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Rare Metals 2010年第1期29卷 86-91页

作者： CHU Ke, jia Chengchang, liang Xuebing, and CHEN Hui School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China School of Materials Science and Engineering University of Science and Technology Beijing

Two powder mixing processes, mechanical mixing （MM） and mechanical alloying （MA）, were used to prepare mixed Al/diamond powders, which were subsequently consolidated using spark plasma sintering （SPS） to produce bulk Al/diamond composites. The effects of the powder mixing process on the morphologies of the mixed powders, the microstructure and the thermal conductivity of the composites were investigated. The results show that the powder mixing process can significantly affect the microstructure and the thermal conductivity of the composites. Agglomerations of the particles occurred in mixed powders using MM for 30 min, which led to high pore content and weak interfacial bonding in the composites and resulted in low relative density and low thermal conductivity for the composites. Mixed powders of homogeneous distribution of diamond particles could be obtained using MA for 10 min and MM for 2 h. The composite prepared through MA indicated a high relative density but low thermal conductivity due to its defects, such as damaged particles, Fe impurity, and local interfacial debonding, which were mainly introduced in the MA process. In contrast, the composite made by MM for 2 h demonstrated high relative density and an excellent thermal conductivity of 325 W.m^-1.K^-1, owing to its having few defects and strong inter-facial bonding.

关键词： metal matrix composites thermal properties sintering powder mixing

Structurally modulated Li-rich cathode materials through cooperative cation doping and anion hybridization

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Science China Chemistry 2017年第12期60卷 1554-1560页

作者： Xu-Dong Zhang Ji-Lei Shi jia-Yan liang Ya-Xia Yin Yu-Guo Guo Li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesInstitute of Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering University of Chinese Academy of Sciences

High capacity Li-rich materials are mighty contenders for building rechargeable batteries that coincide with the demand in energy density. Fully realizing the extraordinary capacity involves oxygen evolution and related cation migration, resulting in phase transitions and deteriorations that would hinder their practical application. In an attempt to enhance the anodic redox participation and stabilize the structure at the same time, we proposed a structural modulation strategy with modification on anion hybridization intensifying and cation doping. Spectator ions with large ionic radius were introduced into the lattice during calcination with stannous chloride and the d-p hybridization between transition metal 3 d and oxygen 2 p orbitals was subsequently intensified along with expelling weakly bonded chloride species in the reheating process. Both of the reversible capacity and stability upon cycling were remarkably improved through the cooperation of bond alteration and dopant. This strategy might provide new insight into the modulation of the structure to truly fulfill the potential of Li-rich materials.

关键词： Li-ion batteries cathode materials structural modification doping anodic redox

Expression of p53 in myocardium following coronary microembolization inrats and its significance

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Journal of Geriatric Cardiology 2017年第5期14卷 292-300页

作者： Yu-Han SUN Qiang SU Lang LI Xian-Tao WANG Yuan-Xi LU jia-Bao liang Department of Cardiology the First Affiliated Hospital of Guangxi Medical University Nanning China

Background Cardiomyocyte apoptosis is a primary cause for coronary microembolization （CME）-induced cardiac dysfunction, p53induces cell growth retardation and apoptosis through stress pathway. The present study investigated the mechanism of p53-induced myocar-dial apoptosis and cardiac dysfunction by activating the mitochondrion apoptotic pathway following CME. Methods Forty SD rats wereequally divided into microembolization （CME）, sham operation （sham）, CME＋siRNA-p53, and CME＋control-p53 groups. The CME ratmodel was established by injecting microembolization spheres via the left ventricle. Cardiac ultrasound, TUNEL, fluorescence quantitativePCR, and Western blot were used to assess the cardiac function indicators, cardiomyocyte apoptosis, and the expressions of mRNA and pro-tein in myocardial tissues, respectively. Results Echocardiography revealed a significantly reduced cardiac function of the CME group thanthe sham group while the CME-induced cardiac dysfunction was improved in the CME＋siRNA-p53 group. The indicators of myocardialapoptosis in the CME group increased significantly than the sham group; those of the CME＋siRNA-p53 group decreased significantly thanthe CME group. Fluorescence quantitative PCR and Western blot demonstrated that p53, Bbc3 （PUMA）, and cleaved caspase-3 expressionswere significantly increased, and BCL-2 expression was declined in myocardial tissues of the CME group compared to the sham group. Acontrasting result was observed in the CME＋siRNA-p53 group as compared to the CME group. Conclusions P53 is involved in theCME-induced cardiac dysfunction, which may up-regulate Bbc3 to activate BCL-2/caspase3 mitochondrial apoptotic pathway and inducemyocardial apoptosis. Inhibiting the p53 expression can effectively suppress this pathway, thereby reducing myocardial apoptosis and car-diac dysftmction.

关键词： Bbc3 BCL-2 Cardiac dysfunction Coronary microembolization Myocardial apoptosis p53

Controlling Directional Emission of Ions Attached on Surface of Nanoparticles

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Chinese Physics Letters 2024年第11期41卷 34-44页

作者： Shuai Ben jia-Ying liang Yu Pei Xiao-Hong Song Wei-Feng Yang School of Physics and Optoelectronic Engineering Hainan UniversityHaikou 570288China

The interaction between lasers and nanoparticles holds significant theoretical and practical ***,we investigate the near-field enhancement effects on silver nanotriangles and nanodiscs under ultrafast laser pulses,as well as the dynamics of protons and ions attached to the nanoparticle *** adjusting the size parameters of the nanoparticles,we explore the near-field enhancement effects and proton emission dynamics at different laser *** results demonstrate that nanoparticles with varying morphologies substantially impact the proton momentum *** directional proton emission of nanotriangle structures is more pronounced compared to that of nanodiscs,and this effect can be further enhanced by adjusting the laser ***,manipulating the thickness of particles also controls the Mie scattering phenomenon of ***,we qualitatively discuss the emission processes of alpha particles and ^(9)C^(6+)heavy *** research has important implications for proton and heavy ion radiotherapy in cancer treatment and targeted drug delivery,while providing theoretical foundations for understanding,characterizing,and controlling experimental studies of nanosystems with significant potential for expanding research into microdynamic behavior in complex nanomaterial superstructures.

关键词： spectrum. holds silver

Research on Two Types of Buffer Zone Impact on Surrounding Office Space Environment in Winter in Cold Climate Zone—a Fieldwork in Architectural Design Institute Building of Tsinghua University,Beijing

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Journal of Harbin Institute of Technology(New Series) 2014年第5期21卷 33-39页

作者： Ye-Hao Song Jun-Jie Li Ning Zhu jia-liang Wang Shi-Meng Hao School of Architecture Tsinghua University Key Laboratory of Eco Planning & Green Building Ministry of EducationTsinghua University

Building buffer zone space is not only one of essential approaches for better mental quality of interior building space, but also an important factor that may influence interior thermal comfort and energy consumption. This study aims to analyze regulative advantages of buffer zone to the surrounding functional spaces. Based on a fieldwork test in a typical office building in cold climate zone in Beijing,China,the monitor data show interior physical performance in the Winter. The research selects two types of different buffer zones in the same building. One is a south-faced greenhouse which has large dimension with plenty of vegetation,and the other is a simple atrium in the middle of five floor building with mount of skylights. The factors and their influence to surrounding functional spaces and the whole building are found out from the comparisons of collected data by floor to floor monitor test on both buffer zones at the same time. The comparisons of two types of buffer zones conclude that the greenhouse is more effective to air quality regulation but not so clearly wellperformed to thermal buffering as expected due to the dominate active central heating in the Winter. This fieldwork test results for building performance can be helpful for both architects and engineers in the early phase of sustainable design.

关键词： public building buffer zone building performance fieldwork test space effect

Fieldwork Test Research of the Impact on Building Physical Environment on Six Types of Atrium Space in Cold Climates

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Journal of Harbin Institute of Technology(New Series) 2014年第4期21卷 84-90页

作者： Ye-Hao Song Jun-Jie Li Ning Zhu jia-liang Wang Zheng-Hao Lin School of Architecture Tsinghua University Key Laboratory of Urban-Rural Eco Planning & Green Building Ministry of EducationTsinghua University

Since the research on verification to passive design strategies in sustainable building is at the initial stage,and its test method and verification conclusion are not scientific enough to validate,this paper proposes the necessity of building physical environmental monitoring to quantitative optimization of passive strategies efficiency from the perspective of architecture design and building environment. Adopting comparative research method,this research chooses six types of atrium space in cold climate in China as a prototype,focusing on building physical environmental performance difference in and between atrium and building main space. Spatial parameters of the atrium space will be divided into four factors: spatial geometry,interfacial properties,internal and external related categories. With subdividing these four factors into sub-factors,this paper makes crosscomparison among the sub-factors to clarify passive strategies effectiveness in atrium. Data comparison analysis shows that Winter atrium passive strategy in cold regions from traditional view is not obvious in practical application,and test data need to be stratified refined in atrium design in case of optimizing passive strategy from building prototype perspective.

关键词： atrium space building physical environment fieldwork test space effect

Factors influencing willingness to participate in ophthalmic clinical trials and strategies for effective recruitment

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 157-163页

作者： jia-En liang Meng-Yin liang En-En Zhang Yu-Ying Peng Ling-Ling Chen jia-Yu Deng Ting Lin Jun Fu jia-Ni Zhang Shao-Li Li Fei Li Hui-Ming Xaio Wen-Min Huang Yu-Hong Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

AIM:To explore the factors influencing individuals’willingness to participate in ophthalmic clinical ***:A questionnaire survey was conducted from January to April 2021 among patients and their family members at Zhongshan Ophthalmic Center,Sun Yat-sen University,in Guangzhou,*** survey gathered data on respondents’willingness,demographic and socioeconomic profiles,as well as their reasons and concerns regarding engagement in clinical ***:Of the 1078 residents surveyed(mean age 31.2±13.1y;65.8%females)in Guangzhou,749(69.5%)expressed a willingness to participate in future ophthalmic clinical *** characteristics associated with greater willingness included a younger age,lower annual income,higher education,prior participation experience,previous ophthalmic treatment,and a better understanding of clinical *** the exception of age,these characteristics were significantly linked to a higher *** primary barrier to participation,expressed by 64.8%of those willing and 54.4%of those unwilling,was“Uncertain efficacy”.In terms of motivations,the willing group ranked“Better therapeutic benefits”(35.0%),“Professional monitoring”(34.3%),and“Trust in healthcare professionals”(33.1%)as their top three reasons,whereas the unwilling participants indicated“Full comprehension of the protocol”(46.2%)as the key ***:This study reveals a substantial willingness to participate in ophthalmic clinical trials and demonstrates the predictive role of demographic and socioeconomic *** in motivators and concerns between willing and unwilling participants highlight the significance of tailored recruitment ***,the need for and trust in healthcare professionals stand out as powerful motivations,underscoring the importance of enhancing physician-patient relationships,adopting patient-centered communication approaches,and addressing individualized needs to improve accrual rates.

关键词： participation willingness recruitment strategy ophthalmic clinical trial

Values of a novel pyroptosis-related genetic signature in predicting outcome and immune status of pancreatic ductal adenocarcinoma

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Gastroenterology Report 2022年第1期10卷 476-489页

作者： Xiang Xu jia-Hua liang jian-Hui Li Qiong-Cong Xu Xiao-Yu Yin Department of Pancreato-Biliary Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background Pyroptosis is an emerging form of programmed cell death associated with progression in ***,there are few studies reporting on the association between pancreatic ductal adenocarcinoma(PDAC)and ***,we aimed to construct a pyroptosis-related genetic signature to predict the clinical outcome and immune status in PDAC *** RNA-seq data of 176 PDAC patients from The Cancer Genome Atlas(TCGA)and 167 PDAC patients from the Genotype-Tissue Expression Project were analysed for pyroptosis-related differentially expressed genes(DEGs)between PDAC and normal *** risk signature of DEGs was analysed using the least absolute shrinkage and selection operator(LASSO)Cox regression analysis and its accuracy was validated in the Gene Expression Omnibus(GEO)cohort(n=190).Functional enrichment analyses were performed to explore the mechanisms of the *** immune characteristics were evaluated using single-sample gene set enrichment analysis and ESTIMATE algorithms for each *** A nine-gene risk signature was generated from LASSO Cox regression analysis and classified PDAC patients into either a high-or low-risk group according to the median risk *** high-risk group had significantly shorter overall survival than the low-risk group and it was verified in the external GEO database.A nomogrambased on the risk signature was constructed and showed an ideal prediction *** enrichment analyses revealed that pyroptosis might regulate the tumor immune microenvironment in *** infiltration evaluation suggested that immune status was more activated in the low-risk group than in the high-risk *** The risk signature encompassing nine pyroptosis-related genes may be a prognostic marker for *** might affect the prognosis of PDAC patients via regulating the tumor immune microenvironment.

关键词： pancreatic ductal adenocarcinoma pyroptosis prognosis immune

Polyglutamic Acid Based Polyanionic Shielding System for Polycationic Gene Carriers

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Chinese Journal of Polymer Science 2016年第3期34卷 316-323页

作者： jia-liang Xia 田华雨 Jie Chen Zhao-pei Guo Lin Lin Hong-yan Yang Zong-cai Feng School of Chemistry and Chemical Engineering Lingnan Normal University Research Center of Chemistry & Materials Lingnan Normal University Development Center for New Materials Engineering & Technology in Universities of Guangdong Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Science

For the purpose of increasing the in vivo stability of polycation gene carriers, we prepared a kind of p H-sensitive poly（ethylene glycol）-poly（γ-benzyl-L-glutamate-co-glutamic acid）（PEG-PGA（65）, 65 denotes the molar ratio of glutamic acid in poly（γ-benzyl-L-glutamate-co-glutamic acid））. PEG-PGA（65） showed low cytotoxicity and could shield the positive charge of DNA/PEI（1：1） polyplexes efficiently. The transfection was enhanced due to the partially charge shielding in He La cell line at pH of 7.4. There was almost no transfection efficiency when the surface charge of the ternary particles turned to negative at p H of 7.4. However, the transfection efficiency recovered a lot by culturing at p H of 6.0 at the beginning of transfection. Confocal microscopic observation and flow cytometry results showed DNA/PEI polyplexes should be efficiently released and endocytosized at p H 6.0, because of the p H triggered deshielding action of PEG-PGA（65）. Due to the good biocompatibility and suitable p H triggered shielding/deshielding property, PEG-PGA（65） could be a potential shielding system for polycationic gene carriers used in vivo.

关键词： Gene delivery Shielding system PEGylation pH Sensitive

NON-NEWTONIAN COMPUTATIONAL HEMODYNAMICS IN TWO PATIENT-SPECIFIC CEREBRAL ANEURYSMS WITH DAUGHTER SACCULES

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Journal of Hydrodynamics 2010年第5期22卷 639-646页

作者： WANG Sheng-zhang CHEN jia-liang DING Guang-hong LU Gang ZHANG Xiao-long Department of Mechanics and Engineering Science Fudan University Shanghai 200433 China Center of Interventional Therapy Huashan Hospital Affiliated to Fudan University Shanghai 200040 China

Hemodynamic factors play important roles in the formation, progression and rupture of cerebral aneurysms, and the Wall Shear Stress （WSS） and Oscillatory Shear Index （OSI） on the aneurysms are considered to be correlated with their growth and rupture. In this article, two computational models based on patient-specific cerebral aneurysms with daughter saccule are constructed from 3D-RA image data, one is lateral aneurysm located in middle cerebral artery （CA1） and the other is terminal aneurysm located in anterior communicating artery （CA2）, The corresponding models of the two aneurysms by removing daughter saccule are established in order to investigate the initiation and growth of the daughter saccule. The flow patterns and the distributions of hemodynamic factors in the two aneurysms before and after daughter saccule is removed are obtained by solving the governing equations with the commercial CFD software Ansys CFX11.0 under the non-Newtonian fluid assumption. By analyzing the flow patterns, it is concluded that the aneurysms with daughter saccules have more complex and unstable flow patterns and hence are prone to rupture. By comparing the distribution of OSI, a hypothesis that a high OSI causes the growth of the daughter saccule is presented.

关键词： cerebral aneurysm computational hemodynamics non-Newtonian patient-specific