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Improving cognitive impairment by Tongxinluo via inhibiting expression of beta-secretase 1/beta-amyloid peptide in experimental vascular dementia

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neural Regeneration Research 2008年第3期3卷 262-266页

作者： jia jia Wenbin Zhu Lihui Wang Yun Xu Department of neurology Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing 210008 Jiangsu Province China The State Key Laboratory of Pharmaceutical Biotechnology Nanjing University Nanjing 210008 Jiangsu Province China

BACKGROUnD： Tongxinluo has been clinically proven to be effective in improving memory and cognitive function in patients with post-stroke vascular dementia. Is the mech.nism related to the deposition of beta-amyloid peptide （A β ） in hippocampus？ OBJECTIVE： To observe the effect of Tongxinluo on cognitive impairment in a mouse model with vascular dementia and the ch.nges of A β deposition and β -secretase 1 （BACE1） expression. DESIGn： Randomized controlled study. SETTInG： State Key Laboratory of Pharmaceutical Biotechnology of nanjing University and Affiliated Drum Tower Hospital of nanjing University Medical School. MATERIALS： The experiment was carried out in the State Key Laboratory of Pharmaceutical Biotechnology of nanjing University and Affiliated Drum Tower Hospital of nanjing University Medical School from March 2006 to January 2007. A total of 36 healthy Kunming mice, 18 of each gender, were chosen. The study was conducted in accordance with the national Regulations of Experimental Animal Administration, and all animal experiments were approved by the Committee of Experimental Animal Administration of nanjing University. Tongxinluo was provided by Shijiazhuang Yiling Pharmaceutical Co., Ltd. METHODS： All mice were randomly divided into 6 groups, including naive control （n=6）, sham-operated control （n=6） and experimental groups treated with different doses of Tongxinluo （0.2, 0.4, and 0.6 g/kg/d; n=6 for each group） or vehicle （n=6）. Five groups were subjected to bilateral common carotid arteries （2-VO） occlusion to produce a vascular dementia model （no occlusion was performed in sham-operated group）. The mice in the Tongxinluo treatment groups were intragastricly administered daily with a Tongxinluo suspension （40 g/L in distilled water） at doses of 0.2, 0.4 or 0.6 g/kg/d from day 1 to day 30 post-surgery. The animals in vehicle, sham-operated and naive groups were administered an equal volume of distilled water. MAIn OUTCOME MEASURES： ①Escape latency time

关键词： vascular dementia tongxinluo β -amyloid protein β -secretase 1

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nutrient-hormone relations:Driving root plasticity in plants

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Molecular Plant 2022年第1期15卷 86-103页

作者： Zhongtao jia Ricardo F.H.Giehl nicolaus von Wirén Molecular Plant nutrition Department of Physiology&Cell BiologyLeibniz Institute of Plant Genetics and Crop Plant Research(IPK)Corrensstr.306466 Stadt SeelandOT GaterslebenGermany

Optimal plant development requires root uptake of 14 essential mineral elements from the *** the bioavailability of these nutrients underlies large variation in space and time,plants must dynamically adjust their root architecture to optimize nutrient access and *** information on external nutrient availability and whole-plant demand is translated into cellular signals that often involve phytohormones as intermediates to trigger a systemic or locally restricted developmental *** and extent of such local root responses depend on the overall nutritional status of the plant that is transmitted from shoots to roots in the form of phytohormones or other systemic long-distance *** integration of these systemic and local signals then determines cell division or elongation rates in primary and lateral roots,the initiation,emergence,or elongation of lateral roots,as well as the formation of root ***,we review the cascades of nutrient-related sensing and signaling events that involve hormones and highlight nutrient-hormone relations that coordinate root developmental plasticity in plants.

关键词： root development root plasticity nutrient sensing nutrient signaling plant hormones nutrient use efficiency

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C–C formation mediated by photoinduced electrons from crystallized carbon nitride nanobelts under visible light irradiation

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Journal of Energy chemistry 2019年第3期28卷 152-161页

作者： Qiaohui jia Sufen Zhang Quan Gu Key Laboratory of Applied Surface and Colloid chemistry Ministry of Education School of Chemistry and Chemical Engineering Shaanxi Normal University

Crystal structure and crystallinity of carbon nitride support, size and dispersity of active-metal nanoparticles(nPs), and surface engineering of composites have great roles in generation and separation of photogenerated charge carries and photocatalyzed organic reactions for the conversion of solar energy into chemical energy. Herein, we deposited well-dispersed Pd nPs with small size on crystallized carbon nitride(Cn–C) to construct a Schottky-type Pd/Cn–C hybrid for photocatalyzed Ullmann C–C homocoupling of aryl halides under visible light irradiation at room temperature. Compared to Pd nPs supported g-C_3n_4(Pd/g-C_3n_4), Pd/Cn–C exhibits excellent visible light photocatalytic activity for Ullmann C–C coupling of aryl halides due to high crystallinity of Cn–C support, high dispersion and smaller size of Pd nPs, and the interfacial heterojunction of Pd/Cn–C. Upon visible light irradiation, more photogenerated electrons from Cn–C flow across the Schottky junction to metallic Pd and trigger the Ullmann C–C coupling of aryl halides. The photogenerated holes on Cn–C surface are captured by a protic solvent(such as EtOH). In the presence of base K_2CO_3, the solvent undergoes dissociation, dehydrogenation, and finally can be oxidized by captured photogenerated holes. Moreover, Pd/Cn–C has general applicability for various substrates and shows excellent stability and reusability for more than nine cycles.

关键词： Crystallized carbon nitride Pd nanoparticles Photocatalyst C–C coupling Ullmann reaction

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Vertical SnS2/Si heterostructure for tunnel diodes

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Science ch.na(Information Sciences) 2020年第2期63卷 189-195页

作者： Rundong jia Qianqian HUAnG Ru HUAnG Key Laboratory of Microelectronic Devices and Circuits (MOE) Institute of Microelectronics Peking University

Tunneling FET（TFET） is considered as one of the most promising low-power electronic devices,however, suffers from the low drive current. Heterostructure TFET with low effective tunnel barrier height based on traditional 3D materials can obtain large tunnel current but deteriorated off-state current induced by the lattice mismatch. van der Waals heterostructure TFET based on 2D materials can obtain danglingbond-free interface for suppressed off-state current but face the challenge of controllable and stable doping technology. As the critical building block of the TFET, tunnel diode based on the 2D/3D heterostructure is proposed in this study and experimentally demonstrated. Combination of the pristine interface of 2D materials and matured doping technology in the traditional 3D bulk materials, tunnel diodes based on the 2D/3D heterostructures are expected to realize low leakage current and high on current simultaneously,showing great potential in low-power electronics. The n+SnS2/P+Si heterostructure with effective tunnel barrier of 0.17 eV theoretically is considered for the first time and selected as the optimal material platform for tunnel diodes. The n+SnS2/P+Si tunnel diode demonstrated experimentally shows the high current density of 1 μA/μm2, which is the highest one among the reported tunnel diodes based on the 2D/group IV materials. The tunneling current is also confirmed by low-temperature measurements. This study shows the great potential of the 2D/3D heterostructure for low-power tunneling devices.

关键词： 2D/3D heterostructure SnS2/Si tunnel barrier tunnel diode energy-efficient

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Synthesis of gold nanocubes/PEI-wrinkled CoSe_(2) nanomaterials and its application in electrochemical immunosensors for detection of dipropyl phthalate

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Rare Metals 2021年第5期40卷 1099-1109页

作者： Bao-Shan He jia-Wen Li School of Food Science and Technology Henan University of TechnologyZhengzhou 450001China

CoSe_(2) nanosheet materials with a wrinkled sheet structure and large surface area were synthesized via a simple hydrothermal *** polyethyleneimine(PEI)was used to functionalize wrinkled CoSe_(2)(w-CoSe_(2))to make gold nanocubes(AunCs)uniformly anchored onto the surface of PEI-w-CoSe_(2) via Au-n *** its application in electrochemical immunosensors for the detection of dipropyl phthalate(DPrP)was *** obtained material was characterized by the Fourier transform infrared spectroscopy(FTIR),transmission electron microscope(TEM),energydispersive spectroscopy(EDS),X-ray diffraction(XRD)and Raman *** effective surface area and conductivity of the electrode were enhanced by the introduction of AunCs/PEI-w-CoSe_(2) *** voltammetry(CV),differential pulse voltammetry(DPV)and electrochemical impedance spectroscopy(EIS)were used to characterize the performance of *** DPrP binds to antibodies via the antigen-antibody interaction,[Fe(Cn)6]3-/4-was used as a signal probe to monitor the ch.nge of oxidation current of different DPrP *** optimal conditions,the electrochemical responses of the prepared immunosensor were linear when the DPrP concentrations ranged from 1×10^(-11) to 1×10^(-5) mol·L-1,with a detection limit of 1.39×10^(-12) mol·L^(-1).The coefficient of determination(R2)is 0.995,indicating that the degree of fitting is ***,the constructed immunosensor exhibited acceptable reproducibility,selectivity,and ***,it may be found that the composite material has good application prospects in the electrochemical sensors field.

关键词： CoSe_(2)nanosheets Polyethyleneimine Gold nanocubes Dipropyl phthalate

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Abdominal compartment syndrome in patients with severe acute pancreatitis in early stage

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World Journal of Gastroenterology 2008年第22期14卷 3541-3548页

作者： Hong ch.n Fei Li jia-Bang Sun jian-Guo jia Department of General Surgery Xuan Wu Hospital of Capital Medical University Beijing 100053 China

AIM: To study retrospectively the influence of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) in patients with early acute pancreatitis (AP) (during the first week after admission) on physiological functions, and the association of the presence of IAH/ACS and outcome. METHODS: Patients (n = 74) with AP recruited in this study were divided into two groups according to intra-abdominal pressure (IAP) determined by indirect measurement using the transvesical route via Foley bladder catheter during the first week after admission. Patients (n = 44) with IAP ≥ 12 mmHg were assigned in IAH group, and the remaining patients (n = 30) with IAP n normal IAP group. For analysis of the influence of IAH/ACS on organ function and outcome, the physiological parameters and the occurrence of organ dysfunction during intensive care unit (ICU) stay were recorded, as were the incidences of pancreatic infection and in-hospital mortality. RESULTS: IAH within the first week after admission was found in 44 patients (59.46%). Although the APAchE Ⅱ scores on admission and the Ranson scores within 48 h after hospitalization were elevated in IAH patients in early stage, they did not show the statistically significant differences from patients with normal IAP within a week after admission (16.18 ± 3.90 vs 15.70 ± 4.25, P = 0.616; 3.70 ± 0.93 vs 3.47 ± 0.94, P = 0.285, respectively). ACS in early AP was recorded in 20 patients (27.03%). During any 24-h period ofthe first week after admission, the recorded mean IAP correlated significantly with the Marshall score calculated at the same time interval in IAH group (r = 0.635, P nts had obvious amelioration in physiological variables within 24 h after decompression, the incidences of pancreatitic infection, septic shock, multiple organ dysfunction syndrome (MODS) and death in the patients with ACS were significantly higher than that in other patients without ACS (pancreatitic infectio

关键词： Acute pancreatitis Abdominal compartment syndrome Intra-abdominal pressure Intra-abdominal hypertension Organ dysfunction

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Particle Simulation of the Fast Ignition Mech.nism for Laser Fusion

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ch.nese Physics Letters 2001年第6期18卷 799-801页

作者： ZHAnG jia-Tai He Bin n.E.Andreev Institute of Applied Physics and Computational Mathematics P.O.Box 8009Beijing 100088 Joint Institute for High Temperature Russian Academy of SciencesMoscow 127412Russia

We have developed the two and half-dimension electromagnetic relativistic electron and mobile ion cloud-in-cell(CIC)*** of the fast ignition and interaction of ultra-intense and ultra-short pulse laser with plasma are analysed theoretically and simulated numerically using CIC *** flows of relativistic electron and form of the ch.nnel are *** results show that the temperature of superhot electron is about MeV to tens of MeV,and the boring velocity is 0.05c-0.1c with c being the light *** preliminary scale laws are *** simulation quantitatively reproduces the experimental results at early and long times.

关键词： relativistic intense dimension

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Reversible RnA Modification n^1-methyladenosine(m^1A) in mRnA and tRnA

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Genomics, Proteomics & Bioinformatics 2018年第3期16卷 155-161页

作者： chi Zhang Guifang jia Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry and Molecular EngineeringPeking University

More than 100 modifications have been found in RnA. Analogous to epigenetic DnA methylation, epitranscriptomic modifications can be written, read, and erased by a complex network of proteins. Apart from na-methyladenosine （m6A）, n1-methyladenosine （mXA） has been found as a reversible modification in tRnA and mRnA. mlA occurs at positions 9, 14, and 58 of tRnA, with m1A58 being critical for tRnA stability. Other than the hundreds of m1A sites in mRnA and long non-coding RnA transcripts, transcriptome-wide mapping of m1A also identifies 〉 20 m1A sites in mitoch.ndrial genes, m1A in the coding region of mitoch.ndrial transcripts can inhibit the translation of the corresponding proteins. In this review, we summarize the current understanding of mlA in mRnA and tRnA, covering high-throughput sequencing methods developed for m1A methylome, m1A-related enzymes （writers and erasers）, as well as its functions in mRnA and tRnA.

关键词： Epitranscriptome RnA modification n1-methyladenosine (m1A) m1A writer m1A eraser

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Molecular structure of kerogens from source rocks of the Tarim Basin: A study by Py-GC-MS and methylation-Py-GC-MS

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Science ch.na Earth Sciences 2005年第3期48卷 313-325页

作者： jia Wanglu PEnG Ping'an State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 China

Flash pyrolysis-gas chromatography-mass spectrometry (Py-GC-MS) and in situ methylation-pyrolysis-gas chromatography-mass spectrometry (methylation-Py-GC-MS) have been employed for a study of molecular structure of kerogens from source rocks of the Tarim Basin. The main products from Py-GC-MS of the Ordovician and Triassic kerogens from the Tarim Basin are n-alkanes and n-alk-1-enes which decrease in relative abundance with in- creased carbon number. The major products from methylation-Py-GC-MS are normal saturated fatty acid methyl esters which show maxima at C16 and C18. These aliphatic compounds are mainly from lipids of planktonic algae. Moreover, there are more abundant long-chain fatty acids (C20-C26) and normal n-alkanes and n-alk-1-enes (C15-C25) in pyrolysates of Triassic kerogens than that of Ordovician kerogens, reflecting the discrepancies in sources of the Triassic kerogens and the Ordovician kerogens. Besides these aliphatic compounds, methoxyl benzoic acid methyl esters were detected only in products from methylation-Py-GC-MS of late Ordovician kerogen TAC1-1, which possibly was the first molecular evidence for the appearance of moss or other terrestrial plants in the Tarim Basin. In addition, the relative intensity of 17β(H)-trisnorhopane, 17 β(H),21 α(H)-30-normoretane and 17 β(H)-moretane is lower, but 17α(H)-trisnorhopane and 17 α(H)-30-norhopane is higher in the pyrolysates of the Ordovician kerogens in comparison with the pyrolysates of the Triassic kerogens. Moreover, Pr-1-ene has been detected in pyrolysates of Triassic kerogens. These differences in pyrolysates consist with maturity of kerogens. In conclu- sion, combination of methylation-Py-GC-MS and Py-GC-MS are useful tools to investigate the molecular structure of geomacromolecules and can be subject to type the organic matter, com- pare the maturity of kerogens and carry out the oil-source correlation.

关键词： methylation-Py-GC-MS, kerogens, molecular structure, maturity, source material, Tarim Basin.

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Phospholipase D antagonist 1-butanol inhibited the mobilization of triacylglycerol during seed germination in Arabidopsis

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Plant Diversity 2018年第6期40卷 292-298页

作者： Yanxia jia Weiqi Li Germplasm Bank of Wild Species Kunming Institute of Botany Chinese Academy of Sciences

Storage oil breakdown plays an important role in the life cycle of many plants by providing the carbon skeletons that support seedling growth immediately following germination. 1-Butanol, a specific inhibitor of phospholipase D(PLD)-dependent production of the signalling molecule phosphatidic acid(PA), inhibited Arabidopsis seed germination. n-Acylethanolamines(nAEs), which have been shown to inhibits PLDa1 activity, have no effect on seed germination. However, mobilization profile of triacylglycerols(TAG) that induced by each compound has not been reported. To gain deeper insights into the mode of mobilization of TAG during nAE 12:0 or 1-butanol treatment, we conducted a detailed comparative analysis of the effect of nAE 12:0, DMSO, 1-butanol and tert-butanol on Arabidopsis seed germination and fatty acid composition, tert-butanol and DMSO served as the corresponding controls treatment respectively. Our data show that 1-butanol, but not the inactive tert-butanol isomer, inhibited Arabidopsis seed germination, which is accompanied by a with retardation of the mobilization of triacylglycerols(TAG). In contrast, nAE 12:0 did not affect mobilization of TAG, nor did it significantly delay seed germination as monitored by radicle and cotyledon emergence. 1-Butanol induced RnA degradation in seeds and seedlings. We speculate that the large-scale degradation of RnA under the induction of 1-butanol may lead to abnormal gene expression in genes necessary for seed germination, including the genes needed for the mobilization of oil bodies, and thus cause a delay of seed germination. To the best of our knowledge, we report for the first time that 1-butanol delays the mobilization of TAG.

关键词： Germination 1-butanol n-Acylethanolamines Triacylglycerols Fatty acid

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