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Dermatitis bullosa caused by the immune checkpoint inhibitor camrelizumab:A case report

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World Journal of Clinical Cases 2025年第8期13卷 15-21页

作者： yuan-Jing jiang Lu Wu Xiao yang yu Pu Bing-Jie Ning Na Peng Xiao-Ju Zhu Cancer Center Daping HospitalArmy Medical UniversityChongqing 400042China

BACKGROUND Since the advent of the 20th century,alongside the progression of medical science and technological advancements,immunotherapy has emerged as a pivotal thera-peutic approach for tumor patients subsequent to undergoing radiotherapy and ***(camrelizumab),a flagship drug in the realm of immuno-therapy,functions as a monoclonal antibody specifically targeting the progra-mmed death protein 1(PD-1).This drug engages with the human PD-1 receptor,effectively inhibiting the PD-1/programmed death ligand 1 signaling *** inhibition results in the restoration of T cell activity and the induction of an anti-tumour ***,it is noteworthy that such interference could lead to immune-related adverse events resembling autoimmune *** grow-ing availability and clinical use of immune checkpoint inhibitors have raised sig-nificant clinical concerns regarding their *** instances of immune-related adverse reactions and the associated management strategies have been extensively *** identification and diagnosis,coupled with multidi-sciplinary consultation and the prompt administration of immunosuppressants,can effectively address severe immune-related adverse *** SUMMARY Arimab(camrelizumab),a monoclonal antibody targeting programmed death protein 1(PD-1),disrupts the PD-1/programmed death ligand 1(PD-L1)inter-action,reactivating T cell function and triggering anti-tumor ***,this disruption may trigger immune-mediated adverse events akin to autoim-mune *** 2.8%of such events manifest as immune-related dermatologic reactions,with 0.7%classified as grade 3,which are infrequently ***,this study describes a case of grade 3 bullous dermatitis occur-ring 15 days after initiating camrelizumab *** patient,a 67-year-old male with oesophageal squamous cell carcinoma,received camrelizumab plus paclitaxel alongside chemotherapy and radiotherapy in early ***

关键词： Camrelizumab Anti-programmed cell death protein-1 blockade Skin-related adverse events Immune-related dermatitis Case report

体外诱导大鼠骨髓间质干细胞分化为胰岛素分泌细胞(英文)

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中国当代儿科杂志 2003年第5期5卷 393-397,F004页

作者：贾延劼钟乐宋建辉罗芳孙吉平杨于嘉中南大学湘雅医院儿科湖南长沙410008

目的探索大鼠骨髓间质干细胞体外诱导分化为胰岛素分泌细胞的方法。为解决胰岛移植物来源匮乏这一问题提供新的思路。方法采用横向分化技术,将成年大鼠骨髓间质干细胞诱导成为胰岛素分泌细胞。间接免疫荧光法鉴定诱导前后细胞nestin、... 详细信息

目的探索大鼠骨髓间质干细胞体外诱导分化为胰岛素分泌细胞的方法。为解决胰岛移植物来源匮乏这一问题提供新的思路。方法采用横向分化技术,将成年大鼠骨髓间质干细胞诱导成为胰岛素分泌细胞。间接免疫荧光法鉴定诱导前后细胞nestin、胰岛素、胰高血糖素、生长抑素及Pdx-1的表达,RT-PCR法检测诱导前后细胞nestin,胰岛素-1,葡萄糖转运子-2,葡萄糖激酶及其转录因子Isl-1,Pdx-1,Pax-4和Pax-6 mRNA的表达;测定24 h胰岛素分泌量和胰岛素刺激实验评价诱导前后细胞的功能。结果诱导5 h,nestin阳性细胞为(44.6±7.3)％;诱导24 h,nestin阳性细胞增至(61.8±8.4)％;此后,nestin阳性细胞数目开始下降,诱导第14天后,nestin表达基本消失。诱导后的胰岛素分泌细胞可以表达胰岛素、胰高血糖素、生长抑素和Pdx-1等蛋白;表达胰岛素-1、葡萄糖转运子-2、葡萄糖激酶及其多种转录因子mRNA;胰岛素分泌量增加;胰岛素刺激实验反应敏感等。而诱导前MSCc不县备上述特点。结论大鼠骨髓间质干细胞体外可以诱导成为胰岛素分泌细胞,为胰岛移植开辟新的研究思路。

关键词：骨髓间质干细胞胰岛素分泌细胞细胞分化胰岛移植

Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

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World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei Zhang Liang Li Hao-yu Qu Guang-yu Chen Meng-Zhou Xie Yan-Kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

Construction schedule risk analysis of high roller-compacted concrete dams based on improved CSRAM

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Science China(Technological Sciences) 2015年第6期58卷 1021-1030页

作者： ZHONG DengHua yang ShiRui CHANG HaoTian yu jia YAN FuGen State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin University

The applied technology of high roller-compacted concrete(RCC) dams is quite complicated because of various risk factors, including the weather condition, supply of concrete aggregate, efficiency of transport machinery and dam surface machinery, and so on. In order to ensure the comprehensiveness, accuracy and objectivity of construction schedule risk analysis, a mathematical model called improved correlated schedule risk analysis model(CSRAM) is proposed in this paper. This model takes into account not only the construction features of high RCC dams, but also the stochastic variations of risk factors with the construction schedule, as well as their comprehensive effects. Using Monte Carlo method to solve this model enables the completion probability of a high RCC dam construction within plan time, and uncertainty analysis of risk factors. Compared with the conventional CSRAM, the improved CSRAM has higher completion probability and more convergent distribution of a simulation period, making analysis results more accurate and closer to actual engineering conditions. Among the ten risk factors selected, efficiency of dam surface machinery and proficiency of workers are found to be of the maximum uncertainty.

关键词： high RCC dam construction risk analysis improved CSRAM Monte Carlo

西藏狮泉河地区渐新世钾质火山岩成因及其地质意义

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岩石学报 2025年第1期41卷 151-166页

作者：俞嘉嘉陈伟唐菊兴李阳中国地质科学院矿产资源研究所北京100037 中国地质大学(北京)地球科学与资源学院北京100083

新生代钾质-超钾质火山岩与南北向裂谷关系密切,是认识青藏高原隆升过程的重要途径。本次工作在中拉萨地块狮泉河左左区识别出一套钾质粗面岩,为探讨其成因及构造背景指示,本文对其进行了年代学、岩石地球化学以及Lu-Hf同位素研究。锆石... 详细信息

新生代钾质-超钾质火山岩与南北向裂谷关系密切,是认识青藏高原隆升过程的重要途径。本次工作在中拉萨地块狮泉河左左区识别出一套钾质粗面岩,为探讨其成因及构造背景指示,本文对其进行了年代学、岩石地球化学以及Lu-Hf同位素研究。锆石U-Pb年龄确定该套火山岩形成于24.2Ma和22.3Ma,从而将原属于则弄群朗久组的火山岩重新厘定为渐新世。地球化学分析表明其具有高硅(64.6%

关键词：钾质-超钾质火山岩粗面岩南北向裂谷狮泉河地区

Geohazards and risk assessment along highway in Sichuan Province, China

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Journal of Mountain Science 2023年第6期20卷 1695-1711页

作者： yang Hong-zhi DONG jia-yu GUO Xu-liang School of Highway Chang’an UniversityXi'an 710064China

Geohazards along highways are the main natural hazards that could affect the safety and operation of highway *** the risks faced by highways in areas affected by geohazards is an urgent problem to be *** study used historical geohazard events from Sichuan Province and highway network data to propose a geohazard risk index that reflects the risk geohazards along ***,this work applied the entropy method and expert scoring to calculate the weight of the *** spatial distributions of landslides,debris flows,collapses,and unstable slopes along the highways were analysed based on ArcGIS spatial statistics,and the highway geohazard intensity index were *** relationships between slope,rainfall,vegetation coverage,rock type,land use,and incision depth with geohazards were analysed,and the highway geohazard susceptibility index was calculated by the weighted information *** on the intensity and susceptibility index,we obtained a geohazard risk index which can better evaluate the risk of highways,and made a highway geohazard risk map to aid the prevention and mitigation of geohazards along highways and assist with highway network planning.

关键词： Geohazards Highway network Geohazard risk index Intensity index Susceptibility

Identifying candidate genes involved in trichome formation on carrot stems by transcriptome profiling and resequencing

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Journal of Integrative Agriculture 2022年第12期21卷 3589-3599页

作者： WU Zhe yang Xuan ZHAO yu-xuan jia Li College of Horticulture Shanxi Agricultural UniversityTaigu 030801P.R.China Key Laboratory of Genetic Improvement and Ecophysiology of Horticultural Crop of Anhui Province Institute of HorticultureAnhui Academy of Agricultural SciencesHefei 230001P.R.China

Trichomes are specialized structures developed from epidermal cells and can protect plants against biotic and abiotic *** cover carrots during the generative ***,the morphology of the carrot trichomes and candidate genes controlling the formation of trichomes are still *** study found that carrot trichomes were nonglandular and unbranched hairs distributed on the stem,leaf,petiole,pedicel,and seed of *** analysis of a trichome mutant with sparse and short trichomes(sst)and a wild type(wt)with long and dense trichomes on carrot stems was conducted.A total of 15396 genes containing nonsynonymous mutations in sst were obtained,including 42 trichomerelated *** also analyzed the transcriptome of the trichomes on secondary branches when these secondary branches were 10 cm long between wt and sst and obtained 6576 differentially expressed genes(DEGs),including 24 trichome-related ***-PCR validation exhibited three significantly up-regulated DEGs,20 significantly downregulated,and one with no *** considered both the resequencing and transcriptome sequencing analyses and found that 12 trichome-related genes that were grouped into five transcription factor families containing nonsynonymous mutations and significantly down-regulated in ***,these genes are potentially promising candidate genes whose nonsynonymous mutations and down-regulation may result in scarce and short trichomes mutation on carrot stems in sst.

关键词： carrot trichome resequencing transcriptome candidate genes

Metabolic reprogramming: a new option for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第4期20卷 1042-1057页

作者： jiangjie Chen Jinyang Chen Chao yu Kaishun Xia Biao yang Ronghao Wang Yi Li Kesi Shi yuang Zhang Haibin Xu Xuesong Zhang Jingkai Wang Qixin Chen Chengzhen Liang Department of Orthopedics The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang ProvinceChina Orthopedics Research Institute of Zhejiang University Zhejiang UniversityHangzhouZhejiang ProvinceChina Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province HangzhouZhejiang ProvinceChina Clinical Research Center of Motor System Disease of Zhejiang Province HangzhouZhejiang ProvinceChina Qiandongnan Prefecture People’s Hospital KailiGuizhou ProvinceChina Department of Orthopedics Fourth Medical CenterChinese PLA General HospitalBeijingChina

Spinal cord injuries impose a notably economic burden on society,mainly because of the severe after-effects they *** the ongoing development of various therapies for spinal cord injuries,their effectiveness remains ***,a deeper understanding of metabolism has opened up a new therapeutic opportunity in the form of metabolic *** this review,we explore the metabolic changes that occur during spinal cord injuries,their consequences,and the therapeutic tools available for metabolic *** spinal cord metabolism is characterized by independent cellular metabolism and intercellular metabolic ***,spinal cord injury results in metabolic disorders that include disturbances in glucose metabolism,lipid metabolism,and mitochondrial *** metabolic disturbances lead to corresponding pathological changes,including the failure of axonal regeneration,the accumulation of scarring,and the activation of *** rescue spinal cord injury at the metabolic level,potential metabolic reprogramming approaches have emerged,including replenishing metabolic substrates,reconstituting metabolic couplings,and targeting mitochondrial therapies to alter cell *** available evidence suggests that metabolic reprogramming holds great promise as a next-generation approach for the treatment of spinal cord *** further advance the metabolic treatment of the spinal cord injury,future efforts should focus on a deeper understanding of neurometabolism,the development of more advanced metabolomics technologies,and the design of highly effective metabolic interventions.

关键词： axons glycolysis metabolic reprogramming metabolism mitochondria neural regeneration neuroprotection oxidative phosphorylation spinal cord injury therapy

Size and Dynamics of Ring Polymers under Different Topological Constraints

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Chinese Journal of Polymer Science 2023年第4期41卷 516-524,I0006页

作者： jiang-yang Mo Zhen-Hua Wang yu-yuan Lu Li-jia An State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China University of Science and Technology of China Hefei230026China

The impact of ring polymer length N and the influence of interchain and intrachain interactions on the size and dynamic behaviors of ring polymers,including the structural relaxation time τ_(R) and self-diffusion coefficient D,remain poorly understood at present due to a lack of systematic studies with relatively large N *** work addressed this issue by applying dynamic Monte Carlo simulations with independently tuned interchain and intrachain interactions to investigate the size and dynamics of the ring melts with chain lengths over a wide range of 0.2N_(e)≤N≤80N_(e)(N_(e) is the entanglement length of corresponding linear chains)under different topological constraints,including all-crossing and intercrossing *** found that it was inappropriate to treat the unknotting constraint free energy of the ring chains in the melts as the free energy contributed by the excluded volume interactions of polymers in a good *** exponents of 2.5 and 1.5 reflecting the Ndependence of τ_(R) were obtained for long ring chains in non-crossing and intra-crossing systems,respectively,suggesting that the ring chains behaved as individual clusters and exhibited Zimm-like dynamics in intra-crossing systems.A single scaling exponent of-2 reflecting the Ndependence of D was obtained for ring chains in non-crossing and intra-crossing systems,indicating that the intrachain constraints affected only the value of D,and had little influence on the scaling relationship between D and ***,the extended Stokes-Einstein relation broke down for the ring chains in the non-crossing and intra-crossing systems because the structural relaxation and translational diffusion were decoupled for the short ring systems,while both the translational diffusion and rotational relaxations,as well as diffusion at short and long time scales,were decoupled for long ring systems.

关键词： Ring polymer Topological constraint Extended Stokes-Einstein relation Monte Carlo simulation