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Boeravinone B ameliorates allergic nasal inflammation by modulating the GATA-3/T-bet signaling pathway in a mouse model of allergic rhinitis

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 245-252页

作者： Ben Ye ji-zhe Wang Department of Otorhinolaryngology Second Hospital of Dalian Medical UniversityDalian116000China Department of Otorhinolaryngology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250000China

Objective:To evaluate the anti-allergic effect of boeravinone B against ovalbumin-induced allergic rhinitis in mice and explore its possible ***:For the induction of allergic rhinitis,mice were intraperitoneally sensitized and intranasally challenged with ovalbumin,as well as orally received various concentrations of boeravinone *** mucosal inflammation,and the levels of nitric oxide,β-hexosaminidase,IFN-γ,LTC-4,myeloperoxidase,Nrf2,HO-1,GATA-3,ROR-γ,T-bet,antioxidant parameters,and allergen-specific cytokines were ***:Boeravinone B markedly reduced ovalbumin-induced increase in the number of episodes of nasal sneezing,rubbing,and discharge,as well as the levels of IgE,IgG1,andβ-hexosaminidase(P<0.05).It also significantly reduced differential cell count,myeloperoxidase,oxide-nitrosative stress,and the levels of IL-1β,IL-4,IL-5,IL-6,IL-13,IL-17,tumor necrosis factor-α,GATA-3,and ROR-γwhile enhancing the level of ***:Boeravinone B is a potential therapeutic agent for allergic rhinitis by modulating various inflammatory mediators and immune responses.

关键词： Allergic reaction Boeravinone B Oxidative stress Inflammation Ovalbumin

Index-free triangle-based graph local clustering

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Frontiers of Computer Science 2024年第3期18卷 143-153页

作者： zhe YUAN zhewei WEI Fangrui LV ji-Rong WEN The Country and Area Studies Academy Beijing Foreign Studies UniversityBeijing 100089China Gaoling School of Artificial Intelligence Renmin University of ChinaBeijing 100872China

Motif-based graph local clustering(MGLC)is a popular method for graph mining tasks due to its various ***,the traditional two-phase approach of precomputing motif weights before performing local clustering loses locality and is impractical for large *** some attempts have been made to address the efficiency bottleneck,there is still no applicable algorithm for large scale graphs with billions of *** this paper,we propose a purely local and index-free method called Index-free Triangle-based Graph Local Clustering(TGLC^(*))to solve the MGLC problem w.r.t.a ***^(*)directly estimates the Personalized PageRank(PPR)vector using random walks with the desired triangleweighted distribution and proposes the clustering result using a standard sweep *** demonstrate TGLC^(*)’s scalability through theoretical analysis and its practical benefits through a novel visualization ***^(*)is the first algorithm to solve the MGLC problem without precomputing the motif *** experiments on seven real-world large-scale datasets show that TGLC^(*)is applicable and scalable for large graphs.

关键词： graph local clustering triangle motif index-free sampling method visualization

Nuclearity and Finite-Representability in the System of Completely Integral Mapping Spaces

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Acta Mathematica Sinica,English Series 2024年第5期40卷 1197-1214页

作者： zhe DONG ji Cheng TAO Ya Fei ZHAO Department of Mathematics Zhejiang UniversityHangzhou 310027P.R.China Department of Mathematics China Jiliang UniversityHangzhou 310018P.R.China Department of Mathematics Zhejiang International Studies UniversityHangzhou 310023P.R.China

In this paper,we investigate local properties in the system of completely integral mapping *** introduce notions of injectivity,local reflexivity,exactness,nuclearity,finite-represent ability and WEP in the system of completely integral mapping *** we obtain that any finite-dimensional operator space is injective in the system of completely integral mapping *** we prove that C is the unique nuclear operator space and the unique exact operator space in this *** also show that C is the unique operator space which is finitely representable in{T_(n)}n∈Nin this *** corollaries,Kirchberg’s conjecture and QWEP conjecture in the system of completely integral mapping spaces are false.

关键词： Completely integral mapping space injectivity exactness nuclearity finite-representability WEP

A novel control strategy for reproducing the floor motions of high-rise buildings by earthquake-simulating shake tables

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Earthquake Research Advances 2024年第1期4卷 67-75页

作者： Yuteng Cao zhe Qu Xiaodong ji Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin150080China Key Laboratory of Civil Engineering Safety and Durability of China Education Ministry Department of Civil EngineeringTsinghua UniversityBeijing100084China

To enable the experimental assessment of the seismic performance of full-scale nonstructural elements with multiple engineering parameters(EDPs),a three-layer testbed named Nonstructural Element Simulator on Shake Table(NEST)has been *** testbed consists of three consecutive floors of steel *** bottom two floors provide a space to accommodate a full-scale *** fully explore the flexibility of NEST,we propose a novel control strategy to generate the required shake table input time histories for the testbed to track the target floor motions of the buildings of interest with high *** control strategy contains two parts:an inverse dynamic compensation via simulation of feedback control systems(IDCS)algorithm and an offline iteration procedure based on a refined nonlinear numerical model of the *** key aspects of the control strategy were introduced in this *** tests were conducted to simulate the seismic responses of a full-scale office room on the 21^(st)floor of a 42-story high-rise *** test results show that the proposed control strategy can reproduce the target floor motions of the building of interest with less than 20%errors within the specified frequency range.

关键词： Shake table test Nonstructural element High-rise building Open-loop IDCS algorithm Off-line iteration

ChMYB1-ChbHLH42-ChTTG1 module regulates abscisic acidinduced anthocyanin biosynthesis in Cerasus humilis

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Horticultural Plant Journal 2024年第1期10卷 51-65页

作者： Xiaolong ji zhe Li Mingyu Zhang Shaoyu Lang Xingshun Song State Key Laboratory of Tree Genetics and Breeding Northeast Forestry UniversityHarbinHeilongjiang 150040China Department of Genetics College of Life ScienceNortheast Forestry UniversityHarbinHeilongjiang 150040China

Cerasus humilis is a kind of economic fruit tree peculiar to China,which is widely used in the food,landscape,and pharmaceutical *** are a phenolic metabolite that plays an essential role in fruit ***,the regulatory network of *** in anthocyanin biosynthesis is still *** this study,the R2R3-MYB transcription factor ChMYB1 was isolated from the full genome of the *** one-hybrid,dual-luciferase assays,and GUS staining showed that ChMYB1 significantly increased anthocyanin contents in *** fruit by promoting the expression of ChCHS and ChUFGT by binding MBS(MYB-binding elements).ChMYB1 interacted with ChbHLH42and ChTTG1 to form the MBW complex and further enhanced the expression of *** addition,abscisic acid(ABA)treatment promoted the expression of ChMYB1 and anthocyanin accumulation in *** ***,ABA treatment enhanced the interaction between ChMYB1 and ***,ChABI5 inhibited the interaction between ChMYB1 and *** data elucidated the primary molecular mechanism of anthocyanin biosynthesis in *** fruit,deepening the understanding of the regulatory network affecting anthocyanin metabolism in edible fruit crops.

关键词： Cerasus humilis Anthocyanin ChMYB1 Fruit ABA

Effects of brinzolamide on rabbit ocular blood flow in vivo and ex vivo

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International Journal of Ophthalmology(English edition) 2018年第5期11卷 719-725页

作者： Ya-Ru Dong Shi-Wei Huang ji-zhe cui Takeshi Yoshitomi Department of Ophthalmology the Second Hospital of Jilin University Department of Ophthalmology Akita University School of Medicine

AIM：To investigate if significant improvement of optic disc blood flow（ODBF） occurs after instillation of brinzolamide onto rabbit ***：Testing of bilateral intraocular pressure（IOP） and left ODBF in 10 male rabbits took place every 3 h over a 24 h ***（1% ophthalmic solution,two drops at 9：00 and 21：00） was administered to the left ***,assessed using laser speckle flowgraphy,was determined as the mean blur rate（MBR）.Furthermore,the effect of brinzolamide on isolated rabbit ciliary arteries using isometric tension recording system was ***：After brinzolamide instillation,IOP was significantly decreased in the left ***-vessel was greater at 18：00 and 21：00（P〈0.05） than in the *** and MBR-average were greater at 18：00（P〈0.05） than in the *** isolated arteries pre-contracted with a high-K solution,brinzolamide induced concentration-dependent relaxation,reaching 46.1%±9%（n=21） at 1 mmol/*** Ca^2＋-free solutions,incubation with brinzolamide suppressed 1 μmol/L histamine-induced contractions（P〈0.05）.CONCLUSION：Brinzolamide decreases IOP and increases ocular blood *** direct vasodilatory effect of brizolamide is mediated by suppression of Ca^2＋ release from intracellular calcium stores.

关键词： brinzolamide ocular blood flow vasodilation intraocular pressure ciliary artery

A Brief Overview of the Development and Significance of Modern Scientific Medicine in China:Take Chinese Academy of Medical Science and Peking Union Medical College as an Example

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Chinese Medical Sciences Journal 2024年第2期39卷 140-143页

作者： Pu-An cui zhe-Xi Gong Zhong He School of Humanities and Social Sciences Chinese Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China

Since the early 20th century,China has gradually established a clinical,educational,and research system centered around modern scientific medicine,which has now become the dominant force in China's medical and health system and services,with the construction and development of the Chinese Academy of Medical Sciences and Peking Union Medical College as the most prominent *** scientific medicine in the new era requires close cooperation across multiple disciplines and fields to build a high-quality and efficient medical and health service *** also involves combining the excellent traditional Chinese culture with Western medicine to explore a unique path of modern scientific medicine with Chinese characteristics.

关键词： modern scientific medicine cultural confidence multiple view

Cognitive Navigation for Intelligent Mobile Robots:A Learning-Based Approach With Topological Memory Configuration

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 1933-1943页

作者： Qiming Liu Xinru cui zhe Liu Hesheng Wang Department of Automation Shanghai Jiao Tong UniversityShanghai 200240China MoE Key Laboratory of Artificial Intelligence AI InstituteShanghai Jiao Tong UniversityShanghai 200240China Department of Automation Key Laboratory of System Control and Information Processing of Ministry of EducationKey Laboratory of Marine Intelligent Equipment and System of Ministry of EducationShanghai Engineering Research Center of Intelligent Control and ManagementShanghai Jiao Tong UniversityShanghai 200240China

Autonomous navigation for intelligent mobile robots has gained significant attention,with a focus on enabling robots to generate reliable policies based on maintenance of spatial *** this paper,we propose a learning-based visual navigation pipeline that uses topological maps as memory *** introduce a unique online topology construction approach that fuses odometry pose estimation and perceptual similarity *** tackles the issues of topological node redundancy and incorrect edge connections,which stem from the distribution gap between the spatial and perceptual ***,we propose a differentiable graph extraction structure,the topology multi-factor transformer(TMFT).This structure utilizes graph neural networks to integrate global memory and incorporates a multi-factor attention mechanism to underscore elements closely related to relevant target cues for policy *** from photorealistic simulations on image-goal navigation tasks highlight the superior navigation performance of our proposed pipeline compared to existing memory *** validation through behavior visualization,interpretability tests,and real-world deployment further underscore the adapt-ability and efficacy of our method.

关键词： Graph neural networks(GNNs) spatial memory topological map visual navigation

Potential application of radiant floor cooling systems for residential buildings in different climate zones

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Building Simulation 2024年第4期17卷 543-560页

作者： Mengying cui Yang Song Yudong Mao Kaimin Yang jiying Liu zhe Tian School of Thermal Engineering Shandong Jianzhu UniversityJinan250101China School of Environmental Science and Engineering Tianjin UniversityTianjin300072China Key Lab of Building Environment and Energy of Tianjin Tianjin UniversityTianjin300072China

A radiant floor cooling system(RFCS)is a high-comfort and low energy consumption system suitable for residential *** floor systems usually work with fresh air,and their operating performance is affected by climatic *** and outdoor environmental disturbances and the system’s control strategy affect the indoor thermal comfort and energy efficiency of the ***,a multi-story residential building model was established in this *** system simulation program was used to study the operation dynamics of three control strategies of the RFCS based on the calibrated ***,the performance of the control strategies in five climate zones in China were compared using multi-criteria decision-making in *** results show that control strategy has a negligible effect on condensation risk,but the thermal comfort and economic performance differ for different control *** adaptability of different control strategies varies in different climate zones based on the consideration of multiple *** performance of the direct-ground cooling source system is better in Hot summer and warm winter *** variable air volume control strategy scores higher in Serve cold and Temperate zones,and the hours exceeding thermal comfort account for less than 3%of the total simulation ***,it is suggested to choose the RFCS control strategy for residential buildings according to the climate zone characteristics,to increase the energy *** results provide a reliable reference for implementing RFCSs in residential buildings.

关键词： control strategy radiant floor cooling system residential building energy efficiency climate zones