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LonP1 Links Mitochondria–ER Interaction to Regulate Heart Function

Research 2024年第1期2023卷 595-609页

作者： Yujie Li Dawei Huang Lianqun jia Fugen Shangguan Shiwei Gong Linhua Lan Zhiyin song Juan Xu Chaojun Yan Tongke Chen Yin Tan Yongzhang Liu Xingxu Huang Carolyn K.Suzuki Zhongzhou Yang Guanlin Yang Bin Lu The Affiliated Nanhua Hospital and School of Basic Medical Sciences Hengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhouZhejiang 325035China National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangshaHunan 410008China Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications Ministry of Education of ChinaLiaoning University of Traditional Chinese MedicineShenyangLiaoning 110847China Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Hubei Key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhanHubei 430072China Nanjing Maternity and Child Health Care Hospital Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical UniversityNanjing 210004China Animal Center Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Cardiology The First Affiliated Hospital of University of South ChinaHengyangHunanChina School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China Department of Microbiology Biochemistry and Molecular GeneticsNew Jersey Medical School-RutgersThe State University of New JerseyNewarkNJUSA State Key Laboratory of Pharmaceutical Biotechnology Department of CardiologyNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease StudyModel Animal Research CenterNanjing UniversityNanjing 210061China

Interorganelle contacts and communications are increasingly recognized to play a vital role in cellular function and *** particular,the mitochondria–endoplasmic reticulum(ER)membrane contact site(MAM)is known to regulate ion and lipid transfer,as well as signaling and organelle ***,the regulatory mechanisms of MAM formation and their function are still ***,we identify mitochondrial Lon protease(LonP1),a highly conserved mitochondrial matrix protease,as a new MAM tethering *** removal of LonP1 substantially reduces MAM formation and causes mitochondrial ***,deletion of LonP1 in the cardiomyocytes of mouse heart impairs MAM integrity and mitochondrial fusion and activates the unfolded protein response within the ER(UPR^(ER)).Consequently,cardiac-specific LonP1 deficiency causes aberrant metabolic reprogramming and pathological heart *** findings demonstrate that LonP1 is a novel MAM-localized protein orchestrating MAM integrity,mitochondrial dynamics,and UPR^(ER),offering exciting new insights into the potential therapeutic strategy for heart failure.

关键词： offering programming insight

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai Lei Ye Tao song Shuai Huang jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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Nanodiamond:a promising metal-free nanoscale material in photocatalysis and electrocatalysis

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Rare Metals 2024年第8期43卷 3501-3552页

作者： Xiao-Wu Gao Zi-Wei Zhao Yang He Sai-Fei Fan Ke-Ran jiao Si-Yu Lou Xin-Yue Han Peng-Fei song Rong Cai Zhun Hu Zhong-Jie jiang Yong-Jie Wang jia-Qi Zhu Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic Systems School of ScienceHarbin Institute of TechnologyShenzhen 518055China National Key Laboratory of Science and Technology on Advanced Composites in Special Environments Harbin Institute of TechnologyHarbin 150080China School of Advanced Technology Xi'an Jiaotong-Liverpool UniversitySuzhou215000China Department of Biosciences Rice UniversityHoustonTX 77251USA Institute of Industrial Catalysis School of Chemical Engineering and TechnologyXi'an Jiaotong UniversityXi'an 710049China Guangzhou Key Laboratory for Surface Chemistry of Energy Materials New Energy Research Institute&Guangdong Engineering and Technology Research Center for Surface Chemistry of Energy MaterialsCollege of Environment and EnergySouth China University of TechnologyGuangzhou 510006China

Benefiting from its surface-rich functional groups,eco-friendliness,impressive electrochemical properties,excellent light absorption,structural tunability at the atomic/morphological level,and ultra-high stability under harsh conditions,nanodiamond has emerged as a promising carbon-based non-metallic material in the field of energy conversion such as electrocatalysis and ***,nanodiamond,as a new generation of green catalysts,can overcome the poisoning of catalysts by complex pollutants in advanced oxidation processes,thus effectively removing organic matter from water,which is unparalleled in reducing the cost of water purification and avoiding secondary cross-contamination of water by traditional heavy metal-based ***,we review the research and development of nanodiamonds as major electrocatalysts and photocatalysts for energy conversion and for air/water treatment for environmental *** relevant properties,trimming strategy,mechanistic understanding,and design principles of nanodiamond as a catalyst are described,as well as the challenges and prospects of this emerging field.

关键词： Carbon materials Nanodiamond Electrocatalysis Photocatalysis Energy conversion Pollutant treatment

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Research on the Collaborative Education Mechanism among In-School Mentors,Enterprise Mentors,and Counselors from the Perspective of Sanquan Education

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Journal of Contemporary Educational Research 2024年第10期8卷 159-164页

作者： Jie jia Yipin Wan Hailong Fan Tingting Gao Xuding song School of Construction Machinery Chang’an UniversityXi’an 710064Shaanxi ProvinceChina Engineering College Xi’an Siyuan UniversityXi’an 710038Shaanxi ProvinceChina

This study addresses the issues existing in the current cultivation process of outstanding graduate students and explores the collaborative education mechanism among in-school mentors,enterprise mentors,and counselors in the cultivation of outstanding engineers in the mechanical field based on the perspective of Sanquan education(i.e.,holistic,full-course,and all-round education).Through exploring this mechanism,we attempt to construct a more scientific and efficient education model to enhance students’comprehensive quality and practical skills,thereby meeting society’s demand for high-quality talents in the mechanical field.

关键词： Graduate students Mechanical field Sanquan education Collaborative education Practical exploration

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不同加载速率下冻融砂岩的动态劈裂特性

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东北大学学报（自然科学版） 2024年第1期45卷 111-119页

作者：贾蓬毛松泽钱一锦卢佳亮东北大学资源与土木工程学院辽宁沈阳110819

为研究加载速率和冻融循环对砂岩动态劈裂特性的影响,对冻融0,25,50,75,100次的砂岩进行了静态和不同加载速率的动态劈裂试验,分析了冻融砂岩的静动态抗拉强度及冲击荷载作用下耗散能变化规律.研究结果表明:冻融砂岩的静动态抗拉强度、... 详细信息

为研究加载速率和冻融循环对砂岩动态劈裂特性的影响,对冻融0,25,50,75,100次的砂岩进行了静态和不同加载速率的动态劈裂试验,分析了冻融砂岩的静动态抗拉强度及冲击荷载作用下耗散能变化规律.研究结果表明:冻融砂岩的静动态抗拉强度、纵波波速、质量损失率均随冻融次数增加而劣化.随冻融次数、加载速率增加,动强度增加因子(DIF)不断增大,且砂岩冻融损伤越大,DIF随加载速率增加越明显.建立的基于冻融损伤和加载速率的动态抗拉强度预测模型可以很好地反映砂岩的强度变化.砂岩的冻融损伤越大,动态抗拉强度随加载速率的变化速率越快;冲击荷载作用下的耗散能随冻融次数增加而减小,随加载速率增加而增大.

关键词：冻融循环加载速率损伤动态抗拉强度能量耗散

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Contactin-associated protein-like 2(CNTNAP2)mutations impair the essentialα-secretase cleavages,leading to autism-like phenotypes

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1625-1636页

作者： Qing Zhang Mengen Xing Zhengkai Bao Lu Xu Yang Bai Wanqi Chen Wenhao Pan Fang Cai Qunxian Wang Shipeng Guo Jing Zhang Zhe Wang Yili Wu Yun Zhang jia-Da Li Weihong song Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)Zhejiang Key Laboratory of Alzheimer's DiseaseZhejiang Provincial Clinical Research Center for Mental DisordersSchool of Mental Health and Wenzhou Kangning HospitalThe Second Affiliated Hospital and Yuying Children's HospitalInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang 325035China Townsend Family Laboratories Department of PsychiatryBrain Research CenterThe University of British Columbia2255 Wesbrook MallVancouverBC V6T 1Z3Canada Chongqing Key Laboratory of Translational Medical Research in Cognitive Development and Learning and Memory Disorders Ministry of Education Key Laboratory of Child Development and DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400014China Center for Medical Genetics Hunan Key Laboratory of Animal Models for Human DiseasesHunan Key Laboratory of Medical GeneticsHunan International Scientific and Technological Cooperation Base of Animal Models for Human DiseasesSchool of Life SciencesCentral South UniversityChangsha 410078 HunanChina The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijing 100053Chin

Mutations in the Contactin-associated protein-like 2(CNTNAP2)gene are associated with autism spectrum disorder(ASD),and ectodomain shedding of the CNTNAP2 protein plays a role in its ***,key enzymes involved in the C-terminal cleavage of CNTNAP2 remain largely unknown,and the effect of ASD-associated mutations on this process and its role in ASD pathogenesis remain *** this report we showed that CNTNAP2 undergoes sequential cleavages by furin,ADAM10/17-dependent a-secretase and presenilindependent *** identified that the cleavage sites of ADAM10 and ADAM17 in CNTNAP2 locate at its C-terminal residue I79 and L96,and the main a-cleavage product C79 by ADAM10 is required for the subsequent y-secretase cleavage to generate CNTNAP2 intracellular domain(CICD).ASD-associated CNTNAP2 mutations impair the a-cleavage to generate C79,and the inhibition leads to ASDIlike repetitive and social behavior abnormalties in the Cntnap2l1254T knock-in ***,exogenous expression of 79 improves autism-ike phenotypes in the Cntnap2^(11254T) knock-in and Cntnap2^(-/-)knockout *** data demonstrates that the a-secretase is essential for CNTNAP2 processing and its *** study indicates that inhibition of the cleavage by pathogenic mutations underlies ASD pathogenesis,and upregulation of its C-terminal fragments could have therapeutical potentials for ASD treatment.

关键词： NAP2 cleavage subsequent

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Effect of inflammatory response on joint function after hip fracture in elderly patients:A clinical study

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World Journal of Orthopedics 2024年第4期15卷 337-345页

作者： jia-Ming Wang Yu-Tao Pan Chen-song Yang Ming-Chong Liu Sheng-Chao Ji Ning Han Fang Liu Gui-Xin Sun Department of Traumatic Surgery Shanghai East HospitalSchool of MedicineTongji UniversityShanghai 200092China

BACKGROUND Excellent hip joint function facilitates limb recovery and improves the quality of *** study aimed to investigate the potential risk factors affecting postoperative joint functional activity and outcomes in elderly hip fractures patients and to provide evidence for patient rehabilitation and clinical *** To explore the relationship between inflammatory factors and hip function and the interaction between inflammation and health after hip fracture in elderly *** The elderly patients who had hip fracture surgery at our hospital between January 1,2021,and December 31,2022 were chosen for this retrospective clinical *** with excellent and fair postoperative hip function had their clinical information and characteristics gathered and ***,gender,fracture site,surgical technique,laboratory indices,and other variables that could have an impact on postoperative joint function were all included in a univariate *** further identify independent risk factors affecting postoperative joint function in hip fractures,risk factors that showed statistical significance in the univariate analysis were then included in a multiple logistic regression *** addition to this,we also compared other outcome variables such as visual analogue scale and length of hospital stay between the two *** A total of 119 elderly patients with hip fractures were included in this study,of whom 37 were male and 82 were *** results of univariate logistic regression analysis after excluding the interaction of various factors showed that there was a statistically significant difference in interleukin(IL)-6,IL-8,IL-10,C-reactive protein(CRP),and complement C1q(C1q)between the fair and excellent joint function groups(P20 pg/mL[Odds ratio(OR)3.070,95%CI:1.243-7.579],IL-8>21.4 pg/mL(OR 3.827,95%CI:1.498-9.773),CRP>10 mg/L(OR 2.142,95%CI:1.

关键词： Hip function Fracture Inflammatory factors Risk factors Prevention

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全油气系统理论基本原理

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石油勘探与开发 2024年第4期51卷 679-691页

作者：贾承造庞雄奇宋岩中国石油天然气集团有限公司北京100007 油气资源与工程全国重点实验室中国石油大学(北京)北京102249 中国石油大学(北京)地球科学学院北京102249 中国石油勘探开发研究院北京100083 中国石油大学(北京)非常规油气科学技术研究院北京102249

通过阐释全油气系统基本原理,并阐明全油气系统的结构,进而揭示常规油气—致密油气—页岩油气序列成藏规律以及全油气系统成藏模式与成藏机理;此外,阐述了页岩油气-致密油气储层地质模型、流动模型与开发生产机理,并给出了进一步的研究... 详细信息

通过阐释全油气系统基本原理,并阐明全油气系统的结构,进而揭示常规油气—致密油气—页岩油气序列成藏规律以及全油气系统成藏模式与成藏机理;此外,阐述了页岩油气-致密油气储层地质模型、流动模型与开发生产机理,并给出了进一步的研究方向。研究表明:(1)全油气系统的主要结构包括3类流体动力场、3种油气藏与油气资源,以及两种成藏作用。常规油气—致密油气—页岩油气具有形成时间和空间分布的有序性、基于成因机理的序列合理性,表现出“序列成藏”的地质规律。(2)全油气系统成藏模式可以分为“碎屑岩盆地成藏模式”与“碳酸盐岩盆地(层系)成藏模式”两类。非常规油气的聚集成藏是一种“自封闭成藏”,油气自封闭作用的微观来源是分子间作用力(范德华力)。(3)非常规油气生产实践证实,页岩油气-致密油气储层地质模型、流动模型与开发生产机理是一个全新的领域,极为复杂,有待进一步研究。页岩油气一定是中国油气资源中最重要的资源接替。(4)进一步研究方向包括:碳酸盐岩盆地全油气系统特征及复合盆地演化源储耦合规律;页岩油气与致密油气运移、成藏与开发生产的流动机理;深层超深层页岩油气、致密油气和煤层气油气地质特征与富集规律;全油气系统油气资源评价与新一代盆地模拟技术;地球系统—地球有机岩与化石能源系统—全油气系统研究。

关键词：全油气系统理论全油气系统结构序列成藏规律全油气系统成藏模式自封闭成藏机理页岩油气-致密油气地质模型与流动模型

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High-density lipoprotein regulates angiogenesis by affecting autophagy via miRNA-181a-5p

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Science China(Life Sciences) 2024年第2期67卷 286-300页

作者： Bi-Ang Kang Hua-Ming Li Ya-Ting Chen Meng-Jie Deng Yan Li Yue-Ming Peng jian-Jun Gao Zhi-Wei Mo jia-Guo Zhou Zhi-Jun Ou Jing-song Ou Division of Cardiac Surgery Cardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China NHC key Laboratory of Assisted Circulation(Sun Yat-sen University) Guangzhou 510080China Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases Guangzhou 510080China Division of Vascular Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Department of Pharmacology Cardiac and Cerebral Vascular Research CenterZhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Division of Hypertension and Vascular Diseases Department of CardiologyCardiovascular Diseases InstituteThe First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China Guangdong Provincial Key Laboratory of Brain Function and Disease Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China

We previously demonstrated that normal high-density lipoprotein(nHDL)can promote angiogenesis,whereas HDL from patients with coronary artery disease(d HDL)is dysfunctional and impairs *** plays a critical role in angiogenesis,and HDL regulates ***,it is unclear whether n HDL and d HDL regulate angiogenesis by affecting *** cells(ECs)were treated with n HDL and d HDL with or without an autophagy ***,endothelial nitric oxide synthase(e NOS)expression,miRNA expression,nitric oxide(NO)production,superoxide anion(O2^(·-))generation,EC migration,and tube formation were evaluated.n HDL suppressed the expression of miR-181a-5p,which promotes autophagy and the expression of e NOS,resulting in NO production and the inhibition of O2^(·-)generation,and ultimately increasing in EC migration and tube formation.d HDL showed opposite effects compared to n HDL and ultimately inhibited EC migration and tube *** found that autophagy-related protein 5(ATG5)was a direct target of ***5 silencing or miR-181a-5p mimic inhibited n HDL-induced autophagy,e NOS expression,NO production,EC migration,tube formation,and enhanced O2^(·-)generation,whereas overexpression of ATG5 or miR-181a-5p inhibitor reversed the above effects of d ***5 expression and angiogenesis were decreased in the ischemic lower limbs of hypercholesterolemic low-density lipoprotein receptor null(LDLr^(-/-))mice when compared to C57BL/6 ***5 overexpression improved angiogenesis in ischemic hypercholesterolemic LDLr^(-/-)*** together,nHDL was able to stimulate autophagy by suppressing miR-181a-5p,subsequently increasing e NOS expression,which generated NO and promoted *** contrast,d HDL inhibited angiogenesis,at least partially,by increasing miR-181a-5p expression,which decreased autophagy and e NOS expression,resulting in a decrease in NO production and an increase in O2^(·-)*** findings reveal a nov

关键词： high-density lipoprotein angiogenesis autophagy ATG5 miRNA endothelial nitric oxide synthase

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随机波动驱动的异步元胞自动机及其计算通用性

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电子学报 2024年第5期52卷 1648-1656页

作者：黄鑫李佳葛亮宋伟重庆大学计算机学院

元胞自动机被广泛认为是基于分子自组装技术制造量子计算机、纳米计算机的基本架构，而元胞自动机的复杂度直接影响其并行分布式计算效率以及物理实现的可行性.现有复杂度最低的异步元胞自动机使用3个元胞状态和3条变迁规则能够构造所... 详细信息

元胞自动机被广泛认为是基于分子自组装技术制造量子计算机、纳米计算机的基本架构，而元胞自动机的复杂度直接影响其并行分布式计算效率以及物理实现的可行性.现有复杂度最低的异步元胞自动机使用3个元胞状态和3条变迁规则能够构造所有逻辑电路，具备与图灵机等价的计算通用性（图灵通用性）.为进一步降低通用异步元胞自动机的复杂度，本文提出新型电路元件以及基于该元件的逻辑电路设计方法 .不同于同步电路的逻辑门元件，新型电路元件能够有效处理信号的随机波动，对单电子隧道晶体管等纳米材料技术有积极的应用价值.据此，本文提出新的异步元胞自动机模型，该模型仅需3个元胞状态和2条规则，比现有的通用模型复杂度低.除图灵通用性外，本文通过设计大规模分布式逻辑电路，进一步证明所提的异步元胞自动机具备与所有同步元胞自动机同等的计算能力.

关键词：元胞自动机异步更新布朗运动延迟不敏感电路通用性

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