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Chinese Chemical Letters 2025年第1期36卷 392-396页

作者： Wenbin Zhou Yafei Gao Xinyu Feng Yanqing Zhang Cong Yang Lanxi He Fenghe Zhang Xiaoguang li qing li School and Hospital of Stomatology Cheeloo College of MedicineShandong UniversityJi’nan 250012China China&Shandong Key Laboratory of Oral Tissue Regeneration Ji’nan 250012China China&Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration Ji’nan 250012China Department of Stomatology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJi’nan 250021China

Immunotherapy offers significant potential but is often hampered by the immunosuppressive environment in oral squamous cell carcinoma(OSCC).To address this,we propose an enhanced immunotherapeutic strategy that revitalizes the tumor immune microenvironment(TIME)in OSCC by integrating upconversion-based photodynamic therapy(PDT)with *** a red blood cell membraneinspired biomimetic nanoplatform,our approach concurrently delivers chlorin e6@upconversion nanoparticles(Ce6@UCNP)and doxorubicin(DOX).By leveraging fluorescence resonance energy transfer(FRET)for 980 nm to 660 nm upconversion excitation,we address challenges such as limited tissue penetration and tissue damage,as well as nanoplatform issues including immunogenicity and targeting inaccuracy Our integrated approach enhances PDT and chemotherapy with the goal of transforming immunologically“cold”tumors into“hot”ones through a cascaded therapy,thereby revitalizing the tumor immune microenvironment in OSCC.

关键词： Biomimetic nanoplatform UCNP-PDT Chemotherapy TIME OSCC

多孔金属纤维烧结板多尺度形貌的快速三维建模

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软件学报 2016年第10期27卷 2622-2631页

作者：徐志佳王清辉李静蓉华南理工大学机械与汽车工程学院广东广州510640

针对多孔金属纤维烧结板这一新型功能材料的多尺度形貌建模问题,基于机械加工表面微观形貌中存在的自仿射分形特性,拓展前期发展的三周期极小化曲面与Weierstrass-Mandelbrot分形几何快速合成方法,重点根据多孔金属纤维烧结板的结构特点... 详细信息

针对多孔金属纤维烧结板这一新型功能材料的多尺度形貌建模问题,基于机械加工表面微观形貌中存在的自仿射分形特性,拓展前期发展的三周期极小化曲面与Weierstrass-Mandelbrot分形几何快速合成方法,重点根据多孔金属纤维烧结板的结构特点,对Marching Cubes算法进行优化,以更高效地建立烧结板三维多尺度形貌的几何模型.同时,引入参数表征方法驱动分形TPMS对烧结板的形貌进行调整与控制.实例分析结果表明,所提出的方法可更有效地建立/控制多孔金属纤维烧结板的多尺度形貌模型;模型的有效性通过数值仿真和与其他方法的比较得到了验证.该建模方法可直接用于其他具有多尺度形貌的功能材料的数字化设计中,并促进其数值模拟技术的发展.

关键词：多孔金属纤维烧结板多尺度形貌周期曲面分形几何三维建模功能材料

RGS22 maintains the physiological function of ependymal cells to prevent hydrocephalus

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Science China(life Sciences) 2025年第2期68卷 441-453页

作者： Xue Pang lin Gu Qiu-Ying Han jia-qing Xing Ming Zhao Shao-Yi Huang Jun-Xi Yi Jie Pan Hao Hong Wen Xue Xue-qing Zhou Zhi-Hui Su Xin-Ran Zhang li-Ming Sun Shao-Zhen jiang Dan Luo ling Chen Zheng-Jie Wang Yu Yu Tian Xia Xue-Min Zhang Ai-ling li Tao Zhou Hong Cai Tao li Nanhu Laboratory National Center of Biomedical AnalysisBeijing 100039China School of Basic Medical Sciences Fudan UniversityShanghai 200032China Department of Basic Medical Sciences School of MedicineTsinghua UniversityBeijing 100084China

Ependymal cells line the wall of cerebral ventricles and ensure the unidirectional cerebrospinal fluid(CSF)flow by beating their motile cilia *** ependymal denudation or ciliary dysfunction causes ***,we report that the deficiency of regulator of Gprotein signaling 22(RGS22)results in severe congenital hydrocephalus in both mice and ***,RGS22 is specifically expressed in ependymal cells within the *** conditional knock-out mice,we further demonstrate that the deletion of Rgs22 exclusively in nervous system is sufficient to induce ***,we show that Rgs22 deficiency leads to the ependymal denudation and impaired *** phenomenon can be attributed to the excessive activation of lysophosphatidic acid receptor(LPAR)signaling under Rgs22^(-/-)condition,as the LPAR blockade effectively alleviates hydrocephalus in Rgs22^(-/-)***,our findings unveil a previously unrecognized role of RGS22 in the central nervous system,and present RGS22 as a potential diagnostic and therapeutic target for hydrocephalus.

关键词： RGS22 hydrocephalus ependymal cells

Solar trough receiver with V-grooved light traps for efficiency improvement

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Science China(Technological Sciences) 2025年第1期68卷 142-152页

作者： Bin liU qing li Yu QIU School of Energy Science and Engineering Central South UniversityChangsha 410083China

Parabolic trough collector is a promising technology for both domestic and industrial heat *** enhance the collector efficiency,a modified trough receiver with dozens of V-grooved light traps incorporated into its lower-half absorber was *** assessing the performance of this receiver,a solar-thermal-stress coupled model was *** this model,firstly,the effects of the V-grooved light traps were *** results reveal that,compared to the conventional trough receiver,the modified trough receivers equipped with different traps can reduce their optical losses by 81.9-138.0 Wm^(-1)(i.e.,15.0%-25.2%),improving their optical efficiencies by 1.60%-2.69%.However,these traps also result in increased thermal loss from the ***,there is no single optimal modified trough receiver that consistently outperforms all other receivers across all possible ***,the MTR30-3 and MTR60-3 receivers emerge as the optimized choices due to their better solar-thermal ***,performance evaluation reveals that the two optimized receivers can enhance the receiver efficiencies within the typical solar irradiance range by 0.02%-2.65%and 0.05%-1.70%when the inlet fluid temperatures are below 488 and 523 K,***,the collector efficiencies can be improved by 0.02%-2.49%and 0.05%-1.60%,***,thermal stress analysis verifies that the two optimized receivers remain within safe limits under all typical *** that the heating temperature of a typical solar collector for domestic or industrial heat supply is typically below 523 K,the integration of the two optimized receivers has the capability to effectively enhance the overall collector efficiency.

关键词： parabolic trough collector receiver V-grooved light trap solar-thermal-stress coupled model efficiency improvement

Non-metal plasmonic TiN sensitized 2D CdS nanosheet arrays for efficient visible light-driven photoelectrochemical hydrogen evolution and photocatalytic degradation performance

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Progress in Natural Science:Materials International 2025年第01期 201-214页

作者： Desheng Ni Xinglin jia jianan li Shicheng liu Lei liu Wenzhong Wang Guling Zhang Bin Zou lijuan Wang qing Zhou School of Science Minzu University of China Engineering Research Center of Photonic Design Software Ministry of Education Optoelectronics Research Center Minzu University of China

Here, a novel non-metal plasmonic TiN sensitized two-dimensional（2D） CdS nanosheet arrays（NSAs） were constructed for high-efficiency photoelectrochemical（PEC） hydrogen evolution as well as photocatalytic pollutant degradation under bias-free visible light illumination for the first time. For this patent heterogeneous nanostructures, the large surface area enables 2D CdS NSAs further to facilitate visible light absorption, as well as afford much active regions to absorb TiN nanoparticles（NPs） for boosting light energy utilization through the wide surface plasmon resonance（SPR） absorption feature of TiN. Additionally, the numerous SPR-induced TiN hot electron injection into 2D CdS efficiently augment carrier concentration. Moreover, the establishment of Schottky junction between CdS nanosheet and TiN NPs is in favour of charge migration and separation. The optimized 2D CdS/TiN NSAs achieved an obviously enhanced hydrogen production rate up to 217.2 μmol h-1,2.02-fold higher than that of pure 2D CdS NSAs. Furthermore, the organic dye Congo red degradation efficiency on the 2D CdS/TiN NSAs reached up to 93.1 % under visible light irradiation for 120 min. The remarkably enhanced photocatalytic pollutant degradation and PEC hydrogen evolution of the 2D CdS/TiN NSAs can be attributed to the cooperative action of CdS/TiN Schottky junction and SPR effect of TiN. The demonstrations of present study offer new insights into designing non-metal-based plasmonic photocatalysts for high-efficiency PEC hydrogen generation and photocatalytic pollutant degradation from the perspectives of the visible light absorption and carrier separation and injection.

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辣椒LRR类抗病基因同源序列的克隆与分析

西北农林科技大学学报（自然科学版） 2008年第1期36卷 143-148页

作者：马维巩振辉李大伟贾庆利西北农林科技大学园艺学院陕西杨凌712100

【目的】克隆和分析抗、感疫病辣椒材料的抗病基因同源序列，为辣椒抗疫病相关基因的克隆奠定基础。【方法】根据番茄抗叶霉病基因Cf2和Cf9C端的LRR类保守结构域设计简并引物，对6个不同抗、感疫病的辣椒种质材料基因组DNA进行抗病基因... 详细信息

【目的】克隆和分析抗、感疫病辣椒材料的抗病基因同源序列，为辣椒抗疫病相关基因的克隆奠定基础。【方法】根据番茄抗叶霉病基因Cf2和Cf9C端的LRR类保守结构域设计简并引物，对6个不同抗、感疫病的辣椒种质材料基因组DNA进行抗病基因同源序列的PCR扩增。【结果】得到27个抗病基因同源序列（RGAs），其在GenBank中的登录号为EF064260～EF064286。其中，21个RGAs与番茄抗叶霉病基因Cf2和Cf9有较高的相似性。感病材料的辣椒基因组中也存在抗疫病相关RGAs。【结论】上述21个RGAs可能与辣椒抗疫病作用有关，可为辣椒抗疫病相关基因的克隆提供依据。

关键词：辣椒 LRR 抗病基因克隆同源序列分析

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黄瓜CsPGIP基因的克隆及表达分析

西北植物学报 2012年第1期32卷 11-16页

作者：贾庆利巩振辉李大伟黄炜西北农林科技大学园艺学院陕西杨陵712100

以加工型黄瓜材料NW99为对象,利用RT-PCR技术克隆黄瓜多聚半乳糖醛酸酶抑制蛋白基因(PGIP),并分析其基因编码序列、组织表达特异性和诱导表达模式。结果表明:(1)从黄瓜中克隆到一个PGIP基因,命名为CsPGIP;CsPGIP基因全长1 026bp,读码框9... 详细信息

以加工型黄瓜材料NW99为对象,利用RT-PCR技术克隆黄瓜多聚半乳糖醛酸酶抑制蛋白基因(PGIP),并分析其基因编码序列、组织表达特异性和诱导表达模式。结果表明:(1)从黄瓜中克隆到一个PGIP基因,命名为CsPGIP;CsPGIP基因全长1 026bp,读码框987bp,无内含子,编码328个氨基酸残基,具有xxLxLxxNxLt/sGxIPxxLxxLxxL结构域,属于Pgip基因家族。(2)CsPGIP基因与甜瓜PGIP基因同源性最高,与十字花科Pgip基因同源性较高。(3)CsPGIP在黄瓜各个器官都表达,但表达水平具有组织特异性,在嫩叶中表达量最高,在茎中表达量最低;该基因表达明显受到水杨酸诱导,可能在抵御外界病原菌入侵过程中起重要作用。

关键词：黄瓜多聚半乳糖醛酸酶抑制蛋白基因克隆实时定量PCR 水杨酸

The Security of Using Large Language Models:A Survey With Emphasis on ChatGPT

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IEEE/CAA Journal of Automatica Sinica 2025年第1期12卷 1-26页

作者： Wei Zhou Xiaogang Zhu qing-Long Han lin li Xiao Chen Sheng Wen Yang Xiang the School of Science Computing and Engineering Technologies Swinburne University of Technology IEEE the School of Computer and Mathematical Sciences the University of Adelaide Adelaide the Faculty of Science and Engineering Southern Cross University the School of Information and Physical Sciences the University of Newcastle

ChatGPT is a powerful artificial intelligence(AI)language model that has demonstrated significant improvements in various natural language processing(NLP) tasks. However, like any technology, it presents potential security risks that need to be carefully evaluated and addressed. In this survey, we provide an overview of the current state of research on security of using ChatGPT, with aspects of bias, disinformation, ethics, misuse,attacks and privacy. We review and discuss the literature on these topics and highlight open research questions and future *** this survey, we aim to contribute to the academic discourse on AI security, enriching the understanding of potential risks and mitigations. We anticipate that this survey will be valuable for various stakeholders involved in AI development and usage, including AI researchers, developers, policy makers, and end-users.

关键词： Artificial intelligence (AI) ChatGPT large language models (LLMs) security

Spatiotemporal variation and influencing factors of desertification sensitivity on the qinghai-Xizang Plateau,China

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Journal of Arid Land 2025年第1期17卷 58-73页

作者： PAN Meihui CHEN qing li Chenlu li Na GONG Yifu College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730070China Key Laboratory of Resource Environment and Sustainable Development of Oasis Northwest Normal UniversityLanzhou 730070China

Due to irrational human activities and extreme climate,the qinghai-Xizang Plateau,China,faces a serious threat of *** has a detrimental effect on the ecological environment and socioeconomic *** this study,the desertification sensitivity index(DSI)model was established by integrating the spatial distance model and environmentally sensitive area index evaluation method,and then the model was used to quantitatively analyze the spatial and temporal characteristics of desertification sensitivity of the qinghai-Xizang Plateau from 1990 to *** results revealed that:(1)a general increasing tendency from southeast to northwest was identified in the spatial distribution of desertification *** low-sensitivity areas were mostly concentrated in the Hengduan and Nyaingqêntanglha mountains and surrounding forest and meadow *** high-sensitivity areas were located mainly in the Kunlun and Altun mountains and surrounding decertified *** center of gravity of all types of desertification-sensitive areas moved to the northwest,and the desertification sensitivity showed a decreasing trend as a whole;(2)the area of highly sensitive desertification areas decreased by 8.37%,with extreme sensitivity being the largest change among the sensitivity *** desertification sensitivity transfer was characterized by a greater shift to lower sensitivity levels(24.56%)than to higher levels(2.03%),which demonstrated a declining trend;(3)since 1990,the change in desertification sensitivity has been dominated by the stabilizing type Ⅰ(29.30%),with the area of continuously increasing desertification sensitivity accounting for only 1.10%,indicating that the management of desertification has achieved positive results in recent years;and(4)natural factors have had a more significant impact on desertification sensitivity on the Xizang Plateau,whereas socioeconomic factors affected only localized *** main factors influencing deserti

关键词： desertification sensitivity geodetector gravity center transfer model spatiotemporal change qinghai-Xizang Plateau

Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway

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Chinese Journal of Integrative Medicine 2025年第2期31卷 118-130页

作者： li Zhu-qing ZHANG Feng li Qi WANG li SUN Xiao-qiang li Chao YIN Xue-mei liU Chun-lei WANG Yan-xin DU Xiao-yu LU Cheng-zhi Department of Cardiology Tianjin First Central HospitalTianjin300192China The First Central Clinical School Tianjin Medical UniversityTianjin300070China Department of Cardiology The First College of Clinical Medical ScienceChina Three Gorges University&Yichang Central People’s HospitalYichangHubei Province443003China School of Medicine Nankai UniversityTianjin300071China

Objective:To evaluate the protective effects of gentiopicroside(GPS)against reactive oxygen species(ROS)-induced NOD-like receptor family,pyrin domain containing 3(NLRP3)inflammasome activation in endothelial cells,aiming to reduce ***:Eight-week-old male ApoE-deficient mice were randomly divided into 2 groups(n=10 per group):the vehicle group and the GPS treatment *** groups were fed a high-fat diet for 16 ***(40 mg/kg per day)was administered by oral gavage to the GPS group,while the vehicle group received an equivalent volume of the vehicle *** the end of the treatment,blood and aortic tissues were collected for assessments of atherosclerosis,lipid profiles,oxidative stress,and molecular expressions related to NLRP3 inflammasome activation,ROS production,and ***,in vitro experiments on human aortic endothelial cells treated with oxidized low-density lipoprotein(ox-LDL)were conducted to evaluate the effects of GPS on NLRP3 inflammasome activation,pyroptosis,apoptosis,and ROS production,specifically examining the role of the sirtuin 1(SIRT1)/nuclear factor erythroid 2-related factor 2(Nrf2)***1 and Nrf2 inhibitors were used to confirm the pathway's ***:GPS treatment significantly reduced atherosclerotic lesions in the en face aorta(Plike protein containing a CARD,cleaved-caspase-1,and cleavedgasdermin D expressions(all P<0.01).GPS also decreased ROS production,apoptosis,and pyroptosis,with the beneficial effects being significantly reversed by SIRT1 or Nrf2 ***:GPS exe

关键词： endothelial dysfunction gentiopicroside NLRP3 inflammasome SIRT1 nuclear factor erythroid 2-related factor 2 Chinese medicine