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Mn、S共掺杂g-C_(3)N_(4)活化过硫酸盐降解四环素的影响因素探究

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广州化工 2024年第6期52卷 120-123,138页

作者：黄继明刘润清皮军龙泽荣何炳林李方庆李莲王清宇铜仁学院材料与化学工程学院贵州铜仁554300

四环素因其应用广泛、难以自然降解性以及潜在的生态风险,成为水环境污染物中的重点关注对象。开发低成本、高效的光催化剂活化过硫酸氢钾(PMS)降解有机污染物被认为是治理环境污染的重要途径。本研究采用简单的煅烧法制备了Mn、S共掺杂... 详细信息

四环素因其应用广泛、难以自然降解性以及潜在的生态风险,成为水环境污染物中的重点关注对象。开发低成本、高效的光催化剂活化过硫酸氢钾(PMS)降解有机污染物被认为是治理环境污染的重要途径。本研究采用简单的煅烧法制备了Mn、S共掺杂g-C_(3)N_(4)催化剂,用于协同光活化PMS降解四环素。采用X射线衍射仪(XRD)对其进行表征,设计单因素试验探究Mn、S共掺杂g-C_(3)N_(4)降解四环素效果和最佳条件。单因素试验结果表明,最佳Mn、S共掺杂g-C_(3)N_(4)投加量为0.2 g/L,过硫酸氢钾浓度为5 mmol/L,四环素溶液初始pH为3,初始浓度为10 mg/L(100 mL)时去除效果最好,四环素去除率为90.4%。这项研究为使用g-C_(3)N_(4)基光催化剂降解抗生素提供了一种新的策略。

关键词： Mn、S掺杂石墨相氮化碳过硫酸盐四环素光催化降解

Deceased donor liver transplantation for Budd–Chiari syndrome:long-segmental thrombosis of the inferior vena cava with extensive collateral circulation

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hepatobiliary & Pancreatic Diseases International 2020年第3期19卷 288-290页

作者： Zi-Xi Liu ji-Qiao Zhu jun Ma jian-Tao Kou Xian-liang Li Qiang he Department of hepatobiliary and Pancreaticosplenic Surgery Beijing Chaoyang HospitalCapital Medical UniversityNo.8 Gongtinan RoadChaoyang DistrictBeijing 100020China

Budd–Chiari syndrome(BCS)is an infrequent clinical disease resulting from obstruction of the hepatic venous outflow tract anywhere from small hepatic veins to the inferior vena cava(IVC)[1].Currently,step-wise treatment strategy has been proposed and widely adopted based on the patient's status,which contains anticoagulation,thrombolysis,percutaneous recanalization,transjugular intrahepatic portosystemic shunt(TIPS)and surgical shunt[2].

关键词： Chiari hepatic vena

Polypeptide from Moschus Suppresses Lipopolysaccharide-Induced Inflammation by Inhibiting NF-κB-ROS/NLRP3 Pathway

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中国结合医学杂志:英文版 2023年第10期29卷 895-904页

作者： YI jing LI Li YIN Zhu-jun QUAN Yun-yun TAN Rui-rong CheN Shi-long LANG ji-rui LI jiao ZENG jin LI Yong SUN Zi-jian ZHAO jun-ning Department of Pharmacology Southwest Medical UniversityLuzhouSichuan Province646000China Sichuan Institute for Translational Chinese Medicine Translational Chinese Medicine Key Laboratory of Sichuan ProvinceSichuan Academy of Chinese Medicine SciencesChengdu610000China Hunan Provincial Key Laboratory of the Research and Development of Novel Pharmaceutical Preparations College of PharmacyChangsha Medical UniversityChangsha410219China Sichuan Fengchun Pharmaceutical Co. Ltd.DeyangSichuan Province618100China Sichuan Ant Recommendation Biotechnology Co. Ltd.Chengdu610000China

Objective To examine the anti-inflammatory effects and potential mechanisms of polypeptide from Moschus(PPM)in lipopolysaccharide(LPS)-induced THP-1 macrophages and BALB/c *** The polypeptide was extracted from Moschus and analyzed by high-performance liquid chromatography and sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE).Subsequently,LPS was used to induce inflammation in THP-1 macrophages and BALB/c *** LPS-treated or untreated THP-1 macrophages,cell viability was observed by cell counting kit 8 and lactate dehydrogenase release assays;the proinflammatory cytokines and reactive oxygen species(ROS)were measured by enzyme-linked immunosorbent assay and flow cytometry,respectively;and protein and mRNA levels were measured by Western blot and real-time quantitative polymerase chain reaction(qRT-PCR),*** LPS-induced BALB/c mice,the proinflammatory cytokines were measured,and lung histology and cytokines were observed by hematoxylin and eosin(he)and immunohistochemical(IHC)staining,*** The SDS-PAGE results suggested that the molecular weight of purified PPM was in the range of 10–26 *** vitro,PPM reduced the production of interleukin 1β(IL-1β),IL-18,tumor necrosis factorα(TNF-α),IL-6 and ROS in LPS-induced THP-1 macrophages(Phe inhibitory effects of PPM on the mRNA levels of TXNIP,NLRP3,ASC,and caspase-1(Phermore,in LPS-induced BALB/c mice,PPM reduced TNF-αand IL

关键词： Moschus polypeptide inflammation NLRP3 inflammasome thioredoxin interacting protein nuclear factorκB Chinese medicine

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带分舱板海上风电筒型基础承载特性试验研究

岩土力学 2016年第10期37卷 2746-2752页

作者：练继建贺蔚吴慕丹王海军天津大学水利工程仿真与安全国家重点实验室

为正确评估分舱对于海上风电筒型基础承载特性的影响,对有、无分舱板的相同钢筒进行室内模型对比试验,分别得出在水平荷载及弯矩共同作用下和竖直荷载作用下的荷载-位移曲线,及筒内外侧壁土压力及顶盖土压力的分布规律,同时进行有限元... 详细信息

为正确评估分舱对于海上风电筒型基础承载特性的影响,对有、无分舱板的相同钢筒进行室内模型对比试验,分别得出在水平荷载及弯矩共同作用下和竖直荷载作用下的荷载-位移曲线,及筒内外侧壁土压力及顶盖土压力的分布规律,同时进行有限元分析模拟。试验和计算结果表明:在竖向荷载作用下,分舱板使基础的极限承载力略有提高,分舱板分担了筒顶盖和筒壁的竖向承载,降低了顶盖的承载比例;在水平荷载和弯矩共同作用下,分舱板为筒型基础提供了较大的抗拔承载力,使筒型基础在水平和弯矩荷载作用下的极限承载力提高了20.2%,降低了极限状态下的水平位移和倾角。总之,分舱板不但可以提高海上风电基础施工浮运过程的稳定性,还可以提高基础运行时的极限承载力。

关键词：筒型基础分舱板海上风电机模型试验有限元模拟

Effects of HBV X gene and arsenic trioxide on the expression of p53 in cultured hepG2 cells

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Chinese Medical Journal 2007年第24期120卷 2181-2184页

作者： LEI jian-hua he Xing-e YANG Xu ZHANG Min lian jun LUO Hong-yu wang Wen-long Liver Disease Research Center Second Xiangya Hospital CentralSouth University Changsha 410011 China

Background hepatitis B virus （HBV） X protein （HBx） and p53 could mutually down-regulate at transcriptional level and HBx could bind with p53 protein within its transactivation domain and inhibit the function of p53 protein. In recent years, effects of arsenic trioxide （As2O3） on the expression of p53 protein have been widely studied, while little is known about the activity of p53 protein. This study was undertaken to delineate the effect of HBV X gene and AS203 on p53 protein expression （level and activity） in hepG2 cells by small hairpin RNA （shRNA）-mediated RNA interference （RNAi） technique. Methods Cell line hepG2 and cells with stable expression of HBV X gene （hepG2-X） were treated with 2 pmol/L AS203, with corresponding untreated cells serving as controls. Cell lysates and nuclear extracts were extracted. Total level and the relative activity of p53 protein were detected by modified enzyme-linked immunosorbent assay （ELISA）. HBV X gene sequence-specific shRNA expression vector （pXi-1 and pXi-2） and sequence-unrelated control （pXi-3） were transfected into hepG2-X. Single cell clone with stable expression of shRNA was selected and exposed to propagating culture. The effect of As2O3 on p53 protein expression and activity was re-observed. Results Total p53 protein level was up-regulated and its relative activity ratio was enhanced by As2O3 in hepG2 and hepG2-X cells. The total p53 protein level induced by As2O3 was up-regulated by HBV X gene expression, while its relative activity was significantly suppressed. The suppression was removed after HBV X gene expression was repressed by shRNA. Conclusions As2O3 up-regulates p53 protein expression and enhance its activity. HBV X up-regulates As2O3 induced-p53 protein expression while suppresses its activity.

关键词： hepatitis B virus gene X arsenic trioxide RNA interference tumor suppressor protein p53

Effect of notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion

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World Journal of Gastroenterology 2008年第1期14卷 29-37页

作者： Wei-Xing Chen Fang wang, Yu-Ying Liu, Qing-jiang Zeng, Kai Sun, Xin Xue, Xiang Li, ji-Ying Yang, Li-Hua An,Bai-he Hu, jin-Hui Yang, Chuan-She wang, Zhi-Xin Li, lian-Yi Liu, Yan Li, jun Zheng, Fu-long Liao, Dong Han,jing-Yu Fan, jing-Yan Han Fang wang Yu-Ying Liu Qing-jiang Zeng Kai Sun Xin Xue Xiang Li ji-Ying Yang Li-Hua An Bai-he Hu jin-Hui Yang Chuan-She wang Zhi-Xin Li lian-Yi Liu Yan Li jun Zheng Fu-long Liao Dong Han jing-Yu Fan jing-Yan Han Tasly Microcirculation Research Center Peking University Health Science Center Beijing 100083 China Department of Pharmacology Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Department of Integrated Chinese and Western Medicine School of Basic Medical Sciences Peking University Beijing 100083 China

AIM： To assess the effect of notoginsenoside R1 on hepatic microcirculatory disturbance induced by gut ischemia/reperfusion （I/R） in mice. METHODS： The superior mesenteric artery （SMA） of C57/BL mice was ligated for 15 min to induce gut ischemia followed by 30-rain reperfusion. In another set of experiments, R1 was continuously infused （10 mg/kg per hour） from 10 min before I/R until the end of the investigation to study the influence of R1 on hepatic microcirculatory disturbance induced by gut I/R. hepatic microcirculation was observed by inverted microscopy, and the vascular diameter, red blood cell （RBC） velocity and sinusoid perfusion were estimated. Leukocyte rolling and adhesion were observed under a laser confocal microscope. Thirty and 60 min after reperfusion, lactate dehydrogenase （LDH）, alanine aminotransferase （ALl＇） and aspartate transaminase （AST） in peripheral blood were determined. The expression of adhesion molecules CD11b/CD18 in neutrophils and tumor necrosis factor- alpha （TNF-α）, interleukin-6 （IL-6） and monocyte chemotactic protein-1 （MCP-1） in plasma were evaluated by flow Oltometry. E-selectin and intercellular adhesion molecule-1 （ICAM-1） in hepatic tissue were examined by ***： After gut I/R, the diameters of terminal portal venules and central veins, RBC velocity and the number of perfused sinusoids were decreased, while the leukocyte rolling and adhesion, the expression of E-selectin in hepatic vessels and CD18 in neutrophils, IL-6, MCP-1, LDH, ALT and AST were increased. R1 treatment attenuated these alterations except for IL-6 and MCP-1. CONCLUSION： R1 prevents I/R-induced hepatic microcirculation disturbance and hepatocyte injury, The effect of R1 is related to its inhibition of leukocyte rolling and adhesion by inhibiting the expression of E-selectin in endothelium and CD18 in neutrophils.

关键词： Ischemia/reperfusion Notoginsenoside R1 Leukoytes adhesion E-selectin hepatic injury

Comparison of total splenic artery embolization and partial splenic embolization for hypersplenism

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World Journal of Gastroenterology 2012年第24期18卷 3138-3144页

作者： Xin-Hong he jian-jian Gu Wen-Tao Li Wei-jun Peng Guo-Dong Li Sheng-Ping wang Li-Chao Xu jun ji Department of Radiology Cancer Hospital/Cancer Institute Shanghai Medical CollegeFudan University Shanghai 200032 China Department of Oncology People's Hos-pital of Tongzhou District Nantong 226300 Jiangsu ProvinceChina

AIM:To evaluate whether total splenic artery embolization(TSAE) for patients with hypersplenism delivers better long-term outcomes than partial splenic embolization(PSE).METHODS:Sixty-one patients with hypersplenism eligible for TSAE(n = 27,group A) or PSE(n = 34,group B) were enrolled into the trial,which included clinical and computed tomography *** on technical success,length of hospital stay,white blood cell(WBC) and platelet(PLT) counts,splenic volume and complications were collected at 2 wk,6 mo,and 1,2,3,4 years ***:Both TSAE and PSE were technically successful in all *** were significantly fewer(P = 0.001),and hospital stay significantly shorter(P = 0.007),in group A than in group *** WBC and PLT counts in group A were significantly higher than those in group B from 6 mo to 4 years(P = 0.001),and post-procedure residual splenic volume in group A was significantly less than that observed in group B at 1,2,3 and 4 years post-procedure(P = 0.001).No significant differences were observed in red blood cell counts and liver function parameters between the two groups following the ***:Our results indicate that TSAE for patients with hypersplenism not only delivers a better longterm outcome,but is also associated with lower complication rates and a shorter hospital stay than PSE.

关键词： Embolization Hypersplenism Complications White cell counts Platelet counts

Diverse structures and antihepatoma effect of sesquiterpenoid dimers from Artemisia eriopoda by AKT/STAT signaling pathway

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Signal Transduction and Targeted Therapy 2023年第3期8卷 898-900页

作者： Xiaofeng he Wenjing Ma jing Hu Tianze Li Changan Geng Yunbao Ma Mengfei wang Kexin Yang Xuemei Zhang ji-jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201PR China University of Chinese Academy of Sciences Beijing 100049PR China

Dear Editor,Liver cancer as a common malignant tumor has become a major source of morbidity and mortality worldwide.1 Currently,four synthetic drugs and three monoclonal antibody drugs have been approved for the treatment of hepatocellular carcinoma(HCC)since ***,the disadvantages of the above drugs such as low response rates,severe side effects,and drug resistance hamper their therapeutic *** and biologically diverse natural products are a major source in the search for novel antihepatoma agents.

关键词： drugs mortality Liver

New experimental measurement of^(nat)Se(n,γ)cross section between 1 eV to 1 keV at the CSNS Back-n facility

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Chinese Physics B 2022年第8期31卷 117-124页

作者： Xin-Rong Hu long-Xiang Liu Wei jiang jie Ren Gong-Tao Fan Hong-Wei wang Xi-Guang Cao long-long Song Ying-Du Liu Yue Zhang Xin-Xiang Li Zi-Rui Hao Pan Kuang Xiao-he wang ji-Feng Hu Bing jiang De-Xin wang Suyalatu Zhang Zhen-Dong An Yu-Ting wang Chun-wang Ma jian-jun he jun Su Li-Yong Zhang Yu-Xuan Yang Sheng jin Kai-jie Chen Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China Key Laboratory of Nuclear Data China Institute of Atomic EnergyBeijing 102413China Xiangtan University Xiangtan 411105China Institute of Nuclear Physics Inner Mongolia University for the NationalitiesTongliao 028000China Sun Yat-sen University Zhuhai 510275China henan Normal University Xinxiang 453007China Beijing Normal University Beijing 100875China School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450052China ShanghaiTech University Shanghai 200120China

The^(74)Se is one of 35 p-nuclei,and^(82)Se is a r-process only nucleus,and their(n,γ)cross sections are vital input parameters for nuclear astrophysics reaction network *** neutron capture cross section in the resonance range of isotopes and even natural selenium samples has not been ***γ-rays originating from neutron-induced capture events were detected by four C_(6)D_(6) liquid scintillator detectors at the Back-n facility of China Spallation Neutron Source(CSNS).The pulse height weighting technique(PHWT)was used to analyze the data in the 1 e V to 100 ke V *** deduced neutron capture cross section was compared with ENDF/B-VIII.0,JEFF-3.2,and JENDL-4.0,and some differences were *** parameters were extracted by the R-matrix code SAMMY in the 1 e V-1 ke V *** the cross sections ofnatSe and resonance parameters are given in the *** datasets are openly available at http://***/10.11922/sciencedb.j00113.00019.

关键词： ^(nat)Se(n γ)cross section CSNS Back-n facility C_6D_6 detectors resolved resonance region Rmatrix