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Changes of sulfur dioxide, nuclear factor-κB, and interleukin-8 levels in pediatric acute lymphoblastic leukemia with bacterial inflammation

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Chinese Medical Journal 2014年第23期127卷 4110-4113页

作者： Wu Wanshui jia yongrui Du Shuxu Tang Hong Sun Yangling Sun Liming J Department of Pediatrics Shijitan Hospital Capital Medical University Beijing 100038 China Health Science Center Peking University Beijing 100191 China

Background Bacterial inflammation is a common complication in patients with leukemia,and sulfur dioxide （SO2） is a bioactive molecule in modulating Gram-negative bacilli *** study aimed to examine the changes in SO2,nuclear factor-κB （NF-κB）,and interleukin-8 （IL-8） levels in pediatric acute lymphoblastic leukemia （ALL） with Gram-negative bacterial *** Fifty-five ALL children were enrolled in this study,including 30 males and 25 females,aged 3-13 years,and the median age was 7.8 *** these children who accepted chemotherapy for ALL were divided into the control group （before chemotherapy）,the infection group （after chemotherapy with infection）,and the recovery group （the infection was controlled after 1 week）.The serum level of SO2 was detected using high performance liquid chromatography with fluorescence assay,and NF-κB and IL-8 levels were measured by enzyme-linked immunosorbent assay （ELISA）.Human THP-1 cells were cultured,induced,and differentiated into macrophages,which were divided into five groups and each group was cultured with different stimulators：lipopolysaccharide （LPS） group,LPS＋L-aspartate-β-hydroxamate （HDX） group,LPS＋SO2 group,SO2,and control ***-κB level and IL-8 protein contents by ELISA were examined in each *** In comparison with those of the control group,levels of serum SO2,NF-κB,and IL-8 of the infection group were significantly increased （P ＜0.05）,while those of the recovery group were significantly decreased （P ＜0.05）.A positive correlation was found between levels of serum SO2 and intracellular NF-κB/IL-8,and the correlation coefficients were 0.671 and 0.798 （P ＜0.05）,*** to the results found in human THP-1 cells,levels of NF-κB and IL-8 in LPS group were significantly increased compared with those of the control group （P ＜0.05）; when compared with those in LPS group,levels of NF-κB in LPS＋HDX group further increased significantly （P ＜0.05）; however,the NF-κB levels of LP

关键词： acute lymphoblastic leukemia child sulfur dioxide nuclear factor-κB interleukin-8

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High-throughput screening system of citrus bacterial cankerassociated transcription factors and its application to the regulation of citrus canker resistance

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Journal of Integrative Agriculture 2024年第1期23卷 155-165页

作者： jia Fu Jie Fan Chenxi Zhang Yongyao Fu Baohang Xian Qiyuan Yu Xin Huang Wen Yang Shanchun Chen yongrui He Qiang Li Integrative Science Center of Germplasm Creation in Western China(Chongqing)Science City Citrus Research InstituteSouthwest UniversityChongqing 400712China School of Advanced Agriculture and Bioengineering Yangtze Normal UniversityChongqing 408100China National Citrus Engineering Research Center Chongqing 400712China

One of the main diseases that adversely impacts the global citrus industry is citrus bacterial canker(CBC),caused by the bacteria Xanthomonas citri ***(Xcc).Response to CBC is a complex process,with both proteinDNA as well as protein–protein interactions for the regulatory *** detect such interactions in CBC resistant regulation,a citrus high-throughput screening system with 203 CBC-inducible transcription factors(TFs),were *** the upstream regulators of target by yeast-one hybrid(Y1H)methods was also performed.A regulatory module of CBC resistance was identified based on this *** TF(CsDOF5.8)was explored due to its interactions with the 1-kb promoter fragment of CsPrx25,a resistant gene of CBC involved in reactive oxygen species(ROS)homeostasis *** mobility shift assay(EMSA),dual-LUC assays,as well as transient overexpression of CsDOF5.8,further validated the interactions and transcriptional *** CsDOF5.8–CsPrx25 promoter interaction revealed a complex pathway that governs the regulation of CBC resistance via *** high-throughput Y1H/Y2H screening system could be an efficient tool for studying regulatory pathways or network of CBC resistance *** addition,it could highlight the potential of these candidate genes as targets for efforts to breed CBC-resistant citrus varieties.

关键词： citrus bacterial canker(CBC) high-throughput screening system transcription factor(TF) yeast-one hybrid(Y1H) CsPrx25

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Immune regulation of hydrogen sulfide in children with acute lymphoblastic leukemia

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Chinese Medical Journal 2014年第21期127卷 3695-3699页

作者： Du Shuxu jia yongrui Tang Hong Sun Yangling Wu Wanshui Sun Liming Du Junbao Geng Bin Tang Chaoshu Jin Hongfang Department of Pediatrics Shijitan Hospital Capital Medical University Beijing 100038 China Health Science Center Peking University Beijing 100191 China Department of Pediatrics Peking University First Hospital Beijing 100034 China Department of Physiology and Pathophysiology Peking University Health Science Center Beijing 100191 China

Background Acute lymphoblastic leukemia （ALL） and chemotherapy can cause immune imbalance,and gaseous molecule hydrogen sulfide （H2S） can participate in the process of immune *** study aimed to investigate the immune regulation of H2S in pediatric *** Children （n=78） with ALL admitted during 2010-2013 were included in this *** blood samples were collected in period of before chemotherapy,bone marrow remission and two days after chemotherapy,*** contents of H2S and cytokines,including interleukin-1β （IL-13）,interleukin-2 （IL-2）,interferon-γ （IFN-γ）,tumor necrosis factor （TNF-α）,interleukin-4 （IL-4）,interleukin-6 （IL-6）,interleukin-10 （IL-10） and macrophage inflammatory protein-1α （MIP-1a）,were detected using ELISA *** regression was used to analyze the correlation between H2S and ***,human Jurkat cells were cultured in vitro,and nucleoprotein of Jurkat cells and peripheral blood mononuclear cells （PBMCs） were collected,contents of cystathionine γ-lyase （CSE） and certain cytokines were measured by Western *** Serum concentrations of H2S,IL-13,IL-6,IL-10 and MIP-1α in children with ALL were increased significantly （P ＜0.01）,while concentrations of IL-2,TNF-α,IFN-γ and IL-4 decreased obviously （P ＜0.01）.In patients after chemotherapy,concentrations of H2S and IL-10 were decreased significantly （P ＜0.05）,but IL-4 and IFN-γ concentrations increased markedly （P ＜0.05）.At remission stage,H2S,IL-13,IL-4,IL-6,IL-10 and MIP-1α concentrations were further decreased markedly （P ＜0.05）,but concentrations of IL-2,TNF-α and IFN-γ increased again （P ＜0.05）.Protein contents of CSE,IL-10,IL-4 and IL-2 of PBMCs also increased markedly in children with ***,changes of CSE protein contents of PBMCs were consistent with serum H2S contents,and there were significant correlation between H2S and certain cytokines based on stepwise regression ***,compared with those of PBMCs group,in vit

关键词： child acute lymphoblastic leukemia hydrogen sulfide cytokine immune

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Antiviral and analgesic activity of the complex of Hypericum Perforatum *** and Lysine monohydrochloride

Antiviral and analgesic activity of the complex of Hypericum...

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第十一届全国神经药理学术会议

作者： Hu Ran Ku Baoshan jia yongrui Zhang Yonghe Yao Haiyan Department of pharmacology, Peking University, Beijing 100083

Part I Screening Research Objective: To screen the antiviral and analgesic activities of the complex of extract of HypericumPerforatum L. (EHPL) and Lysine hydrochloride in mass ratio of 1: 1, 1: 2 and 2: 1 to determinewhich one is better. Methods: In screening test, the antiviral activities on herpes simplex virus type 1(HSV - 1) and varicella - zoster virus (VZV) in Vitro were evaluated by cytopathic effect (CPE) inhi-bition assay and the analgesic activities were tested in carrageenan test and acetic acid induced writhing

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抗抑郁药治疗疱疹后遗神经痛的进展

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国外医学（皮肤性病学分册） 2003年第2期29卷 69-71页

作者：胡然贾永蕊库宝善北京大学医学部基础医学院药理系 100083

主要介绍抗抑郁药治疗疱疹后遗神经痛的临床应用 ,疗效评价 ,探讨其作用机制。三环类抗抑郁药已作为治疗疱疹后遗神经痛的一线药物。其中 ,阿米替林应用最普遍 ,地昔帕明和去甲替林副作用小于阿米替林。去甲替林可作为首选。选择性 5

关键词：抗抑郁药治疗带状疱疹后遗神经痛疗效评价

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Improving Retrieval Performance by Region Constraints and Relevance Feedback

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Journal of Computer Science & Technology 2004年第3期19卷 413-422页

作者： TaoWang yongrui jia-GuangSun DepartmentofComputerScienceandTechnology TsinghuaUniversityBeijing100084P.R.China／／StatisticalComputingGroupIntelChinaResearchCenterBeijing100020P.R.China MicrosoftResearch OneMicrosoftWayRedmondWA98052USA DepartmentofComputerScienceandTechnology TsinghuaUniversityBeijing100084P.R.China

In this paper, region features and relevance feedback are used to improve the performance of CBIR. Unlike existing region-based approaches where either individual regions are used or only simple spatial layout is modeled, the proposed approach simultaneously models both region properties and their spatial relationships in a probabilistic framework. Furthermore, the retrieval performance is improved by an adaptive filter based relevance feedback. To illustrate the performance of the proposed approach, extensive experiments have been carried out on a large heterogeneous image collection with 17,000 images, which render promising results on a wide variety of queries.

关键词： content-based image retrieval (CBIR) region matching probabilistic weight estimation relevance feedback adaptive filter

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增材制造复杂流道水冷电机壳体对驱动电机持续功率影响的研究

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精密成形工程 2024年第2期16卷 174-181页

作者：邓佳明朱茜陈浩铭秦永瑞李佳李坤重庆长安汽车股份有限公司重庆400023 重庆工业职业技术学院重庆401120 重庆大学机械与运载工程学院重庆400044

目的提高量产铸造电机壳体的换热效率,确保电机在高功率持续工作状态下不会过热,从而提高电机的持续功率。方法基于增材思维对电机水冷壳体的流道进行优化,改变流道形状以增大流道表面积、消除流道涡流并减小流道与内壁的间距。通过仿... 详细信息

目的提高量产铸造电机壳体的换热效率,确保电机在高功率持续工作状态下不会过热,从而提高电机的持续功率。方法基于增材思维对电机水冷壳体的流道进行优化,改变流道形状以增大流道表面积、消除流道涡流并减小流道与内壁的间距。通过仿真分析,不断优化迭代得到最佳的流道设计方案。运用选区激光熔化(SLM)增材技术及相应的后处理工艺,制造出复杂流道结构的电机壳体。结果采用SLM增材技术制造的AlSi10Mg铝合金壳体在x、xz、z 3个方向上的屈服强度均大于230 MPa,即使在较小壁厚的条件下,壳体强度仍满足设计要求。采用该壳体后,电机的持续功率从原量产电机的45 kW提升到50.7 kW,且仍能连续稳定运行45 min,同时电机温度未超过130℃。微观组织检测和工业CT测试结果显示,SLM电机壳体结构致密,未见气孔夹杂。该增材制造壳体的质量为6.95 kg,与量产电机壳体相比,减重约19%。结论通过增材制造技术设计制造的电机壳体整体性能良好,可以有效提高换热效率以及电机的持续功率,并实现了电机的减重。

关键词：增材制造驱动电机壳体流道优化持续功率 SLM

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MiRNA 24-3p-rich exosomes functionalized DEGMA-modified hyaluronic acid hydrogels for corneal epithelial healing

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Bioactive Materials 2023年第7期25卷 640-656页

作者： Xiaomin Sun Wenjing Song Lijing Teng yongrui Huang jia Liu Yuehai Peng Xiaoting Lu Jin Yuan Xuan Zhao Qi Zhao Yingni Xu Jingjie Shen Xiaoyun Peng Li Ren School of Materials Science and Engineering South China University of TechnologyGuangzhou510006China National Engineering Research Center for Tissue Restoration and Reconstruction Guangzhou510006China Key Laboratory of Biomedical Engineering of Guangdong Province South China University of TechnologyGuangzhou510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou510006China Innovation Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006China School of Biological Science and Engineering South China University of TechnologyGuangzhou510006China Sino-Singapore International Joint Research Institute Guangzhou510555China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou510005China School of Biology and Engineering Guizhou Medical UniversityGuiyangGuizhou550025China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou510623China

The damage of corneal epithelium may lead to the formation of irreversible corneal opacities and even *** migration rate of corneal epithelial cells directly affects corneal ***,we explored ocu-microRNA 24-3p(miRNA 24-3p)that can promote rabbit corneal epithelial cells migration and cornea ***,an excellent transport carrier,were exacted from adipose derived mesenchymal stem cells for loading with miRNA 24-3p to prepare miRNA 24-3p-rich exosomes(Exos-miRNA 24-3p).It can accelerate corneal epithelial migration in vitro and in *** application in cornea alkali burns,we further modified hyaluronic acid with di(ethylene glycol)monomethyl ether methacrylate(DEGMA)to obtain a thermosensitive hydrogel,also reported a thermosensitive DEGMA-modified hyaluronic acid hydrogel(THH)for the controlled release of Exos-miRNA *** formed a highly uniform and clear thin layer on the ocular surface to resist clearance from blinking and extended the drug-ocular-epithelium contact *** use of THH-3/Exos-miRNA 24-3p for 28 days after alkali burn injury accelerated corneal epithelial defect healing and epithelial *** also reduced corneal stromal fibrosis and macrophage *** 24-3p-rich exosomes functionalized DEGMA-modified hyaluronic acid hydrogel as a multilevel delivery strategy has a potential use for cell-free therapy of corneal epithelial regeneration.

关键词： miRNA 24-3p Exosome Corneal epithelium Cell migration Thermosensitive hydrogel

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CitGVD:a comprehensive database of citrus genomic variations

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Horticulture Research 2020年第1期7卷 2529-2536页

作者： Qiang Li Jingjing Qi Xiujuan Qin Wanfu Dou Tiangang Lei Anhua Hu Ruirui jia Guojin jiang Xiuping Zou Qin Long Lanzhen Xu Aihong Peng Lixiao Yao Shanchun Chen yongrui He Citrus Research Institute Southwest University/Chinese Academy of Agricultural Sciences400712 ChongqingChina Key Laboratory of Plant Hormones and Development Regulation of Chongqing School of Life SciencesChongqing University401331 ChongqingChina

Citrus is one of the most important commercial fruit crops *** the vast genomic data currently available for citrus fruit,genetic relationships,and molecular markers can be assessed for the development of molecular breeding and genomic selection *** this study,to permit the ease of access to these data,a web-based database,the citrus genomic variation database(CitGVD,http://***/home)was developed as the first citrusspecific comprehensive database dedicated to genome-wide variations including single nucleotide polymorphisms(SNPs)and insertions/deletions(INDELs).The current version(V1.0.0)of CitGVD is an open-access resource centered on 1,493,258,964 high-quality genomic variations and 84 phenotypes of 346 organisms curated from in-house projects and public *** integrates closely related information on genomic variation annotations,related gene annotations,and details regarding the organisms,incorporating a variety of built-in tools for data accession and *** an example,CitGWAS can be used for genome-wide association studies(GWASs)with SNPs and phenotypic data,while CitEVOL can be used for genetic structure *** features make CitGVD a comprehensive web portal and bioinformatics platform for citrus-related *** also provides a model for analyzing genome-wide variations for a wide range of crop varieties.

关键词： database analysis comprehensive

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企业推荐奖励与广告投入联合优化问题研究

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工业工程与管理 2022年第4期27卷 8-15页

作者：段永瑞秦玉静尹佳同济大学经济与管理学院上海200092

随着移动互联网的发展,消费者推荐奖励作为一种新型的口碑营销工具正被越来越多的企业运用,并作为传统广告的补充。本文考虑消费者愉悦阈值对推荐过程的影响,构建了推荐奖励和广告投入的联合优化模型,得到了不同愉悦阈值下企业最优的推... 详细信息

随着移动互联网的发展,消费者推荐奖励作为一种新型的口碑营销工具正被越来越多的企业运用,并作为传统广告的补充。本文考虑消费者愉悦阈值对推荐过程的影响,构建了推荐奖励和广告投入的联合优化模型,得到了不同愉悦阈值下企业最优的推荐奖励-广告策略。研究发现:消费者愉悦阈值较低时,企业不提供推荐奖励,仅进行广告投入,且投入水平较高;消费者愉悦阈值中等时,企业联合使用奖励和广告投入;消费者愉悦阈值较高时,企业不考虑消费者推荐,仅进行广告投入,且投入水平较低。最后分析产品价格、愉悦阈值、广告成本系数等关键参数对最优推荐奖励和广告投入的影响。

关键词：推荐奖励广告投入口碑效应愉悦阈值

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