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Asian Pacific Journal of Tropical Medicine 2015年第7期8卷 536-540页

作者： Jang-Gi choi ji-young choi Su-Hyun Mun Ok-Hwa Kang Preeti Bharaj Dong-Won Shin Myong-Soo Chong Dong-Yeul Kwon Department of Oriental Pharmacy College of Pharmacy Wonkwang University Wonkwang Oriental Medicines Research Institute Center of Excellence in Infectious Disease Research Department of Biomedical Sciences Paul L. Foster School of Medicine Texas Tech University Health Sciences Center Department of Third Medicine Professional Graduate School of Oriental Medicine Wonkwang University BK21 Plus Team Professional Graduate School of Oriental Medicine Wonkwang University Department of Oriental Medicine Resources Sunchon National University

Objective: To investigate the antibacterial activity of SHHextracted with either water or ethanol against methicillin-resistant Staphylococcus aureus(MRSA) and combinatory antimicrobial effect with ciprofloxacin(CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan(SHH) water extract(SHHW) and SHH ethanol extract(SHHE) ranged from 250 to 2000 μg/m L and 125 to 1000 μg/m L against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.

关键词： Sami-Hyanglyun-Hwan Methicillin-resistant Staphylococcus aureus Ciprofloxacin Synergy

Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan choi Soo-Ho choi Keun-young Kim Yury I.Miller Won-Kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon Koh Hyo jin Cho Xuelian jin Byung Gon Kim Jun young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of Geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

韩国20-64岁成人核黄素摄入水平与营养状况评价

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韩国20-64岁成人核黄素摄入水平与营养状况评价

MicroRNA miR-252-5p regulates the Notch signaling pathway by targeting Rab6 in Drosophila wing development

作者： ji young choi young-Nam Kim Youn-OK Cho 边祥雨郭长江天津卫生学环境医学研究所

前言:核黄素(维生素B2)是一种水溶性维生素,膳食中常以黄素单核苷酸和黄素腺嘌呤二核苷酸辅酶形式和蛋白质结合存在,进入人体消化系统后转变成游离状态,经吸收后作为电子载体参与代谢中的多种氧化还原反应,并且在其它B族维生素、药物和...

前言:核黄素(维生素B2)是一种水溶性维生素,膳食中常以黄素单核苷酸和黄素腺嘌呤二核苷酸辅酶形式和蛋白质结合存在,进入人体消化系统后转变成游离状态,经吸收后作为电子载体参与代谢中的多种氧化还原反应,并且在其它B族维生素、药物和脂质代谢过程中扮演重要角色。据报道,包括美国、英国、法国、波兰和日本在内的多个国家,人群核黄素摄入不足的情况比较明显。前期的研究表明,核黄素缺乏会增加肺、胃、食道和直肠癌变的风险,

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Insect Science 2023年第5期30卷 1431-1444页

作者： Do-Hwan Lim Min-Seok choi ji Won Jeon young Sik Lee School of Systems Biomedical Science Soongsil UniversitySeoulRepublic of Korea College of Life Sciences and Biotechnology Korea UniversitySeoulRepublic of Korea Institute of Animal Molecular Biotechnology Korea UniversitySeoulRepublic of Korea

The Notch signaling pathway plays a central role in the development of various ***,dysregulation of microRNAs(miRNAs),which are crucial regulators of gene expression,can disrupt signaling pathways at all stages of *** Notch signaling is involved in wing development in Drosophila,the mechanism underlying miRNA-based regulation of the Notch signaling pathway is ***,we report that loss of Drosophila miR-252 increases the size of adult wings,whereas the overexpression of miR-252 in specific compartments of larval wing discs leads to patterning defects in the adult *** miR-252 overexpression-induced wing phenotypes were caused by aberrant Notch signaling with intracellular accumulation of the full-length Notch receptor during development,which could be due to defects in intracellular Notch trafficking associated with its recycling to the plasma membrane and autophagy-mediated ***,we identified Rab6 as a direct target of miR-252-5p;Rab6 encodes a small Ras-like GTPase that regulates endosomal trafficking *** with this finding,RNAi-mediated downregulation of Rab6 led to similar defects in both wing patterning and Notch ***,co-overexpression of Rab6 completely rescued the wing phenotype associated with miR-252 overexpression,further supporting that Rab6 is a biologically relevant target of miR-252-5p in the context of wing ***,our data indicate that the miR-252-5p-Rab6 regulatory axis is involved in Drosophila wing development by controlling the Notch signaling pathway.

关键词： Drosophila miR-252-5p Notch signaling Rab6 wing development

Assessment of the clear-sky bias issue using continuous PM10 data from two AERONET sites in Korea

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Journal of Environmental Sciences 2017年第3期29卷 151-160页

作者： Yongjoo choi young Sung Ghim Department of Environmental Science Hankuk University of Foreign StudiesYongin 449-791Korea

A bias in clear-sky conditions that will be involved in estimating particulate matter （PM） concentration from aerosol optical depth （AOD） was examined using PM10 from two Aerosol Robotic Network sites in Korea. The study periods were between 2004 and 2007 at Anmyon and between 2003 and 2011 at Gosan, when both PM10 and AOD were available. Mean PM10 when AOD was available （PMAOD） was higher than that from all PM10 data （PMall） by 5.1 and 9.9 μg/m3 at Anmyon and Gosan, which accounted for 11% and 26% of PMall, respectively. Because of a difference between mean PM10 under daytime clear-sky conditions （PMclear） and PMAoD, the variations in APM10, the difference of PMan from PMdear rather than from PMAoD, were investigated. Although monthly variations in APMlo at the two sites were different, they were positively correlated to those in AT, similarly defined as APM10 except for temperature, at both sites. APM10 at Anmyon decreased to a negative value in January due to an influence of the Siberian continental high-pressure system while APM10 at Gosan was high in winter due to an effect of photochemical production at higher temperatures than at Anmyon.

关键词： AERONETData recovery rateCloud amountWind speedPhotochemical productionSiberian high

A Self‑Regenerable Fiber Sloughing Its Heavy Metal Skin for Ultrahigh Separation Capability

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Advanced Fiber Materials 2023年第6期5卷 2127-2142页

作者： youngkyun Jung ji Su Park Kyung‑Won Jung young Gun Ko Jae‑Woo choi Center for Water Cycle Research Korea Institute of Science and TechnologySeoul 02792Republic of Korea Center for Bionics Korea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Chemical Engineering and Materials Science Sangmyung UniversitySeoul 03016Republic of Korea Division of Energy&Environment Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea

Developing efficient separation materials for recovering metal resources from aqueous environments is crucial for the sustainable water–food–energy nexus,which addresses the interdependence between energy production,water production,and energy *** material-based separation processes have demonstrated outstanding ***,electric energy and chemicals are used to frequently replace the separation materials used in such processes owing to their short life *** study presents a methodology for designing the self-regenerable fiber(SRF)according to the types of metals through a self-regeneration *** SRF can semi-permanently recover the metal resources from water through a repetitive adsorption–crystallization–detachment process of metal ions on its *** ionic metal resources are adsorbed and crystallized with the counter-anions on the SRF ***,the metal crystals are self-detached from the SRF surface by the collision between the crystals and curvature and non-sticky surface of the ***,a module containing the SRF maintains its metal recovery capability even during continuous injection of the metal solution without its *** findings highlight the significance of interfacial engineering and further guide the rational design of energy/environmentally friendly resource recovery modules.

关键词： Self-regeneration model Self-regenerable fiber Semi-permanent adsorption capability Metal crystal growth-detachment

Ex situ aging effect on sulfonated poly(ether ether ketone) membrane:Hydration-dehydration cycling and hydrothermal treatment

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Journal of Energy Chemistry 2022年第7期31卷 583-592,I0014页

作者： Seung-young choi Kyeong Sik jin Polymer&Materials Chemistry Department of ChemistryLund UniversitySE-22100Sweden Center for Hydrogen·Fuel Cell Research Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and Technology(POSTECH)PohangKyungbuk 37673Republic of Korea

Prolonged hydrothermal treatment for sulfonated poly(ether ether ketone) membranes induces mechanical degradation and developing hydrophilic-hydrophobic phase separation, simultaneously. The enhanced phase separation provides incremental proton conductivity to the membranes, whereas mechanical degradation drastically reduces device stability. On this basis, we describe here the effects of two different ex situ aging processes on sulfonated poly(ether ether ketone) membranes: hydrationdehydration cycling and prolonged hydrothermal treatment. Both aged membranes exhibited enhanced phase separation under the hydrated conditions, as characterized by small angle X-ray ***, when the aged membranes were dried again, the nanostructure of the membranes aged via the hydration-dehydration cycling was recoverable, whereas that of the membranes aged via prolonged hydrothermal treatment was irreversible. Furthermore, the two differently aged membranes showed clear differences in thermal, mechanical, and electrochemical properties. Finally, we implemented both aged membranes in fuel cell application. The sample aged via hydration-dehydration cycling maintained its improved cell performance, whereas the sample aged via hydrothermal treatment showed drastically reduced cell performance after durability test for 50 h.

关键词： Sulfonated poly(ether ether ketone) Humidity cycle test Ex situ aging Proton exchange membrane Fuel cell

Pediatric schwannoma of the tongue:A case report and review of literature

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World Journal of Clinical Cases 2021年第24期9卷 7212-7217页

作者： Chang Bin Yun young-Mo Kim Jeong-Seok choi ji Won Kim Department of Otorhinolaryngology-Head and Neck Surgery Inha University College of MedicineIncheon 22212South Korea

BACKGROUND Neurogenic tumors account for about ten percent of all tumors of childhood,and benign tumor originating from Schwann cells is rare in peripheral *** of the tongue is quite rare in *** SUMMARY We present the case of an 8-year-old male with schwannoma in the anterolateral *** mass was slow-growing for one year with no pain and *** underwent transoral mass excision under general *** examination revealed a smooth surfaced,17 mm×14 mm×7 mm sized,encapsulated nodule with a clear resection *** of the tongue was confirmed by the pathological *** reported no motor or sensory change,such as dysgeusia or paresthesia,or phonation difficulty during postoperative 12 mo *** Schwannoma of the tongue is a rare benign neoplasm in *** a painless firm mass is encountered in the tongue of a child,solid tumors like schwannoma should be considered in the differential diagnosis.

关键词： Schwannoma Tongue Child Pediatric Neurogenic Tumor Case report

Comparison of the meibomian gland dysfunction in patients with chronic ocular graft-versus-host disease and Sjogren's syndrome

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 393-400页

作者： Won choi Jun young Ha Ying Li Jung Han choi Yong Sok ji Kyung Chul Yoon Department of Ophthalmology and Research Institute of Medical Sciences Chonnam National University Medical School and Hospital

AIM: To investigate the abnormalities in the meibomian gland in patients with dry eye disease(DED) associated with chronic ocular graft-versus-host disease(coGVHD) in comparison with Sj?gren's syndrome(SS), a major form of aqueous deficient DED and meibomian gland dysfunction(MGD), a common cause of evaporative ***: A total 135 eyes of 135 subjects included in this study: patients with DED associated with coGVHD(n=30), patients with SS(n=35), patients with MGD(n=35), and normal controls(n=35). All participants completed the Ocular Surface Disease Index(OSDI) questionnaire, ocular surface examination [Schirmer test, tear film breakup time(TFBUT), and ocular surface staining], and meibomian gland assessment [meiboscore(gland dropout detected on meibography using infrared camera of the Keratograph 5 M), meibum expressibility score(MES), meibum quality score(MQS), lid margin abnormality]. In addition, correlations of meibomian gland characteristics with ocular surface parameters as well as disease severity score were investigated in coGVHD ***: The coGVHD group showed significantly higher meiboscore, MES, and MQS than the other 3 groups(all P<0.05). In the coGVHD group, parameters of meibomian gland showed a significant correlation each other and those of ocular surface. The correlation between meibomian gland parameters and severity score of co GVHD was also established(meiboscore, r=0.62; MES, r=0.47; MQS, r=0.47; lid margin abnormality score, r=0.55; all P<0.05).CONCLUSION: Patients with DED associated with co GVHD show poorer gland morphology and worse glandfunction than other types of DED. In addition, meibomian gland damage is not only associated with ocular surface damage but also disease severity of coGVHD.

关键词： chronic ocular graft-versus-host disease Sjogren's syndrome dry eye disease meibomian gland dysfunction meibography