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Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu ji-Chuan Liu Zi-Ling Shi quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

Innovative dual-mode device integrating capacitive desalination and solar vapor generation for high-efficiency seawater desalination

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Journal of Energy Chemistry 2025年第1期100卷 171-179页

作者： jiacheng Wang Zhaoyu Chen Ruduan Yuan jiaxin Luo Ben Zhang Keju ji Meng Li Juanxiu Xiao Kuan sun National Innovation Center for Industry-Education Integration of Energy Storage Technology MOE Key Laboratory of Low-grade Energy Utilization Technologies and SystemsCollege of Energy & Power Engineering Chongqing University Xuefeng Mountain Energy Equipment Safety National Observation and Research Station CQU-NUS Renewable Energy Materials & Devices Joint Laboratory Chongqing University Southwest Technology and Engineering Research Institute jiangsu Provincial Key Laboratory of Bionic Functional Materials College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics State Key Laboratory of Marine Resources Utilization in South China Sea Collaborative Innovation Center of Marine Science and Technology School of Marine Science and Engineering Hainan University

Solar-driven interface evaporation with high solar-to-steam conversion efficiency has shown great potential in seawater ***,due to the influence of latent heat and condensation efficiency,the water yield from solar-driven interface evaporation remains insufficient,posing a significant challenge that requires *** this work,we designed a dual-mode high-flux seawater desalination device that combines solar-driven interface evaporation and capacitive *** utilizing coupled desalination materials exhibiting both photothermal conversion and capacitance activity,the device demonstrated photothermal evaporation rates of 1.41 and 0.97 kg m-2h-1for condensate water yield under one-sun ***,the device exhibited a salt adsorption capacity of up to48 mg g-1and a salt adsorption rate of 2.1 mg *** addition,the salt adsorption capacity increased by approximately 32% under one-sun ***,photo-enhanced capacitive desalination performance was explored through numerical simulations and theoretical *** calculations and characterizations confirmed that the defect energy levels formed by the introduction of sulfur vacancies can effectively widen the light absorption range,improve photothermal conversion performance,and stimulate more photoelectrons to participate in capacitive ***,the electron distribution state of molybdenum disulfide with sulfur vacancies and surface defect sites contributes to ion/electron transport at the solid-liquid *** work provides a novel pathway for integrating solar vapor generation with other low-energy desalination technologies.

关键词： Desalination

A versatile synthetic strategy towards rare earth based metal-organic frameworks

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Science China Chemistry 2025年

作者： quan Shi Yun-Hao Xu Ming-Hui Chen Peng Zhao Wen-Bo Deng ji Xiong Kai Guo Ya-Qing Feng Bao Zhang School of Chemical Engineering and Technology Tianjin University Tianjin Collaborative Innovation Center of Chemical Science and Engineering Guangdong Laboratory Chemistry & Fine Chemical Industry jieyang Center

Rare earth metal-organic frameworks (RE-MOFs) have drawn wide attention owing to diverse network structures and various application ***,due to the unpredictable formation of the nodes,it is still challenging to design novel RE-MOFs.A novel versatile strategy was developed employing a RE-acetate complex (RE2(CH3COO)6·4H2O) as a precursor to construct RE-MOFs.2D RE-MOFs (RE-DBP) and 3D RE-MOFs (RE-TCPP) could be obtained by using dicarboxylic porphyrin ligands H2DBP and tetracarboxylic porphyrin ligands H2TCPP,*** RE-MOFs were further synthesized to verify the universality of the *** crystalline RE-MOFs could also be prepared at room temperature via the developed strategy,which could significantly promote large-scale preparation and practical application of *** proof of the concept,the performance of porphyrin-based RE-MOFs was investigated in the photocatalytic cycloaddition of CO2with *** the RE-DBP(Co) MOFs,Tb-DBP(Co) exhibited the best photocatalytic performance,which was also greater than that of the corresponding 3D MOF Tb-TCPP(Co) due to the optimal 2D structure and thus the accelerated photogenerated charge separation and transfer *** work not only provides a novel versatile strategy to design and develop RE-MOFs,but also proposes a promising approach for the potential bulk production of RE-MOFs at room temperature.

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Construction of Power Trading Supply Guarantee System of High Proportion of Hydropower in the Southwest Power Grid Under Extreme Climate Scenarios

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Dianwang jishu/Power System Technology 2025年第1期49卷 113-123页

作者： Wen, Xu Zhou, quan sun, Tian Yang, Yang Mao, Rui Wen, Siao Southwest Branch of State Grid Corporation of China Sichuan Province Chengdu 610041 China Beijing Power Trading Center Co. Ltd. Xicheng District Beijing 100031 China

Currently, the Southwest Power Grid is promoting the construction of a new power system. The southwest power grid has a large-scale integration of clean energy, mainly hydropower, which depends on the weather. The system operation is facing serious challenges due to the lack of reliable power supply and the frequent occurrence of extreme climate. Firstly, this paper introduces China's Southwest Power Grid and market operation pattern. Secondly, learning from the power supply issues in the Sichuan-Chongqing region of the Southwest Power Grid under the extreme drought, and high-temperature climate scenarios in the summer of 2022, and based on the perspectives of the regional power grid and the marketization, the paper summarizes the four shortcomings of current power supply scheme of Southwest Power Grid, namely limited warning levels, short supply cycle, limited supply space, and a single supply resource. Therefore, research methods and framework for the power supply of Southwest Power Grid are proposed based on the concept of "double-level, full-lifecycle, full-space, and full-resources" ("one-double three-full"). Thirdly, the power trading system for supply sufficiency in Southwest Power Grid under extreme climate scenarios is constructed: 1) proposing the concept and level determination method of power supply warning and response for regional power grids, and constructing a double-level power trading supply warning and response mechanism for "provincial power grid + regional power grid";2) proposing medium and long term interruptible power supply varieties and constructing a "medium and long term + spot + emergency" full-lifecycle power trading supply guarantee system;3) proposing the concept of inter-regional and intra-provincial market power supply, designing spatiotemporal exchange transactions of large-scale hydropower and constructing a "inter-regional + inter-provincial + intra-provincial" full-space power trading system for supply sufficiency;4) proposing p

关键词： Commerce

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-jie quan Hao Liang Yong-Hong Tang Li jiang Xiong-Ying ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Occluded Gait Emotion Recognition Based on Multi-Scale Suppression Graph Convolutional Network

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Computers, Materials & Continua 2025年第1期82卷 1255-1276页

作者： Yuxiang Zou Ning He jiwu sun Xunrui Huang Wenhua Wang Beijing Key Laboratory of Information Service Engineering Beijing Union UniversityBeijing100101China College of Smart City Beijing Union UniversityBeijing100101China

In recent years,gait-based emotion recognition has been widely applied in the field of computer ***,existing gait emotion recognition methods typically rely on complete human skeleton data,and their accuracy significantly declines when the data is *** enhance the accuracy of gait emotion recognition under occlusion,this paper proposes a Multi-scale Suppression Graph ConvolutionalNetwork(MS-GCN).TheMS-GCN consists of three main components:Joint Interpolation Module(ji Moudle),Multi-scale Temporal Convolution Network(MS-TCN),and Suppression Graph Convolutional Network(SGCN).The ji Module completes the spatially occluded skeletal joints using the(K-Nearest Neighbors)KNN interpolation *** MS-TCN employs convolutional kernels of various sizes to comprehensively capture the emotional information embedded in the gait,compensating for the temporal occlusion of gait *** SGCN extracts more non-prominent human gait features by suppressing the extraction of key body part features,thereby reducing the negative impact of occlusion on emotion recognition *** proposed method is evaluated on two comprehensive datasets:Emotion-Gait,containing 4227 real gaits from sources like BML,ICT-Pollick,and ELMD,and 1000 synthetic gaits generated using STEP-Gen technology,and ELMB,consisting of 3924 gaits,with 1835 labeled with emotions such as“Happy,”“Sad,”“Angry,”and“Neutral.”On the standard datasets Emotion-Gait and ELMB,the proposed method achieved accuracies of 0.900 and 0.896,respectively,attaining performance comparable to other ***,on occlusion datasets,the proposedmethod significantly mitigates the performance degradation caused by occlusion compared to other methods,the accuracy is significantly higher than that of other methods.

关键词： KNN interpolation multi-scale temporal convolution suppression graph convolutional network gait emotion recognition human skeleton

Consistency check of degradation mechanism between natural storage and enhancement test for missile servo system

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Journal of Systems Engineering and Electronics 2019年第2期30卷 415-424页

作者： Wang Xu sun quan College of Information Systems and Management National University of Defense Technology The Second Academy of China Aerospace Science and Industry Corporation Hunan Ginkgo Reliability Technology Institute Limited Corporation

Reliability enhancement testing(RET) is an accelerated testing which hastens the performance degradation process to surface its inherent defects of design and manufacture. It is an important hypothesis that the degradation mechanism of the RET is the same as the one of the normal stress condition. In order to check the consistency of two mechanisms, we conduct two enhancement tests with a missile servo system as an object of the study, and preprocess two sets of test data to establish the accelerated degradation models regarding the temperature change rate that is assumed to be the main applied stress of the servo system during the natural storage. Based on the accelerated degradation models and natural storage profile of the servo system, we provide and demonstrate a procedure to check the consistency of two mechanisms by checking the correlation and difference of two sets of degradation data. The results indicate that the two degradation mechanisms are significantly consistent with each other.

关键词： reliability enhancement testing (RET) degradation model accelerated equation consistency check Pearson correlation coefficient

Design of the upstream decay pipe window of the long baseline neutrino facility

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Nuclear Science and Techniques 2021年第11期32卷 134-145页

作者： Hai-jing Wang Ye Yuan jing-Yu Tang quan ji Ling Kang Chang-Jun Ning ji-Lei sun Shao-Hong Wei Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

The beam windows of high-energy beam lines are important,and it is sometimes difficult to design because it is necessary to ensure particle propagation with minimum disturbance and fulfill mechanical requirements at the same *** upstream decay pipe window of the long baseline neutrino facility at Fermilab has an extremely large diameter(1.8 m),with a thickness of only 1.5 mm to separate the helium atmosphere in the decay pipe and the nitrogen atmosphere on the other ***,the center of this dish-shaped window is expected to be a200-mm-diameter beryllium dish welded to the outside aluminum alloy A6061,and this welded combination must withstand extreme conditions of a 2.4-MW,high-energy proton beam without *** severe conditions make the design of this window an unprecedented *** paper describes the static thermal-structural analyses based on which the structure has been optimized,as well as dynamic analyses for understanding the shockwave effects originating in the *** optimization,the maximum von Mises stresses in the window decreased significantly in both normal operation and accident cases,making our design very reasonable.

关键词： Decay pipe window Structure optimization Dynamic analyses Long baseline neutrino facility

Sites of Protonation and Unimolecular Fragmentation of Protonated N-Hydroxyphthalimide in the Gas Phase

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Chemical Research in Chinese Universities 1998年第2期14卷 63-67页

作者： SHE Yi-min sun Yu-quan ji Yi-ping LIU Shu-ying Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun130022

The low energy collisioninduced dissociation, linked scan techniques and isotopic labeling experiment were used to investigate the unimolecular fragmentation of protonated N-hydroxyphthalimide under electron impact and chemical ionization conditions. It was found that this compound shows an unusual reactivity towards protonation. Two possible sites of protonation have been proposed to explain the corresponding fragmentation processes, one is that the protonation takes place on the oxygen atom of hydroxyl group, resulting in the loss of water and the other is the formation of an intermediary protonbound complex in the fragmentation process, giving rise to the fragment ions of m/z 133 and m/z 135. The results show both cases are coexistence in the fragmentations of protonated N-hydroxyphthalimide, and the unimolecular fragmentation pathways are available.

关键词： Sites of protonation Unimolecular fragmentation Collisioninduced dissociation Nhydroxyphthalimide