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Ascochlorin overcomes chemoresistance and regulates the plasticity of doxorubicin induced EMT via modulation of the NF-кB pathway in hepatocellular carcinoma

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中国药理学与毒理学杂志 2015年第S1期29卷 79-80页

作者： Xiao-yunDAI KwangSeokAHN ChulwonKIM MuthuKSHANMUGAM FengLI ji-zhongshi AlanPremKUMAR Ling-zhiWANG BoonCherGOH JunjiMAGAE TinaHONG KamMHUI GautamSETHI Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 College of Oriental Medicine Kyung Hee University Seoul 130-701 Republic of Korea Cancer Science Institute of Singapore Cancer Science Singapore 117599 Department of Haematology-Oncology National University Health System Singapore 117599 Magae Bioscience Institute 49-4 Fujimidai Tsukuba 300-1263 Japan Division of Cellular and Molecular Research Humphrey Oei Institute of Cancer Research National Cancer Centre Singapore 169610

OBJECTIVE Doxorubicin-based therapy has been found to be not significantly effective for the treatment of advanced stage hepatocellular carcinomas(HCCs),which often undergo epithelial-mesenchymal transition(EMT)during tumor *** evidence suggest(s)that epithelial cell transformation to mesenchymal state canenhance the ability to self-renew and confer greater resistance to the conventional chemotherapeutic *** aim of this study was to examine the potential efficacyof ascochlorin,an isoprenoid antibiotic to overcome drug resistance induced by doxorubicin in HCC cell lines and to elucidate its underlying mechanism(s)of *** The effect of doxorubicin and ascochlorin on HCC cell lines was determined by MTT,Western blotting,immunofluorescence and NF-кB DNA binding *** Our results indicate that HCC cells that show a mesenchymal-like phenotype,are resistance to the doxorubicin therapy which directly correlated with an increased slug *** also observed that activation of NF-кB pathway plays an essential role in doxorubicin induced-chemoresistance and pharmacological inhibition of this pathway with ascochlorin can significantly reverse drug-induced invasion/migration and resistance in HCC *** Our results indicate that combination treatment of doxorubicin with ascochlorin has the potential to inhibit HCC growth and metastasis.

关键词： doxorubicin ascochlorin chemoresistance EMT NF-кB

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小城镇基础设施建设投资社会多元化的探讨

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小城镇建设 2006年第5期24卷 12-16页

作者：冀忠实宋又川国家开发银行评审三局国家开发银行

在计划经济时代,以政府为主导的城镇基础设施投资体制,对加快我国城市基础设施项目建设、扩大公共服务规模起到了决定性作用.但随着我国社会主义市场经济体制的建立,城镇化战略的实施,原有的基础设施投资模式已不能适应农村基础设施建... 详细信息

在计划经济时代,以政府为主导的城镇基础设施投资体制,对加快我国城市基础设施项目建设、扩大公共服务规模起到了决定性作用.但随着我国社会主义市场经济体制的建立,城镇化战略的实施,原有的基础设施投资模式已不能适应农村基础设施建设的需要.为做好社会主义新农村建设工作,应尽快建立社会化、多元化的小城镇基础设施建设投资体制.

关键词：社会主义市场经济体制城镇基础设施多元化建设投资基础设施建设城市基础设施投资体制农村建设计划经济项目建设

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嗜水气单胞菌灭活疫苗对鲫鱼的免疫效果

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江苏农业科学 2020年第4期48卷 168-168,169-171页

作者：祭仲石厉成新王中清韦艳张木泓上海市海丰水产养殖有限公司江苏盐城224151

随着食品安全等问题日趋严重,寻找良好而安全的防治细菌性疾病的方法迫在眉睫。本研究利用从患病鲫鱼体内分离的嗜水气单胞菌制备灭活疫苗,用(50±5) g的健康鲫鱼作为试验对象,免疫组腹腔注射制备的疫苗,对照组腹腔注射等量的磷酸缓冲... 详细信息

随着食品安全等问题日趋严重,寻找良好而安全的防治细菌性疾病的方法迫在眉睫。本研究利用从患病鲫鱼体内分离的嗜水气单胞菌制备灭活疫苗,用(50±5) g的健康鲫鱼作为试验对象,免疫组腹腔注射制备的疫苗,对照组腹腔注射等量的磷酸缓冲液。二次免疫后1、7、14、21、28 d检测血清凝集效价、血清中溶菌酶活性和酸性磷酸酶活性;二次免疫28 d后,对免疫组和对照组同时腹腔注射嗜水气单胞菌进行攻毒,观察鲫鱼生长状况,记录死亡量。结果表明,免疫组血清凝集效价在免疫后逐渐升高,在21 d达到峰值,明显高于对照组;血清中溶菌酶活性和酸性磷酸酶活性都于免疫后14 d达到峰值,明显高于对照组;攻毒结果显示,免疫组死亡率10.0%,对照组死亡率83.7%,相对保护率达到88.5%。说明制备的嗜水气单胞菌灭活疫苗可以诱导鲫鱼产生免疫应答反应,对嗜水气单胞菌的感染具有较好的免疫保护作用。

关键词：嗜水气单胞菌疫苗免疫保护鲫鱼血清凝集效价溶菌酶酸性磷酸酶

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几种药物对鲫鱼鱼种的致畸研究

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科学养鱼 2019年第1期41卷 46-47页

作者：祭仲石王中清张木泓宋丽芳上海市海丰水产养殖有限公司 224151

鲫鱼养殖中容易发生车轮虫、指环虫等寄生虫感染,寄生虫大量寄生于鲫鱼鳃部,导致鳃丝上黏液增多,鳃丝浮肿呈灰白色,鳃盖难以闭合,病情严重时往往引发细菌感染,进而导致鲫鱼死亡。这类寄生虫病在鲫鱼苗种养殖阶段经常发生,严重时造成池... 详细信息

鲫鱼养殖中容易发生车轮虫、指环虫等寄生虫感染,寄生虫大量寄生于鲫鱼鳃部,导致鳃丝上黏液增多,鳃丝浮肿呈灰白色,鳃盖难以闭合,病情严重时往往引发细菌感染,进而导致鲫鱼死亡。这类寄生虫病在鲫鱼苗种养殖阶段经常发生,严重时造成池养夏花鱼种大量死亡。

关键词：夏花鱼种鲫鱼寄生虫感染致畸药物大量死亡细菌感染苗种养殖

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Brain age estimation:premise,promise,and problems

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Neural Regeneration Research 2025年第8期20卷 2313-2314页

作者： Jarrad Perron ji Hyun Ko Graduate Program in Biomedical Engineering Price Faculty of EngineeringUniversity of ManitobaWinnipegMBCanada PrairieNeuro Research Centre Kleysen Institute for Advanced MedicineHealth Sciences CentreWinnipegMBCanada Department of Human Anatomy and Cell Science Rady Faculty of Health SciencesUniversity of ManitobaWinnipegMBCanada

Premise:The com bined effects of modern healthcare practices which prolong lifespan and declining birthrates have created unprecedented changes in age demographics worldwide that are especially pronounced in Japan,South Korea,Europe,and North *** old age is the most significant predictor of dementia,global healthcare systems must rise to the challenge of providing care for those with neurodegenerative disorders.

关键词： estimation providing birth

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Effect of cholesterol metabolism on hepatolithiasis

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World Journal of Gastroenterology 2025年第1期31卷 157-162页

作者： Lin Zheng Zi-Yu Ye Jun-ji Ma Department of Gastroenterology The Second Hospital of Hebei Medical UniversityHebei Key Laboratory of GastroenterologyHebei Institute of GastroenterologyHebei Clinical Research Center for Digestive DiseasesNo.215 Heping West RoadShijiazhuang 050000Hebei ProvinceChina

Surgical intervention is currently the primary treatment for hepatolithiasis;how-ever,some patients still experience residual stones and high recurrence rates after *** metabolism seems to play an important role in hepatoli-thiasis pathogenesis.A high cholesterol diet is one of the significant reasons for the increasing incidence of ***,regular diet and appropriate medical intervention are crucial measures to prevent hepatolithiasis and reduce recurrence rate after *** dietary cholesterol and drugs that increase cholesterol stone solubility are key therapeutic approaches in treating *** article discusses the cholesterol metabolic pathways related to the pathogenesis of hepatolithiasis,as well as food intake and targeted therapeutic drugs.

关键词： Hepatolithiasis Cholesterol metabolism High-fat diet 3-hydroxy-3-methylglutaryl-coenzyme A reductase Interlobular bile duct

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Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan Zhang Yi Yang Guangbin ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

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Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： Ke jiang Zhi Chen ji Yu Chen Zheng Shan Huang Ming Wang Chongqing Key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

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Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian Luo Chuanhui Xu Linxi Li Yunxiang ji Yezhong Wang Yingjia Li Yongyi Ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

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极端条件下含能材料的模拟研究思考

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高压物理学报 2025年第1期39卷 17-43页

作者：姬广富中国工程物理研究院流体物理研究所冲击波物理与爆轰物理全国重点实验室四川绵阳621999

含能材料在军事、民用和航天等领域具有广泛应用,极端条件下其物理化学性质会发生显著变化。通过模拟研究预测和优化含能材料性能具有重要意义,包括性能预测、优化设计、安全评估、成本效率控制等。为此,综述了极端条件下含能材料的研... 详细信息

含能材料在军事、民用和航天等领域具有广泛应用,极端条件下其物理化学性质会发生显著变化。通过模拟研究预测和优化含能材料性能具有重要意义,包括性能预测、优化设计、安全评估、成本效率控制等。为此,综述了极端条件下含能材料的研究背景、基本性质、模拟研究方法及进展、关键问题以及相关实验研究进展。其中,详细介绍了量子力学、分子动力学、蒙特卡罗和有限元等模拟方法及其研究进展,阐述了高压、高温、激光作用和界面效应等极端条件下模拟研究的关键问题,并列举了含能材料在撞击感度、化学释能规律、3D打印、绿色电合成、爆轰机理和超高含能材料合成等方面的实验研究进展。通过遴选代表性研究,展示了模拟研究在实际问题中的应用和解决方案。同时,介绍了一些最新研究成果,以反映该领域的最新进展和未来趋势。此外,详细讨论了跨学科研究的实现方式以及含能材料在极端条件下的安全性问题,包括可能的风险和预防措施。

关键词：含能材料极端条件模拟研究高压高温激光作用

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