ming Liu Yu-Xuan Zhang jia-jia Chen Ke-Da Chen Zhejiang Chinese Medical University Hangzhou 310053China Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310015China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Background:Hepatocellular carcinoma(HCC)has a poor long-term *** competition of circular RNAs(circRNAs)with endogenous RNA is a novel tool for predicting HCC *** on the alterations of circRNA regulatory networks,the analysis of gene modules related to HCC is ***:Multiple expression datasets and RNA element targeting prediction tools were used to construct a circRNA-microRNA-mRNA network in *** function,pathway,and protein interaction analyses were performed for the differentially expressed genes(DEGs)in this regulatory *** the proteinprotein interaction network,hub genes were identified and subjected to regression analysis,producing an optimized four-gene signature for prognostic risk stratification in HCC ***-HCC drugs were excavated by assessing the DEGs between the low-and high-risk groups.A circRNA-microRNA-hub gene subnetwork was constructed,in which three hallmark genes,KIF4A,CCNA2,and PBK,were subjected to functional enrichment ***:A four-gene signature(KIF4A,CCNA2,PBK,and ZWINT)that effectively estimated the overall survival and aided in prognostic risk assessment in the The Cancer Genome Atlas(TCGA)cohort and International Cancer Genome Consortium(ICGC)cohort was *** inhibitors,PI3K inhibitors,HDAC inhibitors,and EGFR inhibitors were predicted as four potential mechanisms of drug action(MOA)in high-risk HCC *** analysis has revealed that PBK,CCNA2,and KIF4A play a crucial role in regulating the tumor microenvironment by promoting immune cell invasion,regulating microsatellite instability(MSI),and exerting an impact on HCC ***:The present study highlights the role of the circRNA-related regulatory network,identifies a four-gene prognostic signature and biomarkers,and further identifies novel therapy for HCC.

关键词： Hepatocellular carcinoma circRNA-related ceRNA network Biomarker Least absolute shrinkage and selection operator Bioinformatics

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Moving doubly heavy baryon in a strongly coupled plasma via holography

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Chinese Physics C 2024年第8期48卷 42-55页

作者： Xuan Liu jia-jie jiang Xun Chen Mitsutoshi Fujita Akira Watanabe School of Nuclear Science and Technology University of South ChinaHengyang 421001China School of Mathematics and Physics University of South ChinaHengyang 421001China

Gauge/gravity duality is used to study the properties of the doubly heavy baryon(QQq)at finite rapidity and temperature in heavy-ion *** investigate the impact of rapidity on string breaking and screening of QQq and compare these effects with the results for QQ¯in *** reveal that the string-breaking distances of QQq and QQ¯are close in the confined state,and the effects of rapidity and temperature on the string breaking are not *** interesting result shows that QQq cannot be determined at sufficiently high temperatures and ***,QQ¯can exist under any conditions as long as the separation distance is sufficiently ***,the screening distances of QQq and QQ¯are compared at finite rapidity and *** on the above analysis,we infer that QQ¯is more stable than QQq at finite rapidity and temperature.

关键词： holographic QCD QGP heavy quark

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Hepatic perivascular epithelioid cell tumors:The importance of preoperative diagnosis

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World Journal of Gastroenterology 2024年第13期30卷 1926-1933页

作者： Shuai Yan jia-jie Lu Lin Chen Wei-Hua Cai Jin-Zhu Wu Department of Medical School Nantong UniversityNantong 226300Jiangsu ProvinceChina Department of Hepatobiliary Surgery Affiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina Nantong Institute of Liver Disease Affiliated Nantong Hospital 3 of Nantong UniversityNantong 226006Jiangsu ProvinceChina

Accurate preoperative diagnosis is highly important for the treatment of perivascular epithelioid cell tumors(PEComas)because PEComas are mainly benign tumors and may not require surgical *** analyzing the causes,properties and clinical manifestations of PEComas,we summarize the challenges and solutions in the diagnosis of PEComas.

关键词： Hepatic perivascular epithelioid cell tumors Liver Preoperative diagnosis Angiomyolipomas Mesenchymal tissue-derived tumors

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Identification of a novel inflammatory-related gene signature to evaluate the prognosis of gastric cancer patients

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 945-967页

作者： jia-Li Hu Mei-Jin Huang Halike Halina Kun Qiao Zhi-Yuan Wang jia-jie Lu Cheng-Liang Yin Feng Gao Department of Gastroenterology People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830001Xinjiang Uygur Autonomous RegionChina Xinjiang Clinical Research Center for Digestive Disease Urumqi 830001Xinjiang Uygur Autonomous RegionChina Department of Oncology 920th Hospital of PLA Joint Logistics Support ForceKunming 650032Yunnan ProvinceChina Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

BACKGROUND Gastric cancer(GC)is a highly aggressive malignancy with a heterogeneous nature,which makes prognosis prediction and treatment determination *** is now recognized as one of the hallmarks of cancer and plays an important role in the aetiology and continued growth of *** also affects the prognosis of GC *** reports suggest that a number of inflammatory-related biomarkers are useful for predicting tumour ***,the importance of inflammatory-related biomarkers in predicting the prognosis of GC patients is still *** To investigate inflammatory-related biomarkers in predicting the prognosis of GC *** constructed using the least absolute shrinkage and selection operator Cox regression model based on the GEO *** patients from the GSE26253 cohort were used for *** and multivariate Cox analyses were used to determine the independent prognostic factors,and a prognostic nomogram was *** calibration curve and the area under the curve based on receiver operating characteristic analysis were utilized to evaluate the predictive value of the *** decision curve analysis results were plotted to quantify and assess the clinical value of the *** set enrichment analysis was performed to explore the potential regulatory pathways *** relationship between tumour immune infiltration status and risk score was analysed via Tumour Immune Estimation Resource and ***,we analysed the association between risk score and patient sensitivity to commonly used chemotherapy and targeted therapy *** A prognostic model consisting of three inflammatory-related genes(MRPS17,GUF1,and PDK4)was *** prognostic analysis revealed that the risk score was a separate prognostic factor in GC *** to the risk score,GC patients were stratified into high-and low-risk groups,and patients in the high-risk group ha

关键词： Gastric cancer Inflammation Immune infiltration Prognosis signature Subt

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Ultrafast pulse-dilation framing camera and its application for time-resolved X-ray diagnostic

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Nuclear Science and Techniques 2024年第7期35卷 101-114页

作者： Hou-Zhi Cai Qiu-Yan Luo Kai-Xuan Lin Xuan Deng Jun-Kai Liu Kai-Zhi Yang Dong Wang jia-jie Chen jia-Heng Wang Jing-Hua Long Li-Hong Niu Yun-Fei Lei Jin-Yuan Liu Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Shenzhen Key Laboratory of Photonics and BiophotonicsCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060China

An ultrafast framing camera with a pulse-dilation device,a microchannel plate(MCP)imager,and an electronic imaging system were *** camera achieved a temporal resolution of 10 ps by using a pulse-dilation device and gated MCP imager,and a spatial resolution of 100μm by using an electronic imaging system comprising combined magnetic *** spatial resolution characteristics of the camera were studied both theoretically and *** results showed that the camera with combined magnetic lenses reduced the field curvature and acquired a larger working area.A working area with a diameter of 53 mm was created by applying four magnetic lenses to the ***,the camera was used to detect the X-rays produced by the laser-targeting *** diagnostic results indicated that the width of the X-ray pulse was approximately 18 ps.

关键词： Inertial confinement fusion Plasma diagnostics Framing camera Combined lenses Pulse-dilation

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朝鲜时代女性对楚辞的接受研究

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南通大学学报（社会科学版） 2024年第2期40卷 75-84页

作者：贾捷南通大学文学院

朝鲜时代的女性是接受楚辞的典型群体。经考,朝鲜时代接受楚辞且有作品存世的女性有闺秀9人、妓生5人。其作品内容涉及拟骚作品的承袭、楚辞作家的评价、香草美人意象的运用、楚辞作品的解读、楚辞文献的编撰五方面。其接受的特点有:对... 详细信息

朝鲜时代的女性是接受楚辞的典型群体。经考,朝鲜时代接受楚辞且有作品存世的女性有闺秀9人、妓生5人。其作品内容涉及拟骚作品的承袭、楚辞作家的评价、香草美人意象的运用、楚辞作品的解读、楚辞文献的编撰五方面。其接受的特点有:对楚辞的情感,褒贬皆有;中韩两国古代女性文人的楚辞接受表达出相似的情感倾向;与朝鲜时代男性楚辞接受作品相比,朝鲜时代女性文人在接受楚辞时仍独具女性自身的特点。

关键词：朝鲜时代女性楚辞屈原

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Practice and Exploration of Ideological and Political Education for Postgraduate Students Under the Mentor Responsibility System

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Journal of Contemporary Educational Research 2024年第4期8卷 29-34页

作者： Yipin Wan jie jia Tingting Gao Xuding Song School of Construction Machinery Chang’an UniversityXi’an 710018Shaanxi ProvinceChina Engineering College Xi’an Siyuan UniversityXi’an 710038Shaanxi ProvinceChina

This study aims to address the problems existing in the ideological and political education of postgraduate students,and combines the implementation of the mentor responsibility system to explore the role orientation,work content,and practical effects of mentors in the ideological and political education of postgraduate *** questionnaire surveys,interviews,and other research methods,the current situation of ideological and political education of postgraduate students under the mentor responsibility system is analyzed,and corresponding optimization strategies are proposed.

关键词： Mentor responsibility system Postgraduate students Ideological and political education Practical exploration

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论依法治税中的“府院失衡”及其协调——以行政强制与司法执行的协同为中心

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行政法学研究 2024年第2期 71-83页

作者：谷佳杰西南政法大学法学院重庆401120

税务机关与人民法院之间的“府院互动”是实现我国依法治税中执法司法协同的有效路径,但我国依法治税中存在的“府院失衡”现象直接影响了“府院互动”目的之实现。“府院失衡”现象具体表现为行政强制措施与司法保全措施之间、行政强... 详细信息

税务机关与人民法院之间的“府院互动”是实现我国依法治税中执法司法协同的有效路径,但我国依法治税中存在的“府院失衡”现象直接影响了“府院互动”目的之实现。“府院失衡”现象具体表现为行政强制措施与司法保全措施之间、行政强制措施与司法强制执行之间、行政强制执行与司法保全措施之间以及行政强制执行与司法强制执行之间的协同困境。这是由于行政强制权与司法强制执行权并轨运行存在冲突、执法司法协同规范存在缺失以及利益导向下的不规范执法问题所导致的。为协调“府院失衡”现象,首先应协同配置以税务机关行政强制为主、法院司法强制执行为辅的税务强制执行权;其次应明确税务机关与法院在依法治税中的角色定位,税务机关的主导地位不动摇,法院仅应发挥监督与协助执行作用;最后通过允许税务机关参与法院执行款的分配、限制税收优先权的实现程序、限制“先税后证”的适用范围、建立涉税信息共享机制,实现依法治税中“府院联动”的路径优化。

关键词：依法治税府院联动行政强制司法强制执行

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Physicochemical characterization of Dendrobium officinale polysaccharides and regulation of immunometabolic homeostasis in Sub-health mice based on the CD4-Th17/Treg immunity axis

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Food Science and Human Wellness 2024年

作者： Bo Li Ze-Hua Zhang Hao-Ru Guan Xing-Li-Shang He Ning Wang Ying-jie Dong Mei Rong Jiu-jie jia Ting-Ting Chen Zhi-Yuan Li Gui-Yuan Lv Lin-Nan Zhang Su-Hong Chen Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang University of Technology Zhejiang Provincial Key Laboratory of TCM for Innovative R & D and Digital Intelligent Manufacturing of TCM Great Health Products.Huzhou College of Pharmaceutical Science Zhejiang Chinese Medical University

The aim of this study was to investigate the role of DOPS and DOPS100 in attenuating immune dysfunction in subfertile mice. The results of the study revealed several noteworthy findings. First， DOPS and DOPS100 treatments led to significant improvement in weight gain and reversal of fatigue-related behaviors compared to the normal group. Second， both DOPS and DOPS100 showed effectiveness in reducing immune organ swelling， modulating immunoglobulin （IgA and IgM） levels， and restoring complement （C3c and C4） levels. In addition， they demonstrated a significant ability to enhance the integrity of the intestinal mechanical barrier by differentially upregulating the tight junction proteins Occludin and ZO-1. In addition， it was found that DOPS100 specifically enhanced the CD4+-Th17/Treg immune axis in the gut， as evidenced by increased expression of Foxp3 as well as decreased expression of RORγt， and further modulation of IL-10， IL-22， and IL-17A expression levels of inflammatory factors. These findings collectively suggest that DOPS100 holds significant potential in improving sub-healthy status by repairing the intestinal barrier， restoring local immune homeostasis， and activating the intestinal immune regulatory network. The study's outcomes provide valuable insights into the therapeutic implications of DOPS and DOPS100 in addressing immune dysfunction in sub-healthy conditions.

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“手脑感知-手脑运动”理论在脑卒中后上肢康复中的应用

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康复学报 2024年第4期34卷 311-315,322页

作者：贾杰复旦大学附属华山医院上海200040

上肢运动功能障碍是脑卒中后患者面临的主要问题,寻求更多有效的康复技术对减轻患者功能障碍程度、提升生活质量具有重要意义。本研究关注感觉功能对上肢运动功能恢复的重要作用,并对“手脑感知-手脑运动”理论开展进一步的解读。在该... 详细信息

上肢运动功能障碍是脑卒中后患者面临的主要问题,寻求更多有效的康复技术对减轻患者功能障碍程度、提升生活质量具有重要意义。本研究关注感觉功能对上肢运动功能恢复的重要作用,并对“手脑感知-手脑运动”理论开展进一步的解读。在该理论的指导下,课题组就手脑感知康复评估与训练系统创建手脑感知训练五步法(感觉评估、感觉宣教、感觉训练、任务导向性训练和感觉认知)、手脑感知-脑机接口训练范式、手脑感知-镜像疗法训练范式和“手脑感知-手脑运动”理论的其他应用进行阐述,分析了“手脑感知-手脑运动”理论与“中枢-外周-中枢”闭环康复理论的关系,以期为康复医务人员在治疗脑卒中后上肢感觉、运动功能障碍提供参考依据与启发。

关键词：脑卒中上肢康复运动功能感觉功能手脑感知手脑运动

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