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空心钉内固定治疗股骨颈骨折:关节功能恢复的影响因素分析

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中国组织工程研究 2017年第19期21卷 2999-3004页

作者：王秀萍孙瑞波刘又文张颖贾宇东杨玉霞王会超河南洛阳正骨医院(河南省骨科医院) 河南省洛阳市471000

背景:目前,髋关节置换和空心加压螺钉内固定是治疗老年股骨颈骨折的主要方法。但老年患者由于骨质疏松,内固定往往失败。目的:分析空心钉内固定治疗股骨颈骨折患者术后关节功能,并探索影响空心钉内固定后髋关节功能的相关因素。方法:回... 详细信息

背景:目前,髋关节置换和空心加压螺钉内固定是治疗老年股骨颈骨折的主要方法。但老年患者由于骨质疏松,内固定往往失败。目的:分析空心钉内固定治疗股骨颈骨折患者术后关节功能,并探索影响空心钉内固定后髋关节功能的相关因素。方法:回顾性分析空心钉内固定治疗的股骨颈骨折患者并获得完整2年随访的89例患者临床资料,就性别、年龄、骨折类型(Garden分型)、骨量、体质量指数、空心钉固定结构、复位指数、手术时间、内固定后至患肢部分负重时间及2年随访时髋关节功能Harris评分等因素进行分析。应用SPSS 18.0统计学软件进行等级相关分析、有序多分类logistic回归分析。结果与结论:(1)标准正态Q-Q概率图及正态性检验结果显示,所有获得随访的患者术后2年Harris评分呈偏态分布(P=0.000);(2)等级秩相关分析显示:年龄、骨折类型、骨量、复位指数与髋关节功能评分呈相关性(P<0.05或P<0.01);(3)有序多分类Logistic回归分析结果显示:年龄、骨折类型、骨量、复位指数4个自变量对髋关节功能评分的影响具有显著性意义;(4)结果说明,年龄、骨折类型、骨量、复位指数是空心钉内固定治疗股骨颈骨折术后髋关节功能的重要影响因素。

关键词：股骨颈骨折内固定器髋关节组织工程骨科植入物骨植入物空心钉内固定髋关节功能 Logistic回归分析

A path integral approach to electronic friction of a nanometer-sized tip scanning a metal surface

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Communications in Theoretical Physics 2021年第4期73卷 111-120页

作者： yang Wang yu jia School of Physics Zhengzhou UniversityZhengzhou 450001China International Laboratory for Quantum Functional Materials of Henan and School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China Key Laboratory for Special Functional Materials of Ministry of Education and School of Materials and EngineeringHenan UniversityKaifeng475001China

In this work,we study the dissipation mechanism and frictional force of a nanometer-sized tip scanning a metal surface via a path integral *** metal,with internal degrees of freedom(c,c^(†))and a tip with an internal degree of freedom(d,d^(†))couple with one another by means of an exchanged potential,*** integrated out all internal degrees of freedom,we obtain the in-out ***,we calculate the imaginary part of the in-out amplitude and the frictional *** find the imaginary part of the in-out amplitude to be positive,and correlated to the sliding velocity in most *** frictional force is proportional to the sliding velocity for the case where v0.01,the frictional force demonstrates nonlinear dependence on sliding velocity.

关键词： path integral electronic friction quantum field

Masquelet technique using an allogeneic cortical bone graft for a large bone defect:A case report

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World Journal of Clinical Cases 2025年第5期13卷 36-43页

作者： Hai-yang Zong yu Liu Xing Yin Wei Zhou Nan Li Department of Orthopedics The People’s Liberation Army Joint Logistic Support Force 920th HospitalKunming 650032Yunnan ProvinceChina Department of Orthopedics 96603 Military Hospital of PLAHuaihua 418000Hunan ProvinceChina

BACKGROUND The induced-membrane technique was initially described by Masquelet as an effective treatment for large bone defects,especially those caused by ***,we report a case of chronic osteomyelitis of the radius associated with a 9 cm bone defect,which was filled with a large allogeneic cortical bone graft from a bone *** bony union was achieved after 14 months of *** studies have used autogenous bone as the primary bone source for the Masquelet technique;in our case,the exclusive use of allografts is as successful as the use of autologous bone *** the advent of bone banks,it is possible to obtain an unlimited amount of allograft,and the Masquelet technique may be further improved based on this new way of bone *** SUMMARY In this study,we reported a case of repair of a long bone defect in a 40-year-old male patient,which was characterized by the utilization of allograft cortical bone combined with the Masquelet technique for the treatment of the patient's long bone defect in the *** patient's results of functional recovery of the forearm were surprising,which further deepens the scope of application of Masquelet technique and helps to strengthen the efficacy of Masquelet technique in the treatment of long bones *** Allograft cortical bone combined with the Masquelet technique provides a new method of treatment to large bone defect.

关键词： Osteomyelitis Bone defect Allogeneic cortical bone Masquelet technique Membrane induction technique Case report

Anomalous quality factor evolution of induced transparency in a virtualized coupled-oscillator system

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 148-155页

作者： yunhan yang Han jia Tuo Liu yuzhen yang Jun yang Key Laboratory of Noise and Vibration Research Institute of Acoustics Chinese Academy of Sciences University of Chinese Academy of Sciences State Key Laboratory of Acoustics Institute of Acoustics Chinese Academy of Sciences

The phenomenon of induced transparency, characterized by a high quality(Q) factor, holds significant importance in the fields of high-precision sensing, energy storage and wave manipulation. Conventional transparency systems are often constrained by the limited experimentally accessible parameter space and the lack of independent control over intrinsic parameters, thereby hindering advanced research on high-Q effects. Here we propose a virtualized coupled-oscillator system that enables reconfigurable induced transparency in the reflection spectrum. By virtually incorporating a pair of coupled oscillators into an individual acoustic meta-atom, we achieve the manipulation of induced transparency in a decoupled, wide-ranging, and elaborate manner. Exploiting the diverse evolutions across the intrinsic parameter space, we show experimentally a counter-intuitive increase in the Q-factor of the transparency window, which is attributed to the enhanced dissipation of the bright ***, a constant group delay at the center frequency is observed accompanying this evolution. Our work demonstrates an intriguing platform as well as a novel strategy to engineer high-Q induced transparency phenomenon, and paves the way towards applications in programmable acoustic sensors, filters and slow-wave devices.

关键词：

Homozygous phytosterolemia and a literature review:A case report

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World Journal of Clinical Cases 2025年第10期13卷 46-52页

作者： Chun-Xin jiang Guang yang Lian-Ping Shi Peng-yu Su Department of Cardiovascular North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChina

BACKGROUND Phytosterolemia,also known as sitosterolemia,is a rare autosomal recessive disease characterized by elevated plasma plant sterol levels and xanthomata,which is easily misdiagnosed as familial *** with homozygous phytosterolemia often have severe clinical manifestations,with xanthomata in childhood and premature *** patient had a milder clinical *** SUMMARY This report describes a patient with homozygous phytosterolemia who presented with only elevated cholesterol and low-density lipoprotein cholesterol(LDL-C)without xanthomata,arteriosclerosis,or hematological *** mutation of ABCG5 which encodes an ATP-binding cassette transporter,was detected by whole exome sequencing and diagnosed as *** of the patient’s plasma plant sterol levels detected significant elevations in stigmasterol,rapeseed oil-derived plant sterol,andβ-glutaminol *** was started and a low plant sterol diet was *** patient’s blood lipid profile was reexamined one month later and showed significant decreases in total cholesterol and LDL-C *** has similar clinical features as familial hypercholesterolemia,is highly susceptible to misdiagnosis,and has a very low incidence,and therefore clinicians need to consider a genetic diagnosis of a definitively hyperlipidemic disorder when statin drugs fail to lower lipid *** Phytosterolemia is easily misdiagnosed as familial hypercholesterolaemia and can be treated by dietary modification and cholesterol absorption inhibitors to lower blood lipids.

关键词： Hypercholesterolemia Cholesterol Low-density lipoprotein Phytosterolemia Liquid chromatography ABCG5/ABCG8 Sitosterolemia

“品管圈”活动对降低医院制剂氢定乳膏配制损耗率的效果分析

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中国现代应用药学 2018年第2期35卷 284-287页

作者：郑雪花杨祎蓂房建伟盖琦李绅赵松刘佳王玉杨君杨跃辉中国医科大学附属盛京医院药学部沈阳110004

目的开展品质管理圈(品管圈)活动,降低医院制剂氢定乳膏的配制损耗率,控制质量,节约成本。方法按照品管圈十大步骤,收集2016年6月—12月所配制的8批次氢定乳膏的损耗率数据,分析造成氢定乳膏配制损耗率高的主要原因,制定相应对策并实施... 详细信息

目的开展品质管理圈(品管圈)活动,降低医院制剂氢定乳膏的配制损耗率,控制质量,节约成本。方法按照品管圈十大步骤,收集2016年6月—12月所配制的8批次氢定乳膏的损耗率数据,分析造成氢定乳膏配制损耗率高的主要原因,制定相应对策并实施,并评价对策的有效性。结果氢定乳膏配制损耗率由品管圈活动前的104.73‰降至活动后的53.24‰,且圈员解决问题能力、责任心、团队精神、脑力开发等无形成果均得到了提高。结论通过品管圈活动的实施,有效降低了氢定乳膏的配制损耗率,提升了医院制剂管理水平。

关键词：品管圈医院制剂损耗率

Prevalence of Helicobacter pylori infection in Chinese military personnel:A cross-sectional,multicenter-based study

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World Journal of Gastroenterology 2025年第3期31卷 42-49页

作者： Han-Chen Min Chun-Yan Zhang Fang-yu Wang Xiao-Hui yu Shan-Hong Tang Hong-Wu Zhu Ya-Gang Zhao Ji-Luo Liu jian Wang Jing-Han Guo Xiao-Mei Zhang yun-Sheng yang Chinese People’s Liberation Army Medical School Chinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology and Hepatology The First Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Sixth Healthcare Department The Second Medical CenterChinese People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology The 940th Hospital of Joint Logistic Support Force of Chinese People’s Liberation ArmyLanzhou 730050Gansu ProvinceChina Department of Gastroenterology General Hospital of Western Theater CommandChengdu 610011Sichuan ProvinceChina Department of Gastroenterology General Hospital of Southern Theater CommandGuangzhou 510010Guangdong ProvinceChina Department of Epidemiology Naval Medical UniversityShanghai 200433China School of Medicine Nankai UniversityTianjin 300071China National Clinical Research Center for Geriatric Diseases Chinese People’s Liberation Army General HospitalBeijing 100853China

BACKGROUND Helicobacter pylori(***)infection is a prevalent disease encountered in military internal medicine and recognized as the main cause of dyspepsia,gastritis,and peptic ulcer,which are common diseases in military *** guidelines in China state all patients with evidence of active infection with *** are offered ***,the prevalence of *** infection and its regional distribution in the military population remain unclear,which hinders effective prevention and treatment *** the prevalence of *** infection in the military population will aid in the development of customized strategies to better manage this infectious *** To investigate the prevalence of *** infection in the Chinese military population in different geographic *** This multicenter,retrospective study included 22421 individuals from five tertiary hospitals located in north,east,southwest,and northwest cities of *** infection was identified using the urea breath test,which had been performed between January 2020 and December *** Of the 22421 military service members,7416(33.1%)were urea breath *** highest prevalence of *** was in the 30-39 years age group for military personnel,with an infection rate of 34.9%.The majority of infected subjects were younger than 40-years-old,accounting for 70.4%of the infected *** individuals serviced in Lanzhou and Chengdu showed a higher infection prevalence than those in Beijing,Nanjing,and Guangzhou,with prevalence rates of 44.3%,37.9%,29.0%,31.1%,and 32.3%,*** *** infection remains a common infectious disease among military personnel in China and has a relatively high prevalence rate in northwest China.

关键词： Helicobacter pylori Prevalence Military personnel Urea breath test Multicenter study

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： jian yang jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu jiale Liu Lei Bai Xiang Li Zhengquan yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-yu Guan jia-Wei Wu Zi-yun yuan Zhi-yuan Liu Zi-Zhu Liu Zhi-Cong Xiao Jing-Hui Li Cheng-Zhi Huang Jun-jiang Wang Xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus