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Superplasticity of 6016 aluminum alloy at elevated temperatures

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Rare Metals 2015年第6期34卷 387-394页

作者： ji-xiang zhang jin-Xin Fan Yun-Teng Liu Wei Feng College of Mechatronics and Automobile Engineering Chongqing Jiaotong University New Material Institute Shandong Academy of Sciences

The high-temperature plastic deformation be- haviors of 6016 aluminum alloy were investigated with the temperatures ranging from 420 to 540 ℃ and the strain rates ranging from 0.001 to 1.000 s-1. The results show that 6016 aluminum alloys possess superplasticity at 500 ℃ with the strain rates ranging from 0.001 to 0.010 s-1. The grain boundary sliding （GBS） is the main mechanism of superplastic deformation of 6016 aluminum alloy. In addition, a great number of O-type cavities, almost no V type, occur in the microstructure of superplastic deformed 6016 aluminum alloy. The dislocations gather near the grain boundaries to coordinate GBS deformation. The second-phase particles effectively prevent the growth of the recrystallized grains or plastic deformation grains and pin the moving dislocations during deformation.

关键词： 6016 aluminum alloy Strain rate sensitivityindex Grain boundary sliding Cavity

Restricted Arc-Connectivity of Harary Digraphs

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Journal of the Operations Research Society of China 2024年第2期12卷 540-547页

作者： Jun-Hao zhang ji-xiang Meng College of Mathematics and System Science Xinjiang UniversityUrumqi 830046XinJiangChina

The h-restricted arc-connectivity of a digraph is an important parameter to measure fault-tolerance of interconnection *** paper determines that the h-restricted arc-connectivity of the Harary digraph D=G(n;1,2,.:,k)i... 详细信息

关键词： Restricted arc-connectivity λ_(h)(D) Super-λ_(h) λ_(h)-Atom λ_(h)-Superatom

Hugl-1 induces apoptosis in esophageal carcinoma cells both in vitro and in vivo

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World Journal of Gastroenterology 2013年第26期19卷 4127-4136页

作者： jia Song Xiu-Lan Peng Meng-Yao ji Ming-Hua Ai ji-xiang zhang Wei-Guo Dong Department of Gastroenterology Renmin Hospital of Wuhan University Department of Gastroenterology Renmin Hospital of Wuhan University

AIM: To determine whether the human giant larvae homolog 1 gene (Hugl-1/Llg1/Lgl1) exerts tumor suppressor effects in esophageal cancer. METHODS: We constructed a Hugl-1 expression plasmid, pEZ-M29-Hugl1, for gene transfection. We transfected the pEZ-M29-Hugl1 plasmid into Eca109 esophageal cancer cell lines with Lipofectamine 2000 to overexpress Hugl-1. Real-time reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting were performed to determine the effects of the plasmid on Hugl-1 expression. In vitro cell proliferation and apoptosis were examined separately by cell counting Kit-8 (CCK-8) assay, flow cytometry, and Western blotting before and after the transfection of the plasmid into Eca109 cells. Cell cycle distribution was assessed with flow cytometry. The effect of Hugl-1 overexpressing on tumor growth in vivo was performed with a xenograft tumor model in nude mice. Expression of Hugl-1 in xenograft tumor was analyzed by *** transferase-mediated dUTP nick end-labeling (TUNEL) technique was performed to detect and quantitate apoptotic cell. RESULTS: The transfection efficiency was confirmed with real-time RT-PCR and Western blotting. Our results show that compared with control groups the mRNA levels and protein levels of Hugl-1 in pEZ-M29-Hugl1-treated group were remarkably increased (P < 0.05). The CCK-8 assay demonstrated that the growth of cells overexpressing Hugl-1 was significantly lower than control cells. Cell cycle distribution showed there was a G 0 /G 1 cell cycle arrest in cells overexpressing Hugl-1 (64.09% ± 3.14% vs 50.32% ± 4.60%, 64.09% ± 3.14% vs 49.13% ± 2.24%). Annexin V-fluorescein isothiocyanate revealed that apoptosis was significantly increased in cells overexpressing Hugl-1 compared with control group (17.33% ± 4.76% vs 6.90% ± 1.61%, 17.33% ± 4.76% vs 6.27% ± 0.38%). Moreover, we found that Hugl-1 changes the level of the anti-apoptotic protein Bcl-2 and the proapoptotic protein Bax and the ac

关键词： Esophageal squamous cell carcinoma Human giant larvae homolog 1 Proliferation Apoptosis

Long-Term Outcome of A Large Series of Gastric Cancer Patients in China

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Chinese Journal of Cancer Research 2010年第3期22卷 167-175页

作者： Ai-wen Wu jia-fu ji Hong Yang Yan-ning Li Shuang-xi Li Lian-hai zhang Zi-yu Li Xiao-jiang Wu xiang-long Zong Zhao-de Bu ji zhang xiang-qian Su Yi Wang Guang-wei Xu Key Laboratory of Carcinogenesis and Translational Research （Ministry of Education） Department ofGastrointestinal Surgery Peking University School of Oncology Beijing Cancer Hospital ＆ Institute Beijing100142 China

Objective：The outcome of gastric cancer treatment in China is relatively poor compared with those in Japan and *** factors are not quite clear till *** aim of this study is to present data on gastric cancer patients from a single high volume cancer center of China and to illuminate relevant factors regarding unsatisfactory ***：A total of 2312 consecutive pathologically proven gastric carcinoma patients were treated in Beijing Cancer Hospital from January 1995 to December *** information including demographic information,tumor characteristics,therapeutic experience and survival was retrieved from the Database specially designed for Gastric Cancer Collaborative Group,Beijing Cancer ***：There were 1633 males and 679 females with a median age of 58.8 years（range 19-89）.Merely 181 patients were in the early stage（7.8%）.Curative resection was performed in less than 72% of the *** number of lymph nodes harvested varied from 0 to 71（average 9） while the median number of positive lymph node was 2（0-37）.Only in 650 patients the number of lymph nodes harvested was more than *** the end of follow-up,874 patients were still alive while 1132 *** 1,2,5,10-year overall survival were 68.50%,51.88%,36.83%,and 30.49%,*** analysis demonstrated that TNM stage,tumor location,tumor size,surgery,and vascular invasion were independent prognostic ***：The outcome of gastric cancer in China is not as good as *** detection and standardized curative resection should be prompted at present to improve the outcome.

关键词： Gastric cancer Management Outcome

Coordination for a Closed-loop Supply Chain with Recycling Platform Considering Dynamic Setting

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Journal of Systems Science and Systems Engineering 2024年第4期33卷 425-451页

作者： Zehua xiang Ting ji Lingfeng Dong School of Management Zhejiang UniversityHangzhou310058China School of Business Hangzhou City UniversityHangzhou310015China Alibaba Business College Hangzhou Normal UniversityHangzhou311121China

This paper presents a dynamic closed-loop supply chain(CLSC)model,incorporating a manufacturer,a retailer,and an internet recycling platform(IRP),utilizing differential game theory while considering the forgetting effect of *** model encompasses factors such as the quality level of used products and Big Data marketing(BDM),comparing optimal equilibriums under decentralized and cooperative decision *** effectively coordinate the dynamic CLSC at each time point,we propose a revenue-sharing and cost-sharing(RSCS)combined *** addition to ensuring reasonable sharing of revenues and costs,this contract allows the manufacturer to flexibly adjust wholesale prices for final products and transfer prices for used products in order to distribute profits appropriately and achieve Pareto optimality within the CLSC ***,our results indicate that there exists a threshold for Big Data marketing efficiency;high-efficiency BDM not only facilitates increased recycling on Internet platforms but also reduces unit recycling costs for ***,when implementing the combined contract,Big Data marketing efficiency does not impact the transfer price paid by manufacturers to Internet recycling platforms.

关键词： Big Data marketing differential game closed-loop supply chain coordination internet recycling platform

Reviews and Prospects of Clean Steel Production Practices in Ansteel

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Journal of Iron and Steel Research International 2011年第S2期18卷 9-15页

作者： TANG Fu-ping,LI De-gang,LIAO xiang-wei,WANG Xiao-feng,WAN Xue-feng,jiA ji-xiang,zhang ji-gang(Anshan Iron and steel group company,Anshan 114000,Liaoning,China) Anshan Iron & steel Grp Co Anshan 114000 Liaoning Peoples R China

It summarizes the recognition of clean steel through the reviews the historical development and production practices of clean steel of Ansteel in this *** technological characteristic,equipment,controlling capability and new exploratory of clean steel production of Ansteel are *** has also made a new appraisal to the production line of different clean steel from the angle of high efficiency,stabilization and *** prospects of new production technology of clean steel are introduced at the end of the paper.

关键词： clean steel energy-saving and emission reduction low-cost new technology

Development review and the prospect of oil shale in-situ catalysis conversion technology

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Petroleum Science 2024年第2期21卷 1385-1395页

作者： Li Wang Chen-Hao Gao Rui-Ying Xiong Xiao-Jun zhang ji-xiang Guo The Unconventional Oil and Gas Institute China University of Petroleum-BeijingBeijing102200China

As an unconventional resource, oil shale possesses abundant reserves and significant potential for industrial applications. The rational and efficient development of oil shale resources holds immense importance in reducing national energy demand. In-situ catalytic technology, characterized by its high efficiency, low pollution, and minimal energy consumption, represents a key direction for future oil shale development. This paper provides a comprehensive review of research progress in in-situ oil shale mining technology, oil shale pyrolysis catalysts, the pyrolysis mechanism of kerogen, and the compatibility of different heating processes and catalysts. Furthermore, the paper proposes future research directions and prospects for oil shale in-situ catalytic technology, including reservoir modification, highefficiency catalyst synthesis, injection processes, and high-efficiency heating technology. These insights serve as valuable technical references for the advancement of oil shale in-situ catalytic technology.

关键词： Oil shale In-situ catalytic technology Pyrolysis catalyst Kerogen pyrolysis mechanism

Mitochondrial pathway mediated by reactive oxygen species involvement in α-hederin-induced apoptosis in hepatocellular carcinoma cells

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World Journal of Gastroenterology 2018年第17期24卷 1901-1910页

作者： jiao Li Dan-Dan Wu ji-xiang zhang jing Wang jing-jing Ma Xue Hu Wei-Guo Dong Department of Gastroenterology Renmin Hospital of Wuhan University Central Laboratory of Renmin Hospital Department of Gastroenterology Beijing Shijitan Hospital of Capital Medical University Department of Gastroenterology Renmin Hospital of Wuhan University

AIM To investigate the antitumor activity of α-hederin in hepatocellular carcinoma(HCC) cells and its underlying mechanisms in vitro and in *** SMMC-7721, Hep G-2 and Huh-7 HCC cells were cultured in vitro and treated with α-hederin(0, 5 μmol/L, 10 μmol/L, 15 μmol/L, 20 μmol/L, 25 μmol/L, 30 μmol/L, 35 μmol/L, 40 μmol/L, 45 μmol/L, 50 μmol/L, 55 μmol/L, or 60 μmol/L) for 12 h, 24 h, or 36 h, and cell viability was then detected by the Cell Counting Kit-8. SMMC-7721cells were treated with 0, 5 μmol/L, 10 μmol/L, or 20 μmol/L α-hederin for 24 h with or without DL-buthionineS,R-sulfoximine(2 mmol/L) or N-acetylcysteine(5 mmol/L) pretreatment for 2 h, and additional assays were subsequently performed. Apoptosis was observed after Hoechst staining. Glutathione(GSH) and adenosine triphosphate(ATP) levels were measured using GSH and ATP Assay Kits. Intracellular reactive oxygen species(ROS) levels were determined by measuring the oxidative conversion of 2',7'-dichlorofluorescin diacetate. Disruption of the mitochondrial membrane potential was evaluated using JC-1 staining. The protein levels of Bax, Bcl-2, cleaved caspase-3, cleaved caspase-9, apoptosis-inducing factor and cytochrome C were detected by western blotting. The antitumor efficacy of α-hederin in vivo was evaluated in a xenograft tumor *** The α-hederin treatment induced apoptosis of HCC cells. The apoptosis rates in the control, low-dose α-hederin(5 μmol/L), mid-dose α-hederin(10 μmol/L) and highdose α-hederin(20 μmol/L) groups were 0.90% ± 0.26%, 12% ± 2.0%, 21% ± 2.1% and 37% ± 3.8%, respectively(P < 0.05). The α-hederin treatment reduced intracellular GSH and ATP levels, induced ROS, disrupted the mitochondrial membrane potential, increased the protein levels of Bax, cleaved caspase-3, cleaved caspase-9, apoptosis-inducing factor and cytochrome C, and decreased Bcl-2 expression. The α-hederin treatment also inhibited xenograft tumor growth in vivo. CONCLUSION The α-hederin saponin induces

关键词： Hepatic carcinoma α-hederin Apoptosis Reactive oxygen species Mitochondria

Cooperative inhibitory effect of sinomenine combined with5-fluorouracil on esophageal carcinoma

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World Journal of Gastroenterology 2013年第45期19卷 8292-8300页

作者： jing Wang Zi-Rong Yang Wei-Guo Dong ji-xiang zhang Xu-Feng Guo jia Song Shi Qiu Department of Gastroenterology Renmin Hospital of Wuhan University

AIM:To investigate the inhibitory effects of sinomenine(SIN)combined with 5-fluorouracil(5-FU)on esophageal carcinoma in vitro and in ***:Esophageal carcinoma(Eca-109)cells were cultured in *** single or combined growth inhibition effects of SIN and 5-FU on the Eca-109 cells were examined by measuring the absorbance of CCK-8dye in living *** 33258 staining and an Annexin V/PI apoptosis kit were used to detect the percentage of cells undergoing *** blotting was used to investigate the essential mechanism underlying SIN and 5-FU-induced *** at 25mg/kg and 5-FU at 12 mg/kg every 3 d,either combined or alone,was injected into nude mice and tumor growth inhibition and side effects of the drug treatment were ***:SIN and 5-FU,both in combination and individually,significantly inhibited the proliferation of Eca-109 cells and induced obvious ***,the combined effects were greater than those of the individual agents(P<0.05).Annexin V/PI staining and Hoechst 33258 staining both indicated that the percentage of apoptotic cells induced by SIN and 5-FU combined or alone were significantly different from the control(P<0.05).The up-regulation of Bax and downregulation of Bcl-2 showed that the essential mechanism of apoptosis induced by SIN and 5-FU occurs via the mitochondrial *** and 5-FU alone significantly inhibited the growth of tumor xenografts in vivo,and the combined inhibition rate was even higher(P<0.05).During the course of chemotherapy,no obvious side effects were observed in the liver or ***:The combined effects of SIN and 5-FU on esophageal carcinoma were superior to those of the individual compounds,and the drug combination did not increase the side effects of chemotherapy.

关键词： Esophageal carcinoma Chemotherapy Sinomenine 5-Fluorouracil