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Chinese Chemical Letters 2006年第1期17卷 85-88页

作者： Qing Song ZHOU Xue Hua jiang jia Rui YU Ke jia LI West China School of Pharmacy Sichuan University Chengdu 610041

Highly water soluble esters of scutellarin with variable molecular weight polyethylene glycol （PEG） were prepared via PEGylation. The physicochemical properties and the stabilities under different conditions were investigated. By PEG modification, the greatly increased water solubility and desirable partition coefficient of scuteUarin were obtained, and the results showed that these conjugates were potential prodrugs for the oral delivery of scuteUarin.

关键词： Scutellarin PEGylation prodrug physicochcmical properties stability.

Mechanism Exploration of Euphorbia fischeriana Steud. for Liver Cancer Based on Aspartic Acid Identification in Metabolomics

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Chinese Journal of Integrative Medicine 2024年第6期30卷 507-514页

作者： ZHAO Jing TIAN Xin-chen ZHANG jia-qi HUANG Chen SUN Yan QIAO Sen jiang Shu-long Clinical Medical Laboratory Center Jining First People’s HospitalJiningShandong Province272000China Cheeloo College of Medicine Shandong UniversityJinan250000China

Objective:To investigate the anti-liver cancer effects and aspartic acid(Asp)-related action mechanism of Euphorbia fischeriana Steud.(LD).Methods:The mice model of liver cancer was established by injection of H22 *** 5 days,mice were randomly divided into model group,sorafenib group(20 mg/kg),LD high-dose(LDH,1.36 g/kg) group,LD medium-dose(LDM,0.68 g/kg) group,and LD low-dose(LDL,0.34 g/kg)group,10 mice each *** were intragastrically administered to the mice once daily for 10 days,*** weight,tumor size and tumor weight were *** index was *** changes of liver cancer tissues were evaluated by hematoxylin and eosin staining and TUNEL *** chromatography-mass spectrometer was used to analyze different metabolites between the model and LDH ***:After LD treatment,tumor weight,tumor size and hepatic index were reduced compared with the model *** and karyorrhexis of tumor cells were ***,61 differential metabolites(18 up-regulated,43 down-regulated) were affirmed and 20 pathways of KEGG(P<0.05) were *** addition,Bel-7402,HepG2 and H22 cell viabilities were significantly increased after adding Asp into the *** then,the cell proliferation effect induced by Asp was ameliorated by ***:The anti-liver cancer efficacy of LD extract was validated in H22 mice model,and inhibition of Asp level might be the underlying mechanism.

关键词： liver cancer Euphorbia fischeriana Steud. aspartic acid metabolomics

Conservation Laws of a Discrete Soliton System

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Communications in Theoretical Physics 2008年第5期49卷 1105-1108页

作者： JI Jie ZHANG Da-Jun ZHANG jia-jiang College of Statistics and Computing Science Zhejiang Gongshang University Hangzou 310018 China Department of Mathematics Shanghai University Shanghai 200444 China

在这篇论文，我们由使用一个可解决的概括 Riccati 方程为一个分离 soliton 系统获得能量守恒定律的一个无限的数字。

关键词：守恒定律离散孤立子系统可积分解题方法

Facile Synthesis of Stable MO2N Nanobelts with High Catalytic Activity for Ammonia Decomposition

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Chinese Journal of Chemistry 2019年第4期37卷 364-372页

作者： Jun Xu Han Yan Zhao Jin Chun-jiang jia Key Laboratory for Colloid and Interface Chemistry Key Laboratory of Special Aggregated MaterialsSchool of Chemistry and Chemical EngineeringShandong UniversityJinanShandong 250100China

In the present work,high quality γ-Mo2N catalysts for ammonia decomposition were successfully synthesized via temperature programmed nitridation of α-MoO3 *** optimal conditions for the synthesis of MoO3 precursors were obtained by using the orthogonal experimental *** MoO3 precursors and the corresponding fresh and used Mo2N catalysts were characterized by various characterization techniques,including transmission electron microscopy,X-ray diffraction and N2 ***,temperature-programmed desorption by N2 or NH3 and X-ray photoelectron spectroscopy analysis were performed to better understand the chemical properties of Mo2N *** results revealed that Mo2N catalyst has good NH3 adsorption ability and facilitates the dissociation adsorption of ***,the morphology and structure of Mo2N catalysts well maintained after the ***,among the three transition metal nitrides(Mo2N,W2N and VN)and some Mo-based catalysts previously reported,Mo2N catalysts showed very high activity and *** 94% con version of NH3 could be reached at 550 ℃ with the gas hourly space velocity of 22 000 cm^3-gcat^-1·h^-1 and no obvious deactivation was observed during a 72 h test.

关键词： Stable MO2N Nanobelts High Catalytic Activity Ammonia Decomposition

Using information flow analysis to detect implicit information leaks for web service composition

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Frontiers of Information Technology & Electronic Engineering 2018年第4期19卷 494-502页

作者： jia-xin jiang Zhi-qiu HUANG Wei-wei MA Yan CAO College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Collaborative Innovation Center of Novel Software Technology and Industrialization Nanjing 210000China

Information leak,which can undermine the compliance of web-service-composition business processes for some policies,is one of the major concerns in web service *** present an automated and effective approach for the detection of implicit information leaks in business process execution language(BPEL)based on information flow *** introduce an adequate meta-model for BPEL representation based on a Petri net for transformation and *** on the concept of Petri net place-based noninterference,the core contribution of this paper is the application of a Petri net reachability graph to estimate Petri net interference and thereby to detect implicit information leaks in web service *** addition,a case study illustrates the application of the approach on a concrete workflow in BPEL notation.

关键词： Information flow analysis Business process execution language Petri net Interference

The Effect of 58S Bioactive Glass Coating on Polyethylene Terephthalates in Graft-Bone Healing

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Journal of Bionic Engineering 2012年第4期9卷 470-477页

作者： Yang Wu Shiyi Chen jia jiang Hong Li Kai Gao Pengyun Zhang Department of Sports Medicine andArthroscopic Surgery Huashan Hospital Sports Medicine CenterFudan University Shanghai 200040 P. R. China Shanghai Research Center of Biomedical Engineering Shanghai 201203 P. R. China

In this study the effects of surface modification of Polyethylene Terephthalates （PET） fibers with 58S bioactive glasses on osteoblasts proliferation and osseointegration in the tibia-articular tendon-bone healing model were investigated. PET sheets were coated with 58S bioactive glass and uncoated PET sheets were used as a control. Scanning Electron Microscope （SEM） and X-ray photoelectron spectrometer were adopted to analyze the surface characteristics of the fibers. MT3T3-E 1 cells were cultured with the PET fibers and the MTT and ALP were tested at 1, 3, 5 days. Twenty-four skeletally mature male New Zealand white rabbits were randomly divided into two groups, the 58S-PET group and the PET group. Both groups underwent a surgical procedure to establish a tibia-articular tendon-bone healing model. Mechanical examinations and histological assays were taken to verify the coating effects in vivo. Results of both MTT and ALP tests show significant differences （P 〈 0.01） between the 58S-PET group and the PET group. At 6 weeks and 12 weeks, the max load-to-failure was significantly higher in the 58S-PET group. In the histological assays, distinct new bone formation was observed only in the 58S-PET group and stronger osseoin- tegration was seen in the 58S-PET group than that in the control group. The 58S-coating on PET could enhance the proliferation and activity of the osteoblasts and therefore promote the new bone formation and tendon-bone healing.

关键词： anterior cruciate ligament polyethylene terephthalates artificial ligament coating bioactive glass

全国中医医术确有专长人员医师资格考核情况统计分析报告

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中国疗养医学 2024年第7期33卷 54-59页

作者：买文军蒋家望吴孟华梁璟艺高泉王亚煌张成岗海南国祥非药物疗法研究院海南三亚572000 海南博鳌超级中医院海南琼海571400 中国中医药研究促进会北京100011 北京中医药大学生命科学学院北京102488

目的通过研究真实有效的行业数据,为国家制定中医药人才培养有关政策、策略和措施提供科学依据。方法收集2018—2023年全国各省级地区中医医术确有专长人员医师资格考核情况的相关数据、公告公示以及相关工作通报,对考核的实施细则、考... 详细信息

目的通过研究真实有效的行业数据,为国家制定中医药人才培养有关政策、策略和措施提供科学依据。方法收集2018—2023年全国各省级地区中医医术确有专长人员医师资格考核情况的相关数据、公告公示以及相关工作通报,对考核的实施细则、考核通告、报名审核、考核合格等工作环节与数据变化情况进行回顾性分析。结果据不完全统计,截至2023年12月31日,除香港特别行政区、澳门特别行政区和台湾地区以外,全国31个省级地区相继发布“中医医术确有专长人员医师资格考核注册管理暂行办法实施细则”,全国中医(专长)医师资格考核报名审核通过人数90707名、实际参加考核人数70931名,考核通过人数11772名,除去无意义对比数量,考核相对通过率约16.60%。结论根据31个省级地区对《中医医术确有专长人员医师资格考核注册管理暂行办法》的执行情况、工作趋势和特点,提出强化政策宣传、严格依法依规、积极引导辅导、规范技能培训、提升素养能力等方面针对性的政策建议,希望能够为中医药人才事业发展提供参考。

关键词：中医药中医医术确有专长医师考核民间中医中医人才

Enhancing thermoelectric performance of p-type SnTe through manipulating energy band structures and decreasing electronic thermal conductivity

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Rare Metals 2024年第7期43卷 3232-3241页

作者： Xin Qian Hao-Ran Guo jia-Xin Lyu Bang-Fu Ding Xing-Yuan San Xiao Zhang jiang-Long Wang Shu-Fang Wang Hebei Key Lab of Optic-Electronic Information and Materials College of Physics Science and TechnologyHebei University College of Electron and Information Engineering Hebei University Research Institute for Frontier Science Beihang University

SnTe has received considerable attention as an environmentally friendly alternative to the representative thermoelectric material of ***,excessive hole carrier concentration in SnTe results in an extremely low Seebeck coefficient and high thermal conductivity,which makes it exhibit relatively inferior thermoelectric *** this work,the thermoelectric performance of p-type SnTe is enhanced through regulating its energy band structures and reducing its electronic thermal conductivity by combining Bi doping with CdSe ***,the carrier concentration of SnTe is successfully suppressed via Bi doping,which significantly decreases the electronic thermal ***,the convergence and flattening of the valence bands by alloying CdSe effectively improves the effective mass of SnTe while restraining its carrier ***,a maximum figure of merit（ZT） of～ 0.87 at 823 K and an average ZT of～ 0.51 at 300-823 K have been achieved in Sn0.96Bi0.04Te-5%*** results indicate that decreasing the electronic thermal conductivity is an effective means of improving the performance of thermoelectric materials with a high carrier concentration.

关键词： Thermoelectric materials SnTe Energy band structure Electronic thermal conductivity ZT value

Recent advances in multifunctional metal-organic frameworks for lithium metal batteries

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Science China Chemistry 2024年第3期67卷 759-773页

作者： jiaqi Li Zheng Weng Zuosu Qin Ying Zhang Ning Zhang Xiaohe Liu Chuankun jia Gen Chen jiang Zhou School of Materials Science and Engineering Key Laboratory of Electronic Packaging and Advanced Functional Materials of Hunan ProvinceCentral South University Zhongyuan Critical Metals Laboratory Zhengzhou University College of Materials Science and Engineering Changsha University of Science&Technology

In view of novel materials in the field of lithium metal batteries(LMBs), metal-organic frameworks(MOFs) have attracted extensive research interest owing to their controllable pore size, unsaturated metal sites and multifunctional organic groups. A variety of MOFs have been elaborately calculated and synthesized to be applied as separator coating, electrolyte modulators and solid-state electrolyte fillers in LMBs. In this mini-review, we summarize the mechanism of MOFs to limit the migration of anions, improve the Li-ion transference number and prolong the lifespan of LMBs. Suitable pore structure of MOFs can physically restrict the movement of Li^(+). Unsaturated metal sites can adsorb anions by electrostatic interaction. In addition,multifunctional organic functional groups that limit the migration of anions are discussed. Finally, the key challenges and perspectives in the development direction of MOFs-based separators and electrolytes are further elaborated.

关键词： metal-organic frameworks lithium metal battery separator electrolyte

Br■nsted acid-catalyzed asymmetric dearomatization of indolyl ynamides: Practical and enantioselective synthesis of polycyclic indolines

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Chinese Chemical Letters 2023年第3期34卷 317-321页

作者： Zhi-Xin Zhang Xuan Wang jia-Tian jiang Jie Chen Xin-Qi Zhu Long-Wu Ye Key Laboratory for Chemical Biology of Fujian Province and State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Catalytic asymmetric dearomatization of indoles and alkynes has received much attention in the past decade because this strategy offers an attractive and alternative way for the efficient synthesis of valuable chiral polycyclic indolines. However, these reactions have been mostly limited to transition-metal catalysts, and the related chiral Br■nsted acid catalysis has been scarcely reported. Herein, we disclose a chiral phosphoric acid-catalyzed asymmetric dearomatization of indolyl ynamides by direct activation of alkynes. This metal-free method enables the practical and atom-economical construction of an array of valuable chiral polycyclic indolines in moderate to good yields with high enantioselectivities.

关键词： Br■nsted acid catalysis Dearomatization Heterocycles Ynamides Stereoselectivity