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Efficacy and safety of remimazolam in bronchoscopic sedation:A meta-analysis

World Journal of Clinical Cases 2024年第6期12卷 1120-1129页

作者： Ying zhou Cheng Zhao Yi-Xun tang ji-Tong Liu Department of Anesthesiology The First Affiliated Hospital of Hunan Normal University(Hunan Provincial People’s Hospital)Changsha 410005Hunan ProvinceChina Department of Anesthesiology Zhangjiajie People's HospitalZhangjiajie 427000Hunan ProvinceChina

BACKGROUND Remimazolam is a new benzodiazepine used for procedural sedation and general anesthesia.Several studies have used remimazolam for bendable bronchoscopy.AIM To assess the safety and efficacy of remimazolam for sedation in patients undergoing bendable bronchoscopy by performing a meta-analysis of randomized controlled trials(RCTs).METHODS We searched the EMBASE,PubMed,Cochrane Library,and Web of Science databases for RCTs on bendable bronchoscopic procedural sedation with remimazolam vs conventional sedatives(CS).RESULTS Five studies with 1080 cases were included.Remimazolam had the same sedation success rate compared with CS[relative risk(RR):1.35,95%CI:0.60-3.05,P=0.474,I2=99.6%].However,remimazolam was associated with a lower incidence of hypotension(RR:0.61;95%CI:0.40-0.95,P=0.027;I2=65.1%)and a lower incidence of respiratory depression(RR:0.50,95%CI:0.33-0.77,P=0.002,I2=42.3%).A subgroup analysis showed a higher success rate of sedation with remimazolam than midazolam(RR:2.45,95%CI:1.76-3.42,P<0.001).Compared with propofol,the incidence of hypotension(RR:0.45,95%CI:0.32-0.64,P<0.001,I2=0.0%),respiratory depression(RR:0.48,95%CI:0.30-0.76,P=0.002,I2=78.4%),hypoxemia(RR:0.36,95%CI:0.15-0.87,P=0.023),and injection pain(RR:0.04,95%CI:0.01-0.28,P=0.001)were lower.CONCLUSION Remimazolam is safe and effective during bronchoscopy.The sedation success rate was similar to that in the CS group.However,remimazolam has a higher safety profile,with fewer inhibitory effects on respiration and circulation.

关键词： Remimazolam Bronchoscopy Procedural sedation Meta-analysis

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High-excited-state splitting and multimode vibrational coupling in Mn^(4+)-activated fluoride phosphor

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 95-101页

作者： Debao Zhang Wanggui Ye Xuguang Cao ji zhou Fei tang Changcheng Zheng jiqiang Ning Shijie Xu Department of Optical Science and Engineering School of Information Science and TechnologyFudan University Shanghai 200438China jiangsu Key Laboratory of Advanced Laser Materials and Devices Schoolof Physics and Electronic Engineering Jiangsu Normal UniversityXuzhou 221116China Division of Natural and Applied Sciences Duke Kunshan UniversityKunshan 215316China

Excited-states play a crucial role in the optical absorption and luminescence of solids and hence their accurate information is highly desired. Herein, we attempt to seize the excited-states information of Mn^(4+)ions in K_(2)SiF_(6) microcrystals via measuring and calculating their variable-temperature photoluminescence excitation(PLE) spectra. At cryogenic temperatures, an unpredicted splitting of the high-excited-state is observed. Moreover, the two-split high-excited-state levels are further revealed to primarily couple with the two hyperfine split modes of quasi-localized ν2 vibration in the distorted Mn-F_(6) octahedral configuration,whereas the coupling strengths are found to be substantially different from each other. The slightly split vibrational mode is firmly supported by the low-temperature Raman spectra. Jahn-Teller lattice distortion is believed to be responsible for the observed splitting of the electronic high-excited-state and the quasi-localized vibrational mode.

关键词： splitting of excited-state photoluminescence excitation spectrum electron-phonon coupling Jahn-Teller effect

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Small Cycles Property of Some Cremer Rational Maps and Polynomials

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Chinese Annals of Mathematics,Series B 2024年第1期45卷 123-136页

作者： Rong FU ji zhou Faculty of Science Yibin UniversityYibin 644000SichuanChina Department of Mathematical Sciences Sichuan Normal UniversityChengdu 610066China

This paper concerns the linearization problem on rational maps of degree d≥2 and polynomials of degree d>2 from the perspective of non-linearizability.The authors introduce a set l_(∞) of irrational numbers and show that if α∈l_(∞),then any rational map is not linearizable and has infinitely many cycles in every neighborhood of the fixed point with multiplier λ=e^(2πiα),Adding more constraints to cubic polynomials,they discuss the above problems by polynomial-like maps.For the family of polynomials,with the help of Yoccoz's method,they obtain its maximum dimension of the set in which the polynomials are non-linearizable.

关键词： Irrationally indifferent fixed point Linearization problem Small cycles property

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Deep-reinforcement-learning-based UAV autonomous navigation and collision avoidance in unknown environments

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Chinese Journal of Aeronautics 2024年第3期37卷 237-257页

作者： Fei WANG Xiaoping ZHU zhou zhou Yang tang School of Astronautics Northwestern Polytechnical UniversityXi’an 710072China School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China

In some military application scenarios,Unmanned Aerial Vehicles(UAVs)need to perform missions with the assistance of on-board cameras when radar is not available and communication is interrupted,which brings challenges for UAV autonomous navigation and collision avoidance.In this paper,an improved deep-reinforcement-learning algorithm,Deep Q-Network with a Faster R-CNN model and a Data Deposit Mechanism(FRDDM-DQN),is proposed.A Faster R-CNN model(FR)is introduced and optimized to obtain the ability to extract obstacle information from images,and a new replay memory Data Deposit Mechanism(DDM)is designed to train an agent with a better performance.During training,a two-part training approach is used to reduce the time spent on training as well as retraining when the scenario changes.In order to verify the performance of the proposed method,a series of experiments,including training experiments,test experiments,and typical episodes experiments,is conducted in a 3D simulation environment.Experimental results show that the agent trained by the proposed FRDDM-DQN has the ability to navigate autonomously and avoid collisions,and performs better compared to the FRDQN,FR-DDQN,FR-Dueling DQN,YOLO-based YDDM-DQN,and original FR outputbased FR-ODQN.

关键词： Faster R-CNN model Replay memory Data Deposit Mechanism(DDM) Two-part training approach Image-based Autonomous Navigation and Collision Avoidance(ANCA) Unmanned Aerial Vehicle(UAV)

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Investigation on UV-curing Reprocessable Thermosets Bearing Hindered Urea Bonds and Their Composites with Modified Zinc Oxide Nanoparticles

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Chinese Journal of Polymer Science 2024年第6期42卷 751-765页

作者： Jun-Hao zhou Li-Ming tang Key Laboratory of Advanced Materials of Ministry of Education of China Department of Chemical EngineeringTsinghua UniversityBeijing100084China

In this study,a series of hindered urea bond(HUB)containing polyurethane-urea methacrylate prepolymers and a none HUB containing polyurethane methacrylate prepolymer were prepared using isobornyl methacrylate as the reactive diluent via one-pot procedure.The prepolymers were characterized fully by various techniques.Then,their thermosets were fabricated via UV curing in presence of a photo initiator,and their mechanical property and thermal behavior were investigated and compared.Different from the none HUB containing thermoset,the HUB containing thermosets(defined as PUT)could be recycled and reprocessed by hot press under relatively mild conditions with high recovery ratio of mechanical property.Furthermore,zinc oxide(ZnO)nanoparticles were modified with 3-(trimethoxysilyl)propyl methacrylate and the modified ZnO(defined as ZnO-TPM)was dispersed and polymerized into PUT matrix to prepare their nanocomposites.The influence of ZnO-TPM on the mechanical performance of the composites was evaluated,which indicated that the Young’s modulus and tensile strength increased gradually to the maximum values at ZnO-TPM content of 1 wt%and then decreased.The composites also displayed good reprocessability with improved recovery ratio compared to the pure PUT sample.In addition,the composite materials exhibited strong UV absorption capacity,implying their potential application in the circumstance where UV-shielding was required.

关键词： Polyurethane-urea methacrylate Hindered urea bond ZnO nanoparticles Reprocessing UV curing

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Effect of structural characteristics on the transport characteristics of solid particles in the thermal storage and release system of circulating fluidized bed

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Particuology 2024年第6期89卷 22-31页

作者： Zengcai ji Guoliang Song Zihua tang Liwei Sun Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China Dalian National Laboratory for Clean Energy Dalian116023China

Coal-fired power generation stands as the most economically viable modulating power source in present-day China.It holds the potential to offer prospective solutions to the challenges posed by the rapid expansion of intermittent,unpredictable,and unstable renewable energy sources.Solid particle thermal storage technology emerges as an effective means to enhance the flexibility of coal-fired circulating fluidized bed power units.To attain an optimized structure for the solid particle thermal storage and release system in circulating fluidized bed units,experimental research was conducted on a 0.1 MWth circulating fluidized bed test platform.This study delved into the impact of ash storage bin geometries and the shapes of their feed-discharge valves on the control properties of solid particle transportation.The experimental outcomes reveal that employing inverted m-shaped valve and dual U-shaped valves for feed control,alongside U-shaped valves and N-shaped valves for discharge control,both enable efficient and rapid storage and release of solid particles within the circulating fluidized bed.Under similar air distribution conditions,the inverted m-shaped valve exhibits lower conveying energy consumption than the dual U-shaped valves,while the N-shaped valve excels in control characteristics over the U-shaped valve.Furthermore,the inverted m-shaped valve and the N-shaped valve demonstrate optimal overflow port heights,and the ash storage bin exhibits an optimum height-to-diameter ratio.

关键词： Solid particle Thermal storage System structure Transport regulation

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Identifying and localizing of seismogenic electromagnetic anomalies from data observed by permanent MT stations

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Science China Earth Sciences 2024年第5期67卷 1698-1713页

作者： Bing HAN Wenbao HU Guoze ZHAO ji tang State Key Laboratory of Earthquake Dynamics Institute of GeologyBeijing 100029China Key Laboratory of Exploration Technologies for Oil and Gas Resources of Ministry of Education Yangtze UniversityWuhan 430100China

In this research, an arbitrarily oriented electric dipole at subsurface is used to simulate Seismogenic Electromagnetic(SEM) radiation emanating from a seismic zone during its gestation phase. Analytical synthesis of responses at the Lijiang magnetotelluric(MT) station has revealed that SEM radiation could induce identifiable anomalies in the electromagnetic(EM)spectrum, apparent resistivity and phase within specific frequency bands. Background variations were extracted from long-term observation data of Dali and Lijiang MT stations, enabling the identification of SEM anomalies related to the Yunlong and Yangbi earthquakes. Multiple parameters of dipole sources at subsurface were obtained by applying the Differential Ant Colony Optimization(DACO) algorithm to anomalous data of two stations with multi-frequencies and various response functions. The spatial distribution of these predicted dipoles is predominantly clustered in or around the seismogenic area, with their azimuthal orientation aligning towards the seismogenic fault in general. This study has demonstrated the potential of using subsurface electric dipole simulations for SEM radiation analysis, offering a feasible approach for the prediction and understanding of seismogenic zones.

关键词： MT responses Identifying SEM anomaly Vector electric dipole responses Localizing SEM sources by inversion

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An efficient physics-guided Bayesian framework for predicting ground settlement profile during excavations in clay

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1411-1424页

作者： Cong tang Shuyu He Wanhuan zhou State Key Laboratory of Internet of Things for Smart City and Department of Civil and Environmental Engineering University of MacaoChina

Recently,the application of Bayesian updating to predict excavation-induced deformation has proven successful and improved prediction accuracy significantly.However,updating the ground settlement profile,which is crucial for determining potential damage to nearby infrastructures,has received limited attention.To address this,this paper proposes a physics-guided simplified model combined with a Bayesian updating framework to accurately predict the ground settlement profile.The advantage of this model is that it eliminates the need for complex finite element modeling and makes the updating framework user-friendly.Furthermore,the model is physically interpretable,which can provide valuable references for construction adjustments.The effectiveness of the proposed method is demonstrated through two field case studies,showing that it can yield satisfactory predictions for the settlement profile.

关键词： Bayesian updating Excavations Ground settlement profile Simplified model Uncertainty

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Predicting the International Roughness Index of JPCP and CRCP Rigid Pavement:A Random Forest(RF)Model Hybridized with Modified Beetle Antennae Search(MBAS)for Higher Accuracy

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1557-1582页

作者： zhou ji Mengmeng zhou Qiang Wang jiandong Huang College of Civil and Environmental Engineering Hunan University of Science and EngineeringYongzhou425006China School of Mines China University of Mining and TechnologyXuzhou221116China School of Civil Engineering Guangzhou UniversityGuangzhou510006China

To improve the prediction accuracy of the International Roughness Index(IRI)of Jointed PlainConcrete Pavements(JPCP)and Continuously Reinforced Concrete Pavements(CRCP),a machine learning approach is developed in this study for the modelling,combining an improved Beetle Antennae Search(MBAS)algorithm and Random Forest(RF)model.The 10-fold cross-validation was applied to verify the reliability and accuracy of the model proposed in this study.The importance scores of all input variables on the IRI of JPCP and CRCP were analysed as well.The results by the comparative analysis showed the prediction accuracy of the IRI of the newly developed MBAS and RF hybrid machine learning model(RF-MBAS)in this study is higher,indicated by the RMSE and R values of 0.2732 and 0.9476 for the JPCP as well as the RMSE and R values of 0.1863 and 0.9182 for the CRCP.The accuracy of this obtained result far exceeds that of the IRI prediction model used in the traditional Mechanistic-Empirical Pavement Design Guide(MEPDG),indicating the great potential of this developed model.The importance analysis showed that the IRI of JPCP and CRCP was proportional to the corresponding input variables in this study,including the total joint faulting cumulated per KM(TFAULT),percent subgrade material passing the 0.075-mm Sieve(P_(200))and pavement surface area with flexible and rigid patching(all Severities)(PATCH)which scored higher.

关键词： Cement pavement JPCP CRCP RF-MBAS IRI

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Research on modeling and self-excited vibration mechanism in magnetic levitation-collision interface coupling system

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 873-890页

作者： jinghu tang Chaofeng LI jin zhou Zhiwei WU School of Mechanical Engineering&Automation Northeastern UniversityShenyang 110819China Key Laboratory of Vibration and Control of Aero-Propulsion Systems of Ministry of Education of China Northeastern UniversityShenyang 110819China School of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016China

The modeling and self-excited vibration mechanism in the magnetic levitation-collision interface coupling system are investigated.The effects of the control and interface parameters on the system's stability are analyzed.The frequency range of self-excited vibrations is investigated from the energy point of view.The phenomenon of self-excited vibrations is elaborated with the phase trajectory.The corresponding control strategies are briefly analyzed with respect to the vibration mechanism.The results show that when the levitation objects collide with the mechanical interface,the system's vibration frequency becomes larger with the decrease in the collision gap;when the vibration frequency exceeds the critical frequency,the electromagnetic system continues to provide energy to the system,and the collision interface continuously dissipates energy so that the system enters the self-excited vibration state.

关键词： magnetic levitation coupling system self-excited vibration mechanical interface vibration frequency

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