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Dynamic foraging strategy adaptation to heterogeneous environments contributes to social aggregation in snub-nosed monkeys

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Zoological Research 2024年第1期45卷 39-54页

作者： Lan Zhao Sheng-Nan ji Xiao-Bing Du jia-Hui Liu Bo-Lun Zhang Pei-Hua Li Yi-Jun Yang bao-Guo Li Yan-Qing Guo Xiao-Guang Qi College of Life Sciences Northwest UniversityXi’anShaanxi 710069China Chengdu Institute of Biology Chinese Academy of SciencesChengduSichuan 610041China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China

The dynamics of animal social structures are heavily influenced by environmental patterns of competition and *** folivorous colobine primates,prevailing theories suggest that larger group sizes should be favored in rainforests with a year-round abundance of food,thereby reducing feeding ***,paradoxically,larger groups are frequently found in high-altitude or high-latitude montane ecosystems characterized by a seasonal scarcity of *** contradiction is posited to arise from cooperative benefits in heterogeneous *** investigate this hypothesis,we carried out a six-year field study on two neighboring groups of golden snub-nosed monkey(Rhinopithecus roxellana),a species representing the northernmost distribution of colobine *** showed that the groups adjusted their movement and habitat selection in response to fluctuating climates and spatiotemporal variability of resources,indicative of a dynamic foraging ***,during the cold,resource-scarce conditions in winter,the large group occupied food-rich habitats but did not exhibit significantly longer daily travel distances than the smaller neighboring ***,we compiled an eco-behavioral dataset of 52 colobine species to explore their evolutionary *** of this dataset suggested that the increase in group size may have evolved via home range expansion in response to the cold and heterogeneous climates found at higher altitudes or ***,we developed a multi-benefits framework to interpret the formation of larger groups by integrating environmental *** cold and diverse environments,even smaller groups require larger home ranges to meet their dynamic survival *** spatiotemporal distribution of high-quality resources within these expanded home ranges facilitates more frequent interactions between groups,thereby encouraging social aggregation into larger *** process enhances the benefits of collabor

关键词： Social evolution Folivore paradox MLS Rhinopithecus roxellana Multi-benefits framework

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The"4+4"Medical Doctor(MD)Pilot Program at PUMC:Implementation,Performance,and Prospects

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Chinese Medical Sciences Journal 2024年第2期39卷 144-148页

作者： jing-jing Yi wei-wei Xu Chao Ma He Di jing jin Le Zeng Wen-ji Tu Wen-Wen Sun Qin Zhang Office of Educational Affairs Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Chinese Academy of Medical Sciences&Peking Union Medical College Beijing 100730China

Peking Union Medical College(PUMC)launched the"4+4"Medical Doctor(MD)pilot program in 2018,admitting students with non-medical backgrounds from top universities,aligning with national medical talent training policies to foster diverse and eager learners in *** the occasion of the graduation of the first class of the"4+4"MD pilot class at PUMC in 2023,we reviewed the teaching reform in the pilot program and carried out a systematic survey and interviews with students,faculties,and management staff of the pilot *** article reports on the measures taken by the pilot class at PUMC in enrollment and curriculum setting,and demonstrates the achievements of the pilot class in terms of student academic background structure,knowledge acquisition and skill learning,scientific research ability,and course *** results indicated that the pilot class had met the national demand for the"Medicine+X"talent training *** specifically,with a diverse academic backgrounds,the pilot class graduates had academic levels comparable to the eight-year medical education graduates,and their scientific research abilities were *** pilot program at PUMC will optimize the curriculum setting,strengthen the construction of faculty,learning resources,and teaching facilities,and reform the academic evaluation methods,thus deepening the reform of medical education and improving the"4+4"MD program as a novel medical education model.

关键词： "4+4"MD pilot program teaching reform medical education

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Electrostatic Encapsulation of Cobalt Ions into Crystalline Framework Derived Polymer Aerogel:Ultra-light,Pressure Resistant,Hydrophobic,Photothermal Conversion,Heat Insulation and Infrared Stealth

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Chinese Journal of Polymer Science 2024年第7期42卷 946-957,I0007页

作者： Yi-Fan Kang jin-Lu Tang Ming Song wei Wang jia-Cheng Ma Zhan-You ji Tong Liu Wen-Huan Huang China Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi’an710021China College of New Energy Xi’an Shiyou UniversityXi’an710065China Xi’an Key Laboratory of Functional Supramolecular Structure and Materials College of Chemistry and Materials ScienceNorthwest UniversityXi’an710127China

A variety of electromagnetic wave absorption materials(EMWAs)have been reported,but the integration of powder materials and multifunctional devices should be investigated in-depth to adapt to practical ***,carbon-coated cobalt composites were prepared by adsorbing magnetic metal cations into an anionic crystalline framework through an electrostatic encapsulate *** reflection loss(RL_(min))of-40.49 d B and effective absorption bandwidth(EAB)of 5.36 GHz(RLweight composite aerogel that is compressive resistant and heat-holding while also having photothermal conversion *** hydrophobic modification makes it more widely *** study provides a new strategy for EWAMs to integrate versatility and improve their application prospects.

关键词： Electrostatic incorporation Magnetic nanoparticle Co@CN composites Electromagnetic wave absorbing Metal-organic framework

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Intelligent extraction of road cracks based on vehicle laser point cloud and panoramic sequence images

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Journal of Road Engineering 2024年第1期4卷 69-79页

作者： Ming Guo Li Zhu Ming Huang jie ji Xian Ren Yaxuan wei Chutian Gao School of Geomatics and Urban Spatial Informatics Beijing University of Civil Engineering and ArchitectureBeijing 102616China Engineering Research Centre of Representative Building and Architectural Heritage Database Ministry of EducationBeijing 100044China Key Laboratory of Modern Urban Surveying and Mapping National Administration of SurveyingBeijing 102616China School of Civil and Transportation Engineering Beijing University of Civil Engineering and ArchitectureBeijing 102616China

In light of the limited efficacy of conventional methods for identifying pavement cracks and the absence of comprehensive depth and location data in two-dimensional photographs,this study presents an intelligent strategy for extracting road *** methodology involves the integration of laser point cloud data obtained from a vehicle-mounted system and a panoramic sequence of *** study employs a vehicle-mounted LiDAR measurement system to acquire laser point cloud and panoramic sequence image data simultaneously.A convolutional neural network is utilized to extract cracks from the panoramic sequence *** extracted sequence image is then aligned with the laser point cloud,enabling the assignment of RGB information to the vehicle-mounted three dimensional(3D)point cloud and location information to the two dimensional(2D)panoramic ***,a threshold value is set based on the crack elevation change to extract the aligned roadway point *** three-dimensional data pertaining to the cracks can be *** experimental findings demonstrate that the use of convolutional neural networks has yielded noteworthy outcomes in the extraction of road *** utilization of point cloud and image alignment techniques enables the extraction of precise location data pertaining to road *** approach exhibits superior accuracy when compared to conventional ***,it facilitates rapid and accurate identification and localization of road cracks,thereby playing a crucial role in ensuring road maintenance and traffic ***,this technique finds extensive application in the domains of intelligent transportation and urbanization *** technology exhibits significant promise for use in the domains of intelligent transportation and city development.

关键词： Road crack extraction Vehicle laser point cloud Panoramic sequence images Convolutional neural network

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Electronic engineering of Co-Ru diatomic sites and Ru nanoparticles for synergistic promotion of hydrogen evolution

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Nano Research 2024年第5期17卷 3714-3723页

作者： wei Zhang Cong Li Yongyong Cao Jun-Yang ji Zhao-Chen Li Zheng Niu Hongwei Gu Pierre Braunstein jian-Ping Lang College of Chemistry Chemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China College of Biological Chemical Science and EngineeringJiaxing UniversityJiaxing 314001China Universitéde Strasbourg-CNRS Institut de Chimie(UMR 7177 CNRS)4 rue Blaise Pascal-CS 9003267081 StrasbourgFrance

The coexistence of multi-component active sites like single-atom sites,diatomic sites(DAS)and nanoclusters is shown to result in superior performances in the hydrogen evolution reaction(HER).Metal diatomic sites are more complex than single-atom sites but their unique electronic structures can lead to significant enhancement of the HER *** the synthesis and identification of DAS is usually challenging,we report a simple access to a diatomic catalyst by anchoring Co-Ru DAS on nitrogen-doped carbon supports along with Ru nanoparticles(NPs).Experimental and theoretical results revealed the atomic-level characteristics of Co-Ru sites,their strong electronic coupling and their synergy with Ru NPs within the *** unique electronic structure of the catalyst resulted in an excellent HER activity and stability in alkaline *** work provides a valuable insight into a widely applicable design of diatomic catalysts with multi-component active sites for highly efficient HER electrocatalysis.

关键词： Co-Ru diatomic sites Ru nanoparticles multiple active sites synergistic effect hydrogen evolution reaction

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Gene mutations in newly diagnosed multiple myeloma patients detected by next-generation sequencing technology

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Cancer Pathogenesis and Therapy 2024年第3期2卷 205-211页

作者： Yutong Wang Mengzhen Wang Bin Chu Minqiu Lu Lei Shi Shan Gao Yuan Chen Qin Yan Na ji Li bao Department of Hematology Beijing Jishuitan HospitalCapital Medical UniversityBeijing 100035China

Background:Multiple myeloma(MM)is a heterogeneous plasma-derived hematopoietic malignancy with complex genetic mutation contributing to the *** gene sequencing has been applied in MM,genetic features from Chinese MM patients are reported *** investigated the genetic mutation of newly diagnosed multiple myeloma(NDMM)patients and explore its correlation with cytogenetic abnormalities detected by fluorescence in situ hybridization(FISH).Methods:A total of 206 patients with NDMM were *** enriching plasma cells with CD138 magnetic beads,92 MM-related target gene mutations were detected by the Illumina sequencing platform,and six common genetic abnormalities were detected by ***:162 cases(78.6%)had at least one gene mutation detected by *** top 5 mutated genes were KRAS,NRAS,TRAF3,BRAF,and *** abnormalities detected by FISH have a certain correlation with gene mutations,t(11;14)translocations are often accompanied by CCND1 and TP53 mutations,KLHL6 in t(4;14),SP140,CDKN1B and PRKD2 in t(14;16)and t(14;20)*** mutation ratio was higher for EGR1,while lower of CCND1 in patients with gain *** TP53 mutation was more likely in patients with 17p *** gene mutation affects the pathway of the RNA process is more frequently occurring in males and age less than 70 years *** International Staging System(ISS)Stage Ⅲ correlated with gene mutations in the NK-κB pathway while Revised ISS(R-ISS)Stage Ⅲ correlated with the DNA damage repair ***:There are various gene mutations in NDMM patients,mainly RAS/MAPK and NF-κB pathway gene pathways.

关键词： Multiple myeloma Next-generation sequencing Genetics mutation

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波形钢腹板梁T形接头焊接仿真分析与试验研究

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哈尔滨工程大学学报 2024年第4期45卷 691-698页

作者：冀伟张鹏湖南大学土木工程学院湖南长沙410082 兰州交通大学土木工程学院甘肃兰州730070

为了解决波形钢腹板梁焊接温度场和残余应力分布尚不明确的问题,本文基于Simufact Welding软件建立三维有限元模型,对其T形接头的焊接温度场和残余应力进行了预测,并对模拟结果进行了试验验证。波形钢腹板梁的焊接温度场分布与熔池中心... 详细信息

为了解决波形钢腹板梁焊接温度场和残余应力分布尚不明确的问题,本文基于Simufact Welding软件建立三维有限元模型,对其T形接头的焊接温度场和残余应力进行了预测,并对模拟结果进行了试验验证。波形钢腹板梁的焊接温度场分布与熔池中心距离有关,距离熔池中心越近,温度梯度越大;焊接残余应力以纵向残余拉应力为主,而横向残余应力的应力水平相对较低,拉压应力共存;焊接速度和底板厚度的改变只会影响残余应力的峰值大小,不会影响残余应力的分布规律。结果表明:数值模拟结果和试验实测值吻合良好,数值模拟可靠。

关键词：桥梁工程波形钢腹板梁 T形接头焊接温度场焊接残余应力参数分析焊接速度腹板厚度

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波形钢腹板梁焊接残余应力分布及试验验证

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西南交通大学学报 2024年第2期59卷 289-297页

作者：冀伟刘勇湖南大学土木工程学院湖南长沙410082 兰州交通大学土木工程学院甘肃兰州730070

为研究波形钢腹板梁焊接残余应力的分布规律,通过有限元软件建立其三维热弹塑性模型,利用热-力耦合分析技术对其焊接温度场和应力场进行有限元数值仿真,采用双椭球体热源和修改单元材料属性的方法实现能量输入和焊缝填充,并将模拟计算... 详细信息

为研究波形钢腹板梁焊接残余应力的分布规律,通过有限元软件建立其三维热弹塑性模型,利用热-力耦合分析技术对其焊接温度场和应力场进行有限元数值仿真,采用双椭球体热源和修改单元材料属性的方法实现能量输入和焊缝填充,并将模拟计算结果与实测值进行对比分析.结果表明:有限元预测的波形钢腹板梁残余应力分布与实测结果具有相同趋势,在波形钢腹板梁焊缝的弯折角处,残余应力发生一定幅度的连续应力波动;底板和腹板的残余应力峰值均出现在焊缝中心区域,其值分别为材料屈服强度的1.30倍和1.26倍;底板纵向残余拉应力在焊缝中心线两侧78 mm范围内急速下降后缓慢过渡为压应力,在底板较窄一侧压应力线性增大,最大值约为材料屈服强度的0.61倍;在底板较宽一侧压应力线性减小,并在边缘处转化为拉应力;焊接速度对残余应力分布扰动不大,而对残余应力峰值影响较显著;当焊接速度从150 mm/min增加至250 mm/min时,横向和纵向的残余应力最大值分别增加了27.11%和5.88%.

关键词：波形钢腹板梁焊接残余应力热力学数值模拟焊接速度

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Embryo Transfer Strategies for Women with Recurrent Implantation Failure During the Frozen-thawed Embryo Transfer Cycles:Sequential Embryo Transfer or Double-blastocyst Transfer?

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Current Medical Science 2024年第1期44卷 212-222页

作者： Qiao-hang ZHAO Yu-wei SONG jian CHEN Xiang ZHOU ji-lai XIE Qiu-ping YAO Qi-yin DONG Chun FENG Li-ming ZHOU wei-ping FU Min jiN The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou 310052China jiaxing Maternity and Child Health Care Hospital Jiaxing 314051China Huzhou Maternity and Child Care Hospital Huzhou 313002China Ningbo Women and Children's Hospital Ningbo 315000China

Objective Both sequential embryo transfer(SeET)and double-blastocyst transfer(DBT)can serve as embryo transfer strategies for women with recurrent implantation failure(RIF).This study aims to compare the effects of SeET and DBT on pregnancy *** Totally,261 frozen-thawed embryo transfer cycles of 243 RIF women were included in this multicenter retrospective *** to different embryo quality and transfer strategies,they were divided into four groups:group A,good-quality SeET(GQ-SeET,n=38 cycles);group B,poor-quality or mixed-quality SeET(PQ/MQ-SeET,n=31 cycles);group C,good-quality DBT(GQ-DBT,n=121 cycles);and group D,poor-quality or mixed-quality DBT(PQ/MQ-DBT,n=71 cycles).The main outcome,clinical pregnancy rate,was compared,and the generalized estimating equation(GEE)model was used to correct potential confounders that might impact pregnancy *** GQ-DBT achieved a significantly higher clinical pregnancy rate(aOR 2.588,95%CI 1.267–5.284,P=0.009)and live birth rate(aOR 3.082,95%CI 1.482–6.412,P=0.003)than PQ/***,the clinical pregnancy rate was significantly higher in GQ-SeET than in PQ/MQ-SeET(aOR 4.047,95%CI 1.218–13.450,P=0.023).The pregnancy outcomes of GQ-SeET were not significantly different from those of GQ-DBT,and the same results were found between PQ/MQ-SeET and PQ/*** SeET relative to DBT did not seem to improve pregnancy outcomes for RIF patients if the embryo quality was comparable between the two *** clinical pregnancy outcomes could be obtained by transferring good-quality embryos,no matter whether in SeET or *** quality plays a more important role in pregnancy outcomes for RIF patients.

关键词： recurrent implantation failure sequential embryo transfer frozen-thawed embryo transfer embryo transfer strategies

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CD87-targeted BiT E and CAR-T cells potently inhibit invasive nonfunctional pituitary adenomas

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Science China Life Sciences 2024年

作者： Yuan Ren Xinjie bao Ming Feng Bing Xing wei Lian Yong Yao Renzhi Wang Department of Neurosurgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Recently, bispecific T-cell engagers(BiTEs) and chimeric antigen receptor-modified T cells(CAR-Ts) have been shown to have high therapeutic efficacy in hematological tumors. CD87 is highly expressed in solid tumors with an oncogenic function. To assess their cytotoxic effects on invasive nonfunctioning pituitary adenomas(iNFPAs), we first examined CD87 expression and its effects on the metabolism of iNFPA cells. We generated CD87-specific BiTE and CAR/IL-12 T cells, and their cytotoxic effects on iNFPAs cells and in mouse models were determined. CD87 had high expression in i NFPA tissue and cell samples but was undetected in noncancerous brain samples. CD87×CD3BiTE and CD87 CAR/IL-12 T-cells showed antigenic specificity and exerted satisfactory cytotoxic effects, decreasing tumor cell proliferation in vitro and reducing existing tumors in experimental mice. Overall, the above findings suggest that CD87 is a promising target for the immunotherapeutic management of iNFPAs using anti-CD87 BiTE and CD87-specific CAR/IL-12 T cells.

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