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Huge Corneal Dermoid-like Mass in a Malformed Eye

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Huge Corneal Dermoid-like Mass in a Malformed Eye

Polydopamine/poly(sulfobetaine methacrylate)Co-deposition coatings triggered by CuSO_(4)/H_(2)O_(2)on implants for improved surface hemocompatibility and antibacterial activity

2006年浙江省眼科学术会议

作者： Wei Chen,yune Zhao,jia qu 温州医学院附属眼视光医院

Purpose To describe the clinicopathologic features of a patient with a huge corneal dermoid-like mass in the left malformed *** One case report and literature *** The clinical and pathological findings in a patient with a large comeal dermoid-like mass in the left malformed eye are reviewed and *** One patient presented with a huge corneal dermoid-like mass in the left

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Bioactive Materials 2021年第8期6卷 2546-2556页

作者： Zhongqiang Zhu Qiang Gao Ziyue Long Qiuyi Huo Yifan Ge Ntakirutimana Vianney Nishimwe Anodine Daliko Yongchun Meng jia qu Hao Chen Bailiang Wang School of Ophthalmology&Optometry Eye HospitalWenzhou Medical UniversityWenzhou325027China Central Laboratory Yantai Affiliated Hospital of Binzhou Medical University717 Jinbu StreetYantaiShandong264100China

Implanted biomaterials such as medical catheters are prone to be adhered by proteins,platelets and bacteria due to their surface hydrophobicity characteristics,and then induce related infections and ***,the development of a versatile strategy to endow surfaces with antibacterial and antifouling functions is particularly significant for blood-contacting *** this work,CuSO_(4)/H_(2)O_(2)was used to trigger polydopamine(PDA)and poly-(sulfobetaine methacrylate)(PSBMA)co-deposition process to endow polyurethane(PU)antibacterial and antifouling surface(PU/PDA(Cu)/PSBMA).The zwitterions contained in the PU/PDA(Cu)/PSBMA coating can significantly improve surface wettability to reduce protein adsorption,thereby improving its blood *** addition,the copper ions released from the metal-phenolic networks(MPNs)imparted them more than 90%antibacterial activity against *** and ***,PU/PDA(Cu)/PSBMA also exhibits excellent performance in vivo mouse catheter-related infections ***,the PU/PDA(Cu)/PSBMA has great application potential for developing multifunctional surface coatings for blood-contacting materials so as to improve antibacterial and anticoagulant properties.

关键词： Zwitterionic polymer Copper ions Surface modification Hemocompatibility Antibacterial

Design and baseline data of a populationbased metabonomics study of eye diseases in eastern China: the Yueqing Ocular Diseases Investigation

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Eye and Vision 2020年第1期7卷 75-86页

作者： Yuxuan Deng Yuanbo Liang Sigeng Lin Liang Wen Jin Li Yue Zhou Meixiao Shen Jingwei Zheng Kemi Feng Yanting Sun Kwapong Willaim Robert jia qu Fan Lu Clinical and Epidemiological Research Center Eye Hospital of Wenzhou Medical University270 Xueyuan RoadWenzhou 325027ZhejiangChina School of Ophthalmology and Optometry Wenzhou Medical University270 Xueyuan RoadWenzhou 325027ZhejiangChina Qingdao Municipal Hospital 5 Donghai Middle RoadQingdao 266071ShandongChina Wuhu First People’s Hospital 1 Chizhushandong RoadWuhu 241000AnhuiChina Eye Hospital of Fushun City 1 Hupo RoadFushun 113006LiaoningChina Qilu Hospital of Shandong University(Qingdao) 758 Hefei RoadQingdao 266035ShandongChina

Background:China is undergoing a massive transition toward an urban and industrial *** changes will restructure the demographics and economy which will eventually influence the future patterns of *** risk factors of vision-impairing eye diseases remain ambiguous and poorly *** is an ideal tool to understand and shed light on the ocular disease mechanisms for earlier *** article aims to describe the design,methodology and baseline data of the Yueqing Ocular Diseases Investigation(YODI),a developed county population-based study to determine the prevalence and primary causes of visual impairment;also with metabonomics analysis we aimed to identify,predict and suggest some preventive biomarkers that cause ***:A population-based,cross-sectional *** clustering sampling was used to identify adults aged 50 years and older in Xiangyang Town,Yueqing county-level *** interviews covered demographic,behavioral,ocular risk factors and mental health *** ocular examination included visual acuity,autorefraction,intraocular pressure,anterior and posterior segment examinations,fundus photography,retinal tomography and angiography,and visual field *** measurements included height and weight,waist and hip circumference,blood pressure,pulse rate,electrocardiogram,and abdominal ultrasound scan.A venous blood sample was collected for laboratory tests and metabonomics ***:Of the 5319 individuals recruited for the YODI,4769(89.7%)subjects were enrolled for *** median age was 62.0 years,and 45.6%were *** educational level of illiteracy or semi-illiteracy,primary,middle and high school or above was 29.8%,45.5%,20.1%,and 3.3%,*** of the participants were female,younger,and less educated when compared with *** average body mass index and waist-hip ratios were 24.4±3.4 kg/m^(2) and 0.9±0.1 *** sample collection reached

关键词： Population Baseline Ophthalmic epidemiology Visual impairment Screening Metabonomics

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坚持防治近视眼研究的正确方向

中华眼科杂志 2003年第6期39卷 321-324页

作者：瞿佳温州医学院眼视光学院 325003

近视眼是目前全球发生率最高的屈光不正，美国25%以上的成年人患有近视眼，在亚洲部分国家和地区特定人群近视眼发生率高达70%。目前儿童和青少年近视不仅发病年龄提前，发生率增高，且发生后呈进展趋势，已经成为严重的公共卫生问题，... 详细信息

近视眼是目前全球发生率最高的屈光不正，美国25%以上的成年人患有近视眼，在亚洲部分国家和地区特定人群近视眼发生率高达70%。目前儿童和青少年近视不仅发病年龄提前，发生率增高，且发生后呈进展趋势，已经成为严重的公共卫生问题，世界卫生组织（WHO）已将近视眼的防治列入全球防盲计划。近视眼发生和发展机制的研究一直是眼科学家研究的重要课题，近视眼的防治也一直是公众关心的问题。其治疗方法虽层出不穷，但良莠难辨，令公众困惑。笔者将对近视眼的流行病学研究、近视眼的发生、发展机制及近视的矫治方法作一评述。

关键词：防治措施近视眼遗传学矫正方法

玻璃微珠/环氧树脂复合材料的动静态力学性能研究

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复合材料学报 2023年第7期40卷 3874-3880页

作者：刘鑫袁野曲嘉哈尔滨工程大学航天与建筑工程学院哈尔滨150001

玻璃微珠浮力材料是一种由空心玻璃微珠(HGB)和环氧树脂制造的二相复合材料。玻璃微珠材料因其具有低密度、高强度、吸水率低等特点被广泛应用于建材、航海、航天等领域。其静态力学性能已经得到充分地研究,但对其动态力学性能的研究尚... 详细信息

玻璃微珠浮力材料是一种由空心玻璃微珠(HGB)和环氧树脂制造的二相复合材料。玻璃微珠材料因其具有低密度、高强度、吸水率低等特点被广泛应用于建材、航海、航天等领域。其静态力学性能已经得到充分地研究,但对其动态力学性能的研究尚不能满足工程应用需求。采用INSTRON电子万能试验机和分离式霍普金森压杆(SHPB)对HGB/环氧树脂复合材料进行了准静态/动态加载情况下的压缩、劈拉、伪三轴压缩实验。结果表明,HGB/环氧树脂复合材料具有较强的应变率敏感性。其抗压强度、劈裂抗拉强度随应变率增加而增加,表现出应变率增强效应。其破坏形式也存在应变率敏感特性,随着应变率的提高其脆性增加。对比单轴压缩及伪三轴压缩,发现材料在伪三轴压缩情况下较单轴压缩时抗压强度增强。

关键词：空心玻璃微珠复合材料力学性能分离式霍普金森压杆(SHPB) 伪三轴加载应变率敏感性

A comparative proteomics approach to detect unintended effects in transgenic Arabidopsis

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Journal of Genetics and Genomics 2009年第10期36卷 629-639页

作者： Yanfei Ren Jun Lv Hua Wang Linchuan Li Yufa Peng Li-jia qu National Key Laboratory of Protein Engineering and Plant Genetic Engineering College of Life Sciences Peking University Beijing 100871 China lnstitute of Plant Protection Chinese Academy of Agricultural Sciences Beijing 100193 China

Recently, as part of biosafety assessments, unintended effects have been given much attention. In this study, we applied a proteomics approach to elucidate the unintended effects of random T-DNA insertion in transgenic plants. Separated proteins extracted from 12 transgenic Arabidopsis thaliana with different T-DNA insertion sites and from wild-type （ecotype Col-o） were analyzed. In the transgenic plants, 102 significantly altered protein spots were detected, in which 59 were up-regulated and 43 down-regulated. MALDI-TOF MS analysis showed that most of these expression level-altered proteins were involved in energy transfer, oxidative respiration and photosynthesis. However, none of these proteins was a toxic protein or allergen. Using plants with or without cold treatment, a natural environmental stress, as controls, we found that the number of the altered proteins was even less in those transgenic plants than those triggered by the cold treatment, suggesting that the transgenic events had a weaker impact on the plants than the environmental stresses. Interestingly, the phosphinothricin acetyl transferase （PAT）, the BAR-encoded protein, was detected in nine out of twelve different T-DNA insertion lines at five different insertion sites. These data suggest that the most significant impact of transgenic events on the host plants is from the transgene itself, i.e., from the predictable intended effects, rather than unintended effects. This study also suggests that the proteomics approach has the potential to detect the unintended effects in transgenic plants.

关键词： biosafety proteomics Arabidopsis thaliana 2-D PAGE MALDI-TOF unintended effect

A nuclear-encoded mitochondrial gene AtCIB22 is essential for plant development in Arabidopsis

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Journal of Genetics and Genomics 2010年第10期37卷 667-683页

作者： Lihua Han Genji Qin Dingming Kang Zhangliang Chen Hongya Gu Li-jia qu College of Agronomy and Biotechnology China Agricultural University Beijing 100094 China National Laboratory of Protein Engineering and Plant Genetic Engineering Peking University Beijing 100871 China The National Plant Gene Research Center (Beijing) Beijing 100101 China

Complex I （the NADH：ubiquinone oxidoreductase） of the mitochondrial respiratory chain is a complicated, multi-subunit, membrane- bound assembly and contains more than 40 different proteins in higher plants. In this paper, we characterize the Arabidopsis homologue （designated as AtCIB22） of the B22 subunit of eukaryotic mitochondriai Complex I. AtCIB22 is a single-copy gene and is highly con- served throughout eukaryotes. AtCIB22 protein is located in mitochondria and the AtC1B22 gene is widely expressed in different tissues. Mutant Arabidopsis plants with a disrupted AtC1B22 gene display pleiotropic phenotypes including shorter roots, smaller plants and de- layed flowering. Stress analysis indicates that the AtC1B22 mutants＇ seed germination and early seedling growth are severely inhibited by sucrose deprivation stress but more tolerant to ethanol stress. Molecular analysis reveals that in moderate knockdown AtCIB22 mutants, genes including cell redox proteins and stress related proteins are significantly up-regulated, and that in severe knockdown AtCIB22 mu- tants, the alternative respiratory pathways including NDA1, NDB2, AOXla and AtPUMP1 are remarkably elevated. These data demon- strate that AtCIB22 is essential for plant development and mitochondrial electron transport chains in Arabidopsis. Our findings also en- hance our understanding about the physiological role of Complex I in plants.

关键词： mitochondria Complex I B22 subunit ethanol treatment alternative oxidase uncoupling protein

Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization

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National Science Review 2022年第5期9卷 119-128页

作者： Jin-Tao Li Kai-Yue Li Ying Su Yuan Shen Ming-Zhu Lei Fan Zhang Miao Yin Zheng-Jun Chen Wen-Yu Wen Wei-Guo Hu Dan Su jia qu qun-Ying Lei Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Cancer Institutes Key Laboratory of Breast Cancer in ShanghaiShanghai Key Laboratory of Medical EpigeneticsInternational Co-Laboratory of Medical Epigenetics and MetabolismMinistry of Science and Technology Shanghai Medical College Fudan University State Key Laboratory of Cell Biology Shanghai Institute of Biochemistry and Cell Biology Center for Excellence in Molecular Cell ScienceChinese Academy of Sciences Cancer Research Institute Zhejiang Cancer Hospital and Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology of Zhejiang Province Department of Oncology Shanghai Medical College Fudan University State Key Laboratory of Medical Neurobiology Fudan University

BCAT2-mediated branched-chain amino acid(BCAA) catabolism is critical for pancreatic ductal adenocarcinoma(PDAC) development,especially at an early ***,whether a high-BCAA diet promotes PDAC development in vivo,and the underlying mechanism of BCAT2 upregulation,remain ***,we find that a high-BCAA diet promotes pancreatic intraepithelial neoplasia(PanIN)progression in LSL-KrasG12 D/+; Pdx1-Cre(KC) ***,we screened with an available deubiquitylase library which contains 31 members of USP family and identified that USP1 deubiquitylates BCAT2 at the K229 ***,BCAA increases USP1 protein at the translational level via the GCN2-eIF2α pathway both in vitro and in *** importantly,USP1 inhibition recedes cell proliferation and clone formation in PDAC cells and attenuates pancreas tumor growth in an orthotopic transplanted mice ***,a positive correlation between USP1 and BCAT2 is found in KC;LSL-KrasG12D/+;p53flox/+;Pdx1-Cre mice and clinical ***,a therapeutic targeting USP1-BCAT2-BCAA metabolic axis could be considered as a rational strategy for treatment of PDAC and precisive dietary intervention of BCAA has potentially translational significance.

关键词： USP1 deubiquitylation BCAT2 PanIN PDAC

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多体分离抛撒初条件与分离特征参数

宇航学报 2005年第2期26卷 140-142页

作者：杨益农贾区耀北京空气动力研究所北京100074

多次风洞自由飞多体分离抛撒实验均证实了被抛撒物运动初条件对抛离成功与否有决定性影响;为此可采取"戴帽"措施;但数值计算结果与此相反,因而需深入开展研究,解决问题。常规形式的风洞测力方法,无法模拟各分离体之间很大的相对速度。... 详细信息

多次风洞自由飞多体分离抛撒实验均证实了被抛撒物运动初条件对抛离成功与否有决定性影响;为此可采取"戴帽"措施;但数值计算结果与此相反,因而需深入开展研究,解决问题。常规形式的风洞测力方法,无法模拟各分离体之间很大的相对速度。分离过程中"特征时间"是很小的,因而风洞实验以及数值计算必须计及非常小的"特征时间"所反映的非定常气动力。多体分离的实践表明,至少在快速分离过程中运动动力学相似是必需的。

关键词：风洞自由飞实验气动数值计算多体分离