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Bone-targeted lipoplex-loaded three-dimensional bioprinting bilayer scaffold enhanced bone regeneration

Regenerative Biomaterials 2024年第4期3卷 138-148页

作者： Woo-jin Kim Jeong-Hyun Ryu ji Won Kim Ki-Tae Kim Hye-Rim Shin Heein yoon Hyun-Mo Ryoo young-Dan Cho Department of Molecular Genetics School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul03080Republic of Korea Department of Periodontology School of Dentistry and Dental Research InstituteSeoul National University and Seoul National University Dental HospitalSeoul03080Republic of Korea

Clinical bone-morphogenetic protein 2(BMP2)treatment for bone regeneration,often resulting in complications like soft tissue inflammation and ectopic ossification due to high dosages and non-specific delivery systems,necessitates research into improved biomaterials for better BMP2 stability and *** tackle this challenge,we introduced a groundbreaking bone-targeted,lipoplex-loaded,three-dimensional bioprinted bilayer scaffold,termed the polycaprolactone-bioink-nanoparticle(PBN)scaffold,aimed at boosting bone *** encapsulated BMP2 within the fibroin nanoparticle based lipoplex(Fibroplex)and functionalized it with DSS6 for bone tissue-specific targeting.3D printing technology enables customized,porous PCL scaffolds for bone healing and soft tissue growth,with a two-step bioprinting process creating a cellular lattice structure and a bioink grid using gelatin-alginate hydrogel and DSS6-Fibroplex,shown to support effective nutrient exchange and cell growth at specific pore *** PBN scaffold is predicted through in silico analysis to exhibit biased BMP2 release between bone and soft tissue,a finding validated by in vitro osteogenic differentiation *** PBN scaffold was evaluated for critical calvarial defects,focusing on sustained BMP2 delivery,prevention of soft tissue cell infiltration and controlled fiber membrane pore size in *** PBN scaffold demonstrated a more than eight times longer BMP2 release time than that of the collagen sponge,promoting osteogenic differentiation and bone regeneration in a calvarial defect *** findings suggest that the PBN scaffold enhanced the local concentration of BMP2 in bone defects through sustained release and improved the spatial arrangement of bone formation,thereby reducing the risk of heterotopic ossification.

关键词： 3D bioprinting bone-targeting lipoplex BMP2 bone regeneration

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The CUL3A–LFH1–UBC15 ubiquitin ligase complex mediates SHORT VEGETATIVE PHASE degradation to accelerate flowering at high ambient temperature

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Plant Communications 2024年第4期5卷 224-238页

作者： Suhyun jin Geummin Youn Sun young Kim Taewook Kang Hyun-young Shin ji-Yul Jung Pil Joon Seo ji Hoon Ahn Department of Life Sciences Korea UniversitySeoul 02841Republic of Korea Department of Chemistry Seoul National UniversitySeoul 08826Republic of Korea These authors contributed equally to this article.

Ambient temperature affects flowering time in plants,and the MADS-box transcription factor SHORT VEGETATIVE PHASE(SVP)plays a crucial role in the response to changes in ambient *** protein stability is regulated by the 26S proteasome pathway and decreases at high ambient temperature,but the details of SVP degradation are ***,we show that SVP degradation at high ambient temperature is mediated by the CULLIN3–RING E3 ubiquitin ligase(CRL3)complex in Arabidopsis *** identified a previously uncharacterized protein that interacts with SVP at high ambient temperature and contains a BTB/POZ *** named this protein LATE FLOWERING AT HIGH TEMPERATURE 1(LFH1).Single mutants of LFH1 or CULLIN3A(CUL3A)showed late flowering specifically at 27***1 protein levels increased at high ambient *** found that LFH1 interacts with CUL3A in the cytoplasm and is important for SVP–CUL3A complex *** in CUL3A and/or LFH1 led to increased SVP protein stability at high ambient temperature,suggesting that the CUL3–LFH1 complex functions in SVP *** E2 ubiquitin-conjugating enzymes(UBCs)using RING-BOX PROTEIN 1(RBX1),a component of the CRL3 complex,as bait identified ***15 mutants also showed late flowering at high ambient *** vitro and in vivo ubiquitination assays using recombinant CUL3A,LFH1,RBX1,and UBC15 showed that SVP is highly ubiquitinated in an ATP-dependent ***,these results indicate that the degradation of SVP at high ambient temperature is mediated by a CRL3 complex comprising CUL3A,LFH1,and UBC15.

关键词： temperature-responsiveflowering SVP CUL3 proteasomal degradation ubiquitination

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Origami multi-layer space shield for cylindrical space structure

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Chinese Journal of Aeronautics 2024年第10期37卷 294-312页

作者： ji-Hun CHA ji-Sub NOH Sarath Kumar SATHISH KUMAR Dohyeon jiN Dae-young LEE Chun-Gon KIM Department of Aerospace Engineering Chosun UniversityGwangju 61452Republic of Korea Department of Aerospace and Software Engineering Gyeongsang National UniversityGyeongsangnam-do 52828Republic of Korea Department of Aerospace Engineering Seoul National UniversitySeoul 08826Republic of Korea Department of Aerospace Engineering KAISTDaejeon 34141Republic of Korea

The multidisciplinary space environment,encompassing orbital debris,cosmic radiation,and solar radiative heat,poses significant risks to spacecraft and astronauts,necessitating efficient and effective shielding solutions.A multi-layer shield with wide spacing has been proven to be an effective way to shield the spacecraft from space debris impact;however,due to the limited volume of the payload fairing,it was not feasible to apply a multi-layer shield to the spacecraft *** the origami design,the shield maintains a compact form during launch and subsequently expands in outer space to enhance *** geometric analysis,it has been confirmed that the deployable multi-layer space shield can occupy less space than conventional space shield structures while expanding into wider shield intervals and multiple *** hypervelocity impact experiments,it was confirmed that as the bumper spacing of the multi-layer space shield expands,its ballistic performance becomes superior to conventional space *** deployable multi-layer space shield can reduce not only hypervelocity impacts but also solar radiative heat using the same mechanism as multi-layer *** cosmic radiation dose analysis,it has been confirmed that the multi-layer space shield is effective in cosmic radiation shielding compared to conventional space structures.

关键词： Hybrid composite Origami Hypervelocity impact Space environment Space debris Cosmic radiation

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Effects of Initial and Boundary Conditions on Heavy Rainfall Simulation over the Yellow Sea and the Korean Peninsula:Comparison of ECMWF and NCEP Analysis Data Effects and Verification with Dropsonde Observation

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Advances in Atmospheric Sciences 2024年第9期41卷 1787-1803页

作者： jiwon HWANG Dong-Hyun CHA Donghyuck yoon Tae-young GOO Sueng-Pil JUNG Department of Civil Urban Earth and Environmental Engineering Ulsan National Institute of Science and TechnologyUlsan 44919South Korea Program in Atmospheric and Oceanic Sciences Princeton UniversityPrincetonNew Jersey 08544USA National Institute of Meteorological Sciences NIMSJeju 63568South Korea

This study evaluated the simulation performance of mesoscale convective system(MCS)-induced precipitation,focusing on three selected cases that originated from the Yellow Sea and propagated toward the Korean *** evaluation was conducted for the European Centre for Medium-Range Weather Forecasts(ECMWF)and National Centers for Environmental Prediction(NCEP)analysis data,as well as the simulation result using them as initial and lateral boundary conditions for the Weather Research and Forecasting ***,temperature and humidity profiles from 3D dropsonde observations from the National Center for Meteorological Science of the Korea Meteorological Administration served as validation *** showed that the ECMWF analysis consistently had smaller errors compared to the NCEP analysis,which exhibited a cold and dry bias in the lower levels below 850 *** model,in terms of the precipitation simulations,particularly for high-intensity precipitation over the Yellow Sea,demonstrated higher accuracy when applying ECMWF analysis data as the initial *** advantage also positively influenced the simulation of rainfall events on the Korean Peninsula by reasonably inducing convective-favorable thermodynamic features(i.e.,warm and humid lower-level atmosphere)over the Yellow *** conclusion,this study provides specific information about two global analysis datasets and their impacts on MCS-induced heavy rainfall simulation by employing dropsonde observation ***,it suggests the need to enhance the initial field for MCS-induced heavy rainfall simulation and the applicability of assimilating dropsonde data for this purpose in the future.

关键词： initial conditions dropsonde heavy rainfall forecast global model analysis evaluation

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Indolocarbazole-Based Small Molecule Cathode-Active Material Exhibiting Double Redox for High-Voltage Li-Organic Batteries

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Energy & Environmental Materials 2024年第5期7卷 90-98页

作者： Hyunji Park Hyojin Kye Jong-Sung Lee young-Chang Joo Dong Joo Min Bong-Gi Kim Soo young Park ji Eon Kwon Laboratory for Supramolecular Optoelectronic Materials (LSOM) Department of Materials Science and Engineering Research Institute of Advanced Materials (RIAM) Seoul National University Functional Composite Materials Research Center Jeonbuk Institute of Advanced Composite Materials Korea Institute of Science and Technology (KIST) Department of Organic and Nano System Engineering Konkuk University Department of Materials Science and Engineering Seoul National University Department of JBNU-KIST Industry Academia Convergence Research Jeonbuk National University

Most organic electrode materials （OEMs） for rechargeable batteries employ n-type redox centers, whose redox potentials are intrinsically limited <3.0 V versus Li+/Li. However, p-type materials possessing high redox potentials experience low specific capacities because they are capable of only a single redox reaction within the stable electrochemical window of typical ***, we report 5,11-diethyl-5,11-dihydroindolo[3,2-b]carbazole （DEICZ） as a novel p-type OEM, exhibiting stable plateaus at high discharge potentials of3.44 and 4.09 V versus Li+/Li. Notably, the second redox potential of DEICZ is within the stable electrochemical window. The mechanism of the double redox reaction is investigated using both theoretical calculations and experimental measurements, including density functional theory calculations, ex situ electron spin resonance, and X-ray photoelectron spectroscopy. Finally,hybridization with single-walled carbon nanotubes （SWCNT） improves the cycle stability and rate performance of DEICZ owing to theπ–πinteractions between the SWCNT and co-planar molecular structure of DEICZ, preventing the dissolution of active materials into the electrolyte. The DEICZ/SWCNT composite electrode maintains 70.4%of its initial specific capacity at 1-C rate and also exhibits high-rate capability, even performing well at 100-C rate.

关键词： composite electrodes flexible batteries indolocarbazoles organic rechargeable batteries p-type

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Confluence of ZnO and PTFE Binder for Enhancing Performance of Thin-Film Lithium-Ion Batteries

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Energy & Environmental Materials 2024年第5期7卷 52-60页

作者： Subhashree Behera Swathi Ippili Venkatraju Jella Na-Yeong Kim Seong Cheol Jang ji-Won Jung Soon-Gil yoon Hyun-Suk Kim Department of Materials Science and Engineering Chungnam National University School of Materials Science and Engineering University of Ulsan Department of Energy and Materials Engineering Dongguk University

Developing anode materials with high specific capacity and cycling stability is vital for improving thin-film lithium-ion batteries. Thin-film zinc oxide （ZnO）holds promise due to its high specific capacity, but it suffers from volume changes and structural stress during cycling, leading to poor battery performance. In this research, we ingeniously combined polytetrafluoroethylene （PTFE） with ZnO using a radio frequency （RF）magnetron co-sputtering method, ensuring a strong bond in the thin-film composite electrode. PTFE effectively reduced stress on the active material and mitigated volume change effects during Li+ion intercalation and deintercalation. The composite thin films are thoroughly characterized using advanced techniques such as X-ray diffraction, scanning electron microscopy,and X-ray photoelectron spectroscopy for investigating correlations between material properties and electrochemical behaviors. Notably, the ZnO/PTFE thin-film electrode demonstrated an impressive specific capacity of1305 mAh g-1(=7116 mAh cm-3) at a 0.5C rate and a remarkable capacity retention of 82%from the 1st to the 100th cycle, surpassing the bare ZnO thin film （50%）. This study provides valuable insights into using binders to stabilize active materials in thin-film batteries, enhancing battery performance.

关键词： li-ion batteries metal oxides anodes polytetrafluoroethylene (PTFE) thin films

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Deciphering metastatic route-specific signals and their microenvironment interactions in peritoneal metastasis of gastric cancer

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Cancer Communications 2024年第4期44卷 514-517页

作者： Ki Tae Kim Jae Eun Lee Jae-Ho Cheong In Cho yoon young Choi Department of Molecular Genetics&Dental Pharmacology School of DentistrySeoul National UniversitySeoulRepublic of Korea Dental Research Institute and Dental Multi-omics Center Seoul National UniversitySeoulRepublic of Korea Portrai Inc. SeoulRepublic of Korea Department of Surgery Yonsei University Health SystemYonsei University College of MedicineSeoulRepublic of Korea Department of Surgery Soonchunhyang Bucheon HospitalSoonchunhyang University College of MedicineBucheonRepublic of Korea

Gastric cancer(GC)is a pervasive global malignancy with high mortality rates due to distant metastasis[1].GC metastasis can occur via hematogenous route,peri-toneal route,and specifically through ovarian spread in females[2].Among these,peritoneal metastasis is the most prevalent and challenging condition to treat[3].The Cancer Genome Atlas(TCGA)has uncovered four molec-ular subtypes of GC:microsatellite instability,Epstein-Barr virus-related,chromosomal instability,and genomically stable[4].

关键词： metastasis peritoneal cancer

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Delphi study for developing a checklist of adverse events associated with acupotomy

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Journal of Integrative Medicine 2024年第5期22卷 579-587页

作者： Hyungsun Jun Haebeom Lee Sang-Hoon yoon Chan-young Kwon Damin Jeon Jun-Hwan Lee Jungtae Leem Department of Diagnostics College of Korean MedicineWonkwang UniversityIksan 54538Republic of Korea 7Days Inc. Seoul 06247Republic of Korea Chung-Yeon Korean Medicine Clinic Seoul 06224Republic of Korea Department of Oriental Neuropsychiatry Dong-Eui University College of Korean MedicineBusan 47227Republic of Korea Chonnam National University Hwasun Hospital Hwasun 58128Republic of Korea KM Science Research Division Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea Department of Korean Convergence Medical Science KIOM SchoolUniversity of Science&Technology(UST)Daejeon 34054Republic of Korea Department of Physical Medicine and Rehabilitation Spaulding Rehabilitation HospitalHarvard Medical SchoolBostonMA 02115USA Research Center of Traditional Korean Medicine College of Korean MedicineWonkwang UniversityIksan 54538Republic of Korea

Background Acupotomy,a more invasive procedure than acupuncture,involves the use of a thicker needle with an integrated knife at the tip,necessitating safety *** aimed to define relevant adverse events(AEs)and create a standardized form of the ACUPOtomy-related AEs CHECKlist(ACUPOCHECK).Methods Before conducting the Delphi process,a systematic review and pilot prospective study were conducted to gather information on previously reported *** these data,pilot versions of the ACUPOCHECK and Delphi questionnaires were *** Delphi questionnaire involved selecting types of AE for inclusion,establishing separate criteria for acupotomy-related AEs,and achieving a consensus on AE *** Korean doctors with experience in acupotomy or AE research were recruited to participate in each Delphi *** was considered to have been reached if the critical value for the content validity ratio met or exceeded *** The final ACUPOCHECK was developed using four rounds of the Delphi method and one face-to-face consensus *** included 12 local AEs(pain,hemorrhage,bruise,hematoma,edema,pruritus,rash,infection,nerve damage,dysesthesia,movement impairment,and pneumothorax)and 14 systemic AEs(disease aggravation,needle fatigue,sleepiness,procedural nausea,procedural vomiting,procedural headache,procedural dizziness,sweating,procedural shock,syncope,dyspnea,procedural pain,sleep disorder,and postprocedural infection).Separate criteria were established for pain,hemorrhage and bruising:pain was defined as pain that occurrs during daily activities and persists for longer than 72 h,hemorrhage as bleeding that continues for≥3 min despite pressure application,and bruising as having a bruise with a diameter of≥3 ***-ended descriptions were allowed for AEs not covered by the checklist,and severity and causality were assessed using the Common Terminology Criteria for Adverse Events and modified World Health Organization-Uppsala Monitoring C

关键词： Acupotomy Delphi technique Patient safety Safety management Adverse event

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Long-term outcome of stem cell transplantation with and without anti-tumor necrotic factor therapy in perianal fistula with Crohn’s disease

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World Journal of Stem Cells 2024年第3期16卷 257-266页

作者： Min young Park Yong Sik yoon Jae Ha Park Jong Lyul Lee Chang Sik Yu Division of Colon and Rectal Surgery Department of SurgeryYonsei University College of MedicineSeoul 03722South Korea Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea

BACKGROUND Stem cell transplantation is a promising therapeutic option for curing perianal fistula in Crohn’s disease(CD).Anti-tumor necrotic factor(TNF)therapy combined with drainage procedure is effective as ***,previous studies are limited to proving whether the combination treatment of biologics and stem cell transplantation improves the effect of fistula *** This study aimed to evaluate the long-term outcomes of stem cell transplantation and compare Crohn’s perianal fistula(CPF)closure rates after stem cell transplantation with and without anti-TNF therapy,and to identify the factors affecting CPF closure and *** The patients with CD who underwent stem cell transplantation for treating perianal fistula in our institution between Jun 2014 and December 2022 were *** data were compared according to anti-TNF therapy and CPF *** A total of 65 patients were *** median age of females was 26 years(range:21-31)and that of males was 29(44.6%).The mean follow-up duration was 65.88±32.65 months,and complete closure was observed in 50(76.9%)*** closure rates were similar after stem cell transplantation with and without anti-TNF therapy(66.7%vs 81.6%at 3 year,P=0.098).The patients with fistula closure had short fistulous tract and infrequent proctitis and anorectal stricture(P=0.027,0.002,and 0.008,respectively).Clinical factors such as complexity,number of fistulas,presence of concurrent abscess,and medication were not significant for *** cumulative 1-,2-,and 3-year closure rates were 66.2%,73.8%,and 75.4%,*** Anti-TNF therapy does not increase CPF closure rates in patients with stem cell ***,both refractory and non-refractory CPF have similar closure rates after additional anti-TNF *** tract length,proctitis,and anal stricture are risk factors for non-closure in patients with CPF after stem cell transplantation.

关键词： Crohn’s disease Anus Fistula Stem cell transplantation Tumor necrosis factor-alpha inhibitors Infliximab

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A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-377页

作者： ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II Kim Yoo Min Kim Minah Cho Keun Won Ryu Hong Man yoon young Kyu Park In Gyu Kwon Sung Hoon Noh Kyung Hee Lee In Cho Myoung Won Son Jong Won Kim young-Woo Kim Department of Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Pathology and Translational Genomics Samsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351Republic of Korea Department of Surgery Yonsei University College of MedicineSeoul 03722Republic of Korea Gastric Cancer Center Yonsei Cancer CenterYonsei University Health SystemSeoul 03722Republic of Korea Center for Gastric Cancer National Cancer CenterGoyang 10408Republic of Korea Department of Surgery Chonnam National University Hwasun HospitalChonnam National University College of MedicineGwangju 58128Republic of Korea Department of Surgery Gangnam Severance HospitalYonsei University College of MedicineSeoul 06273Republic of Korea Department of Hematology-Oncology Yeungnam University Medical CenterDaegu 42415Republic of Korea Department of Surgery Soonchunhyang University College of MedicineBucheon 14584Republic of Korea Department of Surgery Soonchunhyang University Cheonan HospitalSoonchunhyang University College of MedicineCheonan 31151Republic of Korea Department of Surgery Chung-Ang University HospitalChung-Ang University College of MedicineSeoul 06973Republic of Korea

Objective:Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy *** this study,we evaluated the clinical feasibility of the single patient classifier(SPC)test,a new clinical-grade prognostic assay,in stageⅡ-Ⅲgastric cancer ***:A prospective multicenter study was conducted,involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine *** SPC test was employed to stratify patients into risk groups,and its feasibility and performance were *** primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative ***,3-year disease-free survivals of risk groups were ***:The SPC test met the primary endpoint *** 99.5%of SPC tests were timely delivered to hospitals before the postoperative treatment *** a clinical setting,the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 ***,3-year disease-free survivals were significantly different between risk groups classified with SPC ***:This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment *** also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test advanced gastric cancer adjuvant chemotherapy feasibility gastrectomy

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