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Multimodal Omics Approaches to Aging and Age‑Related Diseases

Phenomics 2024年第1期4卷 56-71页

作者： Qianzhao ji Xiaoyu jiang Minxian Wang Zijuan Xin Weiqi Zhang jing Qu Guang‑Hui Liu State Key Laboratory of Membrane Biology Instituteof ZoologyChinese Academy of SciencesBeijing 100101China State Key Laboratory of Stem Cell and ReproductiveBiology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academyof Sciences and China National Center for BioinformationBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academyof SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China School of Future Technology University of ChineseAcademy of SciencesBeijing 100190China Advanced Innovation Center for Human Brain Protection National Clinical Research Center for GeriatricDisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China Aging Translational Medicine Center International Centerfor Aging and CancerXuanwu HospitalCapital MedicalUniversityBeijing 100053China

Aging is associated with a progressive decline in physiological capacities and an increased risk of aging-associated *** increasing body of experimental evidence shows that aging is a complex biological process coordinately regulated by multiple factors at diferent molecular ***,it is difcult to delineate the overall systematic aging changes based on single-layer ***,multimodal omics approaches,in which data are acquired and analyzed using complementary omics technologies,such as genomics,transcriptomics,and epigenomics,are needed for gaining insights into the precise molecular regulatory mechanisms that trigger *** recent years,multimodal omics sequencing technologies that can reveal complex regulatory networks and specifc phenotypic changes have been developed and widely applied to decode aging and age-related *** review summarizes the classifcation and progress of multimodal omics approaches,as well as the rapidly growing number of articles reporting on their application in the feld of aging research,and outlines new developments in the clinical treatment of age-related diseases based on omics technologies.

关键词： Multimodal omics approaches Aging Genome Epigenome

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Surface plasmon decorated InGaO deep-UV photodetector array for image sensing and water quality monitoring via highly effective hot electron excitation and interfacial injection

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Science China(Technological Sciences) 2024年第8期67卷 2449-2460页

作者： SHU LinCong SHA ShuLin XI ZhaoYing LI Lei YAO SuHao ZHANG jiaHan ji XueQiang ZHANG ShaoHui BIAN Ang jiANG MingMing GUO YuFeng TANG WeiHua LIU Zeng Innovation Center of Gallium Oxide Semiconductor(IC-GAO) College of Integrated Circuit Science and EngineeringNanjing University of Posts and TelecommunicationsNanjing 210023China School of Electronic Information Engineering Inner Mongolia UniversityHohhot 010021China College of Science MIIT Key Laboratory of Aerospace Information Materials and PhysicsNanjing University of Aeronautics and AstronauticsNanjing 211106China Collaborative Innovation Center of Advanced Microstructures School of Electronic Science and EngineeringNanjing UniversityNanjing 210093China Institute of Biological and Medical Engineering Guangdong Academy of SciencesGuangzhou 510316China School of Science Jiangsu University of Science and TechnologyZhenjiang 212100China School of Integrated Circuits Beijing University of Posts and TelecommunicationsBeijing 100876China

In addition to the plasmon-mediated resonant coupling mechanism,the excitation of hot electron induced by plasmon presents a promising path for developing high-performance optoelectronic devices tailored for various *** study introduces a sophisticated design for a solar-blind ultraviolet(UV)detector array using linear In-doped Ga_(2)O_(3) (InGaO)modulated by platinum(Pt)nanoparticles(PtNPs).The construction of this array involves depositing a thin film of Ga_(2)O_(3) through the plasmonenhanced chemical vapor deposition(PECVD)***,PtNPs were synthesized via radio-frequency magnetron sputtering and annealing *** performance of these highly uniform arrays is significantly enhanced owing to the generation of high-energy hot *** process is facilitated by non-radiative decay processes induced by ***,the array achieves maximum responsivity(R)of 353 mA/W,external quantum efficiency(EQE)of 173%,detectivity(D*)of approximately 10~(13)Jones,and photoconductive gain of *** addition,the standard deviation for photocurrent stays below17%for more than 80%of the array units within the ***,the application of this array extends to photon detection in the deep-UV(DUV)*** includes critical areas such as imaging sensing and water quality *** leveraging surface plasmon coupling,the array achieves high-performance DUV photon *** approach enables a broad spectrum of practical applications,underscoring the significant potential of this technology for the advancement of DUV detectors.

关键词： InGaO PECVD surface plasmon solar-blind UV photodetector array optoelectronic applications

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Anti-Jamming Null Space Projection Beamforming Based on Symbiotic Radio

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工程与科学中的计算机建模(英文) 2024年第1期138卷 679-689页

作者： Baofeng ji Yifan Liu Tingpeng Li Ling Xing Weixing Wang Shahid Mumtaz Xiaolong Shang Wanying Liu Congzheng Han State Key Laboratory of Complex Electromagnetic Environment Effects on Electronics and Information System(CEMEE) Luoyang471000China Research and Innovation Center of Intelligent System Longmen LaboratoryLuoyang471000China College of Information Engineering Henan University of Science and TechnologyLuoyang471000China Institute of Atmospheric Physics Chinese Academy of Sciences(LAGEO)Beijing100000China Instituto de Telecomunicaes Aveiro3800-005Portugal Chinese Academy of Agricultural Mechanization Sciences Beijing100000China

With the development of information technology,more and more devices are connected to the Internet through wireless communication to complete data *** to the broadcast characteristics ofwireless channels,wireless networks have suffered more and more malicious *** layer security has received extensive attention from industry and *** is considered to be one of the most important technologies related to physical layer *** beamforming technology,messages can be transmitted to legitimate users in an offset direction that is as orthogonal as possible to the interference channel to ensure the reception SINR by legitimate *** the symbiotic radio(SR)technology,this paper considers a symbiotic radio antijamming MIMO system equipped with a multi-antenna system at the main base *** order to avoid the interference signal and improve the SINR of the signal received by the *** base station is equipped with a uniform rectangular antenna array,and using Null Space Projection(NSP)Beamforming,Intelligent Reflecting Surface(IRS)can assist in changing the beam’s *** simulation results show that NSP Beamforming could make a better use of the null space of interference,which can effectively improve the received SINR of users under directional interference,and improve the utilization efficiency of signal energy.

关键词： Symbiotic radio anti-jamming MIMO NSP Beamforming physical layer security

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Controlling hydrogenation of C=C and C=O bonds in cinnamaldehyde using Pt_(1)/Ni and Pt_(1)/Co single-atom alloy catalysts

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Rare Metals 2024年第6期43卷 2859-2868页

作者： Huan-Shi Lan Yi-Da Yang Qing-Di Sun Hao Zhang Ying Zhang Qian He Ran Chen Guo-Yi Bai Xiao-Hui He Hong-Bing ji School of Chemistry and Chemical Engineering Guangxi UniversityNanning 530004China Key Laboratory of Bioinorganicand Synthetic Chemistry of Ministry of Education Fine Chemical Industry Research InstituteSchool of ChemistryIGCMESun Yat-sen UniversityGuangzhou510275China UBFC CNRSENSMMFEMTO-ST Institute25030 Besancon CEDEXFrance College of Chemistry and Materials Science Hebei UniversityBaoding 071002China State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology Institute of Green Petroleum Processing and Light Hydrocarbon ConversionCollege of Chemical EngineeringZhejiang University of TechnologyHangzhou 310014China

Selective hydrogenation of C=C and C=O bonds in cinnamaldehyde(CAL)to produce desired products is a challenging task due to the complex conjugate system of the two unsaturated functional *** this study,a simple ball milling method is presented for synthesizing Pt-based single-atom alloy catalysts(SAAs)that can function as a control switch for the selective hydrogenation of CAL into highly valuable products.

关键词： alloy hydrogenation conjugate

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LA-D-B1,a novel Abemaciclib derivative,exerts anti-breast cancer effects through CDK4/6

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BIOCELL 2024年第5期48卷 847-860页

作者： LING MA ZIRUI jiANG XIAO HOU YUTING XU ZIYUN CHEN SIYI ZHANG HANXUE LI SHAOjiE MA GENG ZHANG XIUJUN WANG jiNG ji jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening College of PharmacyJiangsu Ocean UniversityLianyungang222000China School of Medicine Xiamen UniversityXiamen361102China

Background:Regulatory proteins involved in human cellular division and proliferation,cyclin-dependent kinases 4 and 6(CDK4/6)are overexpressed in numerous cancers,including triple-negative breast cancer(TNBC).TNBC is a common pathological subtype of breast cancer that is prone to recurrence and metastasis,and has a single treatment *** one of the CDK4/6 inhibitors,abemaciclib can effectively inhibit the growth of breast *** this study,we synthesized LA-D-B1,a derivative of Abemaciclib,and investigated its anti-tumor effects in breast ***:Cellular viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** cloning and migration abilities were determined by colony formation assay and wound healing *** invasion abilities and adhesion were determined by cell invasion assay and cell adhesion *** impact of compound LA-D-B1 on cell proliferation and the cell cycle was analyzed through Western blotting,which quantified the levels of proteins associated with the cyclin-dependent kinase(CDK)4/6-cyclin D-Rb-E2F *** in vivo anti-tumor activity of compound LA-D-B1 was investigated using a chick chorioallantoic membrane(CAM)***:The study demonstrated that LA-D-B1 effectively suppressed breast cancer cell proliferation,induced apoptosis,and caused cell cycle ***,LA-D-B1 reduced the expression of key proteins in the CDK4/6-cyclin D-Rb-E2F pathway,including CDK4,CDK6 and *** results also indicated significant antitumor activity of LA-D-B1 in a transplanted tumor ***:In this study,LA-D-B1 demonstrated a potent anti-tumor effect by effectively suppressing cell proliferation and inhibiting cell cycle progression in breast *** findings highlight the potential of LA-D-B1 as a valuable compound for enhancing therapeutic outcomes and controlling the progression of breast cancer.

关键词： CDK4/6 inhibitor Breast cancer Antitumor activity Cell cycle

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Controlled fabrication of freestanding monolayer SiC by electron irradiation

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Chinese Physics B 2024年第8期33卷 31-37页

作者：笪蕴力罗瑞春雷宝季威周武 School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Department of Physics and Beijing Key Laboratory of Optoelectronic Functional Materials&Micro-Nano Devices Renmin University of ChinaBeijing 100872China

The design and preparation of novel quantum materials with atomic precision are crucial for exploring new physics and for device *** irradiation has been demonstrated as an effective method for preparing novel quantum materials and quantum structures that could be challenging to obtain *** features the advantages of precise control over the patterning of such new materials and their integration with other materials with different ***,we present a new strategy for fabricating freestanding monolayer SiC within nanopores of a graphene *** regulating the energy of the incident electron beam and the in-situ heating temperature in a scanning transmission electron microscope(STEM),we can effectively control the patterning of nanopores and subsequent growth of monolayer SiC within the graphene *** resultant SiC monolayers seamlessly connect with the graphene lattice,forming a planar structure distinct by a wide direct *** in-situ STEM observations further uncover that the growth of monolayer SiC within the graphene nanopore is driven by a combination of bond rotation and atom extrusion,providing new insights into the atom-by-atom self-assembly of freestanding two-dimensional(2D)monolayers.

关键词： monolayer SiC 2D semiconductor in-situ growth in-situ STEM defect engineering graphene nanopores

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Effects of nanopores and sulfur doping on hierarchically bunched carbon fibers to protect lithium metal anode

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Carbon Energy 2021年第5期3卷 784-794页

作者： ji In Jung Sunwoo Park son Ha Se Youn Cho Hyoung-Joon jin young Soo Yun Program in Environmental and Polymer Engineering Inha UniversityIncheonSouth Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulSouth Korea Carbon Composite Materials Research Center Korea Institute of Science and TechnologyWanju-gunJeollabuk-doSouth Korea Department of Polymer Science and Engineering Inha UniversityIncheonSouth Korea Department of Integrative Energy Engineering Korea UniversitySeoulSouth Korea

Studies on three-dimensional structured carbon templates have focused on how to guide homogeneous lithium metal nucleation and growth for lithium metal anodes(LMAs).However,there is still insufficient evidence for a key factor to achieve their high electrochemical ***,the effects of nanopores and sulfur doping on carbon-based nanoporous host(CNH)electrode materials for LMAs were investigated using natural polymer-derived *** pore-filling behaviors of lithium metal in the nanopores of the CNH electrode materials were first observed by ex situ scanning electron microscopy analysis,where the protective lithium metal nucleation and growth process led to significantly high Coulombic efficiency(CE)of~99.4%and stable 600 *** addition,a comparison study of CNH and sulfurdoped CNH(S-CNH)electrodes,which differ only in the presence or absence of sulfur,revealed that sulfur doping can cause lower electrochemical series resistance,higher CE value,and better cycling stability in a wide range of current densities and number of ***,S-CNH-based LMAs showed high electrochemical performance in full-cell Li-S battery tests using a sulfur copolymer cathode,where a high energy density of 1370Wh kgelectrode−1 and an excellent power density of 4120Wkgelectrode−1 were obtained.

关键词： carbon template Li-S batteries lithium metal anode lithium metal batteries nanoporous carbon sulfur doping

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Plastid phylogenomics provides new insights into the systematics,diversification,and biogeography of Cymbidium(Orchidaceae)

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Plant Diversity 2024年第4期46卷 448-461页

作者： Hai-Yao Chen Zhi-Rong Zhang Xin Yao ji-Dong Ya Xiao-Hua jin Lin Wang Lu Lu De-Zhu Li Jun-Bo Yang Wen-Bin Yu Center for Integrative Conservation&Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China University of Chinese Academy of Sciences Huairou DistrictBeijing 101408China Plant Germplasm and Genomics Center Germplasm Bank of Wild SpeciesKunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China State Key Laboratory of Plant Diversity and Specility Crops Institute of BotanyChinese Academy of SciencesHaidian DistrictBeijing 100093China School of Pharmaceutical Sciences Yunnan Key Laboratory of Pharmacology for Natural Productsand Yunnan College of Modern Biomedical IndustryKunming Medical UniversityKunmingYunnan 650500China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

Cymbidium(Orchidaceae:Epidendroideae),with around 60 species,is widely-distributed across Southeast Asia,providing a nice system for studying the processes that underlie patterns of biodiversity in the ***,phylogenetic relationships of Cymbidium have not been well resolved,hampering investigations of species diversification and the biogeographical history of this *** this study,we construct a plastome phylogeny of 56 Cymbidium species,with four well-resolved major clades,which provides a framework for biogeographical and diversification rate *** dating and biogeographical analyses show that Cymbidium likely originated in the region spanning northern IndoBurma to the eastern Himalayas during the early Miocene(~21.10 Ma).It then rapidly diversified into four major clades in East Asia within approximately a million years during the middle *** *** to the adjacent regions(Borneo,Philippines,and Sulawesi)primarily occurred during the Pliocene-Pleistocene *** analyses indicate that the net diversification rate of Cymbidium has decreased since its origin,and is positively associated with changes in temperature and monsoon *** hydrothermal conditions brought by monsoon intensification in the early Miocene possibly contributed to the initial rapid diversification,after which the net diversification rate was reduced with the cooling climate after the middle *** transition from epiphytic to terrestrial habits may have enabled adaptation to cooler environments and colonization of northern niches,yet without a significant effect on diversification *** study provides new insights into how monsoon activity and temperature changes affected the diversification dynamics of plants in Southeast Asia.

关键词： Cymbidium East Asia Asian monsoons Climate change Biogeographical patterns

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Bone marrow-derived mesenchymal stem cell-derived exosomeloaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage

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World Journal of Diabetes 2024年第9期15卷 1979-2001页

作者： Yue-Ying Wang Ke Li jia-Jun Wang Wei Hua Qi Liu Yu-Lan Sun ji-Ping Qi Yue-jia song Department of Pathology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Endocrinology The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina

BACKGROUND Diabetic intracerebral hemorrhage(ICH)is a serious complication of *** role and mechanism of bone marrow mesenchymal stem cell(BMSC)-derived exosomes(BMSC-exo)in neuroinflammation post-ICH in patients with diabetes are *** this study,we investigated the regulation of BMSC-exo on hyperglycemia-induced *** To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral *** BMSC-exo were isolated from mouse BMSC *** was followed by transfection with microRNA-129-5p(miR-129-5p).BMSC-exo or miR-129-5poverexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucoseaffected BV2 cells for in vitro *** dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1(HMGB1).Quantitative polymerase chain reaction,western blotting,and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors,such as HMGB1,interleukin 6,interleukin 1β,toll-like receptor 4,and tumor necrosis factorα.Brain water content,neural function deficit score,and Evans blue were used to measure the neural function of *** Our findings indicated that BMSC-exo can promote neuroinflammation and functional *** chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in *** of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH ***,we found that miR-129-5p had a targeted binding relationship with HMGB1 *** We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes,thereby improving the neurological function of the brain.

关键词： Bone marrow mesenchymal stem cells Exosome Diabetic cerebral hemorrhage Neuroinflammation MicroRNA-129-5p High mobility group box 1

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A facile synthesis of hierarchical Sn3O4 nanostructures in an acidic aqueous solution and their strong visible- light-driven photocatalytic activity

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Nano Research 2015年第11期8卷 3553-3561页

作者： Hui song Su-young son Seul Ki Kim Gun young Jung School of Materials Science and Engineering Gwangju Institute of Science and Technology (GIST) Gwangju 500-712 Republic of Korea Carbon Convergence Materials Research Center Institute of Advanced Composite Materials Korea Institute of Science and Technology (KIST) Jeollabuk-do 565-905 Republic of Korea

Hierarchical tin（Ⅲ） oxide, Sn3O4, nanospheres were synthesized via hydrothermal reaction under strongly acidic ambient conditions. The morphology of Sn3O4 varied with decreasing pH. The prickly SnaO4 nanospheres changed into SnaO4 nanospheres covered with single-crystalline nanoplates having a high BET surface area of ca. 55.05 m^2·g^-1 and a band gap of ca. 2.25 eV. Small amounts （0.05 g） of the hierarchical Sn3O4 nanostructures completely decomposed a 30% methyl orange （MO） solution in 100 mL deionized water within 15 min under one sun condition （UV ＋ visible light）. The Sn3O4 photocatalyst exhibited a fast decomposition rate of 1.73 ×10^-1 min^-1, which is a 90.86% enhancement relative to that of the commercially available P25 photocatalyst. The high photocatalytic activity of the hierarchical Sn3O4 nanostructures is attributed to its ability to absorb visible light and its high surface-to-volume ratio.

关键词： Sn3O4 hierarchical structure hydrothermal morphology engineering photocatalyst

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